Scholars@Duke
Jonathan Lambert Cook

Jonathan Lambert Cook

Professor of Dermatology
Dermatology
cook0043@mc.duke.edu
Duke Box 3915, Durham, NC 27710
5324 McFarland Dr, Suite 400, Durham, NC 27707

Selected Publications

Reconstruction of Broad Lower Lip Defects Using Karapandzic-Type Flaps.

Journal Article Dermatol Surg · June 1, 2024 BACKGROUND: Reconstruction of lower lip defects is challenging because of the functional and aesthetic demands of the lower face. We review the functional and aesthetic outcomes of the Karapandzic-type flaps for reconstructing lower lip defects. METHODS: A ... Full text Link to item Cite

ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.

Journal Article J Invest Dermatol · October 2021 UVR and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells promote cSCC carcinogenesis, and in other solid tumors, infiltrating regulatory T cells and CD8+ T cells express ectonucleoside triphosphate d ... Full text Link to item Cite

Evidence-based clinical practice guideline: Reconstruction after skin cancer resection.

Journal Article J Am Acad Dermatol · August 2021 A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide e ... Full text Link to item Cite

Evidence-Based Clinical Practice Guideline: Reconstruction after Skin Cancer Resection.

Journal Article Dermatol Surg · July 1, 2021 A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide e ... Full text Link to item Cite

Evidence-Based Clinical Practice Guideline: Reconstruction after Skin Cancer Resection.

Journal Article Plast Reconstr Surg · May 1, 2021 A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide e ... Full text Link to item Cite

Cutaneous Reconstruction of the Nasal Distal Third: Alternative Local Flaps for a Complex Region.

Journal Article Plast Reconstr Surg Glob Open · May 2021 Small-to-medium cutaneous defects of the distal nose pose a significant challenge to reconstructive surgeons, and commonly described reconstructive techniques have their limitations. As the skin of this region is characteristically rigid and sebaceous, car ... Full text Link to item Cite

Expertise in Head and Neck Cutaneous Reconstructive Surgery.

Journal Article Dermatol Surg · June 2019 BACKGROUND: The management of skin cancers has evolved with the development of Mohs micrographic surgery and a greater emphasis on surgical training within dermatology. It is unclear whether these changes have translated into innovations and contributions ... Full text Link to item Cite

The reconstruction of the nasal ala with interpolated flaps from the cheek and forehead: design and execution modifications to improve surgical outcomes.

Journal Article Br J Dermatol · September 2014 The nasal ala, critically important in the function and appearance of the central face, has significant reconstructive demands given the lack of suitable adjacent donor tissue that can be used to repair all but the smallest surgical defects in this area. I ... Full text Link to item Cite

Tunneled and transposed island flaps in facial reconstructive surgery.

Journal Article Dermatol Surg · September 2014 BACKGROUND: Surgical wounds on the central face present reconstructive challenges given the aesthetic prominence of these visually important areas and a general lack of local tissue availability. MATERIALS AND METHODS: Illustrative case examples demonstrat ... Full text Link to item Cite

Reconstruction of scalp wounds with exposed calvarium using a local flap and a split-thickness skin graft: case series of 20 patients.

Journal Article Dermatol Surg · March 2014 OBJECTIVES: To describe the design, execution, outcomes, and advantages of a combined flap and split-thickness skin graft reconstructive technique for the repair of wounds of the scalp with exposed bone after Mohs micrographic surgery. MATERIALS AND METHOD ... Full text Link to item Cite

The reconstruction of two large full-thickness wounds of the upper lip with different operative techniques: when possible, a local flap repair is preferable to reconstruction with free tissue transfer.

Journal Article Dermatol Surg · February 2013 BACKGROUND: Large full-thickness wounds of the upper lip are often referred to operating room-based surgeons for repair given the perceived difficulties in restoring upper lip form and function with simpler operative techniques. OBJECTIVE: To illustrate th ... Full text Link to item Cite

Surgical complications.

Journal Article Dermatol Ther · 2011 Full text Link to item Cite

Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma.

Journal Article Int J Surg Pathol · July 2008 Onychomatricoma is a rare nail tumor with a distinctive architecture. Proximally, there are serum-filled invaginations of nail matrix epithelium into the stroma, and distally, dermal protrusions perforate the nail plate. Because other matrical tumors of fo ... Full text Link to item Cite

Flaps and Grafts in Dermatologic Surgery

Book · January 1, 2008 Authored by experts in the field, this brand-new reference presents a systematic approach to which flap or graft to use in which clinical situation and how to cut and move the skin. More than 350 full-color photographs and line drawings offer you step-by-s ... Full text Cite

Preface

Book · January 1, 2008 Full text Cite

Nasal Reconstruction

Chapter · January 1, 2008 Full text Cite

Ergonomics in office-based surgery: a survey-guided observational study.

Journal Article Dermatol Surg · November 2007 BACKGROUND: The practice of office-based surgery is increasing in many specialties. OBJECTIVE: Using Mohs surgery as a model, we investigated the role of ergonomics in office-based surgery to limit work-related musculoskeletal disorders. METHODS: All Mayo ... Full text Link to item Cite

High-risk cutaneous squamous cell carcinoma without palpable lymphadenopathy: is there a therapeutic role for elective neck dissection?

Journal Article Dermatol Surg · April 2007 PURPOSE: The beneficial role of elective neck dissection (END) in the management of high-risk cutaneous squamous cell carcinoma (CSCC) of the head and neck remains unproven. Some surgical specialists suggest that END may be beneficial for patients with cli ... Full text Link to item Cite

Botulinum toxin treatment of social anxiety disorder with hyperhidrosis: a placebo-controlled double-blind trial.

Journal Article J Clin Psychiatry · January 2006 OBJECTIVE: Given the often prominent and persistent nature of hyperhidrosis in social anxiety disorder (SAD), to compare botulinum toxin type A to placebo for generalized SAD with hyperhidrosis, in combination with paroxetine. METHOD: Adults with severe ax ... Full text Link to item Cite

Megasession: Excision of numerous skin cancers in a single session: Commentary

Journal Article Dermatologic Surgery · December 1, 2005 Cite

The undesirable influence of reconstructive procedures on the symmetry of the nasolabial folds.

Journal Article Dermatol Surg · November 2005 BACKGROUND AND OBJECTIVES: Although considerable attention has been directed toward the nasolabial fold in the esthetic surgery literature, there are infrequent discussions of the fold's importance in reconstructive surgery of the face. Because the use of ... Full text Link to item Cite

Postradiation sarcoma: case report and review of the potential complications of therapeutic ionizing radiation.

Journal Article Dermatol Surg · August 2005 BACKGROUND: Radiation therapy is an acceptable treatment choice for many cutaneous malignancies. A potential late sequela of ionizing radiation is the development of secondary neoplasms within the treatment field. Although there are well-known cutaneous sy ... Link to item Cite

Reconstructive utility of the bilobed flap: lessons from flap successes and failures.

Journal Article Dermatol Surg · August 2005 BACKGROUND: Although the bilobed transposition flap's utility in the reconstruction of difficult facial surgical wounds is often praised, the complicated design of the flap can produce unacceptable esthetic results if the nuances of flap design and executi ... Full text Link to item Cite

Mohs surgery: an informed view.

Journal Article Plast Reconstr Surg · March 2005 Full text Link to item Cite

Random Pattern Cutaneous Flaps

Journal Article · January 1, 2005 Full text Cite

Melanoma arising in a skin graft.

Journal Article Ann Plast Surg · January 2005 Cutaneous melanoma remains an ongoing public health threat, and the cornerstone of management continues to be early diagnosis and treatment. Unfortunately, primary melanomas may have atypical presentations, making early diagnosis difficult and causing sign ... Full text Link to item Cite

Cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia.

Journal Article Skinmed · 2005 Patients with chronic lymphocytic leukemia are at heightened risk for the development of cutaneous malignancies, especially squamous cell carcinoma. These tumors portend a worse prognosis than is typically seen in immunocompetent patients. Patients with ch ... Full text Link to item Cite

Postradiation sarcoma: Case report and review of the potential complications of therapeutic ionizing radiation

Journal Article Dermatologic Surgery · January 1, 2005 BACKGROUND. Radiation therapy is an acceptable treatment choice for many cutaneous malignancies. A potential late sequela of ionizing radiation is the development of secondary neoplasms within the treatment field. Although there are well-known cutaneous sy ... Full text Cite

The incidences of chondritis and perichondritis associated with the surgical manipulation of auricular cartilage.

Journal Article Dermatol Surg · January 2004 BACKGROUND: The cartilage and soft tissues of the ear are frequently employed as donor sites for tissue used in the repair of defects of the nose and external ear after Mohs surgery. Enthusiasm for using these auricular donor sites is occasionally tempered ... Full text Link to item Cite

The examination of several common misconceptions in nasal reconstruction.

Journal Article Semin Cutan Med Surg · December 2003 Because the nose is a very prominent aesthetic feature of the face, wounds located here are particularly challenging from a reconstructive perspective. Poor tissue availability and the potential for introducing anatomic distortion certainly increase surgic ... Full text Link to item Cite

Letter: To the editor [1] (multiple letters)

Journal Article Dermatologic Surgery · September 1, 2003 Full text Cite

Reconstruction of a full-thickness alar wound with a single operative procedure.

Journal Article Dermatol Surg · September 2003 BACKGROUND: The reconstruction of full-thickness alar wounds often requires multiple challenging surgical procedures. These procedures, although often functionally and aesthetically successful, are often staged, and they therefore introduce operative risks ... Full text Link to item Cite

Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity.

Journal Article Dermatol Surg · August 2003 BACKGROUND: Trichilemmal carcinoma is an uncommon cutaneous malignancy that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, trichilemmal carcinoma is often described as havin ... Full text Link to item Cite

Basal cell carcinoma of the umbilicus: a case report and literature review.

Journal Article Cutis · February 2003 We report the case of a 43-year-old woman with basal cell carcinoma (BCC) of the umbilicus. Although BCC is a common skin tumor, only 2 cases of BCC arising within the umbilicus have been reported previously. Our review of the literature shows that truncal ... Link to item Cite

A prospective evaluation of the incidence of complications associated with Mohs micrographic surgery.

Journal Article Arch Dermatol · February 2003 BACKGROUND: Because outpatient surgery is being increasingly scrutinized in the lay press, it is important that dermatologists and dermatologic surgeons accurately characterize the safety of office-based surgery. Although there is abundant anecdotal eviden ... Full text Link to item Cite

Predictable tissue shrinkage during frozen section histopathologic processing for Mohs micrographic surgery.

Journal Article Dermatol Surg · September 2001 BACKGROUND: When confronted with a histologic specimen that is appreciably smaller than the same tissue specimen immediately after acquisition, the Mohs surgeon is faced with two possibilities, namely that the tissue has either shrunken during laboratory p ... Full text Link to item Cite

Reconstruction of the lower lip.

Journal Article Dermatol Surg · August 2001 Full text Link to item Cite

A review of the bilobed flap's design with particular emphasis on the minimization of alar displacement.

Journal Article Dermatol Surg · April 2000 BACKGROUND: The bilobed flap excels in the surgical reconstruction of the distal nose. Unfortunately the aesthetic success of the flap is occasionally limited by the production of distracting alar displacement. OBJECTIVE: To review elements of the bilobed ... Full text Link to item Cite

The lateral femoral cutaneous nerve block.

Journal Article Dermatol Surg · January 2000 Full text Link to item Cite

Aging of the skin: implications for cutaneous surgery.

Journal Article Arch Dermatol · October 1997 There are precious few benefits, save perhaps experience and wisdom, that those of advanced age may claim over those who continue to dwell in their youth. One somewhat paradoxical advantage, however, is the ability of older patients to apparently heal bett ... Link to item Cite