Chang Lung Lee | Scholars@Duke

Chang Lung Lee
Assistant Professor in Radiation Oncology

My lab uses sophisticated mouse models to study mechanisms by which ionizing radiation causes normal tissue injury and cancer.

Current Research Interests

1. Radiation-induced hematologic malignancies
2. Radiation-induced normal tissue injury (hematopoietic, gastrointestinal, cardiovascular)
3. Radiation response of rectal cancer (collaboration with Jatin Roper, MD)

Current Appointments & Affiliations

Assistant Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

Box 3813 Med Ctr, Durham, NC 27708
C127 LSRC Bldg, 308 Research Dr, Box 3813 Med Ctr, Durham, NC 27708
chang-lung.lee@duke.edu (919) 684-8145
Lee lab webpage

Background
Education, Training, & Certifications
- Postdoctoral Associate, Radiation Oncology/Kirsch Laboratory, Duke University School of Medicine 2012 - 2017
- Ph.D., Duke University 2012
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2018 - 2020
- Mitigating the gastrointestinal acute radiation syndrome by blocking calcium/calmodulin-dependent protein kinase kinase 2 awarded by Department of Defense 2019 - 2020
- Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta awarded by Columbia University 2019 - 2020
- Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2020
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
Fellowships, Supported Research, & Other Grants
- Determining the impact of thrombopoietin mimetic (TPOm) on the response of human prostate tumors to radiation therapy awarded by Janssen Research & Development, LLC 2019 - 2020
- Increasing the therapeutic ratio of pelvic radiotherapy for rectal cancer by blocking calcium/calmodulin-dependent protein kinase kinase 2 awarded by Duke Cancer Institute 2019 - 2020
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Daniel, A. R., Lee, C.-L., Oh, P., Luo, L., Ma, Y., & Kirsch, D. G. (2020). Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice. Health Phys, 119(3), 315–321. https://doi.org/10.1097/HP.0000000000001243
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  - Lee, C.-L., Daniel, A. R., Holbrook, M., Brownstein, J., Silva Campos, L. D., Hasapis, S., … Kirsch, D. G. (2019). Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice. Radiat Res, 192(3), 258–266. https://doi.org/10.1667/RR15371.1
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  - Tang, Y. J., Huang, J., Tsushima, H., Ban, G. I., Zhang, H., Oristian, K. M., … Alman, B. A. (2019). Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis. Cell Reports, 28(11), 2837-2850.e5. https://doi.org/10.1016/j.celrep.2019.08.029
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  - Lee, C.-L., Mowery, Y. M., Daniel, A. R., Zhang, D., Sibley, A. B., Delaney, J. R., … Kirsch, D. G. (2019). Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. Jci Insight, 4(13). https://doi.org/10.1172/jci.insight.128698
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  - Clark, D., Holbrook, M., Lee, C.-L., & Badea, C. (2019). Photon-counting cine-cardiac CT in the mouse. https://doi.org/10.1101/660100
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  - Torok, J. A., Oh, P., Castle, K. D., Reinsvold, M., Ma, Y., Luo, L., … Kirsch, D. G. (2019). Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. Cancer Res, 79(4), 773–782. https://doi.org/10.1158/0008-5472.CAN-17-3103
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  - Lee, C.-L., Oh, P., Xu, E. S., Ma, Y., Kim, Y., Daniel, A. R., & Kirsch, D. G. (2018). Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice. Int J Radiat Oncol Biol Phys, 102(5), 1569–1576. https://doi.org/10.1016/j.ijrobp.2018.07.192
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  - Cheung, P. F., Neff, F., Neander, C., Bazarna, A., Savvatakis, K., Liffers, S.-T., … Siveke, J. T. (2018). Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. Cancer Res, 78(17), 4997–5010. https://doi.org/10.1158/0008-5472.CAN-18-0052
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  - Castle, K. D., Daniel, A. R., Moding, E. J., Luo, L., Lee, C.-L., & Kirsch, D. G. (2018). Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. Radiat Res, 189(6), 627–633. https://doi.org/10.1667/RR15001.1
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  - Brownstein, J. M., Wisdom, A. J., Castle, K. D., Mowery, Y. M., Guida, P., Lee, C.-L., … Kirsch, D. G. (2018). Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma. Mol Cancer Ther, 17(4), 858–868. https://doi.org/10.1158/1535-7163.MCT-17-0965
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  - Dodd, R. D., Lee, C.-L., Overton, T., Huang, W., Eward, W. C., Luo, L., … Kirsch, D. G. (2017). NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response. Cancer Res, 77(16), 4486–4497. https://doi.org/10.1158/0008-5472.CAN-16-2643
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  - Moding, E. J., Min, H. D., Castle, K. D., Ali, M., Woodlief, L., Williams, N., … Kirsch, D. G. (2016). An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer. Jci Insight, 1(10). https://doi.org/10.1172/jci.insight.86698
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  - Sachdeva, M., Mito, J. K., Lee, C.-L., Zhang, M., Li, Z., Dodd, R. D., … Kirsch, D. G. (2016). MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest, 126(4), 1606. https://doi.org/10.1172/JCI86573
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  - Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Cahill, J., … Brigman, B. E. (2016). A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine, 8(320), 320ra4. https://doi.org/10.1126/scitranslmed.aad0293
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  - Clark, D. P., Lee, C.-L., Kirsch, D. G., & Badea, C. T. (2015). Spectrotemporal CT data acquisition and reconstruction at low dose. Med Phys, 42(11), 6317–6336. https://doi.org/10.1118/1.4931407
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  - Lee, C.-L., Castle, K. D., Moding, E. J., Blum, J. M., Williams, N., Luo, L., … Kirsch, D. G. (2015). Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. Nat Commun, 6, 8477. https://doi.org/10.1038/ncomms9477
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  - Moding, E. J., Castle, K. D., Perez, B. A., Oh, P., Min, H. D., Norris, H., … Kirsch, D. G. (2015). Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy. Sci Transl Med, 7(278), 278ra34. https://doi.org/10.1126/scitranslmed.aaa4214
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  - Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., … Saur, D. (2014). A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med, 20(11), 1340–1347. https://doi.org/10.1038/nm.3646
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  - Sachdeva, M., Mito, J. K., Lee, C.-L., Zhang, M., Li, Z., Dodd, R. D., … Kirsch, D. G. (2014). MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest, 124(10), 4305–4319. https://doi.org/10.1172/JCI77116
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  - Moding, E. J., Lee, C.-L., Castle, K. D., Oh, P., Mao, L., Zha, S., … Kirsch, D. G. (2014). Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest, 124(8), 3325–3338. https://doi.org/10.1172/JCI73932
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  - Lee, C.-L., Moding, E. J., & Kirsch, D. G. (2014). Reining in radiation injury: HIF2α in the gut. Sci Transl Med, 6(236), 236fs20. https://doi.org/10.1126/scitranslmed.3009155
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  - Lee, C.-L., Lento, W. E., Castle, K. D., Chao, N. J., & Kirsch, D. G. (2014). Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res, 181(5), 445–451. https://doi.org/10.1667/RR13692.1
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  - Lee, C.-L., Min, H., Befera, N., Clark, D., Qi, Y., Das, S., … Kirsch, D. G. (2014). Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. Int J Radiat Oncol Biol Phys, 88(3), 686–693. https://doi.org/10.1016/j.ijrobp.2013.11.238
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  - Lee, C.-L., Blum, J. M., & Kirsch, D. G. (2013). Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis. Transl Cancer Res, 2(5), 412–421.
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  - Perez, B. A., Ghafoori, A. P., Lee, C.-L., Johnston, S. M., Li, Y., Moroshek, J. G., … Kirsch, D. G. (2013). Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice. Front Oncol, 3, 72. https://doi.org/10.3389/fonc.2013.00072
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  - Mito, J. K., Ferrer, J. M., Brigman, B. E., Lee, C.-L., Dodd, R. D., Eward, W. C., … Kirsch, D. G. (2012). Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer, 118(21), 5320–5330. https://doi.org/10.1002/cncr.27458
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  - Lee, C.-L., Moding, E. J., Cuneo, K. C., Li, Y., Sullivan, J. M., Mao, L., … Kirsch, D. G. (2012). p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Sci Signal, 5(234), ra52. https://doi.org/10.1126/scisignal.2002918
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  - Lee, C.-L., Moding, E. J., Huang, X., Li, Y., Woodlief, L. Z., Rodrigues, R. C., … Kirsch, D. G. (2012). Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. Dis Model Mech, 5(3), 397–402. https://doi.org/10.1242/dmm.009084
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  - Sullivan, J. M., Jeffords, L. B., Lee, C.-L., Rodrigues, R., Ma, Y., & Kirsch, D. G. (2012). p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome. Radiat Res, 177(3), 307–310. https://doi.org/10.1667/rr2545.1
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  - Lai, C.-P., Lee, C.-L., Chen, P.-H., Wu, S.-H., Yang, C.-C., & Shaw, J.-F. (2004). Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiology, 134(4), 1586–1597. https://doi.org/10.1104/pp.103.037820
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (n.d.). Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice. https://doi.org/10.1101/2020.08.21.261487
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- Book Sections
  - Palta, M., Lee, C. L., Yusuf, S. W., & Kirsch, D. G. (2017). Radiation therapy and cardiotoxicity. In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease (pp. 161–174). https://doi.org/10.1007/978-3-319-43096-6_7
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- Conference Papers
  - Clark, D. P., Lee, C. L., Kirsch, D. G., & Badea, C. T. (2015). Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT. In Progress in Biomedical Optics and Imaging Proceedings of Spie (Vol. 9412). https://doi.org/10.1117/12.2081379
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Education, Training, & Certifications

Awards & Honors

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers