Research Interests
Current projects revolve around capturing initiation mutations in human cancers, proteomic-coupled CRISPR/Cas9 screens, and genetically engineered mouse models of cancer.
Selected Grants
Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029Regulation of fertility and reproduction by codon usage: a Drosophila model
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program
ResearchPreceptor · Awarded by National Cancer Institute · 2023 - 2028Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform
ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027Genetic dissection of oncogenic RAS-driven tumor initiation in vivo
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027ZEB2 as a cell fate switch in fusion-positive rhabdomyosarcoma
ResearchCollaborator · Awarded by Hyundai Hope on Wheels · 2024 - 2026A Window-of-Opportunity Trial Using Neoadjuvant Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer
ResearchCollaborator · Awarded by Marc Lustgarten Pancreatic Cancer Foundation · 2023 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Adapting K-MDS to detect KRAS-mutant ctDNA
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025Defining and targeting the molecular vulnerabilities of the PAX3-FOXO1 protein in rhabdomyosarcoma
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2025Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models.
ResearchCollaborator · Awarded by American Gastroenterological Association · 2022 - 2025Pharmacological Sciences Training Grant
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025PROMINENT - DUKE
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2022 - 2025PROMINENT - Discovering the molecular signatures of cancer PROMotion to INform prevENTion
ResearchPrincipal Investigator · Awarded by International Agency for Research on Cancer · 2022 - 2025Institutional Summer Undergraduate Research Fellowship (SURF)
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2018 - 2025Viral Oncology Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2025Interrogating the RAS interactome for therapeutic vulnerabilities
ResearchMentor · Awarded by National Institutes of Health · 2020 - 2022Translational Research in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022Defining RAS isoform- and mutation-specific roles in oncogenesis
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2016 - 2022Defining RAS isoform- and mutation-specific roles in oncogenesis
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2016 - 2022Defining RAS isoform- and mutation-specific roles in oncogenesis
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2016 - 2022The role of dietary copper in melanoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2021The role of NRF2 in breast cancer dormancy and recurrence
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2019 - 2020Identification and validation of the PAX3-FOXO1 protein interactome
ResearchCollaborator · Awarded by St. Baldrick's Foundation · 2018 - 2020Genetics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020Pharmacological Sciences Training Program
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020Identifying phosphatidylinositol metabolism vulnerabilities in cancer pathways
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2020Pharmacology Industry Internships for Ph.D. Students
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2017 - 2019Dynamic requirements of Ras signaling during cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2019Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer
EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2013 - 2019RalA signal transduction
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2019Elucidating the Role of Kras Specificity Determinants in Pancreatic Cancer
FellowshipPrincipal Investigator · Awarded by Pancreatic Cancer Action Network · 2017 - 2018Leveraging copper chelation as targeted therapy for BRAF-driven thyroid cancer
ResearchPrincipal Investigator · Awarded by Triangle Community Foundation · 2015 - 2018Center for Molecular & Cellular Studies of Ped Disease
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2018The role of KRAS codon bias in tumorigenesis
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2017The effect of oncogenic Ras signaling strength on cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2017A Platform for Real-time Drug Profiling of Patient-Derived Melanomas
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2016Cancer Biology Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016Examining infection-mediated metastasis with single-cell resolution
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2014 - 2016Pleiotrophin, a paracrine regulator of hematopoietic stem cell fate
ResearchPrincipal Investigator · Awarded by University of California - Los Angeles · 2014 - 2015Copper reduction as a novel therapy in BRAF-mutant positive cancers
ResearchMentor · Awarded by National Institutes of Health · 2013 - 2015Reducing dietary copper for the treatment of BRaf mutation-positive melanoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2015JUN PROTEINS IN EPIDERMAL HOMEOSTASIS AND NEOPLASIA
ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2015Instrumentation for Quantitative Phosphoproteomics and Acetylomics
EquipmentMajor User · Awarded by National Institutes of Health · 2014 - 2015Evaluating the impact of KRas codon bias on pancreatic cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2014The role of RalA in pancreatic tumorigenesis
ResearchMentor · Awarded by National Institutes of Health · 2008 - 2013Small molecular weight eNOS inhibitors for the treatment of pancreatic cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013Preclinical evaluation of NOS inhibitors for the treatment of pancreatic cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2011NF-kB, CDK4 and JNK in Epidermal Growth Regulation
ResearchCo-Mentor · Awarded by National Institutes of Health · 2005 - 2010The Molecular Basis of Telomerase Function & Regulation
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1999 - 2009Developing inhibitors of RalA function for the treatment of pancreatic cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009Targeting Functional Domains in Telomerase
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2004External Relationships
- Duke NUS Graduate Medical School
- Humacyte
- Merlon Inc
- University of Colorado Cancer Center
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.