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Daniel Raphael Saban

Professor of Ophthalmology
Ophthalmology, Corneal Diseases

Selected Grants


Blink, Lacrimation, and Nociception: Precision Mapping and Integrated Atlas Generation of Corneal Trigeminal Afferents in Mice and Humans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

Cellular and Molecular Mechanisms that Contribute to Ocular Surface Disease during Severe Allergic Inflammation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2026

Immune Mechanisms in Ocular Graft versus Host Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2026

Gut-brain dysfunction following combined prenatal stressors: relevance for autism

ResearchCo Investigator · Awarded by National Institute of Environmental Health Sciences · 2021 - 2026

Role of Tissue Resident Macrophages in the Conventional Outflow Function

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2025

Blink, Lacrimation, and Nociception: Precision Mapping and Integrated Atlas Generation of Corneal Trigeminal Afferents in Mice and Humans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

Cellular and Molecular Mechanisms that Contribute to Ocular Surface Disease during Severe Allergic Inflammation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2026

Immune Mechanisms in Ocular Graft versus Host Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2026

Gut-brain dysfunction following combined prenatal stressors: relevance for autism

ResearchCo Investigator · Awarded by National Institute of Environmental Health Sciences · 2021 - 2026

Role of Tissue Resident Macrophages in the Conventional Outflow Function

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2025

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Paradigms of maintaining anterior segment homeostasis

ResearchPrincipal Investigator · Awarded by Thomas Jefferson University · 2023 - 2025

Characterization of the Immune Cell Response to Topical Glaucoma Medications

ResearchMentor · Awarded by American Glaucoma Society · 2023 - 2024

Cellular and Molecular Dynamics of Retinal Microglial in the Context of Photoreceptor Degeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2024

Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration

ResearchCollaborator · Awarded by National Institutes of Health · 2018 - 2023

Macrophage-Nerve Interactions in Neurotrophic Keratitis

ResearchPrincipal Investigator · Awarded by Research To Prevent Blindness, Inc. · 2020 - 2022

Dompe IIR

ResearchPrincipal Investigator · Awarded by DOMPE, s.p.a. · 2019 - 2022

Understanding the roles of ectosomes and the associated microglial response in photoreceptor degeneration

ResearchMentor · Awarded by Knights Templar Eye Foundation, Inc. · 2021 - 2022

Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution

ResearchPrincipal Investigator · Awarded by Schepens Eye Research Institute · 2019 - 2021

The Role of Macrophages in Conventional Outflow Homeostasis

ResearchCo-Mentor · Awarded by American Glaucoma Society · 2020 - 2021

Immunophenotyping the effect of Xiidra treatment in the inflammatory dry eye disease setting with underlying meibomian gland dysfunction

ResearchPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2018 - 2020

Innate immunity, lipoproteins and AMD progression

ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2019

LXR as a novel therapeutic target in diabetic retinopathy

ResearchCo Investigator · Awarded by University of Alabama at Birmingham · 2017 - 2019

Monocytes in Dry Age-Related Macular Degeneration

ResearchAdvisor · Awarded by National Institutes of Health · 2016 - 2019

Role of bona fide microglia in retinal degeneration

ResearchPrincipal Investigator · Awarded by BrightFocus Foundation · 2017 - 2019

RPB: 2014 Nelson Trust Award

ResearchCollaborator · Awarded by Research To Prevent Blindness, Inc. · 2014 - 2019

Macrophages and Treatment-Resistant NVAMD

ResearchAdvisor · Awarded by National Institutes of Health · 2015 - 2019

Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution

ResearchPrincipal Investigator · Awarded by Schepens Eye Research Institute · 2014 - 2018

Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases

ResearchCollaborator · Awarded by Eyedesis Biosciences LLC · 2017 - 2018

The role of a macrophage chemotactic factor in AMD

ResearchCollaborator · Awarded by BrightFocus Foundation · 2015 - 2017

Examining the role of IFN-g+IL-17+ pathogenic Th17 cells in severe ocular allergy

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017

LXR as a novel therapeutic target in diabetic retinopathy

ResearchCo Investigator · Awarded by The Trustees of Indiana University · 2015 - 2017

Macrophages Drive Neovascular Remodeling in NVAMD

ResearchCollaborator · Awarded by BrightFocus Foundation · 2014 - 2016

Bone marrow neuropathy drives diabetic retinopathy

ResearchPrincipal Investigator · Awarded by The Trustees of Indiana University · 2013 - 2016

Neuroinflammation: the role of lymphocytes in glaucoma

ResearchCollaborator · Awarded by BrightFocus Foundation · 2014 - 2016

Molecular Mechanisms of Corneal Recurrent Erosion Formation

ResearchPrincipal Investigator · Awarded by The George Washington University · 2013 - 2015

External Relationships


  • Piximune ( formerly Bex Vision, Inc.)
  • Roche

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.