Danielle Marie Brander
Assistant Professor of Medicine
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016
Contact Information
- 2400 Pratt St Suite 5000, Durham, NC 27710
- DUMC Box 3961, Durham, NC 27710
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danielle.brander@duke.edu
(919) 668-1000
- Background
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Education, Training, & Certifications
- Resident, Internal Medicine, Duke University School of Medicine 2007 - 2010
- M.D., Duke University School of Medicine 2007
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Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017 - 2020
- Medical Instructor in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013 - 2017
- Research
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Selected Grants
- A Phase 1, Multicenter, Open-label, Dose-escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Orally Administered LP-168 in Subjects with Relapsed or Refractory B-cell Malignancies awarded by Newave Pharmaceutical, Inc. 2021 - 2026
- AN OPEN LABEL PHASE Ia/b DOSE ESCALATION FOLLOWED BY DOSE EXPANSION SAFETY AND TOLERABILITY TRIAL OF CAP 100, A HUMANIZED C C CHEMOKINE RECEPTOR 7 ANTIBODY, ADMINISTERED AS MONOTHERAPY IN SUBJECTS WITH R/R CHRONIC LYMPHOCYTIC LEUKEMIA awarded by Catapult Therapeutics BV 2021 - 2026
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- A Phase 3, Randomized study of Zanubrutinnig (BGB-3111) compared with Ibrutinig in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma awarded by BeiGene, Ltd 2019 - 2024
- A Phase I Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ARQ 531 in Selected Subjects with Relapsed or Refractory Hematologic Malignancies awarded by ArQule, Inc. 2019 - 2024
- An Open-Label, Phase 1 Safety and Phase 2 Randomized Study of JCAR017 in Subjects with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004) awarded by Celgene Corporation 2019 - 2024
- A Phase 1, Open-label, study of Voruciclib in Subjects with Relapsed and/or Refractory B Cell Malignancies after failure of prior standard therapies awarded by MEI Pharma, Inc. 2018 - 2023
- BGB-3111-304 An International, Phase 3, Open-label, Randomized Study of BGB-3111 Compared with Bendamustine plus Rituximab in Patients with Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma awarded by BeiGene, Ltd 2018 - 2023
- Phase 1a/1b Study of a Novel BTK Inhibitor, DTRMWXHS-12, and Combination Products, CTRM-505 and DTRM-555, in Patients with Chronic Lymphocytic Leukemia or Other B-Cell Lymphomas awarded by Zhejiang DTRM Biopharma Co.Ltd. 2018 - 2023
- An Open Label Compassionate Use Trial of Ublituximab and TGR-1202 in Combination or as Single Agents in Subjects Currently receiving Treatment on Ublituximab and/or TGR-1202 Trials with B-cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia. awarded by TG Therapeutics, Inc 2018 - 2023
- DFCI Obinutuzumab and Ibrutinib Protocol # 15-283 awarded by Dana-Farber Cancer Institute 2017 - 2022
- A Phase II Study of Ibrutinib in Combination with Fludarabine, Cyclophosphamide and Rituximab (iFCR) in Previously Untreated, Younger Patients with Chronic Lymphocytic Leukemia. awarded by Dana-Farber Cancer Institute 2015 - 2022
- A Phase 2 Study to Assess the Safety and Efficacy of TGR-1202 in Patients with Chronic Lymphocytic Leukemia (CLL) who are Intolerant to Prior BTK or P13K-Delta Inhibitor Therapy awarded by TG Therapeutics, Inc 2016 - 2022
- A Multi¿Center, Open¿Label, Study to Evaluate the Safety and Efficacy of Ublituximab (TG-1101) in Combination with TGR-1202 for Patients Previously Enrolled in Protocol UTX-TGR-304 awarded by TG Therapeutics, Inc 2016 - 2022
- A Phase 3, Randomized Study to Assess the Efficacy and Safety of Ublituximab in Combination with TGR-1202 Compared to Obinutuzumab in Combination with Chlorambucil in Patients with Chronic Lymphocytic Leukemia (CLL) awarded by TG Therapeutics, Inc 2016 - 2022
- Phase III study of ACP-196 vs Ibrutinib in High Risk CLL awarded by Acerta Pharma 2016 - 2022
- Phase 3 Study of Ublituximab in combination with Ibrutinib compared to Ibrutinib Alone in CLL pts. awarded by TG Therapeutics, Inc 2015 - 2022
- Exercise training to promote improved immune resilience in adults with chronic lymphocytic leukemia - a randomized control trial awarded by American Society of Hematology 2020 - 2021
- The Role of Surface Immunoglobulin Isotype in Chronic Lymphocytic Leukemia Disease Biology and Clinical Outcomes in the Era of the Novel Agents awarded by American Society of Hematology 2020 - 2021
- A Phase 1 study of ublituximab and umbralisib in combination with targeted immunotherapy in patients with relapsed-refractory CLL or Richter's transformation of CLL awarded by TG Therapeutics, Inc 2020 - 2021
- Novartis: CVAY736Y2102 Ph1b VAY736 and Ibrutinib patients with CLL on Ibrutinib therapy awarded by Novartis Pharmaceuticals Corporation 2020 - 2021
- TP-0903-102 A Combined Phase 1/2 Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of TP-0903 in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL) awarded by Tolero Pharmaceuticals, Inc 2019 - 2020
- A Phase 2, Single Arm Study Evaluating the Efficacy and Safety of Idelalisib in Combination with Rituximab in Patients with Previously Untreated Chronie Lymphocytic Leukemia with 17p Deletion awarded by Gilead Sciences, Inc. 2014 - 2019
- Screening protocol to determine high risk cytogenetic features in previously treated CLL awarded by TG Therapeutics, Inc 2016 - 2017
- A Phase II Study of PNT2258 in Patients with Richter's Transformation (RT). awarded by ProNAi Therapeutics, Inc. 2016 - 2017
- MedImmune CD-ON-CAT-8015-1053 awarded by MedImmune, Inc. 2015 - 2017
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Idelalisib in Combination with Bendamustine and Rituximab for Previously Untreated Chronic Lymphocytic Leukemia GS-US-312-0123 awarded by Gilead Sciences, Inc. 2014 - 2017
- A Phase I Trial of a Bcl-2 inhibitor and a MEK inhibitor for patients with relapsed indolent B-NHL awarded by Lymphoma Research Foundation of America 2014 - 2016
- A Phase 2, Open-Label Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacodynamics of GS-9973 in Combination with Idelalisib in Subjects with Relapsed or Refractory Hematologic Malignancies awarded by Gilead Sciences, Inc. 2013 - 2015
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External Relationships
- AbbVie Pharmaceuticals
- Alliance for Clinical Trials in Oncology
- ArQule
- AstraZeneca
- BeiGene
- CLL Society
- Clinical Care Options
- DTRM Biopharma
- Genentech, Inc (Roche Holding)
- Juno/celgene/BMS
- NCCN
- Newave Pharma
- Pharmacyclics
- TG Therapeutics
- WebMD/Medscape
- catapult
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Huntington, Scott F., Stephen J. Schuster, Wei Ding, Amber B. Koehler, Danielle M. Brander, Allison C. Rosenthal, Jose F. Leis, et al. “DTRMWXHS-12, a novel Bruton tyrosine kinase inhibitor, in combination with everolimus and pomalidomide in patients with relapsed/refractory lymphomas: An open-label, multicenter, phase 1a/1b study.” Am J Hematol 98, no. 5 (May 2023): 739–49. https://doi.org/10.1002/ajh.26888.Full Text Link to Item
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Ryan, Christine E., Danielle M. Brander, Paul M. Barr, Svitlana Tyekucheva, Liam R. Hackett, Mary C. Collins, Stacey M. Fernandes, et al. “A phase 1b study of ibrutinib in combination with obinutuzumab in patients with relapsed or refractory chronic lymphocytic leukemia.” Leukemia 37, no. 4 (April 2023): 835–42. https://doi.org/10.1038/s41375-023-01830-2.Full Text Link to Item
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Shadman, Mazyar, Beenish S. Manzoor, Kavita Sail, Hande H. Tuncer, John N. Allan, Chaitra Ujjani, Nnadozie Emechebe, et al. “Treatment Discontinuation Patterns for Patients With Chronic Lymphocytic Leukemia in Real-World Settings: Results From a Multi-Center International Study.” Clin Lymphoma Myeloma Leuk, March 24, 2023. https://doi.org/10.1016/j.clml.2023.03.010.Full Text Link to Item
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Artese, Ashley L., Andrea Sitlinger, Grace MacDonald, Michael A. Deal, Erik D. Hanson, Carl F. Pieper, J Brice Weinberg, Danielle M. Brander, and David B. Bartlett. “Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study.” J Geriatr Oncol 14, no. 1 (January 2023): 101373. https://doi.org/10.1016/j.jgo.2022.09.002.Full Text Link to Item
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Brander, D. M. “The Use of Zanubrutinib in Chronic Lymphocytic Leukemia.” Clinical Advances in Hematology and Oncology 20, no. 12 (December 1, 2022): 1–4.
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Brander, Danielle M. “The use of zanubrutinib in chronic lymphocytic leukemia.” Clin Adv Hematol Oncol 20, no. 12 (December 2022): 705–8.Link to Item
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Barrientos, Jacqueline, Anthony Mato, Jeff Sharman, Danielle Brander, Meghan Gutierrez, Linda Wu, Sumeet Panjabi, et al. “CLL-449 Patterns of Treatment and Prognostic Testing Among Black Patients With Chronic Lymphocytic Leukemia (CLL): Results From informCLL, a Prospective, Observational Registry.” Clin Lymphoma Myeloma Leuk 22 Suppl 2 (October 2022): S279. https://doi.org/10.1016/S2152-2650(22)01347-7.Full Text Link to Item
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Hamparsumian, Anahid, Colette Whitney, Dan Blalock, Andrea Sitlinger, Mohammad Shahsahebi, Kevin Oeffinger, Leah Zullig, and Danielle Brander. “CLL-517 Hypertension as an Adverse Event of Ibrutinib: Does Age Matter?” Clin Lymphoma Myeloma Leuk 22 Suppl 2 (October 2022): S282. https://doi.org/10.1016/S2152-2650(22)01353-2.Full Text Link to Item
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Kahl, Brad S., Krzysztof Giannopoulos, Wojciech Jurczak, Martin Šimkovič, Mazyar Shadman, Anders Österborg, Luca Laurenti, et al. “CLL-137 SEQUOIA: Results of a Phase 3 Randomized Study of Zanubrutinib Versus Bendamustine + Rituximab (BR) in Patients With Treatment-Naïve (TN) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/ SLL).” Clin Lymphoma Myeloma Leuk 22 Suppl 2 (October 2022): S269–70. https://doi.org/10.1016/S2152-2650(22)01329-5.Full Text Link to Item
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Tam, Constantine S., Jennifer R. Brown, Brad S. Kahl, Paolo Ghia, Krzysztof Giannopoulos, Wojciech Jurczak, Martin Šimkovič, et al. “Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.” Lancet Oncol 23, no. 8 (August 2022): 1031–43. https://doi.org/10.1016/S1470-2045(22)00293-5.Full Text Link to Item
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Wierda, William G., Jennifer Brown, Jeremy S. Abramson, Farrukh Awan, Syed F. Bilgrami, Greg Bociek, Danielle Brander, et al. “NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022.” J Natl Compr Canc Netw 20, no. 6 (June 2022): 622–34. https://doi.org/10.6004/jnccn.2022.0031.Full Text Link to Item
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Hu, Rachel, Wei Wei, Agrima Mian, Kristen Gonter-Aubin, Charlene Kabel, Anthony Mato, Deborah M. Stephens, et al. “Treatment outcomes with purine nucleoside analog alone or with rituximab for hairy cell leukemia at first relapse.” Eur J Haematol 108, no. 5 (May 2022): 379–82. https://doi.org/10.1111/ejh.13744.Full Text Link to Item
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Mato, Anthony R., Matthew S. Davids, Jeff Sharman, Lindsey E. Roeker, Neil Kay, Arnon P. Kater, Kerry Rogers, et al. “Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: "What's Past Is Prologue" (Shakespeare).” Clin Cancer Res 28, no. 4 (February 15, 2022): 603–8. https://doi.org/10.1158/1078-0432.CCR-21-1237.Full Text Link to Item
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Kleinstern, Geffen, J Brice Weinberg, Sameer A. Parikh, Esteban Braggio, Sara J. Achenbach, Dennis P. Robinson, Aaron D. Norman, et al. “Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.” Leukemia 36, no. 1 (January 2022): 119–25. https://doi.org/10.1038/s41375-021-01344-9.Full Text Link to Item
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Sitlinger, Andrea, Michael A. Deal, Erwin Garcia, Margery Connelly, Dana Thompson, Tiffany Stewart, Grace Macdonald, et al. “Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia.” Front Oncol 12 (2022): 933619. https://doi.org/10.3389/fonc.2022.933619.Full Text Link to Item
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Davids, Matthew S., Owen A. O’Connor, Wojciech Jurczak, Felipe Samaniego, Timothy S. Fenske, Pier Luigi Zinzani, Manish R. Patel, et al. “Integrated safety analysis of umbralisib, a dual PI3Kδ/CK1ε inhibitor, in relapsed/refractory lymphoid malignancies.” Blood Adv 5, no. 23 (December 14, 2021): 5332–43. https://doi.org/10.1182/bloodadvances.2021005132.Full Text Link to Item
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MacDonald, Grace, Andrea Sitlinger, Michael A. Deal, Erik D. Hanson, Stephanie Ferraro, Carl F. Pieper, J Brice Weinberg, Danielle M. Brander, and David B. Bartlett. “A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia.” Sci Rep 11, no. 1 (November 30, 2021): 23137. https://doi.org/10.1038/s41598-021-02352-6.Full Text Link to Item
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Stephens, Deborah M., Ken Boucher, Elizabeth Kander, Sameer A. Parikh, Erin M. Parry, Mazyar Shadman, John M. Pagel, et al. “Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration.” Haematologica 106, no. 11 (November 1, 2021): 2845–52. https://doi.org/10.3324/haematol.2020.256388.Full Text Link to Item
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Ruppert, Amy S., Allison M. Booth, Wei Ding, Nancy L. Bartlett, Danielle M. Brander, Steven Coutre, Jennifer R. Brown, et al. “Adverse event burden in older patients with CLL receiving bendamustine plus rituximab or ibrutinib regimens: Alliance A041202.” Leukemia 35, no. 10 (October 2021): 2854–61. https://doi.org/10.1038/s41375-021-01342-x.Full Text Link to Item
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Gordon, Max J., Andy Kaempf, Andrea Sitlinger, Geoffrey Shouse, Matthew Mei, Danielle M. Brander, Tareq Salous, et al. “The Chronic Lymphocytic Leukemia Comorbidity Index (CLL-CI): A Three-Factor Comorbidity Model.” Clin Cancer Res 27, no. 17 (September 1, 2021): 4814–24. https://doi.org/10.1158/1078-0432.CCR-20-3993.Full Text Link to Item
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Ma, Shuo, John F. Seymour, Danielle M. Brander, Thomas J. Kipps, Michael Y. Choi, Mary Ann Anderson, Kathryn Humphrey, et al. “Efficacy of venetoclax plus rituximab for relapsed CLL: 5-year follow-up of continuous or limited- duration therapy.” Blood 138, no. 10 (September 2021): 836–46. https://doi.org/10.1182/blood.2020009578.Full Text
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Mato, Anthony R., Nilanjan Ghosh, Stephen J. Schuster, Nicole Lamanna, John M. Pagel, Ian W. Flinn, Jacqueline C. Barrientos, et al. “Phase 2 study of the safety and efficacy of umbralisib in patients with CLL who are intolerant to BTK or PI3Kδ inhibitor therapy.” Blood 137, no. 20 (May 20, 2021): 2817–26. https://doi.org/10.1182/blood.2020007376.Full Text Link to Item
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Sitlinger, Andrea, Michael A. Deal, Erwin Garcia, Dana K. Thompson, Tiffany Stewart, Grace A. MacDonald, Nicolas Devos, et al. “Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL).” Cells 10, no. 5 (May 11, 2021). https://doi.org/10.3390/cells10051165.Full Text Link to Item
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Slager, Susan L., Mark C. Lanasa, Gerald E. Marti, Sara J. Achenbach, Nicola J. Camp, Fatima Abbasi, Neil E. Kay, et al. “Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families.” Blood 137, no. 15 (April 15, 2021): 2046–56. https://doi.org/10.1182/blood.2020006322.Full Text Link to Item
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Sharman, Jeff P., Danielle M. Brander, Anthony R. Mato, Nilanjan Ghosh, Stephen J. Schuster, Suman Kambhampati, John M. Burke, et al. “Ublituximab plus ibrutinib versus ibrutinib alone for patients with relapsed or refractory high-risk chronic lymphocytic leukaemia (GENUINE): a phase 3, multicentre, open-label, randomised trial.” Lancet Haematol 8, no. 4 (April 2021): e254–66. https://doi.org/10.1016/S2352-3026(20)30433-6.Full Text Link to Item
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Eyre, Toby A., Nicole Lamanna, Lindsey E. Roeker, Chaitra S. Ujjani, Brian T. Hill, Paul M. Barr, Erick Lansigan, et al. “Comparative analysis of targeted novel therapies in relapsed, refractory chronic lymphocytic leukaemia.” Haematologica 106, no. 1 (January 1, 2021): 284–87. https://doi.org/10.3324/haematol.2019.241539.Full Text Link to Item
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Hanlon, Ashley, and Danielle M. Brander. “Managing toxicities of phosphatidylinositol-3-kinase (PI3K) inhibitors.” Hematology Am Soc Hematol Educ Program 2020, no. 1 (December 4, 2020): 346–56. https://doi.org/10.1182/hematology.2020000119.Full Text Link to Item
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Cuneo, Antonio, Anthony R. Mato, Gian Matteo Rigolin, Alfonso Piciocchi, Massimo Gentile, Luca Laurenti, John N. Allan, et al. “Efficacy of bendamustine and rituximab in unfit patients with previously untreated chronic lymphocytic leukemia. Indirect comparison with ibrutinib in a real-world setting. A GIMEMA-ERIC and US study.” Cancer Med 9, no. 22 (November 2020): 8468–79. https://doi.org/10.1002/cam4.3470.Full Text Link to Item
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Mato, Anthony R., Lindsey E. Roeker, Nicole Lamanna, John N. Allan, Lori Leslie, John M. Pagel, Krish Patel, et al. “Outcomes of COVID-19 in patients with CLL: a multicenter international experience.” Blood 136, no. 10 (September 3, 2020): 1134–43. https://doi.org/10.1182/blood.2020006965.Full Text Link to Item
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Roeker, Lindsey E., Peter Dreger, Jennifer R. Brown, Oscar B. Lahoud, Toby A. Eyre, Danielle M. Brander, Alan Skarbnik, et al. “Allogeneic stem cell transplantation for chronic lymphocytic leukemia in the era of novel agents.” Blood Adv 4, no. 16 (August 25, 2020): 3977–89. https://doi.org/10.1182/bloodadvances.2020001956.Full Text Link to Item
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Mato, Anthony R., Lindsey E. Roeker, Ryan Jacobs, Brian T. Hill, Nicole Lamanna, Danielle Brander, Mazyar Shadman, et al. “Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK Inhibition as an Effective Strategy.” Clin Cancer Res 26, no. 14 (July 15, 2020): 3589–96. https://doi.org/10.1158/1078-0432.CCR-19-3815.Full Text Link to Item
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Sung, Anthony D., Shekeab Jauhari, Sharareh Siamakpour-Reihani, Arati V. Rao, Janet Staats, Cliburn Chan, Everett Meyer, et al. “Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.” Am J Hematol 95, no. 6 (June 2020): 662–71. https://doi.org/10.1002/ajh.25781.Full Text Link to Item
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Sitlinger, Andrea, Danielle M. Brander, and David B. Bartlett. “Impact of exercise on the immune system and outcomes in hematologic malignancies.” Blood Adv 4, no. 8 (April 28, 2020): 1801–11. https://doi.org/10.1182/bloodadvances.2019001317.Full Text Link to Item
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Eichenberger, Emily M., Jennifer Saullo, Danielle Brander, Shih-Hsiu Wang, John R. Perfect, and Julia A. Messina. “A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.” Med Mycol Case Rep 27 (March 2020): 17–21. https://doi.org/10.1016/j.mmcr.2019.12.007.Full Text Link to Item
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Eyre, Toby A., Lindsey E. Roeker, Christopher P. Fox, Satyen H. Gohill, Renata Walewska, Harriet S. Walter, Francesco Forconi, et al. “The efficacy and safety of venetoclax therapy in elderly patients with relapsed, refractory chronic lymphocytic leukaemia.” Br J Haematol 188, no. 6 (March 2020): 918–23. https://doi.org/10.1111/bjh.16271.Full Text Link to Item
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Mato, Anthony R., Jacqueline C. Barrientos, Nilanjan Ghosh, John M. Pagel, Danielle M. Brander, Meghan Gutierrez, Karen Kadish, et al. “Prognostic Testing and Treatment Patterns in Chronic Lymphocytic Leukemia in the Era of Novel Targeted Therapies: Results From the informCLL Registry.” Clin Lymphoma Myeloma Leuk 20, no. 3 (March 2020): 174-183.e3. https://doi.org/10.1016/j.clml.2019.10.009.Full Text Link to Item
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Gordon, Max J., Andrea Sitlinger, Tareq Salous, Hamood Alqahtani, Michael Churnetski, Xavier Rivera, Paul Wisniewski, et al. “A simplified prognostic index for chronic lymphocytic leukemia treated with ibrutinib: Results from a multicenter retrospective cohort study.” Leuk Res 89 (February 2020): 106302. https://doi.org/10.1016/j.leukres.2020.106302.Full Text Link to Item
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Wierda, William G., John C. Byrd, Jeremy S. Abramson, Syed F. Bilgrami, Greg Bociek, Danielle Brander, Jennifer Brown, et al. “Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 2 (February 2020): 185–217. https://doi.org/10.6004/jnccn.2020.0006.Full Text Link to Item
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Davids, Matthew S., Danielle M. Brander, Haesook T. Kim, Svitlana Tyekucheva, Jad Bsat, Alexandra Savell, Jeffrey M. Hellman, et al. “Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial.” Lancet Haematol 6, no. 8 (August 2019): e419–28. https://doi.org/10.1016/S2352-3026(19)30104-8.Full Text Link to Item
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Weinberg, J Brice, Danielle M. Brander, Dale J. Christensen, and Daphne R. Friedman. “Post-translational regulation could be determine functional differences between SET alpha and beta isoform - Response to Cristóbal et al.” Br J Haematol 186, no. 4 (August 2019): 637. https://doi.org/10.1111/bjh.15934.Full Text Link to Item
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Roeker, Lindsey E., Christopher P. Fox, Toby A. Eyre, Danielle M. Brander, John N. Allan, Stephen J. Schuster, Chadi Nabhan, et al. “Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice.” Clin Cancer Res 25, no. 14 (July 15, 2019): 4264–70. https://doi.org/10.1158/1078-0432.CCR-19-0361.Full Text Link to Item
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Mato, Anthony R., Lindsey E. Roeker, Toby A. Eyre, Chadi Nabhan, Nicole Lamanna, Brian T. Hill, Danielle M. Brander, et al. “A retrospective comparison of venetoclax alone or in combination with an anti-CD20 monoclonal antibody in R/R CLL.” Blood Adv 3, no. 10 (May 28, 2019): 1568–73. https://doi.org/10.1182/bloodadvances.2019000180.Full Text Link to Item
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Brander, Danielle M., Daphne R. Friedman, Alicia D. Volkheimer, Dale J. Christensen, Laura Z. Rassenti, Thomas J. Kipps, Eross Guadalupe, et al. “SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia.” Br J Haematol 184, no. 4 (February 2019): 605–15. https://doi.org/10.1111/bjh.15677.Full Text Link to Item
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Wierda, William G., John C. Byrd, Jeremy S. Abramson, Syed F. Bilgrami, Greg Bociek, Danielle Brander, Jennifer Brown, et al. “NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019.” J Natl Compr Canc Netw 17, no. 1 (January 2019): 12–20. https://doi.org/10.6004/jnccn.2019.0002.Full Text Link to Item
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Woyach, Jennifer A., Amy S. Ruppert, Nyla A. Heerema, Weiqiang Zhao, Allison M. Booth, Wei Ding, Nancy L. Bartlett, et al. “Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL.” N Engl J Med 379, no. 26 (December 27, 2018): 2517–28. https://doi.org/10.1056/NEJMoa1812836.Full Text Link to Item
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Mato, Anthony R., Lindsey E. Roeker, John N. Allan, John M. Pagel, Danielle M. Brander, Brian T. Hill, Bruce D. Cheson, et al. “Outcomes of front-line ibrutinib treated CLL patients excluded from landmark clinical trial.” Am J Hematol 93, no. 11 (November 2018): 1394–1401. https://doi.org/10.1002/ajh.25261.Full Text Link to Item
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Mato, Anthony R., Meghan Thompson, John N. Allan, Danielle M. Brander, John M. Pagel, Chaitra S. Ujjani, Brian T. Hill, et al. “Real-world outcomes and management strategies for venetoclax-treated chronic lymphocytic leukemia patients in the United States.” Haematologica 103, no. 9 (September 2018): 1511–17. https://doi.org/10.3324/haematol.2018.193615.Full Text Link to Item
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Mato, Anthony R., Jennifer C. Samp, Geneviève Gauthier, Emi Terasawa, and Danielle M. Brander. “Drivers of treatment patterns in patients with chronic lymphocytic leukemia stopping ibrutinib or idelalisib therapies.” Cancer Biol Ther 19, no. 7 (July 3, 2018): 636–43. https://doi.org/10.1080/15384047.2018.1449616.Full Text Link to Item
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Mato, Anthony R., Chadhi Nabhan, Meghan C. Thompson, Nicole Lamanna, Danielle M. Brander, Brian Hill, Christina Howlett, et al. “Toxicities and outcomes of 616 ibrutinib-treated patients in the United States: a real-world analysis.” Haematologica 103, no. 5 (May 2018): 874–79. https://doi.org/10.3324/haematol.2017.182907.Full Text Link to Item
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Burris, Howard A., Ian W. Flinn, Manish R. Patel, Timothy S. Fenske, Changchun Deng, Danielle M. Brander, Martin Gutierrez, et al. “Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.” Lancet Oncol 19, no. 4 (April 2018): 486–96. https://doi.org/10.1016/S1470-2045(18)30082-2.Full Text Link to Item
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Thompson, Meghan, Danielle Brander, Chadi Nabhan, and Anthony Mato. “Minimal Residual Disease in Chronic Lymphocytic Leukemia in the Era of Novel Agents: A Review.” Jama Oncol 4, no. 3 (March 1, 2018): 394–400. https://doi.org/10.1001/jamaoncol.2017.2009.Full Text Link to Item
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Wierda, William G., John C. Byrd, Jeremy S. Abramson, Seema Bhat, Greg Bociek, Danielle Brander, Jennifer Brown, et al. “Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 15, no. 11 (November 2017): 1414–27. https://doi.org/10.6004/jnccn.2017.0165.Full Text Link to Item
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Mato, A. R., B. T. Hill, N. Lamanna, P. M. Barr, C. S. Ujjani, D. M. Brander, C. Howlett, et al. “Optimal sequencing of ibrutinib, idelalisib, and venetoclax in chronic lymphocytic leukemia: results from a multicenter study of 683 patients.” Ann Oncol 28, no. 5 (May 1, 2017): 1050–56. https://doi.org/10.1093/annonc/mdx031.Full Text Link to Item
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Brander, Danielle M. “Rationale for combinatory chronic lymphocytic leukaemia treatment paradigms in the era of the B-cell receptor pathway and anti-apoptotic inhibitors: how do we mix, match, and move forward?” Br J Haematol 176, no. 3 (February 2017): 337–40. https://doi.org/10.1111/bjh.14446.Full Text Link to Item
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Seymour, John F., Shuo Ma, Danielle M. Brander, Michael Y. Choi, Jacqueline Barrientos, Matthew S. Davids, Mary Ann Anderson, et al. “Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study.” Lancet Oncol 18, no. 2 (February 2017): 230–40. https://doi.org/10.1016/S1470-2045(17)30012-8.Full Text Link to Item
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Strati, Paolo, Mark Lanasa, Timothy G. Call, Jose F. Leis, Danielle M. Brander, Betsy R. LaPlant, Adam M. Pettinger, et al. “Ofatumumab monotherapy as a consolidation strategy in patients with previously untreated chronic lymphocytic leukaemia: a phase 2 trial.” Lancet Haematol 3, no. 9 (September 2016): e407–14. https://doi.org/10.1016/S2352-3026(16)30064-3.Full Text Link to Item
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Friedman, Daphne R., Mark C. Lanasa, Patricia H. Davis, Sallie D. Allgood, Karen M. Matta, Danielle M. Brander, Youwei Chen, et al. “Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies.” Leuk Lymphoma 55, no. 5 (May 2014): 1067–75. https://doi.org/10.3109/10428194.2013.824080.Full Text Link to Item
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Brander, Danielle, David Rizzieri, Jon Gockerman, Louis Diehl, Thomas Charles Shea, Carlos Decastro, Joseph O. Moore, and Anne Beaven. “Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma.” Leuk Lymphoma 54, no. 12 (December 2013): 2627–30. https://doi.org/10.3109/10428194.2013.784969.Full Text Link to Item
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Brander, Danielle M., and Anne W. Beaven. “Update on treatment of follicular non-Hodgkin's lymphoma: focus on potential of bortezomib.” Patient Prefer Adherence 6 (2012): 239–51. https://doi.org/10.2147/PPA.S23241.Full Text Link to Item
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Bean, Gregory R., Andrew D. Bryson, Patrick G. Pilie, Vanessa Goldenberg, Joseph C. Baker, Catherine Ibarra, Danielle M. U. Brander, et al. “Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.” Clin Cancer Res 13, no. 22 Pt 1 (November 15, 2007): 6834–41. https://doi.org/10.1158/1078-0432.CCR-07-0407.Full Text Link to Item
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