Chelsea Dawn Landon | Scholars@Duke

Chelsea Dawn Landon
Assistant Professor of Pathology

With a research background heavily weighted in drug delivery systems in the treatment of cancer, the focus of my work has shifted to vaccination delivery methods as potential anticancer strategies. The goal of my current funding is to identify and develop a vaccine strategy delivered via the intranasal (IN) route that induces a cytotoxic T lymphocyte (CTL) response adequate for the protection/prevention of metastatic lung cancer.

I am currently working under the mentorship of Dr. Herman Staats, and in addition to the cancer immunotherapy studies, I have a strong interest in mucosal immunization and maternal immunization studies, specifically in the rabbit model.

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2020

Contact Information

227, Davison Building, Trent Drive, Durham, NC 27710
Duke Box 3712 or 3180, Durham, NC 27710
chelsea.landon@duke.edu (919) 667-3229

Background
Education, Training, & Certifications
- D.V.M., North Carolina State University 2017
- Ph.D., Duke University 2013
Previous Appointments & Affiliations
- Medical Instructor in Pathology, Pathology, Clinical Science Departments 2020 - 2021
Research
Selected Grants
- Utilizing intranasal immunization to induce a cytotoxic T lymphocyte response and reduce metastatic burden in the lung awarded by National Institutes of Health 2020 - 2021
- The Use of Hyperthermia and Copper Chelation to Overcome Cisplatin Resistance awarded by National Institutes of Health 2011 - 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Crute, Christine E., Samantha M. Hall, Chelsea D. Landon, Angela Garner, Jeffrey I. Everitt, Sharon Zhang, Bevin Blake, et al. “Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.” Sci Total Environ 838, no. Pt 4 (September 10, 2022): 156499. https://doi.org/10.1016/j.scitotenv.2022.156499.
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  - Landon, Chelsea D., Gabriella Dancourt, Vivian Shing, and Herman F. Staats. “Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus).” J Vis Exp, no. 173 (July 31, 2021). https://doi.org/10.3791/62317.
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  - Hofmann, Christina L., Melanie C. O’Sullivan, Alexandre Detappe, Yingjie Yu, Xi Yang, Wei Qi, Chelsea D. Landon, et al. “NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.” Nanoscale 9, no. 36 (September 21, 2017): 13465–76. https://doi.org/10.1039/c7nr02363d.
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  - Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.
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  - Betof, Allison S., Christopher D. Lascola, Douglas Weitzel, Chelsea Landon, Peter M. Scarbrough, Gayathri R. Devi, Gregory Palmer, Lee W. Jones, and Mark W. Dewhirst. “Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.” J Natl Cancer Inst 107, no. 5 (May 2015). https://doi.org/10.1093/jnci/djv040.
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  - Viglianti, Benjamin L., Mark W. Dewhirst, R. J. Boruta, Ji-Young Park, Chelsea Landon, Andrew N. Fontanella, Jing Guo, Ashley Manzoor, Christina L. Hofmann, and Gregory M. Palmer. “Systemic anti-tumour effects of local thermally sensitive liposome therapy.” Int J Hyperthermia 30, no. 6 (September 2014): 385–92. https://doi.org/10.3109/02656736.2014.944587.
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  - McDaniel, Jonathan R., Sarah R. MacEwan, Xinghai Li, D Christopher Radford, Chelsea D. Landon, Mark Dewhirst, and Ashutosh Chilkoti. “Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.” Nano Lett 14, no. 5 (May 14, 2014): 2890–95. https://doi.org/10.1021/nl5009376.
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  - Oliveira, Tiago R., Paul R. Stauffer, Chen-Ting Lee, Chelsea D. Landon, Wiguins Etienne, Kathleen A. Ashcraft, Katie L. McNerny, et al. “Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.” Int J Hyperthermia 29, no. 8 (December 2013): 835–44. https://doi.org/10.3109/02656736.2013.834384.
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  - Cao, Yiting, Joseph M. Eble, Ejung Moon, Hong Yuan, Douglas H. Weitzel, Chelsea D. Landon, Charleen Yu-Chih Nien, et al. “Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.” Cancer Res 73, no. 20 (October 15, 2013): 6230–42. https://doi.org/10.1158/0008-5472.CAN-12-1345.
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  - Landon, Chelsea D., Sarah E. Benjamin, Kathleen A. Ashcraft, and Mark W. Dewhirst. “A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment.” Int J Hyperthermia 29, no. 6 (September 2013): 528–38. https://doi.org/10.3109/02656736.2013.790563.
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  - Dewhirst, Mark W., Chelsea D. Landon, Christina L. Hofmann, and Paul R. Stauffer. “Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 545–61. https://doi.org/10.1016/j.soc.2013.02.009.
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  - Kennedy, Kelly M., Peter M. Scarbrough, Anthony Ribeiro, Rachel Richardson, Hong Yuan, Pierre Sonveaux, Chelsea D. Landon, et al. “Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.” Plos One 8, no. 9 (2013): e75154. https://doi.org/10.1371/journal.pone.0075154.
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  - Manzoor, Ashley A., Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. Dreher, Shiva Das, et al. “Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.” Cancer Res 72, no. 21 (November 1, 2012): 5566–75. https://doi.org/10.1158/0008-5472.CAN-12-1683.
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  - Salahi, Sara, Paolo F. Maccarini, Dario B. Rodrigues, Wiguins Etienne, Chelsea D. Landon, Brant A. Inman, Mark W. Dewhirst, and Paul R. Stauffer. “Miniature microwave applicator for murine bladder hyperthermia studies.” Int J Hyperthermia 28, no. 5 (2012): 456–65. https://doi.org/10.3109/02656736.2012.677931.
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  - Chi, Jen-Tsan, Donald E. Thrall, Chen Jiang, Stacey Snyder, Diane Fels, Chelsea Landon, Linda McCall, et al. “Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.” Clin Cancer Res 17, no. 8 (April 15, 2011): 2549–60. https://doi.org/10.1158/1078-0432.CCR-10-2583.
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  - Yarmolenko, Pavel S., Eui Jung Moon, Chelsea Landon, Ashley Manzoor, Daryl W. Hochman, Benjamin L. Viglianti, and Mark W. Dewhirst. “Thresholds for thermal damage to normal tissues: an update.” Int J Hyperthermia 27, no. 4 (2011): 320–43. https://doi.org/10.3109/02656736.2010.534527.
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  - Landon, Chelsea D., Ji-Young Park, David Needham, and Mark W. Dewhirst. “Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.” Open Nanomed J 3 (January 1, 2011): 38–64. https://doi.org/10.2174/1875933501103010038.
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  - Wills, Lauren P., Cole W. Matson, Chelsea D. Landon, and Richard T. Di Giulio. “Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA.” Aquatic Toxicology (Amsterdam, Netherlands) 99, no. 1 (August 2010): 33–41. https://doi.org/10.1016/j.aquatox.2010.03.015.
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  - Yarmolenko, Pavel S., Yulin Zhao, Chelsea Landon, Ivan Spasojevic, Fan Yuan, David Needham, Benjamin L. Viglianti, and Mark W. Dewhirst. “Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.” Int J Hyperthermia 26, no. 5 (2010): 485–98. https://doi.org/10.3109/02656731003789284.
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- Other Articles
  - Oliveira, Tiago R., Paul R. Stauffer, Chen-Ting Lee, Chelsea Landon, Wiguins Etienne, Paolo F. Maccarini, Brant Inman, and Mark W. Dewhirst. “Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer.” Proc Spie Int Soc Opt Eng, February 26, 2013. https://doi.org/10.1117/12.2005623.
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Teaching & Mentoring
Recent Courses
- PATHOL 735S: Animal Models in Translational Research 2022
Scholarly, Clinical, & Service Activities
Service to the Profession
- Participant. Faculty Short Course on Improving Departmental Climate. Duke Office of Faculty Advancement & Duke Office of Institutional Equity. August 2, 2021 - August 5, 2021 2021

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Other Articles

Recent Courses

Service to the Profession