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Daniel Friedman

Associate Professor of Medicine
Medicine, Cardiology
2301 Erwin Road, Suite 7451, Durham, NC 27701

Overview


My research areas of interest include improving the safety and efficacy of complex ablation and optimal use of pacemakers in patients with heart failure, including cardiac resynchronization therapy and conduction system pacing. I am also interested in non-pharmacologic management of atrial fibrillation, including catheter ablation and left atrial appendage occlusion, and understanding optimal use of novel and emerging technologies.

Current Appointments & Affiliations


Associate Professor of Medicine · 2023 - Present Medicine, Cardiology, Medicine

Recent Publications


Using Machine Learning to Predict Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion.

Journal Article JACC Adv · January 20, 2026 BACKGROUND: Standard cardiovascular risk models generally have limited performance and cannot predict rare outcomes. Machine learning may overcome these limitations. OBJECTIVES: This study sought to determine how predictive performance varies for standard ... Full text Link to item Cite

Long-Term Outcomes Following Left Atrial Appendage Occlusion in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry.

Journal Article J Am Heart Assoc · August 19, 2025 BACKGROUND: Percutaneous left atrial appendage occlusion (LAAO) is an alternative to long-term anticoagulation for preventing ischemic stroke in patients with atrial fibrillation. There are limited long-term outcomes data for "real-world" patients undergoi ... Full text Link to item Cite

Performance of an active fixation stylet-driven lead in left bundle branch area pacing: Results from INSIGHT-LBBA.

Journal Article Heart Rhythm · August 2025 BACKGROUND: Left bundle branch area pacing (LBBAP) has been rapidly adopted despite a lack of leads with approved indications for LBBAP. OBJECTIVE: This study aims to analyze the performance of a 6Fr active fixation, stylet-driven lead in LBBAP. METHODS: T ... Full text Link to item Cite
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Recent Grants


Safety and Effectiveness of Left Bundle Branch Area Pacing versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Clinical TrialPrincipal Investigator · Awarded by Boston Scientific Corporation · 2026 - 2033

Fire-HFpEF

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2024 - 2029

Probing Regional Metabolism During Exercise through Coronary Sinus Sampling

ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2027

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Education, Training & Certifications


Cornell University, Weill Medical College · 2010 M.D.
Cornell University · 2006 B.S.
High School · 2002 C.