Chang Lung Lee | Scholars@Duke

Chang Lung Lee
Assistant Professor in Radiation Oncology

Due to an ever-increasing number of cancer survivors, representing approximately 4.5% of the population in the United States (2014), secondary malignancies related to chemotherapy and/or radiotherapy is a significant concern in public health. However, underlying mechanisms for the development secondary malignancies are poorly understood. This knowledge gap represents a substantial barrier to assess the risk of secondary cancers and to develop novel strategies for preventing and mitigating this clinically significant side effect of cancer therapy. The long-term goal of my research is using sophisticated mouse models to study how ionizing radiation alters the microenvironment and cell competition within the stem/progenitor pool to promote the development of hematological malignancies. Ultimately, I will exploit this knowledge for prevention and mitigation of therapy-related hematological malignancies in cancer survivors.

Current Research Interests

1. Radiation-induced hematologic malignancies
2. Radiation-induced normal tissue injury (hematopoietic, gastrointestinal, cardiovascular)

Current Appointments & Affiliations

Assistant Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

Box 3813 Med Ctr, Durham, NC 27708
C127 LSRC Bldg, 308 Research Dr, Box 3813 Med Ctr, Durham, NC 27708
chang-lung.lee@duke.edu (919) 684-8145
Lee Lab webpage

Background
Education, Training, & Certifications
- Postdoctoral Associate, Radiation Oncology/Kirsch Laboratory, Duke University School of Medicine 2012 - 2017
- Ph.D., Duke University 2012
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2018 - 2020
- Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2019
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
- Defining the role of miR-182 in HZE-induced tumorignesis awarded by National Aeronautics and Space Administration 2014 - 2018
- Janssen Research AGreement awarded by Janssen Research & Development, LLC 2014 - 2016
- Defining the Cellular Target of Radiation Therapy awarded by National Institutes of Health 2014 - 2015
- Mechanisms of Late Effects of Exposure to Radiation awarded by National Institutes of Health 2008 - 2013
Publications & Artistic Works
Selected Publications
- Book Sections
  - Palta, M, Lee, CL, Yusuf, SW, and Kirsch, DG. "Radiation therapy and cardiotoxicity." In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 161-174. April 11, 2017. Full Text
- Conference Papers
  - Clark, DP, Lee, CL, Kirsch, DG, and Badea, CT. "Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT." January 1, 2015. Full Text
- Journal Articles
  - Cheung, PF, Neff, F, Neander, C, Bazarna, A, Savvatakis, K, Liffers, S-T, Althoff, K, Lee, C-L, Moding, EJ, Kirsch, DG, Saur, D, Bazhin, AV, Trajkovic-Arsic, M, Heikenwalder, MF, and Siveke, JT. "Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting." Cancer Research 78, no. 17 (September 2018): 4997-5010. Full Text
  - Castle, KD, Daniel, AR, Moding, EJ, Luo, L, Lee, C-L, and Kirsch, DG. "Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome." Radiation Research 189, no. 6 (June 2018): 627-633. Full Text
  - Brownstein, JM, Wisdom, AJ, Castle, KD, Mowery, YM, Guida, P, Lee, C-L, Tommasino, F, Tessa, CL, Scifoni, E, Gao, J, Luo, L, Campos, LDS, Ma, Y, Williams, N, Jung, S-H, Durante, M, and Kirsch, DG. "Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma." Molecular Cancer Therapeutics 17, no. 4 (April 2018): 858-868. Full Text
  - Dodd, RD, Lee, C-L, Overton, T, Huang, W, Eward, WC, Luo, L, Ma, Y, Ingram, DR, Torres, KE, Cardona, DM, Lazar, AJ, and Kirsch, DG. "NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response." Cancer Research 77, no. 16 (August 2017): 4486-4497. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." Journal of Clinical Investigation 126, no. 4 (April 1, 2016): 1606-1606. Full Text
  - Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, C-L, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O'Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer." Science Translational Medicine 8, no. 320 (January 2016): 320ra4-null. Full Text
  - Clark, DP, Lee, C-L, Kirsch, DG, and Badea, CT. "Spectrotemporal CT data acquisition and reconstruction at low dose." Medical Physics 42, no. 11 (November 2015): 6317-6336. Full Text Open Access Copy
  - Lee, C-L, Castle, KD, Moding, EJ, Blum, JM, Williams, N, Luo, L, Ma, Y, Borst, LB, Kim, Y, and Kirsch, DG. "Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma." Nature Communications 6 (September 24, 2015): 8477-null. Full Text
  - Moding, EJ, Castle, KD, Perez, BA, Oh, P, Min, HD, Norris, H, Ma, Y, Cardona, DM, Lee, C-L, and Kirsch, DG. "Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy." Science Translational Medicine 7, no. 278 (March 2015): 278ra34-null. Full Text
  - Schönhuber, N, Seidler, B, Schuck, K, Veltkamp, C, Schachtler, C, Zukowska, M, Eser, S, Feyerabend, TB, Paul, MC, Eser, P, Klein, S, Lowy, AM, Banerjee, R, Yang, F, Lee, C-L, Moding, EJ, Kirsch, DG, Scheideler, A, Alessi, DR, Varela, I, Bradley, A, Kind, A, Schnieke, AE, Rodewald, H-R, Rad, R, Schmid, RM, Schneider, G, and Saur, D. "A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer." Nature Medicine 20, no. 11 (November 2014): 1340-1347. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." The Journal of Clinical Investigation 124, no. 10 (October 2014): 4305-4319. Full Text
  - "Erratum to: Lee CL, Min H, Befera N, et al. Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. Int J Radiat Oncol Biol Phys 2014;88:686-693." International Journal of Radiation Oncology*Biology*Physics 89, no. 5 (August 2014): 1145-1145. Full Text
  - Moding, EJ, Lee, C-L, Castle, KD, Oh, P, Mao, L, Zha, S, Min, HD, Ma, Y, Das, S, and Kirsch, DG. "Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium." The Journal of Clinical Investigation 124, no. 8 (August 2014): 3325-3338. Full Text
  - Lee, C-L, Lento, WE, Castle, KD, Chao, NJ, and Kirsch, DG. "Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice." Radiation Research 181, no. 5 (May 2014): 445-451. Full Text
  - Lee, C-L, Moding, EJ, and Kirsch, DG. "Reining in radiation injury: HIF2α in the gut." Science Translational Medicine 6, no. 236 (May 2014): 236fs20-null. Full Text
  - Lee, C-L, Min, H, Befera, N, Clark, D, Qi, Y, Das, S, Johnson, GA, Badea, CT, and Kirsch, DG. "Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation." International Journal of Radiation Oncology, Biology, Physics 88, no. 3 (March 2014): 686-693. Full Text Open Access Copy
  - Lee, C-L, Blum, JM, and Kirsch, DG. "Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis." Translational Cancer Research 2, no. 5 (October 2013): 412-421.
  - Perez, BA, Ghafoori, AP, Lee, C-L, Johnston, SM, Li, Y, Moroshek, JG, Ma, Y, Mukherjee, S, Kim, Y, Badea, CT, and Kirsch, DG. "Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice." Frontiers in Oncology 3 (January 2013): 72-null. Full Text Open Access Copy
  - Mito, JK, Ferrer, JM, Brigman, BE, Lee, C-L, Dodd, RD, Eward, WC, Marshall, LF, Cuneo, KC, Carter, JE, Ramasunder, S, Kim, Y, Lee, WD, Griffith, LG, Bawendi, MG, and Kirsch, DG. "Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging." Cancer 118, no. 21 (November 2012): 5320-5330. Full Text
  - Lee, C-L, Moding, EJ, Cuneo, KC, Li, Y, Sullivan, JM, Mao, L, Washington, I, Jeffords, LB, Rodrigues, RC, Ma, Y, Das, S, Kontos, CD, Kim, Y, Rockman, HA, and Kirsch, DG. "p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice." Science Signaling 5, no. 234 (July 24, 2012): ra52-null. Full Text
  - Lee, C-L, Moding, EJ, Huang, X, Li, Y, Woodlief, LZ, Rodrigues, RC, Ma, Y, and Kirsch, DG. "Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice." Disease Models & Mechanisms 5, no. 3 (May 2012): 397-402. Full Text
  - Sullivan, JM, Jeffords, LB, Lee, C-L, Rodrigues, R, Ma, Y, and Kirsch, DG. "p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome." Radiation Research 177, no. 3 (March 2012): 307-310. Full Text
  - Lai, C-P, Lee, C-L, Chen, P-H, Wu, S-H, Yang, C-C, and Shaw, J-F. "Molecular analyses of the Arabidopsis TUBBY-like protein gene family." Plant Physiology 134, no. 4 (April 2, 2004): 1586-1597. Full Text

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Education, Training, & Certifications

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles