George James Cianciolo
Associate Professor Emeritus of Pathology
My laboratory has two major research interests. The first involves a potent, selective, small-molecule inhibitor of various pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF) or Monocyte Chemoattractant Protein-1 (MCP-1). This molecule, LMP-420, inhibits the transcription of mRNA for both TNF and MCP-1 as well as other pro-inflammatory chemokines such as Interferon Inducible Protein-10 (IP-10). Pro-inflammatory cytokines/chemokines such as these have been implicated in the pathogenesis of a number of major diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis and are also suspected to play a role in other major diseases including asthma, insulin resistance associated with obesity-related diabetes, cachexia associated with cancer and AIDS, and with the replication of HIV itself. LMP-420 has demonstrated potent anti-inflammatory activity in rodents when delivered by a variety of routes including intraperitoneal and subcutaneous injections, aerosolization, and orally. Recently we identified the potential utility of LMP-420 as an effective and safe therapeutic agent for treatment of B-cell chronic lymphocytic leukemia, multiple myeloma, or other hematological malignancies. Our laboratory studies are aimed at determining both the molecular target(s) and mechanism(s) of action of this novel and potentially clinically-useful cytokine/chemokine inhibitor and for identifying new diseases in which it might have potential utility.
The second area of interest involves a series of novel, viral-related peptides which inhibits vascular leak syndrome. These biologically-active sequences have been well-conserved in nature and are found not only in pathogenic retroviruses but in a number of human endogenous retroviral sequences as well. In an animal model of disseminated intravascular coagulation (DIC), one of these peptides fully protected animals from the lethal consequences of DIC. We are investigating this and related peptides for use in treating or preventing hemorrhagic events in diseases such as dengue hemorrhagic fever. We are in the process of characterizing the mechanism of action of these unique molecules and identifying additional diseases in which they might be utilized.
The second area of interest involves a series of novel, viral-related peptides which inhibits vascular leak syndrome. These biologically-active sequences have been well-conserved in nature and are found not only in pathogenic retroviruses but in a number of human endogenous retroviral sequences as well. In an animal model of disseminated intravascular coagulation (DIC), one of these peptides fully protected animals from the lethal consequences of DIC. We are investigating this and related peptides for use in treating or preventing hemorrhagic events in diseases such as dengue hemorrhagic fever. We are in the process of characterizing the mechanism of action of these unique molecules and identifying additional diseases in which they might be utilized.
Current Appointments & Affiliations
- Associate Professor Emeritus of Pathology, Pathology, Clinical Science Departments 2021
Contact Information
- 2424 Erwin Road, Hock Plaza, Suite 405, Durham, NC 27710
- DUMC 3712, Durham, NC 27710
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george.cianciolo@duke.edu
- Background
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Education, Training, & Certifications
- Ph.D., University of Miami 1977
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Previous Appointments & Affiliations
- Associate Professor in Pathology, Pathology, Clinical Science Departments 2017 - 2021
- Associate Professor Emeritus in Pathology, Pathology, Clinical Science Departments 2014 - 2017
- Associate Professor in Pathology, Pathology, Clinical Science Departments 2006 - 2014
- Associate Research Professor in Pathology, Pathology, Clinical Science Departments 1996 - 2006
- Adjunct Associate Professor in Pathology, Pathology, Clinical Science Departments 1995 - 1996
- Recognition
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Awards & Honors
- Expertise
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Subject Headings
- AIDS Vaccines
- Adjuvants, Immunologic
- Amino Acid Sequence
- Animals
- Antigens, Viral
- Ascites
- B-Lymphocytes
- Biological Factors
- Blood
- Boron Compounds
- Capillary Permeability
- Carrageenan
- Cell Adhesion
- Cell Communication
- Cell Count
- Cell Division
- Cell Line
- Cell Membrane
- Cell Movement
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chemistry, Physical
- Chemotactic Factors
- Chromatography
- Concanavalin A
- Culture Media
- Cytokines
- Cytotoxicity, Immunologic
- DNA
- DNA Replication
- Deltaretrovirus
- Diglycerides
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Delivery Systems
- Drug Evaluation, Preclinical
- Endocytosis
- Endothelial Cells
- Endothelium, Vascular
- Enterotoxins
- Enzyme Activation
- Epitopes
- Erythrocytes
- Exudates and Transudates
- Eye Neoplasms
- Female
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Vectors
- Glass
- Granulocyte-Macrophage Colony-Stimulating Factor
- Guanidines
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Homeostasis
- Humans
- Hypersensitivity, Delayed
- Immunity, Cellular
- Immunization
- Immunohistochemistry
- Immunologic Deficiency Syndromes
- Immunologic Surveillance
- Immunosuppression
- Immunosuppressive Agents
- Infant
- Inflammation
- Interferon-gamma
- Interferons
- Interleukins
- Islets of Langerhans
- Islets of Langerhans Transplantation
- Isoquinolines
- Kinetics
- Lectins
- Leukemia Virus, Feline
- Leukemia Virus, Murine
- Leukemia, Experimental
- Leukocytes
- Lipid A
- Liver Neoplasms, Experimental
- Lymph Nodes
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Lymphocytes
- Macrophages
- Male
- Mammary Neoplasms, Experimental
- Mathematics
- Melanoma, Experimental
- Methods
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Molecular Sequence Data
- Molecular Structure
- Molecular Weight
- Monocytes
- Mycoplasma pneumoniae
- N-Formylmethionine Leucyl-Phenylalanine
- Naphthalenes
- Neoplasm Proteins
- Neoplasms
- Neoplasms, Experimental
- Neutrophils
- Nitric Oxide
- Nucleosides
- Oligopeptides
- Ovarian Neoplasms
- Oxygen Consumption
- Peptide Fragments
- Peptides
- Peritonitis
- Phosphorylation
- Physicochemical Phenomena
- Pigment Epithelium of Eye
- Piperazines
- Pleural Effusion
- Pneumonia, Mycoplasma
- Pregnancy Complications, Infectious
- Prognosis
- Protein Binding
- Proteins
- Pulmonary Surfactant-Associated Protein A
- Purine Nucleosides
- Purines
- RNA, Messenger
- Recombinant Proteins
- Retroviridae
- Retroviridae Infections
- Retroviridae Proteins
- Retroviridae Proteins, Oncogenic
- Sarcoma, Experimental
- Sequence Homology, Nucleic Acid
- Signal Transduction
- Solubility
- Specific Pathogen-Free Organisms
- Spleen
- Structure-Activity Relationship
- Sulfonamides
- T-Lymphocytes
- T-Lymphocytes, Helper-Inducer
- Temperature
- Th1 Cells
- Th2 Cells
- Time Factors
- Tissue Extracts
- Transplantation, Homologous
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
- Tumor Virus Infections
- Uveitis
- Vaccines, Synthetic
- Viral Envelope Proteins
- Viral Proteins
- Vitreoretinopathy, Proliferative
- alpha-Macroglobulins
- Research
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Selected Grants
- Cell Receptors In Coagulation And Atherogenesis awarded by National Institutes of Health 1979 - 2008
- A Cooperative Research and Development Agreement awarded by US Army Medical Research 2001 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Cianciolo, George J., and Salvatore V. Pizzo. “Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects.” Plos One 7, no. 12 (2012): e52693. https://doi.org/10.1371/journal.pone.0052693.Full Text Link to Item
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Angaswamy, Nataraju, Naohiko Fukami, Venkataswarup Tiriveedhi, George J. Cianciolo, and T. Mohanakumar. “LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.” Cell Transplant 21, no. 6 (2012): 1285–96. https://doi.org/10.3727/096368911X637371.Full Text Link to Item
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Mowery, Y. M., J. B. Weinberg, M. N. Kennedy, K. M. Bond, J. O. Moore, M. C. Lanasa, J. P. Gockerman, et al. “LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.” Leukemia 24, no. 9 (September 2010): 1580–87. https://doi.org/10.1038/leu.2010.150.Full Text Link to Item
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Bowers, Edith V., Jeffrey J. Horvath, Jennifer E. Bond, George J. Cianciolo, and Salvatore V. Pizzo. “Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.” J Leukoc Biol 86, no. 5 (November 2009): 1259–68. https://doi.org/10.1189/jlb.1008653.Full Text Link to Item
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Ledford, Julie G., Hisatsugu Goto, Erin N. Potts, Simone Degan, Hong Wei Chu, Dennis R. Voelker, Mary E. Sunday, et al. “SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.” J Immunol 182, no. 12 (June 15, 2009): 7818–27. https://doi.org/10.4049/jimmunol.0900452.Full Text Link to Item
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Hale, Laura P., and George Cianciolo. “Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription.” J Inflamm (Lond) 5 (March 10, 2008): 4. https://doi.org/10.1186/1476-9255-5-4.Full Text Link to Item
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Anderson, Ryan B., George J. Cianciolo, Margaret N. Kennedy, and Salvatore V. Pizzo. “Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.” J Leukoc Biol 83, no. 2 (February 2008): 381–92. https://doi.org/10.1189/jlb.0407236.Full Text Link to Item
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Kaczowka, Steven J., Lara S. Madding, Kevin L. Epting, Robert M. Kelly, George J. Cianciolo, and Salvatore V. Pizzo. “Probing the stability of native and activated forms of alpha2-macroglobulin.” Int J Biol Macromol 42, no. 1 (January 1, 2008): 62–67. https://doi.org/10.1016/j.ijbiomac.2007.09.019.Full Text Link to Item
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Bond, Jennifer E., George J. Cianciolo, and Salvatore V. Pizzo. “Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange.” Biochem Biophys Res Commun 357, no. 2 (June 1, 2007): 433–38. https://doi.org/10.1016/j.bbrc.2007.03.151.Full Text Link to Item
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Wassmer, Samuel C., George J. Cianciolo, Valéry Combes, and Georges E. Grau. “[LMP-420, a new therapeutic approach for cerebral malaria?].” Med Sci (Paris) 22, no. 4 (April 2006): 343–45. https://doi.org/10.1051/medsci/2006224343.Full Text Link to Item
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Haraguchi, Soichi, Noorbibi K. Day, Wasu Kamchaisatian, Macarena Beigier-Pompadre, Steffen Stenger, Nutthapong Tangsinmankong, John W. Sleasman, Salvatore V. Pizzo, and George J. Cianciolo. “LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells.” Aids Res Ther 3 (March 31, 2006): 8. https://doi.org/10.1186/1742-6405-3-8.Full Text Link to Item
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Banbula, Agnieszka, Lara S. Chang, Wayne F. Beyer, Charu L. Bohra, George J. Cianciolo, and Salvatore V. Pizzo. “The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins.” J Biochem 138, no. 5 (November 2005): 527–37. https://doi.org/10.1093/jb/mvi162.Full Text Link to Item
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Wassmer, Samuel C., George J. Cianciolo, Valéry Combes, and Georges E. Grau. “Inhibition of endothelial activation: a new way to treat cerebral malaria?” Plos Med 2, no. 9 (September 2005): e245. https://doi.org/10.1371/journal.pmed.0020245.Full Text Link to Item
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Buettner, Maike, Christoph Meinken, Max Bastian, Rauf Bhat, Elmar Stössel, Gerhard Faller, George Cianciolo, et al. “Inverse correlation of maturity and antibacterial activity in human dendritic cells.” J Immunol 174, no. 7 (April 1, 2005): 4203–9. https://doi.org/10.4049/jimmunol.174.7.4203.Full Text Link to Item
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Luangwedchakarn, Voravich, Noorbibi K. Day, Remi Hitchcock, Pam G. Brown, Danica L. Lerner, Rajivi P. Rucker, George J. Cianciolo, Robert A. Good, and Soichi Haraguchi. “A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.” Peptides 24, no. 5 (May 2003): 631–37. https://doi.org/10.1016/s0196-9781(03)00137-2.Full Text Link to Item
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Liao, Hua Xin, George J. Cianciolo, Herman F. Staats, Richard M. Scearce, Dana M. Lapple, Stephen H. Stauffer, James R. Thomasch, et al. “Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF.” Vaccine 20, no. 17–18 (May 22, 2002): 2396–2403. https://doi.org/10.1016/s0264-410x(02)00090-7.Full Text Link to Item
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Cianciolo, G. J., J. J. Enghild, and S. V. Pizzo. “Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity.” Vaccine 20, no. 3–4 (November 12, 2001): 554–62. https://doi.org/10.1016/s0264-410x(01)00361-9.Full Text Link to Item
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Bhattacharjee, G., U. K. Misra, G. Gawdi, G. Cianciolo, and S. V. Pizzo. “Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.” J Cell Biochem 82, no. 2 (2001): 260–70. https://doi.org/10.1002/jcb.1152.Full Text Link to Item
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Haraguchi, S., G. J. Cianciolo, R. A. Good, M. James-Yarish, E. Brigino, and N. K. Day. “Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.” Aids 12, no. 7 (May 7, 1998): 820–23.Link to Item
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Haraguchi, S., R. A. Good, G. J. Cianciolo, R. W. Engelman, and N. K. Day. “Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections.” J Leukoc Biol 61, no. 6 (June 1997): 654–66. https://doi.org/10.1002/jlb.61.6.654.Full Text Link to Item
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Brigino, E., S. Haraguchi, A. Koutsonikolis, G. J. Cianciolo, U. Owens, R. A. Good, and N. K. Day. “Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway.” Proc Natl Acad Sci U S A 94, no. 7 (April 1, 1997): 3178–82. https://doi.org/10.1073/pnas.94.7.3178.Full Text Link to Item
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Hamilton, T. A., and G. Cianciolo. “Dolph Oliver Adams, M.D., Ph.D.” Journal of Leukocyte Biology 60, no. 6 (1996): 675–76.
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Haraguchi, S., R. A. Good, M. James-Yarish, G. J. Cianciolo, and N. K. Day. “Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections.” Proc Natl Acad Sci U S A 92, no. 12 (June 6, 1995): 5568–71. https://doi.org/10.1073/pnas.92.12.5568.Full Text Link to Item
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Jaffe, G. J., W. L. Roberts, H. L. Wong, A. D. Yurochko, and G. J. Cianciolo. “Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells.” Exp Eye Res 60, no. 5 (May 1995): 533–43. https://doi.org/10.1016/s0014-4835(05)80068-5.Full Text Link to Item
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Haraguchi, S., R. A. Good, M. James-Yarish, G. J. Cianciolo, and N. K. Day. “Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.” Proc Natl Acad Sci U S A 92, no. 8 (April 11, 1995): 3611–15. https://doi.org/10.1073/pnas.92.8.3611.Full Text Link to Item
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Haraguchi, S., R. A. Good, M. James-Yarish, G. J. Cianciolo, and N. K. Day. “Erratum: Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein (Proceedings of the National Academy of Sciences of the United States of America (April 11, 1995) 92:8 (3611-3615)).” Proceedings of the National Academy of Sciences of the United States of America 92, no. 19 (January 1, 1995): 9009.
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Cianciolo, G. J., and D. O. Adams. “Section review pulmonary-allergy, dermatological, gastrointestinal and arthritis: Development of drugs that suppress macrophages: Beginning of a new era?” Expert Opinion on Investigational Drugs 3, no. 7 (July 1, 1994): 699–708. https://doi.org/10.1517/13543784.3.7.699.Full Text
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Haraguchi, S., R. A. Good, G. J. Cianciolo, M. James-Yarish, and N. K. Day. “Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein.” J Immunol 151, no. 5 (September 1, 1993): 2733–41.Link to Item
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Cianciolo, G. J. “Antiinflammatory effects of neoplasms.” Res Immunol 144, no. 4 (May 1993): 268–71. https://doi.org/10.1016/0923-2494(93)80104-7.Full Text Link to Item
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Haraguchi, S., R. A. Good, G. J. Cianciolo, and N. K. Day. “A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression.” J Leukoc Biol 52, no. 4 (October 1992): 469–72. https://doi.org/10.1002/jlb.52.4.469.Full Text Link to Item
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Haraguchi, S., W. T. Liu, G. J. Cianciolo, R. A. Good, and N. K. Day. “Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes.” Cell Immunol 141, no. 2 (May 1992): 388–97. https://doi.org/10.1016/0008-8749(92)90157-k.Full Text Link to Item
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Jiang, J. B., M. G. Johnson, J. M. Defauw, T. M. Beine, L. M. Bellas, W. P. Janzen, C. R. Loomis, et al. “Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.” Journal of Medicinal Chemistry 35, no. 23 (1992): 4259–63.
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Kizaki, T., M. Mitani, G. J. Cianciolo, M. Ogasawara, R. A. Good, and N. K. Day. “Specific association of retroviral envelope protein, p15E, with human cell surfaces.” Immunol Lett 28, no. 1 (April 1991): 11–18. https://doi.org/10.1016/0165-2478(91)90121-p.Full Text Link to Item
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Kadota, J., G. J. Cianciolo, and R. Snyderman. “A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.” Microbiol Immunol 35, no. 6 (1991): 443–59. https://doi.org/10.1111/j.1348-0421.1991.tb01575.x.Full Text Link to Item
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Ogasawara, M., G. J. Cianciolo, M. Mitani, T. Kizaki, R. A. Good, and N. K. Day. “The suppressive effect of a synthetic retroviral peptide on the human IFN gamma production is abrogated by the combined stimulation with IL-1 and IL-2.” Cancer Detect Prev 15, no. 3 (1991): 205–9.Link to Item
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Gottlieb, R. A., E. S. Kleinerman, C. A. O’Brian, S. Tsujimoto, G. J. Cianciolo, and W. J. Lennarz. “Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E.” J Immunol 145, no. 8 (October 15, 1990): 2566–70.Link to Item
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Ogasawara, M., S. Haraguchi, G. J. Cianciolo, M. Mitani, R. A. Good, and N. K. Day. “Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL.” J Immunol 145, no. 2 (July 15, 1990): 456–62.Link to Item
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Laurence, J., J. Kulkosky, B. Dong, E. Early, R. Snyderman, and G. J. Cianciolo. “A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E.” Cell Immunol 128, no. 2 (July 1990): 337–52. https://doi.org/10.1016/0008-8749(90)90031-l.Full Text Link to Item
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Gottlieb, R. A., W. J. Lennarz, R. D. Knowles, G. J. Cianciolo, C. A. Dinarello, L. B. Lachman, and E. S. Kleinerman. “Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.” J Immunol 142, no. 12 (June 15, 1989): 4321–28.Link to Item
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Wang, J. M., Z. G. Chen, G. J. Cianciolo, R. Snyderman, F. Breviario, E. Dejana, and A. Mantovani. “Production of a retroviral P15E-related chemotaxis inhibitor by IL-1-treated endothelial cells. A possible negative feedback in the regulation of the vascular response to monokines.” J Immunol 142, no. 6 (March 15, 1989): 2012–17.Link to Item
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Nelson, M., D. S. Nelson, G. J. Cianciolo, and R. Snyderman. “Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products.” Cancer Immunol Immunother 30, no. 2 (1989): 113–18. https://doi.org/10.1007/BF01665962.Full Text Link to Item
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Cianciolo, G. J., H. Bogerd, and R. Snyderman. “Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation.” Immunol Lett 19, no. 1 (September 1988): 7–13. https://doi.org/10.1016/0165-2478(88)90112-5.Full Text Link to Item
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Ogasawara, M., G. J. Cianciolo, R. Snyderman, M. Mitani, R. A. Good, and N. K. Day. “Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein.” J Immunol 141, no. 2 (July 15, 1988): 614–19.Link to Item
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Kleinerman, E. S., L. B. Lachman, R. D. Knowles, R. Snyderman, and G. J. Cianciolo. “A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.” J Immunol 139, no. 7 (October 1, 1987): 2329–37.Link to Item
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Schmidt, D. M., N. K. Sidhu, G. J. Cianciolo, and R. Snyderman. “Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation.” Proc Natl Acad Sci U S A 84, no. 20 (October 1987): 7290–94. https://doi.org/10.1073/pnas.84.20.7290.Full Text Link to Item
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Benomar, A., W. J. Ming, G. Taraboletti, P. Ghezzi, C. Balotta, G. J. Cianciolo, R. Snyderman, J. F. Doré, and A. Mantovani. “Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice.” J Immunol 138, no. 7 (April 1, 1987): 2372–79.Link to Item
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Palker, T. J., T. J. Matthews, M. E. Clark, G. J. Cianciolo, R. R. Randall, A. J. Langlois, G. C. White, B. Safai, R. Snyderman, and D. P. Bolognesi. “A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.” Proc Natl Acad Sci U S A 84, no. 8 (April 1987): 2479–83. https://doi.org/10.1073/pnas.84.8.2479.Full Text Link to Item
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Harris, D. T., G. J. Cianciolo, R. Snyderman, S. Argov, and H. S. Koren. “Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.” J Immunol 138, no. 3 (February 1, 1987): 889–94.Link to Item
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Mitani, M., G. J. Cianciolo, R. Snyderman, M. Yasuda, R. A. Good, and N. K. Day. “Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses.” Proc Natl Acad Sci U S A 84, no. 1 (January 1987): 237–40. https://doi.org/10.1073/pnas.84.1.237.Full Text Link to Item
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Wang, J. M., G. J. Cianciolo, R. Snyderman, and A. Mantovani. “Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants.” J Immunol 137, no. 8 (October 15, 1986): 2726–32.Link to Item
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Cianciolo, G. J. “Antiinflammatory proteins associated with human and murine neoplasms.” Biochim Biophys Acta 865, no. 1 (August 5, 1986): 69–82. https://doi.org/10.1016/0304-419x(86)90014-4.Full Text Link to Item
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Harrell, R. A., G. J. Cianciolo, T. D. Copeland, S. Oroszlan, and R. Snyderman. “Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.” J Immunol 136, no. 10 (May 15, 1986): 3517–20.Link to Item
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Cianciolo, G. J., and R. Snyderman. “Effects of tumor growth on host defenses.” Cancer Metastasis Rev 5, no. 1 (1986): 15–27. https://doi.org/10.1007/BF00049528.Full Text Link to Item
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Cianciolo, G. J., T. D. Copeland, S. Oroszlan, and R. Snyderman. “Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.” Science 230, no. 4724 (October 25, 1985): 453–55. https://doi.org/10.1126/science.2996136.Full Text Link to Item
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Nelson, M., D. S. Nelson, P. B. Spradbrow, V. K. Kuchroo, P. A. Jennings, G. J. Cianciolo, and R. Snyderman. “Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms.” Clin Exp Immunol 61, no. 1 (July 1985): 109–17.Link to Item
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Cianciolo, G. J., G. M. Sciortino, D. M. Schmidt, and R. Snyderman. “Enhanced tumorigenicity of transformed NIH/3T3 cells which produce retroviral P15E.” Proceedings of the American Association for Cancer Research VOL. 26 (January 1, 1985).
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Cianciolo, G. J., H. P. Bogerd, R. J. Kipnis, T. D. Copeland, S. Oroszlan, and R. Snyderman. “Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.” Trans Assoc Am Physicians 98 (1985): 30–41.Link to Item
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Cianciolo, G. J., R. J. Kipnis, and R. Snyderman. “Antibody to a synthetic peptide reacts with envelope proteins of both murine and human type C retroviruses.” Federation Proceedings 44, no. 4 (January 1, 1985): 3121.
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Cianciolo, G. J., R. J. Kipnis, and R. Snyderman. “Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV.” Nature 311, no. 5986 (October 11, 1984): 515. https://doi.org/10.1038/311515a0.Full Text Link to Item
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Snyderman, R., and G. J. Cianciolo. “Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia.” Immunol Today 5, no. 8 (August 1984): 240–44. https://doi.org/10.1016/0167-5699(84)90097-5.Full Text Link to Item
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Cianciolo, G. J., D. Phipps, and R. Snyderman. “Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen.” J Exp Med 159, no. 3 (March 1, 1984): 964–69. https://doi.org/10.1084/jem.159.3.964.Full Text Link to Item
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Cianciolo, G. J., M. E. Lostrom, M. Tam, and R. Snyderman. “Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E.” J Exp Med 158, no. 3 (September 1, 1983): 885–900. https://doi.org/10.1084/jem.158.3.885.Full Text Link to Item
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Laszlo, J., A. T. Huang, W. D. Brenckman, C. Jeffs, H. Koren, G. Cianciolo, R. Metzgar, et al. “Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer.” Cancer Res 43, no. 9 (September 1983): 4458–66.Link to Item
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Cianciolo, G., W. Brenckman, and R. Snyderman. “Effects of interferon therapy on monocyte functions of cancer patients.” Proceedings of the American Association for Cancer Research Vol. 23 (January 1, 1982).
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Snyderman, R., and G. Cianciolo. “Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms.” Adv Exp Med Biol 155 (1982): 343–52. https://doi.org/10.1007/978-1-4684-4394-3_35.Full Text Link to Item
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Cianciolo, G., J. Hunter, J. Silva, J. S. Haskill, and R. Snyderman. “Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.” J Clin Invest 68, no. 4 (October 1981): 831–44. https://doi.org/10.1172/jci110338.Full Text Link to Item
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Cianciolo, G. J., and R. Snyderman. “Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants.” J Clin Invest 67, no. 1 (January 1981): 60–68. https://doi.org/10.1172/JCI110033.Full Text Link to Item
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Cianciolo, G. J., R. B. Herberman, and R. Snyderman. “Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.” J Natl Cancer Inst 65, no. 4 (October 1980): 829–34. https://doi.org/10.1093/jnci/65.4.829.Full Text Link to Item
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Cianciolo, G. J., T. J. Matthews, D. P. Bolognesi, and R. Snyderman. “Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.” J Immunol 124, no. 6 (June 1980): 2900–2905.Link to Item
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Snyderman, R., and G. J. Cianciolo. “Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI.” J Reticuloendothel Soc 26, no. 4 (October 1979): 453–58.Link to Item
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Cianciolo, G. J., and J. A. Jensen. “In vivo and in vitro effects of acute graft-versus-host serum in the rat.” Transplantation 23, no. 4 (April 1977): 303–9. https://doi.org/10.1097/00007890-197704000-00002.Full Text Link to Item
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Shaipanich, T., and G. J. Cianciolo. “The rapid and large scale separation of peritoneal macrophages.” Immunology 22, no. 4 (April 1972): 525–29.Link to Item
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