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Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.

Publication ,  Journal Article
Landon, CD; Park, J-Y; Needham, D; Dewhirst, MW
Published in: Open Nanomed J
January 1, 2011

The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes in general and the Low Temperature-Sensitive Liposome (LTSL) in particular. We give a brief description of the material design of LTSL and highlight the likely mechanism behind temperature-triggered drug release. A complete review of the progress and results of the latest preclinical and clinical studies that demonstrate enhanced drug delivery with the combined treatment of hyperthermia and liposomes is provided as well as a clinical perspective on cancers that would benefit from hyperthermia as an adjuvant treatment for temperature-triggered chemotherapeutics. This review discusses the ideas, goals, and processes behind temperature-sensitive liposome development in the laboratory to the current use in preclinical and clinical settings.

Duke Scholars

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Published In

Open Nanomed J

DOI

ISSN

1875-9335

Publication Date

January 1, 2011

Volume

3

Start / End Page

38 / 64

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Landon, Chelsea D., Ji-Young Park, David Needham, and Mark W. Dewhirst. “Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.Open Nanomed J 3 (January 1, 2011): 38–64. https://doi.org/10.2174/1875933501103010038.

Published In

Open Nanomed J

DOI

ISSN

1875-9335

Publication Date

January 1, 2011

Volume

3

Start / End Page

38 / 64

Location

Netherlands