Research Interests
Utilizing sophisticated mouse models, we aim to study 1) critical signaling pathways that regulate the regeneration of normal tissues following acute radiation injury as well as the development of delayed fibrosis; 2) cell-autonomous and non-cell-autonomous mechanisms underlying the development of radiation-induced cancer.
Ongoing projects:
1. Regeneration of oral mucosal epithelium in response to severe radiation injury (R01DE033404 active)
2. Regeneration of intestinal epithelium in response to severe radiation injury (U01AI186969 active)
3. Radiation-induced intestinal fibrosis (collaboration with Jatin Roper) (U01AI183940 active)
4. Radiation-induced hematologic malignancies and clonal hematopoiesis (R00CA212198 and R03CA249562 completed)
Selected Grants
Mitigation of gastrointestinal acute radiation syndrome by promoting clusterin-mediated intestinal regeneration
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Radioprotective effect of p53 against oral mucositis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2027The impact of a synbiotic product comprising B. infantis and HMO in a mouse model of irradiation
ResearchPrincipal Investigator · Awarded by Prolacta Bioscience, Inc. · 2023 - 2024Translational Studies in FLASH Particle Radiotherapy
ResearchCo Investigator · Awarded by University of Pennsylvania · 2022 - 2024Mitigating the gastrointestinal acute radiation syndrome by activating Yap1
ResearchPrincipal Investigator · Awarded by Columbia University · 2021 - 2023Cabinet Radiation Therapy System for Small Animals
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2022 - 2023Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2022Minimizing the risk of therapy-related myeloid neoplasms by inhibiting genotoxic stress-induced expansion of leukemia-initiating cells
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022Image-Guided Radiation Therapy System for Small Animals
EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2020Mitigating the gastrointestinal acute radiation syndrome by blocking calcium/calmodulin-dependent protein kinase kinase 2
ResearchPrincipal Investigator · Awarded by Department of Defense · 2019 - 2020Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta
ResearchPrincipal Investigator · Awarded by Columbia University · 2019 - 2020Development of CaMKK2 inhibitor drug for acute radiation syndrome
ResearchInvestigator · Awarded by Columbia University · 2018 - 2020Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018Fellowships, Gifts, and Supported Research
The effect of RAD-100 on a murine model of radiation dermatitis ·
January 2021
- January 2022
Principal Investigator ·
Awarded by: Rythera Therapeutics, Inc
Determining the impact of thrombopoietin mimetic (TPOm) on the response of human prostate tumors to radiation therapy ·
November 2019
- September 2020
Principal Investigator ·
Awarded by: Janssen Research & Development, LLC
Increasing the therapeutic ratio of pelvic radiotherapy for rectal cancer by blocking calcium/calmodulin-dependent protein kinase kinase 2 ·
July 2019
- June 2020
Awarded by: Duke Cancer Institute