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Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.

Publication ,  Journal Article
Gong, JZ; Snyder, MJ; Lagoo, AS; Vollmer, RT; Dash, RR; Madden, JF; Buckley, PJ; Jones, CK
Published in: Diagn Cytopathol
July 2004

We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core-needle biopsy were evaluated independently. FNA was diagnostic of diffuse large B-cell lymphoma (DLBL) in 25% (13/53) of cases and small B-cell NHL in 15% (8/53) of cases, whereas core-needle biopsy was diagnostic of DLBL in 37% (27/74) of cases and small B-cell NHL in 8% (6/74) of cases. Subclassification of small B-cell NHL was reached in 3/6 cases by core-needle biopsy. Insufficient cases were observed in both FNA (47%; 25/53) and core-needle biopsy (28%; 21/74) groups. With the combination of FNA and core-needle biopsy, diagnostic cases of DLBL increased to 43% (32/74) and insufficient samples were reduced to 16% (12/74). There was no clear advantage in the diagnosis and classification of small B-cell NHL by adding core-needle biopsy to FNA (14%; 10/74). We conclude that core-needle biopsy is a useful adjunct to FNA in the diagnosis of DLBL and shall be encouraged. In small B-cell NHL, core-needle biopsy does not add to the diagnostic ability of FNA. Cases insufficient for diagnosis may be seen in both core-needle biopsy and FNA. A combined approach reduces the number of insufficient cases and is recommended in routine FNA practice.

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Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

July 2004

Volume

31

Issue

1

Start / End Page

23 / 30

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pathology
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, B-Cell
  • Immunohistochemistry
  • Humans
  • Flow Cytometry
  • Diagnosis, Differential
  • Biopsy, Needle
 

Citation

APA
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MLA
NLM
Gong, J. Z., Snyder, M. J., Lagoo, A. S., Vollmer, R. T., Dash, R. R., Madden, J. F., … Jones, C. K. (2004). Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma. Diagn Cytopathol, 31(1), 23–30. https://doi.org/10.1002/dc.20082
Gong, Jerald Z., Matthew J. Snyder, Anand S. Lagoo, Robin T. Vollmer, Raj R. Dash, John F. Madden, Patrick J. Buckley, and Claudia K. Jones. “Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.Diagn Cytopathol 31, no. 1 (July 2004): 23–30. https://doi.org/10.1002/dc.20082.
Gong JZ, Snyder MJ, Lagoo AS, Vollmer RT, Dash RR, Madden JF, et al. Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma. Diagn Cytopathol. 2004 Jul;31(1):23–30.
Gong, Jerald Z., et al. “Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.Diagn Cytopathol, vol. 31, no. 1, July 2004, pp. 23–30. Pubmed, doi:10.1002/dc.20082.
Gong JZ, Snyder MJ, Lagoo AS, Vollmer RT, Dash RR, Madden JF, Buckley PJ, Jones CK. Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma. Diagn Cytopathol. 2004 Jul;31(1):23–30.

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

July 2004

Volume

31

Issue

1

Start / End Page

23 / 30

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pathology
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, B-Cell
  • Immunohistochemistry
  • Humans
  • Flow Cytometry
  • Diagnosis, Differential
  • Biopsy, Needle