Journal ArticleACR Open Rheumatol · June 2024
OBJECTIVE: RheumMadness is an online learning collaborative that seeks to actively engage the rheumatology community. The objective of this manuscript is to analyze the educational experience of RheumMadness over two years. METHODS: Direct measures of part ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · May 1, 2024
OBJECTIVE: Systemic lupus erythematosus (SLE) flares are associated with increased damage and decreased health-related quality of life. We hypothesized that there is discordance between physicians' and patients' views of SLE flare. In this study, we aimed ...
Full textLink to itemCite
Journal ArticleLupus Sci Med · April 30, 2024
OBJECTIVE: Characterise the relationship between hydroxychloroquine (HCQ) blood levels and the number of missed doses, accounting for dosage, dose timing and the large variability in pharmacokinetics (PK) between patients. METHODS: We externally validated ...
Full textLink to itemCite
Journal ArticleClin Rheumatol · April 2024
BACKGROUND: Type 2 systemic lupus erythematosus (SLE) symptoms, including fatigue, fibromyalgia, and brain fog, contribute to poor health-related quality of life (HRQoL) in patients with lupus. To test the hypothesis that Type 1 (classical inflammatory lup ...
Full textLink to itemCite
Journal ArticleLupus · March 2024
OBJECTIVE: In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationship to inflammati ...
Full textLink to itemCite
Journal ArticleLupus · February 2024
OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Patient Rep Outcomes · December 21, 2023
OBJECTIVE: To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reporte ...
Full textLink to itemCite
Journal ArticleLupus Sci Med · December 17, 2023
OBJECTIVE: Manifestations of SLE can be categorised as type 1 (classic signs and symptoms of SLE) or type 2 (fatigue, widespread pain and brain fog with an unclear relationship to inflammation). While measures of type 1 SLE activity exist, most current phy ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · December 2023
OBJECTIVE: To increase the confidence of rheumatology fellows in training (FITs) in delivering virtual care (VC) and prepare them for independent practice, we developed educational materials addressing gaps in their skills. METHODS: We identified gaps in t ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · December 2023
OBJECTIVE: With the onset of the COVID-19 pandemic, an annual multi-institutional face-to-face rheumatology objective structured clinical examination (ROSCE) was transformed into a virtual format. The educational goals of the virtual ROSCE (vROSCE) were to ...
Full textLink to itemCite
Journal ArticleLupus · December 2023
Women with systemic lupus erythematosus (SLE) who get pregnant while SLE is active or while on teratogens have higher risk of poor pregnancy outcomes. The American College of Rheumatology (ACR) Reproductive Health Guidelines recommend women conceive when S ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · November 2023
OBJECTIVE: To evaluate the educational impact of RheumMadness, an online tournament of rheumatology concepts grounded in social constructivist theory, as viewed through the community of inquiry (CoI) framework. METHODS: The curricular scaffold of RheumMadn ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · March 2023
OBJECTIVE: Despite high rates of medication nonadherence among patients with systemic lupus erythematosus (SLE), effective interventions to improve adherence in SLE are limited. We aimed to assess the feasibility of a pilot intervention and explore its eff ...
Full textOpen AccessLink to itemCite
ConferenceArthritis Care Res (Hoboken) · January 2023
OBJECTIVE: Medication nonadherence is common among patients with systemic lupus erythematosus (SLE), and adherence often fluctuates with time. Underrepresented racial minorities have disproportionately lower rates of medication adherence and more severe SL ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · December 2022
OBJECTIVE: Medication nonadherence is common in patients with systemic lupus erythematosus (SLE) and negatively affects outcomes. To better recognize and address nonadherence in this population, there is a need for an easily implementable tool with interpr ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · September 2022
OBJECTIVE: Underrepresented racial and ethnic minorities are disproportionately affected by systemic lupus erythematosus (SLE). Racial and ethnic minorities also have more severe SLE manifestations that require use of immunosuppressive medications, and oft ...
Full textOpen AccessLink to itemCite
Journal ArticleLupus Sci Med · August 2022
OBJECTIVE: We have developed a new conceptual model to characterise the signs and symptoms of SLE: the Type 1 and 2 SLE Model. Within the original model, Type 1 SLE consists of inflammatory manifestations like arthritis, nephritis and rashes; Type 2 SLE in ...
Full textLink to itemCite
Journal ArticleACR Open Rheumatol · June 2024
OBJECTIVE: RheumMadness is an online learning collaborative that seeks to actively engage the rheumatology community. The objective of this manuscript is to analyze the educational experience of RheumMadness over two years. METHODS: Direct measures of part ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · May 1, 2024
OBJECTIVE: Systemic lupus erythematosus (SLE) flares are associated with increased damage and decreased health-related quality of life. We hypothesized that there is discordance between physicians' and patients' views of SLE flare. In this study, we aimed ...
Full textLink to itemCite
Journal ArticleLupus Sci Med · April 30, 2024
OBJECTIVE: Characterise the relationship between hydroxychloroquine (HCQ) blood levels and the number of missed doses, accounting for dosage, dose timing and the large variability in pharmacokinetics (PK) between patients. METHODS: We externally validated ...
Full textLink to itemCite
Journal ArticleClin Rheumatol · April 2024
BACKGROUND: Type 2 systemic lupus erythematosus (SLE) symptoms, including fatigue, fibromyalgia, and brain fog, contribute to poor health-related quality of life (HRQoL) in patients with lupus. To test the hypothesis that Type 1 (classical inflammatory lup ...
Full textLink to itemCite
Journal ArticleLupus · March 2024
OBJECTIVE: In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationship to inflammati ...
Full textLink to itemCite
Journal ArticleLupus · February 2024
OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Patient Rep Outcomes · December 21, 2023
OBJECTIVE: To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reporte ...
Full textLink to itemCite
Journal ArticleLupus Sci Med · December 17, 2023
OBJECTIVE: Manifestations of SLE can be categorised as type 1 (classic signs and symptoms of SLE) or type 2 (fatigue, widespread pain and brain fog with an unclear relationship to inflammation). While measures of type 1 SLE activity exist, most current phy ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · December 2023
OBJECTIVE: To increase the confidence of rheumatology fellows in training (FITs) in delivering virtual care (VC) and prepare them for independent practice, we developed educational materials addressing gaps in their skills. METHODS: We identified gaps in t ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · December 2023
OBJECTIVE: With the onset of the COVID-19 pandemic, an annual multi-institutional face-to-face rheumatology objective structured clinical examination (ROSCE) was transformed into a virtual format. The educational goals of the virtual ROSCE (vROSCE) were to ...
Full textLink to itemCite
Journal ArticleLupus · December 2023
Women with systemic lupus erythematosus (SLE) who get pregnant while SLE is active or while on teratogens have higher risk of poor pregnancy outcomes. The American College of Rheumatology (ACR) Reproductive Health Guidelines recommend women conceive when S ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · November 2023
OBJECTIVE: To evaluate the educational impact of RheumMadness, an online tournament of rheumatology concepts grounded in social constructivist theory, as viewed through the community of inquiry (CoI) framework. METHODS: The curricular scaffold of RheumMadn ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · March 2023
OBJECTIVE: Despite high rates of medication nonadherence among patients with systemic lupus erythematosus (SLE), effective interventions to improve adherence in SLE are limited. We aimed to assess the feasibility of a pilot intervention and explore its eff ...
Full textOpen AccessLink to itemCite
ConferenceArthritis Care Res (Hoboken) · January 2023
OBJECTIVE: Medication nonadherence is common among patients with systemic lupus erythematosus (SLE), and adherence often fluctuates with time. Underrepresented racial minorities have disproportionately lower rates of medication adherence and more severe SL ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · December 2022
OBJECTIVE: Medication nonadherence is common in patients with systemic lupus erythematosus (SLE) and negatively affects outcomes. To better recognize and address nonadherence in this population, there is a need for an easily implementable tool with interpr ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · September 2022
OBJECTIVE: Underrepresented racial and ethnic minorities are disproportionately affected by systemic lupus erythematosus (SLE). Racial and ethnic minorities also have more severe SLE manifestations that require use of immunosuppressive medications, and oft ...
Full textOpen AccessLink to itemCite
Journal ArticleLupus Sci Med · August 2022
OBJECTIVE: We have developed a new conceptual model to characterise the signs and symptoms of SLE: the Type 1 and 2 SLE Model. Within the original model, Type 1 SLE consists of inflammatory manifestations like arthritis, nephritis and rashes; Type 2 SLE in ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · June 2022
OBJECTIVE: Limited health literacy and numeracy are associated with worse patient-reported outcomes and higher disease activity in systemic lupus erythematosus (SLE), but which factors may mediate this association is unknown. We sought to determine the ass ...
Full textLink to itemCite
Journal ArticleLupus · May 2022
OBJECTIVE: We developed a model that categorizes systemic lupus erythematosus (SLE) activity into two dimensions: Type 1 SLE consists of inflammatory activity, including arthritis, nephritis, and rashes; Type 2 SLE includes fatigue, myalgia, mood disturban ...
Full textLink to itemCite
Journal ArticleClin Rheumatol · August 2021
OBJECTIVE: Myositis autoantibody panel results can offer diagnostic and prognostic information in patients with concern for idiopathic inflammatory myopathy (IIM). However, there has been widespread utilization of myositis autoantibody testing clinically, ...
Full textLink to itemCite
Journal ArticleJ Rheumatol · July 2021
OBJECTIVE: Despite significant racial disparities in systemic lupus erythematosus (SLE) outcomes, few studies have examined how disparities may be perpetuated in clinical encounters. We aimed to explore associations between areas of clinical encounters - p ...
Full textOpen AccessLink to itemCite
Journal ArticleClin Rheumatol · May 2021
We sought to determine if analyzing internal medicine (IM) resident performance on the in-training exam (ITE) might reveal curricular needs in rheumatology education beyond those intuitive to learners and educators from their perceptions and experience. We ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · March 2021
OBJECTIVE: The type 1 and type 2 systemic lupus erythematosus (SLE) categorization system was recently proposed to validate the patients' perspective of disease and to capture a more comprehensive spectrum of symptoms. The objective of this study was to ch ...
Full textLink to itemCite
Journal ArticleJ Physician Assist Educ · September 2020
PURPOSE: To assess the feasibility of an on-site, case-based curriculum delivered by preceptors and to assess preceptors' perceptions of the impact of the curriculum on rotation performance and ability to teach. METHODS: Hospital medicine preceptors were s ...
Full textLink to itemCite
Journal ArticleACR Open Rheumatol · July 2020
OBJECTIVE: Medication nonadherence is more common in African Americans compared with Caucasians. We examined the racial adherence gaps among patients with systemic lupus erythematosus (SLE) and explored factors associated with nonadherence. METHODS: Cross- ...
Full textOpen AccessLink to itemCite
Journal ArticleACR Open Rheumatol · June 2020
OBJECTIVE: To bring recent advances in pregnancy management in lupus to women nationwide, this multidimensional educational intervention sought to equip community rheumatologists with the needed skills, attitudes, and confidence to manage contraceptive dec ...
Full textOpen AccessLink to itemCite
Journal ArticleRheum Dis Clin North Am · February 2020
Objective structured clinical examinations assess learners "showing how" to perform complex clinical tasks. Devised as summative evaluations, these examinations with immediate feedback are useful formative evaluations to improve learner performance. This r ...
Full textLink to itemCite
Journal ArticleObstet Med · December 2018
INTRODUCTION: Rheumatologists are essential partners in planning and managing pregnancies in women with lupus. Whether they know the essentials of contraceptive and medical treatment in pregnancy, however, is unknown. METHOD: Anonymous in-lecture surveys w ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · June 2018
OBJECTIVE: Infusible disease-modifying antirheumatic drugs (DMARDs) are commonly prescribed in rheumatology and other fields. There are no published formal educational curricula that rheumatology fellowship programs can use to teach infusion reaction manag ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · March 2018
OBJECTIVE: Some sources urge caution when prescribing hydroxychloroquine (HCQ) to patients with G6PDH deficiency, presumably due to a risk of hemolytic anemia. There are limited published data, however, to support this risk. Additionally, not all patients ...
Full textLink to itemCite
Journal ArticleBMJ Open Qual · 2018
Teratogenic medications are often prescribed to women of childbearing age with autoimmune diseases. Literature suggests that appropriate use of contraception among these women is low, potentially resulting in high-risk unintended pregnancies. Preliminary r ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Physician Assist Educ · December 2017
PURPOSE: The number of physician assistants (PAs) practicing hospital medicine is rapidly expanding. Little research has been done to determine which inpatient medicine rotation experiences are most helpful to prepare PA students for a career in inpatient ...
Full textLink to itemCite
Journal ArticleRheumatology (Oxford) · November 1, 2017
OBJECTIVE: The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM. METHODS: Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consen ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · June 2017
OBJECTIVE: Measurement is necessary to gauge improvement. US training programs have not previously used shared standards to assess trainees' mastery of the knowledge, skills, and attitudes necessary to practice rheumatology competently. In 2014, the Accred ...
Full textLink to itemCite
Journal ArticleArthritis Rheumatol · May 2017
OBJECTIVE: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). METHODS: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater i ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · November 2016
OBJECTIVE: The Rheumatology Research Foundation's Clinician Scholar Educator (CSE) award is a 3-year career development award supporting medical education research while providing opportunities for mentorship and collaboration. Our objective was to documen ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · August 2016
OBJECTIVE: Graduate medical education is a critical time in the training of a rheumatologist, and purposeful evaluation of abilities during this time is essential for long-term success as an independent practitioner. The internal medicine subspecialties co ...
Full textLink to itemCite
Journal ArticleMed Educ · July 2016
CONTEXT: Graduate medical trainees have a critical role in the teaching of other trainees. Improving their teaching requires an understanding of their attitudes towards teaching and their motivation to teach. Both have been incompletely explored in this po ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · June 2016
OBJECTIVE: Enhancing rheumatology fellows' teaching skills in the setting of inpatient consultation may have a broad positive impact. Such efforts may improve fellows' clinical skills and overall patient care. Most importantly, effective resident-fellow te ...
Full textLink to itemCite
Journal ArticleAm J Med Qual · 2016
Interested faculty enrolled in this 6-month-long quality improvement (QI) course to facilitate independent QI project work. The course included monthly 1.5-hour sessions: 20-minute presentations covering key QI concepts, then small group activities to faci ...
Full textLink to itemCite
ConferenceArthritis Care Res (Hoboken) · July 2015
OBJECTIVE: While several regional fellowship groups conduct rheumatology objective structured clinical examinations (ROSCEs), none have been validated for use across programs. We aimed to establish agreement among subspecialty experts regarding checklist i ...
Full textLink to itemCite
ConferenceArthritis Rheumatol · July 2015
OBJECTIVE: Vitamin D modulates the immune response and blocks induction of an interferon (IFN) signature by systemic lupus erythematosus (SLE) sera. This study was undertaken to investigate the effects of vitamin D supplementation on the IFN signature in p ...
Full textLink to itemCite
Journal ArticleJ Clin Invest · April 2014
Broadly HIV-1-neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnA ...
Full textLink to itemCite
Journal ArticleAnn Rheum Dis · September 1, 2013
OBJECTIVE: While increased disease activity is the best predictor of preterm birth in women with systemic lupus erythematosus (SLE), even women with low disease activity are at increased risk of this complication. Biomarkers that would identify at-risk pre ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · June 2013
OBJECTIVE: American Council on Graduate Medical Education program requirements mandate that rheumatology training programs have written goals, objectives, and performance evaluations for each learning activity. Since learning activities are similar across ...
Full textLink to itemCite
Journal ArticleLupus · January 2013
BACKGROUND: While cyclophosphamide (CYC) can save the life of a young woman with severe rheumatologic disease, it may lead to the long-term side-effects of infertility and premature menopause. We compared the reproductive health histories of young women wi ...
Full textLink to itemCite
Journal ArticlePsychosomatics · 2013
BACKGROUND: Depressive symptoms affect anywhere from 11% to 71% of patients with systemic lupus erythematosus (SLE), which may be related to SLE disease activity, other clinical variables, or sociodemographic factors. OBJECTIVE: We aimed to measure the rat ...
Full textLink to itemCite
Journal ArticleArthritis Care Res (Hoboken) · September 2012
OBJECTIVE: To determine how self-efficacy for pain control and pain catastrophizing, both potentially modifiable pain coping cognitions, are related to pain, stiffness, fatigue, and psychological distress in patients with systemic lupus erythematosus (SLE) ...
Full textLink to itemCite
Journal ArticleJ Autoimmun · May 2011
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antibodies to DNA and other nuclear molecules. While these antibodies can form immune complexes, the mechanisms generating the bound nuclear antigens are not known. These stud ...
Full textLink to itemCite
Journal Article · December 1, 2010
Rashes are among the most common manifestations of systemic lupus erythematosus (SLE), affecting up to 85% of individuals with SLE. Cutaneous lupus without systemic features is even more common than SLE. In many patients, cutaneous involvement can be wides ...
Full textCite
Journal ArticleArthritis Rheum · August 2006
OBJECTIVE: To evaluate diurnal variation of biomarkers in subjects with osteoarthritis (OA) of the knee. METHODS: Twenty subjects with radiographic knee OA were admitted to the General Clinical Research Center of Duke University for an overnight stay to un ...
Full textLink to itemCite
Journal ArticleOsteoarthritis Cartilage · September 2005
PURPOSE: Serum hyaluronan (HA) was evaluated for diurnal variation in participants with osteoarthritis (OA) of the knee. METHODS: Twenty participants with radiographic OA of at least one knee were admitted overnight to the General Clinical Research Center ...
Full textLink to itemCite
Journal ArticleCurr Rheumatol Rep · August 2003
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by B cell hyperactivity in association with autoantibodies, most prominently those directed to components of the cell nucleus. The source of the antigens that drive B cell ...
Full textLink to itemCite
Journal ArticleArthritis Rheum · June 15, 2003
OBJECTIVE: To evaluate the informed consent process for a clinical trial of intravenous doxycycline for rheumatoid arthritis. METHODS: Participants completed a self-administered questionnaire about the consent process at baseline and 16 weeks following enr ...
Full textLink to itemCite
Journal ArticleCurr Opin Rheumatol · May 2002
Tumor necrosis factor-alpha (TNF-alpha) antagonists have rapidly emerged as a valuable class of antirheumatic agents. Etanercept, a dimerized version of the soluble tumor necrosis factor receptor II, and infliximab, a chimeric anti-TNF-alpha monoclonal ant ...
Full textLink to itemCite
Journal ArticleJ Infect Dis · January 1998
The cardiac infiltrate seen in murine Lyme carditis is composed predominantly of macrophages, but small numbers of T cells are also present. To identify the cytokines present in cardiac lesions from susceptible mice, semiquantitative polymerase chain react ...
Full textLink to itemCite