Scholars@Duke
Cherylee Wai Jun Chang

Cherylee Wai Jun Chang

Professor of Neurology
Neurology, Neurocritical Care
cherylee.chang@duke.edu
DUMC Box 3824, Durham, NC 27710
40 Medicine Circle, Durham, NC 27710

Selected Publications

Disorders of Lymphatic Architecture and Flow in Critical Illness.

Journal Article Crit Care Med · March 1, 2025 OBJECTIVES: To provide a narrative review of disordered lymphatic dynamics and its impact on critical care relevant condition management. DATA SOURCES: Detailed search strategy using PubMed and Ovid Medline for English language articles (2013-2023) describ ... Full text Link to item Cite

Status Epilepticus and Refractory Status Epilepticus

Chapter · January 1, 2025 The critical care multi-professional team relies on multifaceted expertise, including knowledge of the nuances of pharmacological mechanisms, interactions, adverse effects, and contraindications of medications used in the management of emergency neurologic ... Full text Cite

In-Hospital Violence and Its Impact on Critical Care Practitioners.

Journal Article Crit Care Med · July 1, 2024 OBJECTIVES: To provide a narrative review of hospital violence (HV) and its impact on critical care clinicians. DATA SOURCES: Detailed search strategy using PubMed and OVID Medline for English language articles describing HV, risk factors, precipitating ev ... Full text Link to item Cite

Entrust But Verify….

Journal Article Crit Care Med · July 1, 2024 Full text Link to item Cite

Using Agitated Saline and Point-of-Care Ultrasound to Confirm Central Venous Catheter Placement: A Quality Improvement Project by Advanced Practice Providers

Journal Article Journal for Nurse Practitioners · June 1, 2024 Central lines placed in the internal jugular or subclavian vein are common among critically ill patients. A chest x-ray serves as the confirmation method in many institutions. However, ultrasound with agitated saline has been proven an effective, faster, a ... Full text Cite

The American Society of Transplant Surgeons Consensus Statement on Normothermic Regional Perfusion.

Journal Article Transplantation · February 1, 2024 On June 3, 2023, the American Society of Transplant Surgeons convened a meeting in San Diego, California to (1) develop a consensus statement with supporting data on the ethical tenets of thoracoabdominal normothermic regional perfusion (NRP) and abdominal ... Full text Link to item Cite

In Search of Clarity.

Journal Article Crit Care Med · February 1, 2024 Full text Link to item Cite

Gamification in Critical Care Education and Practice

Journal Article Critical Care Explorations · January 19, 2024 OBJECTIVES: To explore gamification as an alternative approach to healthcare education and its potential applications to critical care. DATA SOURCES: English language manuscripts addressing: 1) gamification theory and application in healthcare and critical ... Full text Cite

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Journal Article Transl Stroke Res · December 2023 Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ... Full text Link to item Cite

The authors reply.

Journal Article Crit Care Med · November 1, 2023 Full text Link to item Cite

State-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist.

Journal Article Crit Care Med · July 1, 2023 OBJECTIVES: To provide a concise review of knowledge and practice pertaining to the diagnosis and initial management of unanticipated adult patient disorders of consciousness (DoC) by the general intensivist. DATA SOURCES: Detailed search strategy using Pu ... Full text Link to item Cite

Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke.

Journal Article JAMA · June 20, 2023 IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ... Full text Link to item Cite

The History of Neurocritical Care as a Subspecialty.

Journal Article Crit Care Clin · January 2023 The role of the neurointensivist as a subspecialist has been cemented in modern medicine globally. It was forged through the collaboration of neurologists, neurosurgeons, internists, anesthesiologists, general surgeons, emergency medicine physicians, and p ... Full text Link to item Cite

Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.

Journal Article JAMA · September 15, 2020 IMPORTANCE: There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries. OBJECTIVE: To formulate a consensus statement of recommendations on dete ... Full text Link to item Cite

A Perspective from the Neurocritical Care Society and the Society of Critical Care Medicine: Team-Based Care for Neurological Critical Illness.

Journal Article Neurocrit Care · April 2020 The Neurocritical Care Society and the Society of Critical Care Medicine have worked together to create a perspective regarding the Standards of Neurologic Critical Care Units (Moheet et al. in Neurocrit Care 29:145-160, 2018). The most neurologically ill ... Full text Link to item Cite

Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1.

Journal Article Neurocrit Care · February 2020 INTRODUCTION: Neurocritical care focuses on the care of critically ill patients with an acute neurologic disorder and has grown significantly in the past few years. However, there is a lack of data that describe the scope of practice of neurointensivists a ... Full text Link to item Cite

Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2.

Journal Article Neurocrit Care · February 2020 BACKGROUND: Neurocritical care is devoted to the care of critically ill patients with acute neurological or neurosurgical emergencies. There is limited information regarding epidemiological data, disease characteristics, variability of clinical care, and i ... Full text Link to item Cite

Correction to: Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society.

Journal Article Neurocrit Care · August 2019 The authors note that there is a discrepancy between the text of the paper and Table 2 regarding physician subspecialty certification requirements in neurocritical care for Level II centers. ... Full text Link to item Cite

The authors reply.

Journal Article Crit Care Med · May 2019 Full text Link to item Cite

Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society.

Journal Article Neurocrit Care · October 2018 Neurocritical care is a distinct subspecialty focusing on the optimal management of acutely ill patients with life-threatening neurologic and neurosurgical disease or with life-threatening neurologic manifestations of systemic disease. Care by expert healt ... Full text Link to item Cite

A Case for Change in Adult Critical Care Training for Physicians in the United States: A White Paper Developed by the Critical Care as a Specialty Task Force of the Society of Critical Care Medicine.

Journal Article Crit Care Med · October 2018 OBJECTIVES: In the United States, physician training in Critical Care Medicine has developed as a subspecialty of different primary boards, despite significant commonality in knowledge and skills. The Society of Critical Care Medicine appointed a multidisc ... Full text Link to item Cite

Acute Kidney Injury After Craniotomy Is Associated With Increased Mortality: A Cohort Study.

Journal Article Neurosurgery · September 2016 BACKGROUND: Acute kidney injury (AKI) is a serious postoperative complication. OBJECTIVE: To determine whether AKI in patients after craniotomy is associated with heightened 30-day mortality. METHODS: We performed a 2-center, retrospective cohort study of ... Full text Link to item Cite

The practice of pediatric neurocritical care by the child neurologist.

Journal Article Semin Pediatr Neurol · December 2014 Pediatric neurocritical care (NCC) has emerged as a defined subspecialty in child neurology and requires a collaborative effort among child neurologists, pediatric critical care medicine specialists, and pediatric neurosurgeons. Pediatric NCC has evolved d ... Full text Link to item Cite

Sex differences in the use of early do-not-resuscitate orders after intracerebral hemorrhage.

Journal Article Stroke · November 2013 BACKGROUND AND PURPOSE: Studies show that women are more likely to receive do-not-resuscitate (DNR) orders after acute medical illnesses than men. However, the sex differences in the use of DNR orders after acute intracerebral hemorrhage (ICH) have not bee ... Full text Link to item Cite

Impact of methamphetamine on regional metabolism and cerebral blood flow after traumatic brain injury.

Journal Article Neurocrit Care · October 2013 BACKGROUND: Substance abuse is a frequent comorbid condition among patients with traumatic brain injury (TBI), but little is known about its potential additive or interactive effects on tissue injury or recovery from TBI. This study aims to evaluate change ... Full text Link to item Cite

Favorable outcomes for Native Hawaiians and other Pacific Islanders with severe traumatic brain injury.

Journal Article Hawaii J Med Public Health · April 2013 Traumatic brain injury (TBI) disproportionately impacts minority racial groups. However, limited information exists on TBI outcomes among Native Hawaiians and other Pacific Islanders (NHPI). All patients with severe TBI (Glasgow Coma Scale (GCS) <9) who we ... Link to item Cite

Disparities among Asians and native Hawaiians and Pacific Islanders with ischemic stroke.

Journal Article Neurology · February 26, 2013 OBJECTIVES: To evaluate disparities in cardiovascular risk factors among Asians and Native Hawaiians and other Pacific Islanders (NHPI) in Hawaii who are hospitalized with ischemic stroke. METHODS: We performed a retrospective study on consecutive patients ... Full text Link to item Cite

Surfers' myelopathy: a case series of 19 novice surfers with nontraumatic myelopathy.

Journal Article Neurology · November 27, 2012 OBJECTIVE: We report the clinical characteristics of the largest series of nontraumatic spinal cord injury in novice surfers (surfers' myelopathy). METHODS: A retrospective review of the electronic medical record was performed in patients with nontraumatic ... Full text Link to item Cite

MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study.

Journal Article Lancet Neurol · October 2012 BACKGROUND: Whether endovascular stroke treatment improves clinical outcomes is unclear because of the paucity of data from randomised placebo-controlled trials. We aimed to establish whether MRI can be used to identify patients who are most likely to bene ... Full text Link to item Cite

Racial disparities among Native Hawaiians and Pacific Islanders with intracerebral hemorrhage.

Journal Article Neurology · August 14, 2012 OBJECTIVES: To evaluate disparities in stroke risk factors and outcome among the Native Hawaiians and other Pacific Islanders (NHPI) in Hawaii who are hospitalized with intracerebral hemorrhage (ICH). METHODS: We performed a retrospective study on consecut ... Full text Link to item Cite

Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury.

Journal Article J Clin Anesth · June 2012 The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical an ... Full text Link to item Cite

Intensive versus conventional insulin therapy in critically ill neurologic patients.

Journal Article Neurocrit Care · December 2010 BACKGROUND: Previous studies of glycemic control in non-neurologic ICU patients have shown conflicting results. The purpose was to investigate whether intensive insulin therapy (IIT) to keep blood glucose levels from 80 to 110 mg/dl or conventional treatme ... Full text Link to item Cite

Patterns of increased intracranial pressure after severe traumatic brain injury.

Journal Article Neurocrit Care · 2009 INTRODUCTION: Secondary brain injury due to increased intracranial pressure (ICP) contributes to post-traumatic morbidity and mortality. Although it is often taught that increased ICP begins early after traumatic brain injury, some patients develop increas ... Full text Link to item Cite

The impact of substance abuse on mortality in patients with severe traumatic brain injury.

Journal Article J Trauma · September 2008 BACKGROUND: Drug and alcohol use are common in neurotrauma patients. Despite growing methamphetamine use there are few studies of the impact of methamphetamine use on outcome after traumatic brain injury (TBI). METHODS: We conducted a retrospective review ... Full text Link to item Cite

Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care.

Journal Article J Neurosurg Anesthesiol · April 2001 Analysis of patient data from a new neuroscience intensive care unit (NSICU) permitted evaluation of whether such a specialty ICU favorably altered clinical outcomes in critically ill neuroscience patients, and whether such a care model produced an efficie ... Full text Link to item Cite

Neurologic complications of critical illness and transplantation

Journal Article Current Opinion in Critical Care · January 1, 1999 The improvement of survival after organ and tissue transplantation increases the chances that the transplant recipient will survive to experience medical complications. The frequency of neurologic complications after liver transplantation has been reported ... Full text Cite

Altered mental status in thrombotic thrombocytopenic purpura is secondary to nonconvulsive status epilepticus.

Journal Article Ann Neurol · August 1996 Thrombotic thrombocytopenic purpura (TTP) is a syndrome with numerous neurological manifestations including altered mental status and seizures. At least 10% of the patients with TTP seen at our institution had nonconvulsive status epilepticus as a cause of ... Full text Link to item Cite

Regional myocardial perfusion of cardioplegic solutions.

Journal Article Ann Thorac Surg · May 1987 We compared the regional myocardial perfusion of blood cardioplegic solution (BCP) and crystalloid cardioplegic solution (CCP) in 14 mongrel dogs. Cardiopulmonary bypass was established at 28 degrees C, and a hydraulic occluder was placed around the proxim ... Full text Link to item Cite