Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.

Publication ,  Journal Article
McDaniel, JR; MacEwan, SR; Li, X; Radford, DC; Landon, CD; Dewhirst, M; Chilkoti, A
Published in: Nano Lett
May 14, 2014

This paper demonstrates the first example of targeting a solid tumor that is externally heated to 42 °C by "heat seeking" drug-loaded polypeptide nanoparticles. These nanoparticles consist of a thermally responsive elastin-like polypeptide (ELP) conjugated to multiple copies of a hydrophobic cancer drug. To rationally design drug-loaded nanoparticles that exhibit thermal responsiveness in the narrow temperature range between 37 and 42 °C, an analytical model was developed that relates ELP composition and chain length to the nanoparticle phase transition temperature. Suitable candidates were designed based on the predictions of the model and tested in vivo by intravital confocal fluorescence microscopy of solid tumors, which revealed that the nanoparticles aggregate in the vasculature of tumors heated to 42 °C and that the aggregation is reversible as the temperature reverts to 37 °C. Biodistribution studies showed that the most effective strategy to target the nanoparticles to tumors is to thermally cycle the tumors between 37 and 42 °C. These nanoparticles set the stage for the targeted delivery of a range of cancer chemotherapeutics by externally applied mild hyperthermia of solid tumors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nano Lett

DOI

EISSN

1530-6992

Publication Date

May 14, 2014

Volume

14

Issue

5

Start / End Page

2890 / 2895

Location

United States

Related Subject Headings

  • Temperature
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Elastin
  • Drug Delivery Systems
  • Colonic Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McDaniel, J. R., MacEwan, S. R., Li, X., Radford, D. C., Landon, C. D., Dewhirst, M., & Chilkoti, A. (2014). Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors. Nano Lett, 14(5), 2890–2895. https://doi.org/10.1021/nl5009376
McDaniel, Jonathan R., Sarah R. MacEwan, Xinghai Li, D Christopher Radford, Chelsea D. Landon, Mark Dewhirst, and Ashutosh Chilkoti. “Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.Nano Lett 14, no. 5 (May 14, 2014): 2890–95. https://doi.org/10.1021/nl5009376.
McDaniel JR, MacEwan SR, Li X, Radford DC, Landon CD, Dewhirst M, et al. Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors. Nano Lett. 2014 May 14;14(5):2890–5.
McDaniel, Jonathan R., et al. “Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.Nano Lett, vol. 14, no. 5, May 2014, pp. 2890–95. Pubmed, doi:10.1021/nl5009376.
McDaniel JR, MacEwan SR, Li X, Radford DC, Landon CD, Dewhirst M, Chilkoti A. Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors. Nano Lett. 2014 May 14;14(5):2890–2895.
Journal cover image

Published In

Nano Lett

DOI

EISSN

1530-6992

Publication Date

May 14, 2014

Volume

14

Issue

5

Start / End Page

2890 / 2895

Location

United States

Related Subject Headings

  • Temperature
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Elastin
  • Drug Delivery Systems
  • Colonic Neoplasms