George James Cianciolo

Journal Article PloS one · January 2012 Malignant and inflammatory tissues sometimes express endogenous retroviruses or their proteins. A highly-conserved sequence from retroviral transmembrane (TM) proteins, termed the "immunosuppressive domain (ID)", is associated with inhibition of immune and ... Full text Cite

LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.

Journal Article Cell Transplant · 2012 Inflammatory insults following islet transplantation (ITx) hinders engraftment and long-term function of the transplanted (Tx) islets. Using a murine model of ITx, we determined the role of LMP-420, a novel TNF-α inhibitor, both individually and in combina ... Full text Link to item Cite

LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.

Journal Article Leukemia · September 2010 B-cell chronic lymphocytic leukemia (CLL) is characterized by slow accumulation of malignant cells, which are supported in the microenvironment by cell-cell interactions and soluble cytokines such as tumor necrosis factor (TNF). We evaluated the effect of ... Full text Link to item Cite

Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.

Journal Article J Leukoc Biol · November 2009 alpha(2)M* targets antigens to APCs for rapid internalization, processing, and presentation. When used as an antigen-delivery vehicle, alpha(2)M* amplifies MHC class II presentation, as demonstrated by increased antibody titers. Recent evidence, however, s ... Full text Link to item Cite

SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.

Journal Article J Immunol · June 15, 2009 The lung is constantly challenged during normal breathing by a myriad of environmental irritants and infectious insults. Pulmonary host defense mechanisms maintain homeostasis between inhibition/clearance of pathogens and regulation of inflammatory respons ... Full text Link to item Cite

Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription.

Journal Article J Inflamm (Lond) · March 10, 2008 BACKGROUND: LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells. METHODS: This study investigated the efficacy of LMP-420 as an anti-inflammatory agent i ... Full text Link to item Cite

Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.

Journal Article J Leukoc Biol · February 2008 Featured Publication CpG oligodeoxynucleotides (ODN) stimulate the immune system and are under evaluation as treatments and vaccine adjuvants for infectious diseases, cancer, and immune system disorders. Although they have shown promising results in numerous clinical trials, t ... Full text Link to item Cite

Probing the stability of native and activated forms of alpha2-macroglobulin.

Journal Article Int J Biol Macromol · January 1, 2008 Featured Publication alpha2-Macroglobulin (alpha2M) is a 718 kDa homotetrameric proteinase inhibitor which undergoes a large conformational change upon activation. This conformational change can occur either by proteolytic attack on an approximately 40 amino acid stretch, the ... Full text Link to item Cite

Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange.

Journal Article Biochem Biophys Res Commun · June 1, 2007 Featured Publication alpha(2)-Macroglobulin (alpha(2)M) is a proteinase inhibitor that functions by a trapping mechanism which has been exploited such that the receptor-recognized, activated form (alpha(2)M( *)) can be employed to target antigens to antigen-presenting cells. A ... Full text Link to item Cite

[LMP-420, a new therapeutic approach for cerebral malaria?].

Journal Article Med Sci (Paris) · April 2006 Full text Link to item Cite

LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells.

Journal Article AIDS Res Ther · March 31, 2006 Featured Publication BACKGROUND: Co-infections of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (M. Tb) are steadily increasing and represent a major health crisis in many developing countries. Both pathogens individually stimulate tumor necrosis factor-alp ... Full text Link to item Cite

The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins.

Journal Article J Biochem · November 2005 We have characterized native and activated forms of rabbit alpha1M and compared them to rabbit and human alpha2M. Similar to human alpha2M, rabbit alpha1M is a tetramer associated via disulfide bonds and non-covalent interactions that exhibits autolysis in ... Full text Link to item Cite

Inhibition of endothelial activation: a new way to treat cerebral malaria?

Journal Article PLoS Med · September 2005 Featured Publication BACKGROUND: Malaria is still a major public health problem, partly because the pathogenesis of its major complication, cerebral malaria (CM), remains incompletely understood. However tumor necrosis factor (TNF) is thought to play a key role in the developm ... Full text Link to item Cite

Inverse correlation of maturity and antibacterial activity in human dendritic cells.

Journal Article J Immunol · April 1, 2005 Dendritic cells (DCs) are a key part of host defense against microbial pathogens, being part of the innate immune system, but also instructing the adaptive T cell response. This study was designed to evaluate whether human DCs directly contribute to innate ... Full text Link to item Cite

A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.

Journal Article Peptides · May 2003 Featured Publication CKS-17, a synthetic peptide representing a unique amino acid motif which is highly conserved in retroviral transmembrane proteins and other immunoregulatory proteins, induces selective immunomodulatory functions, both in vitro and in vivo, and activates in ... Full text Link to item Cite

Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF.

Journal Article Vaccine · May 22, 2002 Featured Publication Critical to the success of HIV-1 subunit vaccines is the development of strategies to augment vaccine immunogenicity. Successful adjuvants must not only improve immunogenicity above current adjuvant levels, but must also decrease the dose of immunogen requ ... Full text Link to item Cite

Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity.

Journal Article Vaccine · November 12, 2001 Featured Publication A safe, effective, more potent adjuvant than currently available would be beneficial in developing new therapeutics and diagnostic reagents. We report here a technique for the rapid, efficient incorporation of non-proteolytic antigens into alpha(2)-macrogl ... Full text Link to item Cite

Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.

Journal Article J Cell Biochem · 2001 Thioglycollate (TG)-elicited murine, peritoneal macrophages express two receptors for activated forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*)--namely, the low density lipoprotein receptor-related protein (LRP) and the alpha2M signaling ... Full text Link to item Cite

Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.

Journal Article AIDS · May 7, 1998 Featured Publication Link to item Cite

Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections.

Journal Article J Leukoc Biol · June 1997 Featured Publication Studies of the effects of retroviruses on the immune system, which date back through thirty years of investigations, are reviewed. In the earliest published studies in the 1960s, it was demonstrated that mice infected with oncogenic viruses were immunosupp ... Full text Link to item Cite

Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects.

LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.

LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.

Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.

SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.

Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription.

Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.

Probing the stability of native and activated forms of alpha2-macroglobulin.

Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange.

[LMP-420, a new therapeutic approach for cerebral malaria?].

Journal Article Med Sci (Paris) · April 2006 Full text Link to item Cite

LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells.

The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins.

Inhibition of endothelial activation: a new way to treat cerebral malaria?

Inverse correlation of maturity and antibacterial activity in human dendritic cells.

A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.

Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF.

Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity.

Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.

Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.

Journal Article AIDS · May 7, 1998 Featured Publication Link to item Cite

Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections.

Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway.

Journal Article Proc Natl Acad Sci U S A · April 1, 1997 Featured Publication HIV-1 Nef protein shares a significant homology with the immunosuppressive and highly conserved retroviral transmembrane protein p15E. In the present study, extracellular Nef protein is shown to induce interleukin (IL)-10 mRNA expression in human periphera ... Full text Link to item Cite

Dolph Oliver Adams, M.D., Ph.D.

Journal Article Journal of leukocyte biology · 1996 Cite

Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections.

Journal Article Proc Natl Acad Sci U S A · June 6, 1995 Featured Publication A synthetic heptadecapeptide, CKS-17, represents the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 has been demonstrated to exhibit suppressive properties for numerou ... Full text Link to item Cite

Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells.

Journal Article Exp Eye Res · May 1995 Monocytes and retinal pigment epithelial cells are intimately associated in membranes of eyes with proliferative vitreoretinopathy and in certain types of uveitis. The goal of this study was to determine whether monocytes modulate cytokine expression in re ... Full text Link to item Cite

Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.

Journal Article Proc Natl Acad Sci U S A · April 11, 1995 The influence of a synthetic retroviral peptide, CKS-17, on T helper type 1 (Th1)- or Th2-related cytokines was investigated in human blood mononuclear cells. Cells were stimulated with staphylococcal enterotoxin A, anti-CD3 plus anti-CD28 monoclonal antib ... Full text Link to item Cite

Erratum: Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein (Proceedings of the National Academy of Sciences of the United States of America (April 11, 1995) 92:8 (3611-3615))

Journal Article Proceedings of the National Academy of Sciences of the United States of America · January 1, 1995 Cite

Section review pulmonary-allergy, dermatological, gastrointestinal and arthritis: Development of drugs that suppress macrophages: Beginning of a new era?

Journal Article Expert Opinion on Investigational Drugs · July 1, 1994 Drugs, currently in development and targeted toward macrophages, are principally aimed at the down-regulation of macrophage function to treat the wide variety of diseases caused by excessive activity of these cells. The principal current strategy for devel ... Full text Cite

Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein.

Journal Article J Immunol · September 1, 1993 Featured Publication We have previously shown that a synthetic peptide (CKS-17) homologous to retroviral envelope protein suppresses the accumulation of superantigen staphylococcal enterotoxin-induced TNF-alpha mRNA in human PBMC and in highly purified human monocytes. The pre ... Link to item Cite

Antiinflammatory effects of neoplasms.

Journal Article Res Immunol · May 1993 Featured Publication Full text Link to item Cite

Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.

Journal Article J Med Chem · November 13, 1992 A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 microM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further eval ... Full text Link to item Cite

A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression.

Journal Article J Leukoc Biol · October 1992 Featured Publication We investigated the influence of CKS-17, a synthetic heptadecapeptide that corresponds to a highly conserved domain of the immunosuppressive retroviral envelope protein p15E, on staphylococcal enterotoxin B (SEB)-induced TNF-alpha gene expression in human ... Full text Link to item Cite

Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes.

Journal Article Cell Immunol · May 1992 CKS-17, a synthetic amino acid peptide homologous to a highly conserved region of retroviral transmembrane protein exerts a suppressive action on staphylococcal enterotoxin A (SEA)-induced the production of IFN-gamma by human peripheral blood mononuclear c ... Full text Link to item Cite

Specific association of retroviral envelope protein, p15E, with human cell surfaces.

Journal Article Immunol Lett · April 1991 Experiments were carried out to analyze the binding sites on human cells for highly purified retroviral protein p15E isolated from Feline Leukemia Virus, Rickard Strain. Binding of 125I-labeled p15E was tested with surfaces of human peripheral blood lympho ... Full text Link to item Cite

The suppressive effect of a synthetic retroviral peptide on the human IFN gamma production is abrogated by the combined stimulation with IL-1 and IL-2.

Journal Article Cancer Detect Prev · 1991 Certain retroviral envelope proteins and peptides have been shown to be highly immunosuppressive. Recently, we have demonstrated that a synthetic 17 amino acid peptide (CKS-17*) homologous to a highly conserved region in the transmembrane portion of the en ... Link to item Cite

A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.

Journal Article Microbiol Immunol · 1991 CKS-17, an immunosuppressive peptide homologous to certain retroviral transmembrane envelope protein, has been shown to inhibit lymphocyte proliferation in response to mitogens or alloantigens when covalently attached to bovine serum albumin (CKS-17-BSA). ... Full text Link to item Cite

Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E.

Journal Article J Immunol · October 15, 1990 Retroviral infection is associated with immunosuppression, which has been shown to be due, in part, to the action of the envelope protein p15E. We studied a synthetic peptide (CKS-17) homologous to a highly conserved domain of the retroviral envelope prote ... Link to item Cite

Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL.

Journal Article J Immunol · July 15, 1990 A synthetic 17 amino acid peptide (CKS-17) homologous to a highly conserved region of human and animal retroviral transmembrane proteins was investigated for its influence on the generation of murine alloantigen-specific CTL activity in vitro. CKS-17 coupl ... Link to item Cite

A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E.

Journal Article Cell Immunol · July 1990 Featured Publication Soluble suppressor factor (SSF), first described in association with HIV-1 infection in vivo, is a molecule(s) capable of inhibiting T cell-dependent immune reactivity. Its relationship to human immunodeficiency virus (HIV) was further defined as supernata ... Full text Link to item Cite

Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.

Journal Article J Immunol · June 15, 1989 We studied the mode of action of the synthetic peptide CKS-17, which is a heptadecapeptide homologous to a highly conserved region of the immunosuppressive retroviral envelope protein p15E, as well as to envelope proteins of the human T cell leukemia virus ... Link to item Cite

Production of a retroviral P15E-related chemotaxis inhibitor by IL-1-treated endothelial cells. A possible negative feedback in the regulation of the vascular response to monokines.

Journal Article J Immunol · March 15, 1989 The effects of IL-1 on vascular endothelium result in a complex set of alterations which are potentially disruptive of vessel wall and underlying tissue integrity. The present study was aimed at investigating possible regulation of such potentially destruc ... Link to item Cite

Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products.

Journal Article Cancer Immunol Immunother · 1989 CKS-17 is a heptadecapeptide corresponding to a region highly conserved in retroviral transmembrane proteins such as p15E. Because a relationship had previously been determined between p15E and immunosuppressive tumor cell products, we examined the effect ... Full text Link to item Cite

Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation.

Journal Article Immunol Lett · September 1988 Immunosuppression frequently accompanies infections with the human retroviruses HTLV-1 and HIV. Previous studies have shown that UV-inactivated and detergent-disrupted preparations of either virus can produce immune dysfunction in vitro although the active ... Full text Link to item Cite

Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein.

Journal Article J Immunol · July 15, 1988 A synthetic 17 amino acid peptide (CKS-17) homologous to a highly conserved region of human and animal retroviral transmembrane proteins was investigated for its influence on the in vitro production of IFN-gamma from human peripheral mononuclear cells. The ... Link to item Cite

Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation.

Journal Article Proc Natl Acad Sci U S A · October 1987 Retroviral envelope protein p15E and antigenically related proteins have been implicated as potential mediators of immune dysfunction associated with retroviral infections and with neoplasia. Due to its extreme hydrophobicity, purified p15E has not been av ... Full text Link to item Cite

A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.

Journal Article J Immunol · October 1, 1987 The synthetic peptide CKS-17 has homology to a highly conserved region of the immunosuppressive retroviral envelope protein P15E, to envelope proteins of HTLV I, II, III, and to that encoded by an endogeneous C-type human retroviral DNA. CKS-17 inhibits th ... Link to item Cite

A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.

Journal Article Proc Natl Acad Sci U S A · April 1987 A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids f ... Full text Link to item Cite

Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice.

Journal Article J Immunol · April 1, 1987 The present study was designed to characterize the production of chemoattractants by human melanoma lines with high (M4Be, M3Da, NTerDa) or low tumorigenic (Doc8, M1Do) potential when heterotransplanted in nude mice. Supernatants from the Doc8 and M1Do cel ... Link to item Cite

Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.

Journal Article J Immunol · February 1, 1987 It has been shown previously that the retroviral envelope protein p15E suppresses certain monocyte and lymphocyte functions. In this paper, we describe the effects on natural killer (NK) activity of a synthetic peptide (CKS-17) with homology to a region of ... Link to item Cite

Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses.

Journal Article Proc Natl Acad Sci U S A · January 1987 Purified feline leukemia virus, UV light-inactivated feline leukemia virus, and a synthetic peptide (CKS-17) homologous to a well-conserved region of the transmembrane components of several human and animal retroviruses were each studied for their effects ... Full text Link to item Cite

Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants.

Journal Article J Immunol · October 15, 1986 Two sets of seemingly contradictory evidence have been reported concerning the effects of tumor cell products on the regulation of monocyte migration in vitro and presumably the extravasation of macrophages into tumors in vivo. The present study was design ... Link to item Cite

Antiinflammatory proteins associated with human and murine neoplasms.

Journal Article Biochim Biophys Acta · August 5, 1986 The immune mechanisms by which a host recognizes and destroys a growing tumor are undoubtedly complex and, as yet, incompletely understood. It is apparent, however, that mononuclear phagocytes play an important role in the defense against neoplastic diseas ... Full text Link to item Cite

Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.

Journal Article J Immunol · May 15, 1986 Link to item Cite

Effects of tumor growth on host defenses.

Journal Article Cancer Metastasis Rev · 1986 Monocytes and macrophages play an important role in host defense against neoplasia. Studies from our and other laboratories have demonstrated that patients with a variety of cancers have a defect in monocyte chemotactic responses. Tumor-bearing mice are al ... Full text Link to item Cite

Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.

Journal Article Science · October 25, 1985 Featured Publication The retroviral transmembrane envelope protein p15E is immunosuppressive in that it inhibits immune responses of lymphocytes, monocytes, and macrophages. A region of p15E has been conserved among murine and feline retroviruses; a homologous region is also f ... Full text Link to item Cite

Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms.

Journal Article Clin Exp Immunol · July 1985 Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of B ... Link to item Cite

Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.

Journal Article Trans Assoc Am Physicians · 1985 Link to item Cite

Enhanced tumorigenicity of transformed NIH/3T3 cells which produce retroviral P15E

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

Antibody to a synthetic peptide reacts with envelope proteins of both murine and human type C retroviruses

Journal Article Federation Proceedings · January 1, 1985 Cite

Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV.

Journal Article Nature · October 11, 1984 Featured Publication Full text Link to item Cite

Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia.

Journal Article Immunol Today · August 1984 Type C retroviral infections can cause profound immunosuppression as well as neoplasms. The retroviral envelope protein p15E has both immunosuppressive and anti-inflammatory activities which may contribute to the pathogenicity of retroviruses. Murine and h ... Full text Link to item Cite

Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen.

Journal Article J Exp Med · March 1, 1984 Virus-related oncogenes have been demonstrated in human tumor cells and may play a role in neoplastic transformation. Cancerous effusions contain inhibitors of monocyte function and are absorbed by monoclonal antibodies to the immunosuppressive retroviral ... Full text Link to item Cite

Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E.

Journal Article J Exp Med · September 1, 1983 Murine tumors contain low molecular weight factors that inhibit macrophage accumulation at inflammatory foci. Certain oncogenic murine leukemia viruses contain similar inhibitory activity and the active component of the retroviruses was shown to be the env ... Full text Link to item Cite

Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer.

Journal Article Cancer Res · September 1983 An extensive Phase I evaluation of human lymphoblastoid interferon has been completed which, in addition to describing its clinical and pharmacological effects, emphasized a broad-scale evaluation of the immune response as a function of interferon dosage. ... Link to item Cite

Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms.

Journal Article Adv Exp Med Biol · 1982 Full text Link to item Cite

Effects of interferon therapy on monocyte functions of cancer patients

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.

Journal Article J Clin Invest · October 1981 Individuals with cancer have previously been shown to have abnormal chemotactic responsiveness. Surgical removal of the tumor often resulted in normalization of monocyte function, which suggests that human neoplasms might inhibit monocyte chemotaxis by rel ... Full text Link to item Cite

Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants.

Journal Article J Clin Invest · January 1981 The chemotactic migration of leukocytes is preceded by an alteration in the cells' shape from round to a characteristic polar configuration. We have developed an assay that shows that human monocytes, when exposed to chemoattractant in suspension, assume t ... Full text Link to item Cite

Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.

Journal Article J Natl Cancer Inst · October 1980 Extracts prepared from spontaneous mouse mammary adenocarcinomas, as well as plasma and urine from inbred C3H/HeN mice carrying murine mammary tumor virus and bearing such tumors, significantly inhibited the accumulation of macrophages at inflammatory site ... Full text Link to item Cite

Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.

Journal Article J Immunol · June 1980 Low m.w. extracts from three known oncogenic viruses, Friend, Moloney, and Rauscher, inhibited the accumulation of macrophages at sites of delayed inflammatory reactions in mice. The potential biologic significance of these proteins is suggested by their p ... Link to item Cite

Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI.

Journal Article J Reticuloendothel Soc · October 1979 Link to item Cite

In vivo and in vitro effects of acute graft-versus-host serum in the rat.

Journal Article Transplantation · April 1977 Pooled serum from 6- to 8-week-old female Lewis x Brown Norwegian F1 hybrid (LBNF1) rats undergoing acute local graft-versus-host (GVH) reactions was found to have the ability, when compared with normal F1 serum, to increase node weight in a popliteal lymp ... Full text Link to item Cite

The rapid and large scale separation of peritoneal macrophages.

Journal Article Immunology · April 1972 A simple method for rapid and large scale (over 109 cells) separation of peritoneal macrophages by incubation in a glass-bead column and elution with buffered ethylenediamine tetraacetic acid (EDTA) solution is described. Macrophages obtained were about 90 ... Link to item Cite