
Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.
Publication
, Journal Article
Dewhirst, MW; Landon, CD; Hofmann, CL; Stauffer, PR
Published in: Surg Oncol Clin N Am
July 2013
Because of the limitations of surgical resection, thermal ablation is commonly used for the treatment of hepatocellular carcinoma and liver metastases. Current methods of ablation can result in marginal recurrences of larger lesions and in tumors located near large vessels. This review presents a novel approach for extending treatment out to the margins where temperatures do not provide complete treatment with ablation alone, by combining thermal ablation with drug-loaded thermosensitive liposomes. A history of the development of thermosensitive liposomes is presented. Clinical trials have shown that the combination of radiofrequency ablation and doxorubicin-loaded thermosensitive liposomes is a promising treatment.
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Published In
Surg Oncol Clin N Am
DOI
EISSN
1558-5042
Publication Date
July 2013
Volume
22
Issue
3
Start / End Page
545 / 561
Location
United States
Related Subject Headings
- Prognosis
- Oncology & Carcinogenesis
- Liver Neoplasms
- Liposomes
- Hyperthermia, Induced
- Humans
- Catheter Ablation
- Carcinoma, Hepatocellular
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Dewhirst, M. W., Landon, C. D., Hofmann, C. L., & Stauffer, P. R. (2013). Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am, 22(3), 545–561. https://doi.org/10.1016/j.soc.2013.02.009
Dewhirst, Mark W., Chelsea D. Landon, Christina L. Hofmann, and Paul R. Stauffer. “Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 545–61. https://doi.org/10.1016/j.soc.2013.02.009.
Dewhirst MW, Landon CD, Hofmann CL, Stauffer PR. Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am. 2013 Jul;22(3):545–61.
Dewhirst, Mark W., et al. “Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.” Surg Oncol Clin N Am, vol. 22, no. 3, July 2013, pp. 545–61. Pubmed, doi:10.1016/j.soc.2013.02.009.
Dewhirst MW, Landon CD, Hofmann CL, Stauffer PR. Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am. 2013 Jul;22(3):545–561.

Published In
Surg Oncol Clin N Am
DOI
EISSN
1558-5042
Publication Date
July 2013
Volume
22
Issue
3
Start / End Page
545 / 561
Location
United States
Related Subject Headings
- Prognosis
- Oncology & Carcinogenesis
- Liver Neoplasms
- Liposomes
- Hyperthermia, Induced
- Humans
- Catheter Ablation
- Carcinoma, Hepatocellular
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis