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Daniel Friedman

Associate Professor of Medicine
Medicine, Cardiology
2301 Erwin Road, Suite 7451, Durham, NC 27701

Research Interests


My research areas of interest include improving the safety and efficacy of complex ablation and optimal use of pacemakers in patients with heart failure, including cardiac resynchronization therapy and His bundle pacing. I am also interested in non-pharmacologic management of atrial fibrillation, including catheter ablation and left atrial appendage occlusion, and understanding optimal use of novel and emerging technologies.

Selected Grants


Fire-HFpEF

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2024 - 2029

PR Interval Study

ResearchPrincipal Investigator · Awarded by Medtronic, Inc. · 2023 - 2025

Atrial Fibrillation Ablation Program

Inst. Training Prgm or CMECo-Principal Investigator · Awarded by St. Jude Medical Business Services Inc. · 2022 - 2025

Left Bundle Branch Lead Device

Clinical TrialPrincipal Investigator · Awarded by Boston Scientific Corporation · 2023 - 2025

CRT-DRIVE

Clinical TrialPrincipal Investigator · Awarded by XSPLINE SPA · 2023 - 2024

Fire-HFpEF

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2024 - 2029

PR Interval Study

ResearchPrincipal Investigator · Awarded by Medtronic, Inc. · 2023 - 2025

Atrial Fibrillation Ablation Program

Inst. Training Prgm or CMECo-Principal Investigator · Awarded by St. Jude Medical Business Services Inc. · 2022 - 2025

Left Bundle Branch Lead Device

Clinical TrialPrincipal Investigator · Awarded by Boston Scientific Corporation · 2023 - 2025

CRT-DRIVE

Clinical TrialPrincipal Investigator · Awarded by XSPLINE SPA · 2023 - 2024

Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)

ResearchPrincipal Investigator · Awarded by Yale University · 2021 - 2024

Reinvent-CRT

Clinical TrialPrincipal Investigator · Awarded by Inova Health Care Services · 2023 - 2024

Fellowships, Gifts, and Supported Research


Loan Repayment Program · 2015 - 2018 NIH
T32 · 2015 - 2017 NIH
Use of cryoballoon versus radiofrequency ablation in patients undergoing atrial fibrillation ablation. Get With the Guidelines Young Investigator Award · 2019 - 2020 PI · Get With the Guidelines Young Investigator Award Database Seed Grant
Howard Hughes Medical Institute Undergraduate Summer Research Fellow · 2005 HHMI
Cornell Tradition Fellow · 2002 - 2006 Cornell University
Loan Repayment Program · 2015 - 2018 NIH
T32 · 2015 - 2017 NIH
Use of cryoballoon versus radiofrequency ablation in patients undergoing atrial fibrillation ablation. Get With the Guidelines Young Investigator Award · 2019 - 2020 PI · Get With the Guidelines Young Investigator Award Database Seed Grant
Howard Hughes Medical Institute Undergraduate Summer Research Fellow · 2005 HHMI
Cornell Tradition Fellow · 2002 - 2006 Cornell University
Use, outcomes, and comparative effectiveness of the Watchman left atrial appendage occlusion device: A report from the Get With the Guidelines AF Registry · 2019 PI · Boston Scientific · $58,583.99
Defibrillation threshold testing among subcutaneous ICD patients. 00158-ICD Registry · 2015 - 2016 PI · National Cardiovascular Data Registry
The association between prolonged PR interval, QRS characteristics, and outcomes among patients undergoing cardiac resynchronization therapy. 00121-ICD Registry · 2015 - 2016 National Cardiovascular Data Registry
Longitudinal comparative effectiveness of a S-ICD versus TV-ICD in the ICD Registry. 00151-ICD · 2016 - 2021 PI · National Cardiovascular Data Registry
Early use of the Subcutaneous ICD in US. 00101-ICD · 2015 - 2016 National Cardiovascular Data Registry
CRT and outcomes among patients with advanced CKD. 00079-ICD Registry · 2014 - 2015 National Cardiovascular Data Registry
SNARE complex research · 2005 - 2005 Human Ecology Research Association Grant
Left ventricular lead implant failure in the United States: A Report from the NCDR ICD Registry · 2021 - 2022 PI · Merit Medical
Power of Bayesian Methods, RCTs, and Decision Models to Inform CRT Uncertainties. 1R01HL131754-01A1. · 2017 - 2021 NIH

External Relationships


  • Abbott (St. Jude Medical)
  • Boston Scientific Corporation
  • Microport CRM

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.