Scholars@Duke
Lawrence Edward Crawford

Lawrence Edward Crawford

Professor of Medicine
Medicine, Cardiology
crawf036@mc.duke.edu
Duke Box 3126, Durham, NC 27710
2301 Erwin Rd., Room 7412, Durham, NC 27710

Selected Publications

Effects of a 12-Week mHealth Program on FunctionalCapacity and Physical Activity in Patients With PeripheralArtery Disease.

Journal Article Am J Cardiol · September 1, 2018 Supervised exercise is beneficial for peripheral artery disease (PAD) patients limited by intermittent claudication (IC). However, supervised exercise for PAD remains widely underutilized. Mobile health (mHealth) provides an intermediate solution between s ... Full text Link to item Cite

Use of Anticoagulants and Antiplatelet Agents in Stable Outpatients with Coronary Artery Disease and Atrial Fibrillation. International CLARIFY Registry.

Journal Article PLoS One · 2015 BACKGROUND: Few data are available regarding the use of antithrombotic strategies in coronary artery disease patients with atrial fibrillation (AF) in everyday practice. We sought to describe the prevalence of AF and its antithrombotic management in a cont ... Full text Link to item Cite

Atherothrombosis and coronary artery disease

Journal Article · December 1, 2007 Full text Cite

Late thrombosis following treatment of in-stent restenosis with drug-eluting stents after discontinuation of antiplatelet therapy.

Journal Article Catheter Cardiovasc Interv · August 2005 Drug-eluting stent usage has become commonplace for the percutaneous treatment of de novo coronary lesions, but the safety and efficacy profile for their evolving usage in restenotic lesions is largely unknown. We report three cases of angiographically con ... Full text Link to item Cite

Hand-held echocardiographic examination of patients with symptoms of acute coronary syndromes in the emergency department: the 30-day outcome associated with normal left ventricular wall motion.

Journal Article Am Heart J · December 2004 BACKGROUND: Acute chest pain is a common complaint for patients presenting to emergency departments. Electrocardiography (ECG) results and biochemical markers have strong positive predictive value, but an equally available, inexpensive, and non-invasive te ... Full text Link to item Cite

Experience with enhanced external counterpulsation (EECP®) in coronary artery disease

Journal Article Today's Therapeutic Trends · September 1, 2002 The ischemia resulting from arterial narrowing in coronary artery disease (CAD) typically leads to symptoms of angina pectoris in affected patients. The frequent chest pain, shortness of breath and fatigue associated with angina significantly restrict pati ... Cite

Effects of enhanced external counterpulsation on Health-Related Quality of Life continue 12 months after treatment: a substudy of the Multicenter Study of Enhanced External Counterpulsation.

Journal Article J Investig Med · January 2002 BACKGROUND: The Multicenter Study of Enhanced External Counterpulsation (MUST-EECP) was the first prospective, randomized, blinded, sham-controlled study of enhanced external counterpulsation (EECP) in the treatment of chronic stable angina. We previously ... Full text Link to item Cite

The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes.

Journal Article J Am Coll Cardiol · June 1999 OBJECTIVES: The purpose of this study was to assess safety and efficacy of enhanced external counterpulsation (EECP). BACKGROUND: Case series have shown that EECP can improve exercise tolerance, symptoms and myocardial perfusion in stable angina pectoris. ... Full text Link to item Cite

Enhanced external counterpulsation in the management of patients with cardiovascular disease.

Journal Article Clin Cardiol · March 1999 Studies over the past several decades support the hypothesis that enhanced external counterpulsation (EECP) can provide long-term benefits in patients with angina secondary to chronic coronary disease. Numerous non-sham controlled trials have recently been ... Full text Link to item Cite

Superoxide-mediated actin response in post-hypoxic endothelial cells.

Journal Article J Biol Chem · October 25, 1996 The mechanism leading to changes in the superstructure of endothelial cells exposed to ischemia and reperfusion remains uncharacterized. We show that in post-hypoxic endothelial cells, the simple re-addition of oxygen induces a profound reorganization of t ... Full text Link to item Cite

EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.

Journal Article Circ Res · February 1996 Transformation of fibroblast-like cells (NIH 3T3) by a constitutively activated GTP-bound isoform of p21ras (EJ-Ras) produces morphogenic changes characterized by decreased attachment to the substratum, with retraction and rounding of the cell body. Transf ... Full text Link to item Cite

Actin regulation and surface catalysis.

Journal Article Adv Exp Med Biol · 1994 Full text Link to item Cite