Current Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Medical Oncology,
Medicine
Chief, Division of Medical Oncology
·
2021 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Genomic and immune profiling of breast cancer brain metastases.
Journal Article Acta Neuropathol Commun · May 12, 2025 BACKGROUND: Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic ... Full text Link to item CiteTriple Negative Breast Cancer and Brain Metastases.
Journal Article Clin Breast Cancer · December 2023 The treatment of metastatic breast cancer (MBC) has improved over the past decade, however prognosis continues to be mitigated by the fact that about 1 in 5 patients with MBC will develop brain metastases (BrM) during their metastatic disease course. 1 Thi ... Full text Link to item CiteSystemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases.
Journal Article Curr Treat Options Oncol · October 2022 Brain metastasis arising from breast cancer is associated with a poor prognosis. Various systemic chemotherapy and targeted therapies which are effective against breast cancer often fail to provide benefits against brain metastasis. This is mainly due to l ... Full text Link to item CiteRecent Grants
Prospective Registry of Trastuzumab Deruxtecan in Patients with Active/Progressive HER2-Positive Breast Cancer Brain Metastases
ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2025 - 2030DATO-BASE: A phase 2 trial of DATOpotamab-deruxtecan for breast cancer Brain metAstaSEs
Clinical TrialPrincipal Investigator · Awarded by Dana-Farber Cancer Institute · 2024 - 2029BGB-43395-101 (CDK-4) - A Phase 1a/1b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of the CDK4 Inhibitor BGB-43395
Clinical TrialPrincipal Investigator · Awarded by BeiGene USA, Inc. · 2024 - 2029View All Grants
Education, Training & Certifications
East Carolina University, Brody School of Medicine ·
2002
M.D.