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Chang Lung Lee

Associate Professor in Radiation Oncology
Radiation Oncology
Box 91006, Durham, NC 27708
B220 LSRC Bldg, 308 Research Dr, Box 91006, Durham, NC 27708

Overview


The overall goal of the Lee lab is to improve the therapeutic window of radiation therapy and the survivorship of cancer patients by minimizing the acute and late effects of radiation. The lab focuses on dissecting mechanisms underlying radiation-induced tissue injury and regeneration to develop novel medical countermeasures and predictive biomarkers. The Lee lab is supported by active NIH grants studying radiation-induced oral mucositis (R01DE033404), radiation-induced intestinal fibrosis (U01AI183940), and gastrointestinal acute radiation syndrome (U01AI186969).

Current Appointments & Affiliations


Associate Professor in Radiation Oncology · 2024 - Present Radiation Oncology, Clinical Science Departments
Assistant Professor in Pathology · 2020 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2018 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Mis-splicing drives loss of function of p53E224D point mutation.

Journal Article PLoS One · 2025 BACKGROUND: The tumor suppressor p53 (Trp53), also known as p53, is the most commonly mutated gene in cancer. Canonical p53 DNA damage response pathways are well characterized and classically thought to underlie the tumor suppressive effect of p53. Challen ... Full text Link to item Cite

Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes.

Journal Article Blood Adv · October 8, 2024 Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected dupl ... Full text Link to item Cite

Mechanisms Underlying the Development of Murine T-Cell Lymphoblastic Lymphoma/Leukemia Induced by Total-Body Irradiation.

Journal Article Cancers (Basel) · June 14, 2024 Exposure to ionizing radiation is associated with an increased risk of hematologic malignancies in myeloid and lymphoid lineages in humans and experimental mice. Given that substantial evidence links radiation exposure with the risk of hematologic malignan ... Full text Link to item Cite
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Recent Grants


Mitigation of gastrointestinal acute radiation syndrome by promoting clusterin-mediated intestinal regeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Radioprotective effect of p53 against oral mucositis

ResearchPrincipal Investigator · Awarded by National Institute of Dental and Craniofacial Research · 2023 - 2028

Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure

ResearchCo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027

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Education, Training & Certifications


Duke University · 2012 Ph.D.

External Links


Lee lab webpage