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B lymphocytes and systemic lupus erythematosus.

Publication ,  Journal Article
Criscione, LG; Pisetsky, DS
Published in: Curr Rheumatol Rep
August 2003

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by B cell hyperactivity in association with autoantibodies, most prominently those directed to components of the cell nucleus. The source of the antigens that drive B cell responses in SLE is unknown, although recent studies suggest mechanisms by which the self-antigens become immunogenic and stimulate responses. Among these mechanisms, abnormalities in the generation of apoptotic cells or their clearance may increase the availability of nuclear antigens to drive responses. In addition, autoantibody crossreactivity may promote induction of responses to disparate antigens, foreign and self, and enable a single autoantibody to cause disease by crossreactive binding. In addition to reflecting increased exposure to self-antigen, autoantibody responses in SLE may result from abnormalities in B cell signaling and regulation by cytokines. New approaches to therapy aim to abrogate autoantibody production by targeting specific steps in B cell activation, including blockade of T cell costimulation.

Duke Scholars

Published In

Curr Rheumatol Rep

DOI

ISSN

1523-3774

Publication Date

August 2003

Volume

5

Issue

4

Start / End Page

264 / 269

Location

United States

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Lupus Erythematosus, Systemic
  • Immunity, Cellular
  • Humans
  • Cytokines
  • B-Lymphocytes
  • Arthritis & Rheumatology
  • Antigens, Nuclear
  • Antibodies, Antinuclear
  • 3202 Clinical sciences
 

Citation

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ICMJE
MLA
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Criscione, L. G., & Pisetsky, D. S. (2003). B lymphocytes and systemic lupus erythematosus. Curr Rheumatol Rep, 5(4), 264–269. https://doi.org/10.1007/s11926-003-0004-x
Criscione, Lisa G., and David S. Pisetsky. “B lymphocytes and systemic lupus erythematosus.Curr Rheumatol Rep 5, no. 4 (August 2003): 264–69. https://doi.org/10.1007/s11926-003-0004-x.
Criscione LG, Pisetsky DS. B lymphocytes and systemic lupus erythematosus. Curr Rheumatol Rep. 2003 Aug;5(4):264–9.
Criscione, Lisa G., and David S. Pisetsky. “B lymphocytes and systemic lupus erythematosus.Curr Rheumatol Rep, vol. 5, no. 4, Aug. 2003, pp. 264–69. Pubmed, doi:10.1007/s11926-003-0004-x.
Criscione LG, Pisetsky DS. B lymphocytes and systemic lupus erythematosus. Curr Rheumatol Rep. 2003 Aug;5(4):264–269.
Journal cover image

Published In

Curr Rheumatol Rep

DOI

ISSN

1523-3774

Publication Date

August 2003

Volume

5

Issue

4

Start / End Page

264 / 269

Location

United States

Related Subject Headings

  • Receptors, Antigen, B-Cell
  • Lupus Erythematosus, Systemic
  • Immunity, Cellular
  • Humans
  • Cytokines
  • B-Lymphocytes
  • Arthritis & Rheumatology
  • Antigens, Nuclear
  • Antibodies, Antinuclear
  • 3202 Clinical sciences