Scholars@Duke
Claudia Kay Jones

Claudia Kay Jones

Associate Professor Emeritus of Pathology
Pathology
claudia.jones@duke.edu
Rm. 3425 Duke Hosp South, Duke Box 3712, Durham, NC 27710
Rm. 3425 Duke Hosp South, Durham, NC 27710

Selected Publications

Pathologist-performed ultrasound-guided fine needle aspiration biopsies of extrathyroidal sites: An observational study.

Journal Article Diagn Cytopathol · April 2023 BACKGROUND: Pathologist-performed ultrasound-guided fine needle aspiration (USFNA) biopsies have become an increasingly important component of the interventional cytopathologist's toolbox. However, its application varies between institutions, and there is ... Full text Link to item Cite

Pathologist-performed ultrasound-guided fine-needle aspirations of the thyroid: A single institution observational study.

Journal Article Cancer Cytopathol · September 2022 BACKGROUND: Ultrasound-guided fine-needle aspiration biopsies (USFNAs) are increasingly performed by pathologists. This study was designed to assess the diagnostic yield and characterization of thyroid nodules biopsied at a teaching hospital setting in whi ... Full text Link to item Cite

Performance of repeat cytology with reflex ThyroSeq genomic classifier for indeterminant thyroid cytology.

Journal Article Cancer Cytopathol · June 2022 BACKGROUND: The American Thyroid Association recommends either repeat fine-needle aspiration biopsy (FNAB) or molecular testing (eg, ThyroSeq) of Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance [AUS ... Full text Link to item Cite

Pilot Study of the Performance of 19-G Needle in Endobronchial Ultrasound-guided Transbronchial Aspiration for the Diagnosis and Testing of Molecular Markers in Lung Cancer.

Journal Article J Bronchology Interv Pulmonol · July 1, 2021 BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become the standard for diagnosis and staging of lung cancer. Historically, 21- and 22-G needles have been paired with EBUS. We evaluated the performance of EBUS-T ... Full text Link to item Cite

Evaluation of pelvic washing specimens in patients with endometrial cancer: Cytomorphological features, diagnostic agreement, and pathologist experience.

Journal Article Cancer Cytopathol · July 2021 BACKGROUND: Pelvic washings for patients with endometrial cancer is recommended but not used for staging. The International System for Reporting Serous Fluid Cytology (TIS) has standardized diagnostic categories, but the criteria remain incomplete. The 3 p ... Full text Link to item Cite

High-risk and intermediate-high-risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution.

Journal Article Cancer Cytopathol · August 2020 BACKGROUND: The ThyroSeq panel tests for genetic alterations to risk-stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center. METHODS: Results from Thyro ... Full text Link to item Cite

The utility of thyroglobulin washout studies in predicting cervical lymph node metastases: One academic medical center's experience.

Journal Article Diagn Cytopathol · December 2016 BACKGROUND: Fine-needle aspiration cytology (FNAC) is useful for evaluating cervical lymph nodes for metastases from thyroid carcinomas. Reports have illustrated that with application of standardized technique and appropriate cutoffs, thyroglobulin (TG) wa ... Full text Link to item Cite

Thyroid carcinoma showing thymus-like differentiation (CASTLE): case report with cytomorphology and review of the literature.

Journal Article Diagn Cytopathol · March 2011 Thyroid carcinoma showing thymus-like differentiation (CASTLE) is a rare tumor of the thyroid gland or adjacent soft tissues of the neck. Given the comparatively good prognosis of CASTLE, it is crucial to distinguish this neoplasm from other more aggressiv ... Full text Link to item Cite

Use of the ThinPrep method in bile duct brushings: analysis of morphologic parameters associated with malignancy and determination of interobserver reliability.

Journal Article Diagn Cytopathol · September 2008 Recent work suggests the ThinPrep method can improve diagnostic sensitivity and accuracy in bile duct brushings. However, the proportion of atypical and suspicious diagnoses remains high. The aim of this study was to identify the most useful morphologic fe ... Full text Link to item Cite

Diagnosis of hyperparathyroidism following fine-needle aspiration of bone lesions

Conference AMERICAN JOURNAL OF CLINICAL PATHOLOGY · October 1, 2006 Link to item Cite

Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.

Journal Article Appl Immunohistochem Mol Morphol · March 2006 Epidermal growth factor receptor (EGFR) overexpression occurs in a significant percentage of cases of glioblastoma multiforme (GBM), and amplification has been found in approximately 40% of these neoplasms. Controversy exists as to the prognostic significa ... Full text Link to item Cite

The value of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration.

Journal Article Arch Pathol Lab Med · December 2004 CONTEXT: Molecular genetic analyses have been predicted to improve the diagnostic accuracy of fine-needle aspiration of B-cell non-Hodgkin lymphoma. OBJECTIVE: To determine the value of routine molecular genetic assays, polymerase chain reaction (PCR) and ... Full text Link to item Cite

Metastases in the pancreas from nonhematologic neoplasms: report of 20 cases evaluated by fine-needle aspiration.

Journal Article Diagn Cytopathol · October 2004 We reviewed fine-needle aspiration (FNA) samples of metastatic tumor in the pancreas from nonhematologic neoplasms over a 5-year period. In 1,050 total procedures, 20 metastases were diagnosed: 9 renal-cell carcinomas (RCCs), 3 melanomas, 2 pulmonary small ... Full text Link to item Cite

Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.

Journal Article Diagn Cytopathol · July 2004 We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core- ... Full text Link to item Cite

Primary pancreatic lymphoma evaluated by fine-needle aspiration: findings in 14 cases.

Journal Article Am J Clin Pathol · June 2004 Fine-needle aspiration (FNA) is a popular method for evaluating pancreatic lesions. There is considerable literature on FNA evaluation of primary pancreatic carcinomas, but few studies address the FNA diagnosis of primary pancreatic lymphoma. We reviewed 1 ... Full text Link to item Cite

Statistical analysis of cytologic features useful in separation of metastatic urothelial carcinoma from other metastatic epithelial malignancies.

Journal Article Diagn Cytopathol · December 2003 The identification of a site of origin and direction of differentiation for metastatic neoplasms is clinically important, but is often difficult purely by cytologic analysis of aspirated material. Cytologic separation of metastatic urothelial carcinoma (UC ... Full text Link to item Cite

Cytologic distinction of goiterous nodules from morphologically normal thyroid: analyses of cytomorphologic features.

Journal Article Cancer · August 25, 2003 BACKGROUND: Fine-needle aspiration (FNA) is the predominant method for triaging thyroid nodules into operative and nonoperative lesions. Accurate needle placement assuring representative sampling of a suspicious nodule is required. Criteria are well establ ... Full text Link to item Cite

Fine-needle aspiration in non-Hodgkin lymphoma: evaluation of cell size by cytomorphology and flow cytometry.

Journal Article Am J Clin Pathol · June 2002 We studied 48 non-Hodgkin lymphoma (NHL) fine-needle aspiration (FNA) specimens with initial cytomorphology (CM) and flow cytometry (FC) and subsequent surgical biopsy of the same lesion to determine whether a reliable diagnosis of large cell lymphoma or l ... Full text Link to item Cite

Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions?

Journal Article Cancer · April 25, 2002 BACKGROUND: Utilization of fine-needle aspiration (FNA) for the diagnosis of musculoskeletal lesions has been de-emphasized by many clinicians because of concerns regarding the technique's ability to supply all information necessary for prognostication and ... Full text Link to item Cite

Institutional review of outside cytology materials: a retrospective analysis of two institutions' experiences.

Journal Article Diagn Cytopathol · January 2002 Discrepancy rates between original and review histopathologic diagnoses have been well-studied, and range as high as 30% in some studies. While the sensitivity and specificity rates for a variety of cytologic specimens are well-known, few data exist as to ... Full text Link to item Cite

Abdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls.

Journal Article Diagn Cytopathol · March 2001 Abdominal fat pad fine-needle aspiration biopsy (FNAB) is considered the method of choice for confirmation of systemic amyloidosis. Due to our impression that positive results are rare in our FNA service, we retrospectively analyzed our results. Forty-five ... Full text Link to item Cite

Infantile fibromatosis of the external genitalia: diagnosis and management strategy.

Journal Article J Urol · February 1993 Infantile fibromatosis is a process that is difficult to distinguish from fibrosarcoma. It is found in neonates and infants but only rarely has it been reported to involve the external genitalia or scrotum. A 10-month-old boy is described with histological ... Full text Link to item Cite

Metastatic ciliary body carcinoid tumor.

Journal Article Arch Ophthalmol · November 1990 A 50-year-old man with a history of systemic carcinoid had decreased right eye vision and a darkly pigmented cilio-choroidal mass. Results of ultrasonographic and fluorescein angiographic examinations were consistent with a malignant melanoma. Fine-needle ... Full text Link to item Cite

A developmental approach to preschool vision screening.

Journal Article J Pediatr Ophthalmol Strabismus · 1981 A developmental approach to preschool vision screening is described. The choice of acuity testing material in this test is determined by the child's capabilities, assessed prior to acuity testing. When compared with the Society for Prevention of Blindness ... Full text Link to item Cite