Chang Lung Lee
Assistant Professor in Radiation Oncology

Due to an ever-increasing number of cancer survivors, representing approximately 4.5% of the population in the United States (2014), secondary malignancies related to chemotherapy and/or radiotherapy is a significant concern in public health. However, underlying mechanisms for the development secondary malignancies are poorly understood. This knowledge gap represents a substantial barrier to assess the risk of secondary cancers and to develop novel strategies for preventing and mitigating this clinically significant side effect of cancer therapy. The long-term goal of my research is using sophisticated mouse models to study how ionizing radiation alters the microenvironment and cell competition within the stem/progenitor pool to promote the development of hematological malignancies. Ultimately, I will exploit this knowledge for prevention and mitigation of therapy-related hematological malignancies in cancer survivors.  

Current Research Interests

1. Radiation-induced hematological malignancies
2. Radiation-induced normal tissue injury (hematopoietic, gastrointestinal, cardiovascular)

Current Appointments & Affiliations

Contact Information

  • Box 3813 Med Ctr, Durham, NC 27708
  • C127 LSRC Bldg, 308 Research Dr, Box 3813 Med Ctr, Durham, NC 27708

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