Current Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Medical Oncology,
Medicine
Chief, Division of Medical Oncology
·
2021 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Real-world treatment patterns and clinical outcomes with tucatinib-based therapy in patients with HER2-positive metastatic breast cancer: analyses of two nationwide administrative health claims databases.
Journal Article Int J Clin Oncol · October 2025 PURPOSE: To describe real-world characteristics and clinical outcomes among patients with HER2+ MBC receiving tucatinib-based treatments. METHODS: This retrospective study included patients diagnosed with HER2+ MBC between January 2017 and December 2022 fr ... Full text Link to item CiteA HER3-targeting antibody-drug conjugate for leptomeningeal metastasis.
Journal Article Nat Med · August 2025 Full text Link to item CiteGenomic and immune profiling of breast cancer brain metastases.
Journal Article Acta Neuropathol Commun · May 12, 2025 BACKGROUND: Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic ... Full text Link to item CiteRecent Grants
Phase 2 Study of Zelenectide Pevedotin in Participants with NECTIN4 Amplified Advanced Breast Cancer
Clinical TrialPrincipal Investigator · Awarded by BicycleTx Limited · 2025 - 2030DATO-BASE: A phase 2 trial of DATOpotamab-deruxtecan for breast cancer Brain metAstaSEs
Clinical TrialPrincipal Investigator · Awarded by Dana-Farber Cancer Institute · 2024 - 2029BGB-43395-101 (CDK-4) - A Phase 1a/1b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of the CDK4 Inhibitor BGB-43395
Clinical TrialPrincipal Investigator · Awarded by BeiGene USA, Inc. · 2024 - 2029View All Grants
Education, Training & Certifications
East Carolina University, Brody School of Medicine ·
2002
M.D.