Scholars@Duke
David Thomas

David Thomas

Adjunct Professor in the Department of Pathology
Pathology

Selected Publications

Assessment of a computerized quantitative quality control tool for whole slide images of kidney biopsies.

Journal Article J Pathol · March 2021 Inconsistencies in the preparation of histology slides and whole-slide images (WSIs) may lead to challenges with subsequent image analysis and machine learning approaches for interrogating the WSI. These variabilities are especially pronounced in multicent ... Full text Link to item Cite

Lactobacillus acidophilus Endocarditis Complicated by Pauci-Immune Necrotizing Glomerulonephritis

Journal Article Case Reports in Medicine · August 12, 2020 Infective endocarditis (IE) is more common in patients with predisposing cardiac lesions and has many potential complications, including stroke and arterial thromboembolisms. Renal manifestations have an estimated prevalence of ∼20%. Rapidly progre ... Full text Open Access Cite

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy.

Journal Article PLoS One · 2019 African polymorphisms in the gene for Apolipoprotein L1 (APOL1) confer a survival advantage against lethal trypanosomiasis but also an increased risk for several chronic kidney diseases (CKD) including HIV-associated nephropathy (HIVAN). APOL1 is expressed ... Full text Open Access Link to item Cite

Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome

Journal Article American Journal of Physiology-Renal Physiology · April 1, 2018 The p38 MAPK pathway plays a crucial role in various glomerulopathies, with activation being associated with disease and inhibition being associated with disease amelioration. We hypothesized that the downstream targets of p38 MAPK, MAPK-activated ... Full text Open Access Cite

The potential role of complements in cocaine-induced thrombotic microangiopathy.

Journal Article Clin Kidney J · February 2018 Thrombotic microangiopathy (TMA) is a rare disorder characterized by microvascular injury and occlusion resulting in tissue ischemia and dysfunction. TMA occurs in a variety of settings including cocaine use. Although cocaine is widely used in the United S ... Full text Open Access Link to item Cite

Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor

Journal Article Journal for ImmunoTherapy of Cancer · December 2017 Full text Open Access Cite

APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.

Journal Article JCI insight · July 2017 APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or AP ... Full text Open Access Cite

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease.

Journal Article J Am Soc Nephrol · December 2016 APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to humans and some primates, we created transgenic (Tg) mice using the promoter of ... Full text Open Access Link to item Cite

Renal Involvement in Systemic Lupus Erythematosus and Vasculitides

Chapter · November 25, 2016 New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. ... Cite

Semaphorin3a Promotes Advanced Diabetic Nephropathy

Journal Article Diabetes · May 1, 2015 The onset of diabetic nephropathy (DN) is highlighted by glomerular filtration barrier abnormalities. Identifying pathogenic factors and targetable pathways driving DN is crucial to developing novel therapies and improving the disease outcome. Sema ... Full text Open Access Cite

Pauci-Immune and Antineutrophil Cytoplasmic Autoantibody–Mediated Crescentic Glomerulonephritis and Vasculitis

Chapter · July 11, 2014 Authored by the world’s most accomplished renal pathologists, this image-rich text conveys the intricacies and comprehensiveness of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical ... ... Cite

Diabetic nephropathy: Is it time yet for routine kidney biopsy?

Journal Article World J Diabetes · December 15, 2013 Diabetic nephropathy (DN) is one of the most important long-term complications of diabetes. Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality, cardiovascular mortality, and kidney failure. The clinical diagnosi ... Full text Open Access Link to item Cite

Catastrophic antiphospholipid syndrome with concurrent thrombotic and hemorrhagic manifestations.

Journal Article Lupus · July 2013 Antiphospholipid syndrome (APS) is a distinct autoimmune prothrombotic disorder due to pathogenic autoantibodies directed against proteins that bind to phospholipids. APS is characterized by arterial and venous thrombosis and their clinical sequelae. Catas ... Full text Open Access Link to item Cite

Association of Histologic Variants in FSGS Clinical Trial with Presenting Features and Outcomes

Journal Article Clinical Journal of the American Society of Nephrology · March 2013 SummaryBackground and objectivesFSGS histologic variants have correlated with outcomes in retrospective studies. The FSGS Clinical Trial provided a uni ... Full text Open Access Cite

Neutrophil gelatinase–associated lipocalin is instrumental in the pathogenesis of antibody‐mediated nephritis in mice

Journal Article Arthritis & Rheumatism · May 2012 AbstractObjectiveThe mechanism by which anti‐DNA antibodies mediate lupus nephritis has yet to be conclusively determined. Previously, we found that treatment of mesangial cells with anti‐ ... Full text Cite

Membranous nephropathy following intravitreal injection of bevacizumab

Journal Article Canadian Journal of Ophthalmology · February 2012 Full text Cite

Immune reconstitution renal-limited sarcoidosis presenting as acute kidney injury

Journal Article International Journal of STD & AIDS · January 2012 An HIV-infected asymptomatic woman developed acute kidney injury six weeks after initiation of combination antiretroviral therapy (cART). A renal biopsy revealed both renal-limited sarcoidosis and HIV nephropathy. The acute renal injury reversed w ... Full text Cite

Transcriptome Analysis of Human Diabetic Kidney Disease

Journal Article Diabetes · September 1, 2011 OBJECTIVEDiabetic kidney disease (DKD) is the single leading cause of kidney failure in the U.S., for which a cure has not yet been found. The aim of our study was to provide ... Full text Cite

Hypertension, Chronic Kidney Disease, and Renal Pathology in a Child with Hermansky-Pudlak Syndrome

Journal Article International Journal of Nephrology · 2011 We report a child with Hermansky-Pudlak Syndrome (HPS) and chronic kidney disease (stage II) with histological diagnosis of focal segmental glomerulosclerosis (FSGS). A 15-year-old male of Puerto Rico ancestry with history of HPS, hypertension (HTN ... Full text Cite