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Chelsea Dawn Landon

Assistant Professor of Pathology
Pathology
Duke Box 3712 OR 3180, Durham, NC 27710
227, Davison Building, Trent Drive, Durham, NC 27710

Selected Publications


Evaluation of repRNA vaccine for induction and in utero transfer of maternal antibodies in a pregnant rabbit model.

Journal Article Mol Ther · April 5, 2023 Mother-to-child transmission is a major route for infections in newborns. Vaccination in mothers to leverage the maternal immune system is a promising approach to vertically transfer protective immunity. During infectious disease outbreaks, such as the 201 ... Full text Link to item Cite

Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.

Journal Article Toxicol Sci · February 17, 2023 Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal and i ... Full text Link to item Cite

Veterinary Management of Harderian Gland Tumors in Cancer Rainbow (crainbow) HER2-Positive Mice.

Journal Article Comp Med · December 1, 2022 A Cancer Rainbow mouse line that expresses 3 fluorescently labeled isoforms of the tumor-driver gene HER2 (HER2BOW) was developed recently for the study of tumorigenesis in the mammary gland. The expression of 1 of the 3 HER2 isoforms in HER2BOW mice is in ... Full text Link to item Cite

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.

Journal Article Sci Total Environ · September 10, 2022 Mixtures of per- and polyfluoroalkyl substances (PFAS) are often found in drinking water, and serum PFAS are detected in up to 99% of the population. However, very little is known about how exposure to mixtures of PFAS affects maternal and fetal health. Th ... Full text Link to item Cite

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus).

Journal Article J Vis Exp · July 31, 2021 Due to similarities in placentation and antibody transfer with humans, rabbits are an excellent model of maternal immunization. Additional advantages of this research model are the ease of breeding and sample collection, relatively short gestation period, ... Full text Link to item Cite

NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.

Journal Article Nanoscale · September 21, 2017 Motivated by the goal of developing a fully biodegradable optical contrast agent with translational clinical potential, a nanoparticle delivery vehicle was generated from the self-assembly of poly(ethylene-glycol)-block-poly(trimethylene carbonate-co-capro ... Full text Link to item Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.

Journal Article J Natl Cancer Inst · May 2015 Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted orthotopically into syngeneic mice ( ... Full text Open Access Link to item Cite

Systemic anti-tumour effects of local thermally sensitive liposome therapy.

Journal Article Int J Hyperthermia · September 2014 PURPOSE: There were two primary objectives of this study: (1) to determine whether treatment of a tumour site with systemically administered thermally sensitive liposomes and local hyperthermia (HT) for triggered release would have dual anti-tumour effect ... Full text Link to item Cite

Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.

Journal Article Nano Lett · May 14, 2014 This paper demonstrates the first example of targeting a solid tumor that is externally heated to 42 °C by "heat seeking" drug-loaded polypeptide nanoparticles. These nanoparticles consist of a thermally responsive elastin-like polypeptide (ELP) conjugated ... Full text Link to item Cite

Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.

Journal Article Int J Hyperthermia · December 2013 PURPOSE: This paper describes a preclinical investigation of the feasibility of thermotherapy treatment of bladder cancer with magnetic fluid hyperthermia (MFH), performed by analysing the thermal dosimetry of nanoparticle heating in a rat bladder model. M ... Full text Link to item Cite

Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.

Journal Article Cancer Res · October 15, 2013 Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that controls cellular homeostasis. Although its activation benefits normal tissue, HIF-1 activation in tumors is a major risk factor for angiogenesis, therapeutic resistance, and poor pro ... Full text Link to item Cite

A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment.

Journal Article Int J Hyperthermia · September 2013 PURPOSE: Hyperthermia enhances cytotoxic effects of chemotherapeutic agents such as cisplatin. However, the underlying molecular mechanisms remain unclear. We hypothesised that hyperthermia increases cisplatin accumulation and efficacy by modulating functi ... Full text Link to item Cite

Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.

Journal Article Surg Oncol Clin N Am · July 2013 Because of the limitations of surgical resection, thermal ablation is commonly used for the treatment of hepatocellular carcinoma and liver metastases. Current methods of ablation can result in marginal recurrences of larger lesions and in tumors located n ... Full text Link to item Cite

Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer.

Other Proc SPIE Int Soc Opt Eng · February 26, 2013 BACKGROUND: Despite positive efficacy, thermotherapy is not widely used in clinical oncology. Difficulties associated with field penetration and controlling power deposition patterns in heterogeneous tissue have limited its use for heating deep in the body ... Full text Link to item Cite

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

Journal Article PLoS One · 2013 Lactate accumulation in tumors has been associated with metastases and poor overall survival in cancer patients. Lactate promotes angiogenesis and metastasis, providing rationale for understanding how it is processed by cells. The concentration of lactate ... Full text Link to item Cite

Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Journal Article Cancer Res · November 1, 2012 Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. However, ... Full text Link to item Cite

Miniature microwave applicator for murine bladder hyperthermia studies.

Journal Article Int J Hyperthermia · 2012 PURPOSE: Novel combinations of heat with chemotherapeutic agents are often studied in murine tumour models. Currently, no device exists to selectively heat small tumours at depth in mice. In this project we modelled, built and tested a miniature microwave ... Full text Link to item Cite

Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.

Journal Article Clin Cancer Res · April 15, 2011 PURPOSE: While hyperthermia is an effective adjuvant treatment to radiotherapy, we do not completely understand the nature of the response heterogeneity. EXPERIMENTAL DESIGN: We performed gene expression analysis of 22 spontaneous canine sarcomas before an ... Full text Link to item Cite

Thresholds for thermal damage to normal tissues: an update.

Journal Article Int J Hyperthermia · 2011 The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the consecutive years from 2002-2009. The first review on this subject was published in 2003. It included an ... Full text Link to item Cite