Scholars@Duke
Clarissa Jonas Diamantidis

Clarissa Jonas Diamantidis

Adjunct Associate Professor of Medicine
Medicine, General Internal Medicine
clarissa.diamantidis@duke.edu
Box 104427, Durham, NC 27701
710 W. Main St, Durham, NC 27701

Selected Publications

Single-Ancestry versus Multi-Ancestry Polygenic Risk Scores for CKD in Black American Populations.

Journal Article J Am Soc Nephrol · November 1, 2024 KEY POINTS: The predictive performance of an African ancestry–specific polygenic risk score (PRS) was comparable to a European ancestry–derived PRS for kidney traits. However, multi-ancestry PRSs outperform single-ancestry PRSs in Black American population ... Full text Link to item Cite

Racial Differences in Over-the-Counter Non-steroidal Anti-inflammatory Drug Use Among Individuals at Risk of Adverse Cardiovascular Events.

Journal Article J Racial Ethn Health Disparities · October 2024 PURPOSE: Black Americans are disproportionately affected by adverse cardiovascular events (ACEs). Over-the-counter (OTC) non-steroidal anti-inflammatory drugs (NSAIDs) confer increased risk for ACEs, yet racial differences in the use of these products rema ... Full text Link to item Cite

Clinical Outcomes Among High-Risk Primary Care Patients With Diabetic Kidney Disease: Methodological Challenges and Results From the STOP-DKD Study.

Journal Article Med Care · October 1, 2024 BACKGROUND/OBJECTIVE: Slowing the progression of diabetic kidney disease (DKD) is critical. We conducted a randomized controlled trial to target risk factors for DKD progression. METHODS: We evaluated the effect of a pharmacist-led intervention focused on ... Full text Open Access Link to item Cite

A methylation risk score for chronic kidney disease: a HyperGEN study.

Journal Article Sci Rep · August 1, 2024 Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA methylation at cytosine-phosphate-guanine (CpG) sites, hav ... Full text Link to item Cite

A reappraisal of risk factors for hypertension after pediatric acute kidney injury.

Journal Article Pediatr Nephrol · May 2024 BACKGROUND: Acute kidney injury (AKI) is common in hospitalized children and increases the risk of chronic kidney disease (CKD) and hypertension, but little is known about the patient level risk factors for pediatric hypertension after AKI. The aims of thi ... Full text Link to item Cite

Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study.

Journal Article Kidney Med · April 2024 RATIONALE & OBJECTIVE: The extent to which depression affects the progression of chronic kidney disease (CKD) and leads to adverse clinical outcomes remains inadequately understood. We examined the association of depressive symptoms (DS) and antidepressant ... Full text Link to item Cite

Residential Structural Racism and Prevalence of Chronic Health Conditions.

Journal Article JAMA Netw Open · December 1, 2023 IMPORTANCE: Studies elucidating determinants of residential neighborhood-level health inequities are needed. OBJECTIVE: To quantify associations of structural racism indicators with neighborhood prevalence of chronic kidney disease (CKD), diabetes, and hyp ... Full text Link to item Cite

Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury.

Journal Article Pediatr Nephrol · October 2023 BACKGROUND: Studies in adults have shown that persistent kidney dysfunction ≥7-90 days following acute kidney injury (AKI), termed acute kidney disease (AKD), increases chronic kidney disease (CKD) and mortality risk. Little is known about the factors asso ... Full text Link to item Cite

Epidemiology of Community-Acquired Acute Kidney Injury Among US Veterans.

Journal Article Am J Kidney Dis · September 2023 RATIONALE & OBJECTIVE: Community-acquired acute kidney injury (CA-AKI) develops outside of the hospital and is the most common form of AKI globally. National estimates of CA-AKI in the United States are absent due to limited availability of laboratory data ... Full text Link to item Cite

CKD and Rapid Kidney Function Decline During the COVID-19 Pandemic.

Journal Article Kidney Med · September 2023 RATIONALE & OBJECTIVE: The direct and indirect effects of the coronavirus disease 2019 (COVID-19) pandemic on kidney function in the chronic kidney disease (CKD) population are not well understood. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: Retros ... Full text Link to item Cite

Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes.

Journal Article Clin J Am Soc Nephrol · July 1, 2023 BACKGROUND: Patients hospitalized with AKI have higher subsequent risks of heart failure, atherosclerotic cardiovascular events, and mortality than their counterparts without AKI, but these higher risks may be due to differences in prehospitalization patie ... Full text Link to item Cite

Association of Acute Kidney Injury and Cardiovascular Disease Following Percutaneous Coronary Intervention: Assessment of Interactions by Race, Diabetes, and Kidney Function.

Journal Article Am J Kidney Dis · June 2023 RATIONALE & OBJECTIVE: Black patients and those with diabetes or reduced kidney function experience a disproportionate burden of acute kidney injury (AKI) and cardiovascular events. However, whether these factors modify the association between AKI and card ... Full text Link to item Cite

Costs Associated With Progression of Mildly Reduced Kidney Function Among Medicare Advantage Enrollees.

Journal Article Kidney Med · June 2023 RATIONALE & OBJECTIVE: The prevalence of early chronic kidney disease (CKD) in older adults has increased in the past 2 decades, yet CKD disease progression, overall, is variable. It is unclear whether health care costs differ by progression trajectory. Th ... Full text Link to item Cite

MyKidneyCoach, Patient Activation, and Clinical Outcomes in Diverse Kidney Transplant Recipients: A Randomized Control Pilot Trial.

Journal Article Transplant Direct · April 2023 UNLABELLED: Kidney transplant (KT) recipients who are not actively engaged in their care and lack self-management skills have poor transplant outcomes, which are disproportionately observed among Black KT recipients. This pilot study aimed to determine whe ... Full text Link to item Cite

Have racial disparities in home dialysis utilization changed over time?

Journal Article Am J Manag Care · March 2023 OBJECTIVES: The Medicare end-stage kidney disease (ESKD) prospective payment system (PPS) for maintenance dialysis, implemented in 2011, resulted in modestly increased access to both home-based peritoneal dialysis (PD) and home hemodialysis (HHD) treatment ... Full text Link to item Cite

A National Registry for People With All Stages of Kidney Disease: The National Kidney Foundation (NKF) Patient Network.

Journal Article Am J Kidney Dis · February 2023 RATIONALE & OBJECTIVE: The National Kidney Foundation (NKF) launched the first national US kidney disease patient registry, the NKF Patient Network, that is open to patients throughout the continuum of chronic kidney disease (CKD). The Network provides ind ... Full text Link to item Cite

Missing Care: the Initial Impact of the COVID-19 Pandemic on CKD Care Delivery.

Journal Article J Gen Intern Med · December 2022 BACKGROUND: Chronic kidney disease (CKD) is a common condition with adverse health outcomes addressable by early disease management. The impact of the COVID-19 pandemic on care utilization for the CKD population is unknown. OBJECTIVE: To examine pandemic C ... Full text Link to item Cite

Association between Gentrification and Health and Healthcare Utilization.

Journal Article J Urban Health · December 2022 There is tremendous interest in understanding how neighborhoods impact health by linking extant social and environmental drivers of health (SDOH) data with electronic health record (EHR) data. Studies quantifying such associations often use static neighbor ... Full text Link to item Cite

Receipt and Sharing of Information to Improve Knowledge About Living Donor Kidney Transplant among Transplant Candidates with Advanced Chronic Kidney Disease.

Journal Article Prog Transplant · September 2022 Introduction: Knowledge about living donor kidney transplant (LDKT) is associated with greater access. Yet, little is known about factors associated with high living donor transplant knowledge. Research Questions: Is receipt of LDKT information from health ... Full text Link to item Cite

What Do Acute Kidney Injury Survivors Want to Know About Their Condition: A Qualitative Study.

Journal Article Kidney Med · April 2022 RATIONALE & OBJECTIVE: Acute kidney injury (AKI) in the hospital often occurs with other serious illnesses that take medical priority. Despite a persistent risk of adverse outcomes following hospital discharge, AKI survivors often receive inadequate educat ... Full text Link to item Cite

Burnout Among Nephrologists in the United States: A Survey Study

Journal Article Kidney Medicine · March 1, 2022 Rationale & Objective: Burnout decreases job satisfaction and leads to poor patient outcomes but remains underinvestigated in nephrology. We explored the prevalence and determinants of burnout among a sample of nephrologists. Study Design: Cross-sectional. ... Full text Cite

Review and Evaluation of mHealth Apps in Solid Organ Transplantation: Past, Present, and Future.

Journal Article Transplant Direct · March 2022 UNLABELLED: With the rapid and widespread expansion of smartphone availability and usage, mobile health (mHealth) has become a viable multipurpose treatment medium for the US healthcare system. METHODS: The purpose of this review is to identify posttranspl ... Full text Link to item Cite

Abstract EP66: Racial Differences In The Use Of Over-the-counter Non-steroidal Anti-inflammatory Drugs Among Individuals At Risk Of Adverse Cardiovascular Events

Journal Article Circulation · March 2022 Introduction: Over-the-counter (OTC) non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used despite conferring risk for adverse cardiovascular events (ACEs). ACEs disproportionately affect B ... Full text Cite

Race, Income, and Medical Care Spending Patterns in High-Risk Primary Care Patients: Results From the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) Study.

Journal Article Kidney Med · January 2022 RATIONALE & OBJECTIVE: Little is known about how socioeconomic status (SES) relates to the prioritization of medical care spending over personal expenditures in individuals with multiple comorbid conditions, and whether this relationship differs between Bl ... Full text Open Access Link to item Cite

Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.

Journal Article Metabolomics · December 20, 2021 INTRODUCTION: Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression. OBJECTIVES: We assessed associations of 10 urine TCA cycle OAs with estimated glomerular f ... Full text Open Access Link to item Cite

Risk of Potentially Inappropriate Medications in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Journal Article Am J Kidney Dis · December 2021 RATIONALE & OBJECTIVE: Adults with chronic kidney disease (CKD) may be at increased risk of adverse effects from use of potentially inappropriate medications (PIMs). Our objective was to assess whether PIM exposure has an independent association with CKD p ... Full text Link to item Cite

Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study.

Journal Article BMC Nephrol · November 11, 2021 BACKGROUND: Individuals with chronic kidney disease (CKD), hypertension (HTN), or diabetes mellitus (DM) are at increased risk for cardiovascular disease (CVD). The extent to which psychosocial factors are associated with increased CVD risk within these in ... Full text Link to item Cite

Clinical events and patient-reported outcome measures during CKD progression: findings from the Chronic Renal Insufficiency Cohort Study.

Journal Article Nephrol Dial Transplant · August 27, 2021 BACKGROUND: Patients with chronic kidney disease (CKD) face risks of not only end-stage kidney disease (ESKD), cardiovascular disease (CVD) and death, but also decline in kidney function, quality of life (QOL) and mental and physical well-being. This study ... Full text Link to item Cite

Multiple, objectively measured sleep dimensions including hypoxic burden and chronic kidney disease: findings from the Multi-Ethnic Study of Atherosclerosis.

Journal Article Thorax · July 2021 BACKGROUND: Poor sleep may contribute to chronic kidney disease (CKD) through several pathways, including hypoxia-induced systemic and intraglomerular pressure, inflammation, oxidative stress and endothelial dysfunction. However, few studies have investiga ... Full text Open Access Link to item Cite

Transplant social worker and donor financial assistance to increase living donor kidney transplants among African Americans: The TALKS Study, a randomized comparative effectiveness trial.

Journal Article Am J Transplant · June 2021 Lack of donors hinders living donor kidney transplantation (LDKT) for African Americans. We studied the effectiveness of a transplant social worker intervention (TALK SWI) alone or paired with living donor financial assistance to activate African Americans ... Full text Link to item Cite

Mobile Health (mHealth) Technology: Assessment of Availability, Acceptability, and Use in CKD.

Journal Article Am J Kidney Dis · June 2021 RATIONALE & OBJECTIVE: Digital and mobile health (mHealth) technologies improve patient-provider communication and increase information accessibility. We assessed the use of technology, attitudes toward using mHealth technologies, and proficiency in using ... Full text Link to item Cite

Racism and Kidney Health: Turning Equity Into a Reality.

Journal Article Am J Kidney Dis · June 2021 Kidney disease continues to manifest stark racial inequities in the United States, revealing the entrenchment of racism and bias within multiple facets of society, including in our institutions, practices, norms, and beliefs. In this perspective, we synthe ... Full text Link to item Cite

Hospitalization Trajectories and Risks of ESKD and Death in Individuals With CKD.

Journal Article Kidney Int Rep · June 2021 INTRODUCTION: Management of chronic kidney disease (CKD) entails high medical complexity and often results in high hospitalization burden. There are limited data on the associations of longitudinal hospital utilization patterns with adverse clinical outcom ... Full text Link to item Cite

Annual wellness visits and care management before and after dialysis initiation.

Journal Article BMC Nephrol · May 5, 2021 INTRODUCTION: Demands of dialysis regimens may pose challenges for primary care provider (PCP) engagement and timely preventive care. This is especially the case for patients initiating dialysis adjusting to new logistical challenges and management of symp ... Full text Link to item Cite

Racial Differences in AKI Incidence Following Percutaneous Coronary Intervention.

Journal Article J Am Soc Nephrol · March 2021 BACKGROUND: Undergoing percutaneous coronary intervention (PCI) is a risk factor for AKI development, but few studies have quantified racial differences in AKI incidence after this procedure. METHODS: We examined the association of self-reported race (Blac ... Full text Link to item Cite

Opioid Prescribing in the 2016 Medicare Fee-for-Service Population.

Journal Article J Am Geriatr Soc · February 2021 BACKGROUND AND OBJECTIVES: Opioid use and misuse are prevalent and remain a national crisis. This study identified beneficiary characteristics associated with filling opioid prescriptions, variation in opioid dosing, and opioid use with average daily doses ... Full text Link to item Cite

Preferences for and Experiences of Shared and Informed Decision Making Among Patients Choosing Kidney Replacement Therapies in Nephrology Care.

Journal Article Kidney Med · 2021 RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) can progress rapidly, and patients are often unprepared to make kidney failure treatment decisions. We aimed to better understand patients' preferences for and experiences of shared and informed decision ... Full text Link to item Cite

Disparities in Chronic Kidney Disease Progression by Medicare Advantage Enrollees.

Journal Article Am J Nephrol · 2021 INTRODUCTION: The prevalence of chronic kidney disease (CKD) in Medicare beneficiaries has quadrupled in the past 2 decades, but little is known about risk factors affecting the progression of CKD. This study aims to understand the progression in Medicare ... Full text Link to item Cite

Racial Differences in the Effectiveness of a Multifactorial Telehealth Intervention to Slow Diabetic Kidney Disease.

Journal Article Med Care · November 2020 BACKGROUND: African Americans are significantly more likely than non-African Americans to have diabetes, chronic kidney disease, and uncontrolled hypertension, increasing their risk for kidney function decline. OBJECTIVE: The objective of this study was to ... Full text Open Access Link to item Cite

Fragmentation of care as a barrier to optimal ESKD management.

Journal Article Semin Dial · November 2020 Caring for patients with end-stage kidney disease (ESKD) in the United States is challenging, due in part to the complex epidemiology of the disease's progression as well as the ways in which care is delivered. As CKD progresses toward ESKD, the number of ... Full text Link to item Cite

"I Wish Someone Had Told Me That Could Happen": A Thematic Analysis of Patients' Unexpected Experiences With End-Stage Kidney Disease Treatment.

Journal Article J Patient Exp · August 2020 BACKGROUND: Preparedness regarding prognosis and treatment options enables patients to cope with uncertainties, make value-based treatment decisions, and set treatment goals. Yet, little is known about the expectedness of end-stage kidney disease (ESKD) pa ... Full text Link to item Cite

Association of Opioids and Nonsteroidal Anti-inflammatory Drugs With Outcomes in CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study.

Journal Article Am J Kidney Dis · August 2020 RATIONALE & OBJECTIVE: Safe analgesic choices are limited in chronic kidney disease (CKD). We conducted a comparative analysis of harm from opioids versus nonsteroidal anti-inflammatory drugs (NSAIDs) in CKD. STUDY DESIGN: Prospective cohort study. SETTING ... Full text Link to item Cite

526-P: Urine Tricarboxylic Acid Cycle Organic Anions and Progression of Diabetic Kidney Disease

Conference Diabetes · June 1, 2020 Background: Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression.Methods: We conducted an ancillary study to the Simu ... Full text Cite

A Patient Safety Educational Tool for Patients With Chronic Kidney Disease: Development and Usability Study.

Journal Article JMIR formative research · May 2020 BackgroundChronic kidney disease (CKD) is a health condition that threatens patient safety; however, few interventions provide patient-centered education about kidney-specific safety hazards.ObjectiveWe sought to develop and test the usab ... Full text Cite

Life Course Socioeconomic Status, Allostatic Load, and Kidney Health in Black Americans.

Journal Article Clin J Am Soc Nephrol · March 6, 2020 BACKGROUND AND OBJECTIVES: Low socioeconomic status confers unfavorable health, but the degree and mechanisms by which life course socioeconomic status affects kidney health is unclear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined the associa ... Full text Link to item Cite

Associations of perceived information adequacy and knowledge with pursuit of live donor kidney transplants and living donor inquiries among African American transplant candidates.

Journal Article Clin Transplant · March 2020 We studied associations between perceived adequacy of live donor kidney transplant (LDKT) information or knowledge with pursuit of LDKT or receipt of live donor inquiries among 300 African American kidney transplant candidates. Participants reported via qu ... Full text Link to item Cite

Primary Care Providers' Acceptance of Pharmacists' Recommendations to Support Optimal Medication Management for Patients with Diabetic Kidney Disease.

Journal Article J Gen Intern Med · January 2020 BACKGROUND: Patients with diabetic kidney disease (DKD) often struggle with blood pressure control. In team-based models of care, pharmacists and primary care providers (PCPs) play important roles in supporting patients' blood pressure management. OBJECTIV ... Full text Open Access Link to item Cite

Advanced CKD Care and Decision Making: Which Health Care Professionals Do Patients Rely on for CKD Treatment and Advice?

Journal Article Kidney Med · 2020 RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) care is often fragmented across multiple health care providers. It is unclear whether patients rely mostly on their nephrologists or non-nephrologist providers for medical care, including CKD treatment an ... Full text Link to item Cite

DASH Diet and Blood Pressure Among Black Americans With and Without CKD: The Jackson Heart Study.

Journal Article Am J Hypertens · September 24, 2019 BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) more effectively in blacks compared to other US racial subgroups. Considering chronic kidney disease (CKD) raises BP through complex mechanisms, DASH may affect ... Full text Link to item Cite

Lab-based and diagnosis-based chronic kidney disease recognition and staging concordance.

Journal Article BMC Nephrol · September 14, 2019 BACKGROUND: Chronic kidney disease (CKD) is often under-recognized and poorly documented via diagnoses, but the extent of under-recognition is not well understood among Medicare beneficiaries. The current study used claims-based diagnosis and lab data to e ... Full text Link to item Cite

A Patient Safety Educational Tool for Patients With Chronic Kidney Disease: Development and Usability Study (Preprint)

Journal Article · September 4, 2019 BACKGROUNDChronic kidney disease (CKD) is a health condition that threatens patient safety; however, few interventions provide patient-centered education about kidney-specific safety haza ... Full text Cite

The relationship between Pittsburgh Sleep Quality Index subscales and diabetes control.

Journal Article Chronic Illn · September 2019 OBJECTIVES:: Data suggest that poor sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) contributes to suboptimal diabetes control. How the subscales comprising the PSQI individually relate to diabetes control is poorly understood. METHO ... Full text Open Access Link to item Cite

Association of functional and structural social support with chronic kidney disease among African Americans: the Jackson Heart Study.

Journal Article BMC Nephrol · July 15, 2019 BACKGROUND: There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an ... Full text Link to item Cite

Use of a Medical-Alert Accessory in CKD: A Pilot Study.

Journal Article Clin J Am Soc Nephrol · July 5, 2019 BACKGROUND AND OBJECTIVES: Poor disease recognition may jeopardize the safety of CKD care. We examined safety events and outcomes in patients with CKD piloting a medical-alert accessory intended to improve disease recognition and an observational subcohort ... Full text Link to item Cite

Primary Care Physicians' Perceived Barriers to Nephrology Referral and Co-management of Patients with CKD: a Qualitative Study.

Journal Article J Gen Intern Med · July 2019 BACKGROUND: Effective co-management of patients with chronic kidney disease (CKD) between primary care physicians (PCPs) and nephrologists is increasingly recognized as a key strategy to ensure the delivery of efficient and high-quality CKD care. However, ... Full text Link to item Cite

Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study.

Internet Publication · June 1, 2019 BACKGROUND: 25-hydroxyvitamin D [25(OH)D] is lower in black compared with white Americans but is not consistently associated with outcomes in this group, possibly due to genetic and other biological differences. We examined the association of plasma 25(OH) ... Full text Open Access Link to item Cite

Long-term exposure to ambient air pollution and renal function in African Americans: the Jackson Heart Study.

Journal Article J Expo Sci Environ Epidemiol · June 2019 Renal dysfunction is prevalent in the US among African Americans. Air pollution is associated with renal dysfunction in mostly white American populations, but has not been studied among African Americans. We evaluated cross-sectional associations between 1 ... Full text Link to item Cite

Addressing Diabetes and Poorly Controlled Hypertension: Pragmatic mHealth Self-Management Intervention.

Journal Article J Med Internet Res · April 9, 2019 BACKGROUND: Patients with diabetes and poorly controlled hypertension are at increased risk for adverse renal and cardiovascular outcomes. Identifying these patients early and addressing modifiable risk factors is central to delaying renal complications su ... Full text Open Access Link to item Cite

Usability Testing of a Sick-Day Protocol in CKD.

Journal Article Clin J Am Soc Nephrol · April 5, 2019 Full text Link to item Cite

Patients' and Nephrologists' Evaluation of Patient-Facing Smartphone Apps for CKD.

Journal Article Clin J Am Soc Nephrol · April 5, 2019 BACKGROUND AND OBJECTIVES: Many aspects of CKD management rely heavily on patient self-care, including medication and dietary adherence, self-monitoring of BP, and daily physical activity. Growing evidence suggests that incorporating smartphone-based appli ... Full text Link to item Cite

Development of a Telehealth Intervention to Improve Access to Live Donor Kidney Transplantation.

Journal Article Transplant Proc · April 2019 BACKGROUND: Live donor kidney transplantation (LDKT) is underutilized by patients with end-stage kidney disease due to knowledge, communication, and logistical barriers. MATERIAL AND METHODS: The Talking About Live Kidney Donation Social Worker Interventio ... Full text Link to item Cite

Abstract 017: Impact of Gentrification on Cardiovascular Disease Surveillance Using Data from the Electronic Health Record

Conference Circulation · March 5, 2019 Introduction: Current static approaches of CVD surveillance may not capture the true health of neighborhoods as the influx of younger, healthier, and wealthier individuals (i.e., gentrification) can i ... Full text Cite

Evaluation of Allostatic Load as a Mediator of Sleep and Kidney Outcomes in Black Americans.

Journal Article Kidney Int Rep · March 2019 INTRODUCTION: Poor sleep associates with adverse chronic kidney disease (CKD) outcomes yet the biological mechanisms underlying this relation remain unclear. One proposed mechanism is via allostatic load, a cumulative biologic measure of stress. METHODS: U ... Full text Open Access Link to item Cite

Low use of routine medical care among African Americans with high CKD risk: the Jackson Heart Study.

Journal Article BMC Nephrol · January 10, 2019 BACKGROUND: Use of routine medical care (RMC) is advocated to address ethnic/racial disparities in chronic kidney disease (CKD) risks, but use is less frequent among African Americans. Factors associated with low RMC use among African Americans at risk of ... Full text Open Access Link to item Cite

Dietary Phosphorus and Ambulatory Blood Pressure in African Americans: The Jackson Heart Study.

Journal Article Am J Hypertens · January 1, 2019 BACKGROUND: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulato ... Full text Link to item Cite

Primary care physicians' perceptions of barriers and facilitators to management of chronic kidney disease: A mixed methods study.

Journal Article PLoS One · 2019 BACKGROUND: Given the high prevalence of chronic kidney disease (CKD), primary care physicians (PCPs) frequently manage early stage CKD. Nonetheless, there are challenges in providing optimal CKD care in the primary care setting. This study sought to under ... Full text Link to item Cite

Putting patients at the center of kidney care transitions: PREPARE NOW, a cluster randomized controlled trial.

Journal Article Contemp Clin Trials · October 2018 UNLABELLED: Care for patients transitioning from chronic kidney disease to kidney failure often falls short of meeting patients' needs. The PREPARE NOW study is a cluster randomized controlled trial studying the effectiveness of a pragmatic health system i ... Full text Link to item Cite

Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study.

Journal Article Nephrol Dial Transplant · June 1, 2018 BACKGROUND: African Americans are at high risk for chronic kidney disease (CKD). Obesity may increase the risk for CKD by exacerbating features of the metabolic syndrome and promoting glomerular hyperfiltration. Whether other factors also affecting these p ... Full text Link to item Cite

Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study: Protocol and baseline characteristics of a randomized controlled trial.

Journal Article Contemp Clin Trials · June 2018 UNLABELLED: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the United States. Multiple risk factors contribute to DKD development, yet few interventions target more than a single DKD risk factor at a time. This man ... Full text Open Access Link to item Cite

Self-reported Medication Adherence and CKD Progression.

Journal Article Kidney Int Rep · May 2018 INTRODUCTION: In the general population, medication nonadherence contributes to poorer outcomes. However, little is known about medication adherence among adults with chronic kidney disease (CKD). We evaluated the association of self-reported medication ad ... Full text Link to item Cite

Medical safety in the care of the person with end-stage kidney disease.

Journal Article Semin Dial · March 2018 Much is written about medical safety as it pertains to patients with chronic kidney disease, yet the transition to end-stage kidney disease and processes inherent to the receipt of dialysis present unique safety challenges in this population. Educational e ... Full text Link to item Cite

Nondepressive Psychosocial Factors and CKD Outcomes in Black Americans.

Journal Article Clin J Am Soc Nephrol · February 7, 2018 BACKGROUND AND OBJECTIVES: Established risk factors for CKD do not fully account for risk of CKD in black Americans. We studied the association of nondepressive psychosocial factors with risk of CKD in the Jackson Heart Study. DESIGN, SETTING, PARTICIPANTS ... Full text Link to item Cite

Racial differences in nocturnal dipping status in diabetic kidney disease: Results from the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) study.

Journal Article J Clin Hypertens (Greenwich) · December 2017 While racial variation in ambulatory blood pressure (BP) is known, patterns of diurnal dipping in the context of diabetic kidney disease have not been well defined. The authors sought to determine the association of race with nocturnal dipping status among ... Full text Open Access Link to item Cite

Patterns of NSAIDs Use and Their Association with Other Analgesic Use in CKD.

Journal Article Clin J Am Soc Nephrol · November 7, 2017 BACKGROUND AND OBJECTIVES: Avoiding nonsteroidal anti-inflammatory drugs is important for safe CKD care. This study examined nonsteroidal anti-inflammatory drug use patterns and their association with other analgesic use in CKD. DESIGN, SETTING, PARTICIPAN ... Full text Link to item Cite

Minding the gap and overlap: a literature review of fragmentation of primary care for chronic dialysis patients.

Journal Article BMC Nephrol · August 29, 2017 BACKGROUND: Care coordination is a challenge for patients with kidney disease, who often see multiple providers to manage their associated complex chronic conditions. Much of the focus has been on primary care physician (PCP) and nephrologist collaboration ... Full text Link to item Cite

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.

Journal Article Ann Intern Med · February 7, 2017 BACKGROUND: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these p ... Full text Link to item Cite

Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.

Journal Article Kidney Int · January 2017 Few investigations have evaluated the incremental usefulness of tubular injury biomarkers for improved prediction of chronic kidney disease (CKD) progression. As such, we measured urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin ... Full text Link to item Cite

A Fundamental Theorem of Telehealth.

Journal Article Adv Chronic Kidney Dis · January 2017 Full text Link to item Cite

A mobile application improves therapy-adherence rates in elderly patients undergoing rehabilitation: A crossover design study comparing documentation via iPad with paper-based control.

Journal Article Medicine (Baltimore) · September 2016 Medication adherence is crucial for success in the management of patients with chronic conditions. This study analyzes whether a mobile application on a tablet aimed at supporting drug intake and vital sign parameter documentation affects adherence in elde ... Full text Link to item Cite

Patient-Reported Safety Events in Chronic Kidney Disease Recorded With an Interactive Voice-Inquiry Dial-Response System: Monthly Report Analysis.

Journal Article J Med Internet Res · May 26, 2016 BACKGROUND: Monitoring patient-reported outcomes (PROs) may improve safety of chronic kidney disease (CKD) patients. OBJECTIVE: Evaluate the performance of an interactive voice-inquiry dial-response system (IVRDS) in detecting CKD-pertinent adverse safety ... Full text Link to item Cite

Self-reported Medication Adherence and Adverse Patient Safety Events in CKD.

Journal Article Am J Kidney Dis · October 2015 BACKGROUND: Promoting medication adherence is a recognized challenge for prescribers. In this study, we examine whether lower medication adherence is associated with adverse safety events in individuals with decreased estimated glomerular filtration rates ... Full text Link to item Cite

Remote Usability Testing and Satisfaction with a Mobile Health Medication Inquiry System in CKD.

Journal Article Clin J Am Soc Nephrol · August 7, 2015 BACKGROUND AND OBJECTIVES: Inappropriate medication use is common in the care of patients with CKD. The feasibility of a simple mobile health tool designed to advise patients on safe medication usage in CKD was examined. DESIGN, SETTING, PARTICIPANTS, & ME ... Full text Link to item Cite

Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial.

Journal Article Transplantation · May 2015 BACKGROUND: Kidney transplant recipients are at increased risk for adverse safety events related to their reduced renal function and many medications. METHODS: We determined the incidence of adverse safety events based on previously defined Agency for Heal ... Full text Link to item Cite

Chronic pain and analgesic use in CKD: implications for patient safety.

Journal Article Clin J Am Soc Nephrol · March 6, 2015 BACKGROUND AND OBJECTIVES: Chronic pain in predialysis CKD is not fully understood. This study examined chronic pain in CKD and its relationship with analgesic usage. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data include baseline visits from 308 pati ... Full text Link to item Cite

The last mile: translational research to improve CKD outcomes.

Journal Article Clin J Am Soc Nephrol · October 7, 2014 The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives that would enhance understanding of kidney function and disease ... Full text Link to item Cite

Patient-reported and actionable safety events in CKD.

Journal Article J Am Soc Nephrol · July 2014 Patients with CKD are at high risk for adverse safety events because of the complexity of their care and impaired renal function. Using data from our observational study of predialysis patients with CKD enrolled in the Safe Kidney Care study, we estimated ... Full text Link to item Cite

Mhealth 2.0: Experiences, possibilities, and perspectives

Journal Article JMIR mHealth and uHealth · April 1, 2014 With more than 1 billion users having access to mobile broadband Internet and a rapidly growing mobile app market, all stakeholders involved have high hopes that this technology may improve health care. Expectations range from overcoming structural barrier ... Full text Cite

Health information technology (IT) to improve the care of patients with chronic kidney disease (CKD).

Journal Article BMC Nephrol · January 9, 2014 Several reports show that patients with chronic disease who are empowered with information technology (IT) tools for monitoring, training and self-management have improved outcomes, however there are few such applications employed in kidney disease. This r ... Full text Link to item Cite

Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study.

Journal Article Clin Nephrol · January 2014 BACKGROUND: Low health literacy in the general population is associated with increased risk of death and hospitalization. The evaluation of health literacy in individuals with predialysis chronic kidney disease (CKD) is limited. METHODS: We conducted a cro ... Full text Link to item Cite

Usability of mobile technology to screen for drug-drug interactions in kidney transplant patients.

Journal Article Am J Nephrol · 2014 BACKGROUND AND OBJECTIVES: Kidney transplant recipients are at increased risk for adverse safety events related to reduced renal function and polypharmacy. Health information technology tools have a precautionary role in improving safety in patients with k ... Full text Link to item Cite

Consideration of ICD-9 code-derived disease-specific safety indicators in CKD.

Journal Article Clin J Am Soc Nephrol · December 2013 BACKGROUND AND OBJECTIVES: The Agency for Healthcare and Research Quality patient safety indicators track adverse safety events in hospitalized patients but overlook safety incidents specific to CKD. This study considers candidate CKD-pertinent patient saf ... Full text Link to item Cite

Directed use of the internet for health information by patients with chronic kidney disease: prospective cohort study.

Journal Article J Med Internet Res · November 15, 2013 BACKGROUND: Health information technology has become common in the care of patients with chronic diseases; however, there are few such applications employed in kidney disease. OBJECTIVE: The aim of the study was to evaluate the use of a website providing d ... Full text Link to item Cite

User profiles of a smartphone application to support drug adherence--experiences from the iNephro project.

Journal Article PLoS One · 2013 PURPOSE: One of the key problems in the drug therapy of patients with chronic conditions is drug adherence. In 2010 the initiative iNephro was launched (www.inephro.de). A software to support regular and correct drug intake was developed for a smartphone p ... Full text Link to item Cite

Usability of a CKD educational website targeted to patients and their family members.

Journal Article Clin J Am Soc Nephrol · October 2012 BACKGROUND AND OBJECTIVES: Web-based technology is critical to the future of healthcare. As part of the Safe Kidney Care cohort study evaluating patient safety in CKD, this study determined how effectively a representative sample of patients with CKD or fa ... Full text Link to item Cite

A varying patient safety profile between black and nonblack adults with decreased estimated GFR.

Journal Article Am J Kidney Dis · July 2012 BACKGROUND: Chronic kidney disease is a high-risk condition for a variety of adverse safety events, yet little is known about differential rates of safety events across racial groups with decreased kidney function. We sought to examine the incidence of an ... Full text Link to item Cite

Influence of creatinine versus glomerular filtration rate on non-steroidal anti-inflammatory drug prescriptions in chronic kidney disease.

Journal Article Am J Nephrol · 2012 BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, are generally contraindicated in chronic kidney disease (CKD). This investigation sought to identify the frequency of NSAID/COX-2 prescription and to ... Full text Link to item Cite

Erythropoiesis-stimulating agents increase the risk of acute stroke in patients with chronic kidney disease.

Journal Article Kidney Int · August 2011 Erythropoiesis-stimulating agents (ESAs) are effective in ameliorating anemia in chronic kidney disease (CKD). A recent trial in diabetic patients with CKD, however, suggested a greater risk of stroke associated with full correction of anemia with ESAs. Us ... Full text Link to item Cite

Primary care-specialist collaboration in the care of patients with chronic kidney disease.

Journal Article Clin J Am Soc Nephrol · February 2011 BACKGROUND AND OBJECTIVES: Collaboration between primary care physicians (PCPs) and nephrologists in the care of patients with chronic kidney disease (CKD) is widely advocated, but physician preferences regarding collaboration are unknown. Physicians' desi ... Full text Link to item Cite