Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • D.V.M., North Carolina State University 2017
  • Ph.D., Duke University 2013
• Research
• 

  Selected Grants

  • Utilizing intranasal immunization to induce a cytotoxic T lymphocyte response and reduce metastatic burden in the lung awarded by National Institutes of Health 2020 - 2025
  • The Use of Hyperthermia and Copper Chelation to Overcome Cisplatin Resistance awarded by National Institutes of Health 2011 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hofmann, Christina L., Melanie C. O’Sullivan, Alexandre Detappe, Yingjie Yu, Xi Yang, Wei Qi, Chelsea D. Landon, et al. “NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.” Nanoscale 9, no. 36 (September 21, 2017): 13465–76. https://doi.org/10.1039/c7nr02363d.
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    • Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.
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    • Betof, Allison S., Christopher D. Lascola, Douglas Weitzel, Chelsea Landon, Peter M. Scarbrough, Gayathri R. Devi, Gregory Palmer, Lee W. Jones, and Mark W. Dewhirst. “Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.” J Natl Cancer Inst 107, no. 5 (May 2015). https://doi.org/10.1093/jnci/djv040.
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    • Viglianti, Benjamin L., Mark W. Dewhirst, R. J. Boruta, Ji-Young Park, Chelsea Landon, Andrew N. Fontanella, Jing Guo, Ashley Manzoor, Christina L. Hofmann, and Gregory M. Palmer. “Systemic anti-tumour effects of local thermally sensitive liposome therapy.” International Journal of Hyperthermia : The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 30, no. 6 (September 2014): 385–92. https://doi.org/10.3109/02656736.2014.944587.
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    • McDaniel, Jonathan R., Sarah R. MacEwan, Xinghai Li, D Christopher Radford, Chelsea D. Landon, Mark Dewhirst, and Ashutosh Chilkoti. “Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.” Nano Lett 14, no. 5 (May 14, 2014): 2890–95. https://doi.org/10.1021/nl5009376.
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    • Oliveira, Tiago R., Paul R. Stauffer, Chen-Ting Lee, Chelsea D. Landon, Wiguins Etienne, Kathleen A. Ashcraft, Katie L. McNerny, et al. “Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.” Int J Hyperthermia 29, no. 8 (December 2013): 835–44. https://doi.org/10.3109/02656736.2013.834384.
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    • Cao, Yiting, Joseph M. Eble, Ejung Moon, Hong Yuan, Douglas H. Weitzel, Chelsea D. Landon, Charleen Yu-Chih Nien, et al. “Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.” Cancer Res 73, no. 20 (October 15, 2013): 6230–42. https://doi.org/10.1158/0008-5472.CAN-12-1345.
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    • Landon, Chelsea D., Sarah E. Benjamin, Kathleen A. Ashcraft, and Mark W. Dewhirst. “A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment.” International Journal of Hyperthermia : The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 29, no. 6 (September 2013): 528–38. https://doi.org/10.3109/02656736.2013.790563.
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    • Dewhirst, Mark W., Chelsea D. Landon, Christina L. Hofmann, and Paul R. Stauffer. “Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 545–61. https://doi.org/10.1016/j.soc.2013.02.009.
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    • Kennedy, Kelly M., Peter M. Scarbrough, Anthony Ribeiro, Rachel Richardson, Hong Yuan, Pierre Sonveaux, Chelsea D. Landon, et al. “Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.” Plos One 8, no. 9 (2013): e75154. https://doi.org/10.1371/journal.pone.0075154.
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    • Manzoor, Ashley A., Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. Dreher, Shiva Das, et al. “Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.” Cancer Res 72, no. 21 (November 1, 2012): 5566–75. https://doi.org/10.1158/0008-5472.CAN-12-1683.
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    • Salahi, Sara, Paolo F. Maccarini, Dario B. Rodrigues, Wiguins Etienne, Chelsea D. Landon, Brant A. Inman, Mark W. Dewhirst, and Paul R. Stauffer. “Miniature microwave applicator for murine bladder hyperthermia studies.” International Journal of Hyperthermia : The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 28, no. 5 (January 2012): 456–65. https://doi.org/10.3109/02656736.2012.677931.
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    • Chi, Jen-Tsan, Donald E. Thrall, Chen Jiang, Stacey Snyder, Diane Fels, Chelsea Landon, Linda McCall, et al. “Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.” Clin Cancer Res 17, no. 8 (April 15, 2011): 2549–60. https://doi.org/10.1158/1078-0432.CCR-10-2583.
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    • Landon, Chelsea D., Ji-Young Park, David Needham, and Mark W. Dewhirst. “Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.” Open Nanomed J 3 (January 1, 2011): 38–64. https://doi.org/10.2174/1875933501103010038.
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    • Yarmolenko, Pavel S., Eui Jung Moon, Chelsea Landon, Ashley Manzoor, Daryl W. Hochman, Benjamin L. Viglianti, and Mark W. Dewhirst. “Thresholds for thermal damage to normal tissues: an update.” Int J Hyperthermia 27, no. 4 (2011): 320–43. https://doi.org/10.3109/02656736.2010.534527.
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    • Wills, Lauren P., Cole W. Matson, Chelsea D. Landon, and Richard T. Di Giulio. “Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA.” Aquat Toxicol 99, no. 1 (August 1, 2010): 33–41. https://doi.org/10.1016/j.aquatox.2010.03.015.
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    • Yarmolenko, Pavel S., Yulin Zhao, Chelsea Landon, Ivan Spasojevic, Fan Yuan, David Needham, Benjamin L. Viglianti, and Mark W. Dewhirst. “Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.” Int J Hyperthermia 26, no. 5 (2010): 485–98. https://doi.org/10.3109/02656731003789284.
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  • Other Articles

    • Oliveira, Tiago R., Paul R. Stauffer, Chen-Ting Lee, Chelsea Landon, Wiguins Etienne, Paolo F. Maccarini, Brant Inman, and Mark W. Dewhirst. “Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer.” Proceedings of Spie  the International Society for Optical Engineering, February 2013. https://doi.org/10.1117/12.2005623.
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