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Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Publication ,  Journal Article
Feng, W; Domeracki, A; Park, C; Shah, S; Chhatbar, PY; Pawar, S; Chang, C; Hsu, P-C; Richardson, E; Hasan, D; Sokhadze, E; Zhang, Q; Liu, H
Published in: Transl Stroke Res
December 2023
Published version (DOI) Link to item

Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.

Duke Scholars

Pratik Yashvant Chhatbar
Author Pratik Yashvant Chhatbar Neurology, Stroke and Vascular Neurology
Swaroop Pawar
Author Swaroop Pawar Neurology, Stroke and Vascular Neurology
Shreyansh Shah
Author Shreyansh Shah Neurology, Neurocritical Care
David Hasan
Author David Hasan Neurosurgery
Cherylee Wai Jun Chang
Author Cherylee Wai Jun Chang Neurology, Neurocritical Care
Wuwei Feng
Author Wuwei Feng Neurology, Stroke and Vascular Neurology

Published In

Transl Stroke Res

DOI

10.1007/s12975-022-01103-7

EISSN

1868-601X

Publication Date

December 2023

Volume

14

Issue

6

Start / End Page

854 / 862

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Stroke Rehabilitation
  • Stroke
  • Laser Therapy
  • Humans
  • Brain Ischemia
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Feng, W., Domeracki, A., Park, C., Shah, S., Chhatbar, P. Y., Pawar, S., … Liu, H. (2023). Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities. Transl Stroke Res, 14(6), 854–862. https://doi.org/10.1007/s12975-022-01103-7
Feng, Wuwei, Alexis Domeracki, Christine Park, Shreyansh Shah, Pratik Y. Chhatbar, Swaroop Pawar, Cherylee Chang, et al. “Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.” Transl Stroke Res 14, no. 6 (December 2023): 854–62. https://doi.org/10.1007/s12975-022-01103-7.
Feng W, Domeracki A, Park C, Shah S, Chhatbar PY, Pawar S, et al. Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities. Transl Stroke Res. 2023 Dec;14(6):854–62.
Feng, Wuwei, et al. “Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.” Transl Stroke Res, vol. 14, no. 6, Dec. 2023, pp. 854–62. Pubmed, doi:10.1007/s12975-022-01103-7.
Feng W, Domeracki A, Park C, Shah S, Chhatbar PY, Pawar S, Chang C, Hsu P-C, Richardson E, Hasan D, Sokhadze E, Zhang Q, Liu H. Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities. Transl Stroke Res. 2023 Dec;14(6):854–862.
Journal cover image

Published In

Transl Stroke Res

DOI

10.1007/s12975-022-01103-7

EISSN

1868-601X

Publication Date

December 2023

Volume

14

Issue

6

Start / End Page

854 / 862

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Stroke Rehabilitation
  • Stroke
  • Laser Therapy
  • Humans
  • Brain Ischemia
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1109 Neurosciences