David Asher Leiman
Assistant Professor of Medicine
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2021
- Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Contact Information
- Background
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Education, Training, & Certifications
- Fellowship in Gastroenterology and Hepatology, Medicine, University of Pennsylvania, School of Medicine 2012 - 2015
- Internal Medicine Residency, Medicine, University of Pennsylvania, School of Medicine 2009 - 2012
- M.D., Vanderbilt University, School of Medicine 2009
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Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2015 - 2020
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Leadership & Clinical Positions at Duke
- Director, Esophageal Research and Quality
- Recognition
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In the News
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OCT 13, 2022 GI Insights - ReachMD -
JUN 1, 2022 Duke Health News
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Awards & Honors
- Research
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Selected Grants
- A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Patients with Moderately to Severely Active Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis Who Have an Inadequate R awarded by Allakos Inc. 2020 - 2025
- A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Patients with Active Eosinophilic Esophagitis awarded by Allakos Inc. 2020 - 2025
- A PHASE 2A, DOUBLE-BLIND, PLACEBOCONTROLLED, MULTI-CENTER STUDY TO ASSESS THE EFFICACY, SAFETY, AND TOLERABILITY OF IRL201104 IN ADULT PARTICIPANTS WITH ACTIVE EOSINOPHILIC ESOPHAGITIS (EOE) awarded by Revolo Biotherapeutics 2022 - 2025
- A PHASE 3, MULTI-CENTER, MULTI-NATIONAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INDUCTION AND MAINTENANCE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CC-93538 IN ADULT AND ADOLESCENT SUBJECTS WITH EOSINOPHILIC ESOPHAGITIS awarded by Celgene Corporation 2021 - 2024
- A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Etrasimod in Adult Subjects with Eosinophilic Esophagitis awarded by Arena Pharmaceuticals, Inc. 2021 - 2024
- A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Studyto Evaluate the Efficacy and Safety of AK002 in Patients with Moderately to Severely Active Eosinophilic Duodenitis who have an Inadequate Response with, Lost Response to, or awarded by Allakos Inc. 2021 - 2024
- Gastroenterology Artificial INtelligence System for Detecting Colorectal Polyps (The GAIN Study) awarded by Verily Life Sciences, LLC 2022 - 2024
- A Phase 3, Multicenter, Open-Label, Extension Study to Evaluate the Efficacy and Safety of AK002 in Patients That Were Previously Enrolled in AK002-016 or AK002-012 Studies and have Eosinophilic Gastritis and/or Eosinophilic Duodenitis awarded by Allakos Inc. 2021 - 2024
- A Phase 3 Randomized Multicenter Study to Evaluate the Efficacy and Safety of Open-Label Dual Therapy with Oral Vonoprazan 20 mg or Double-Blind Triple Therapy with Oral Vonoprazan 20 mg Compared to Double-Blind Triple Therapy with Oral Lansoprazole awarded by Phathom Pharmaceuticals, Inc. 2020 - 2023
- A Phase 3, Randomized, Double-Blind, Two-Phase, Multicenter Study toEvaluate the Efficacy and Safety of Vonoprazan 20 mg Compared to Lansoprazole 30 mg for Healing in Patients with Erosive Esophagitis and to Evaluate the Efficacy and Safety of Vonop awarded by Phathom Pharmaceuticals, Inc. 2020 - 2023
- PREEMPT CRC: PREvention Employing a Multiomics Plasma-based Test for ColoRectal Cancer awarded by Freenome Holdings, Inc. 2021 - 2023
- Eosinophilic Esophagitis (EoE) awarded by Takeda Pharmaceutical Company Limited 2020 - 2022
- A Novel Radiometry-Guided Ablation Catheter to Reliably Treat Barrett's Disease awarded by Symple Surgical, Inc. 2021 - 2022
- A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients with Gastroesophageal Reflux Disease while receiving Proton Pump Inhibitors awarded by Ironwood Pharmaceuticals, Inc. 2018 - 2021
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External Relationships
- Allakos
- American Partnership for Eosinophilic Diseases (APFED)
- AstraZeneca
- Bristol Myers Squibb
- Medtronic (Covidien)
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Canick, Julia, James C. Campbell, Seth M. Cohen, Harrison N. Jones, David A. Leiman, Sudha Raman, and Kathryn N. Porter Starr. “Preoperative dysphagia risk in community-dwelling adults aged ≥50 years: Prevalence and risk factors.” Nutr Clin Pract 38, no. 1 (February 2023): 157–66. https://doi.org/10.1002/ncp.10889.Full Text Link to Item
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Leiman, David A., Afrin N. Kamal, Fouad Otaki, Albert J. Bredenoord, Evan S. Dellon, Gary W. Falk, Nielsen Q. Fernandez-Becker, et al. “Quality Indicators for the Diagnosis and Management of Eosinophilic Esophagitis.” Am J Gastroenterol, January 5, 2023. https://doi.org/10.14309/ajg.0000000000002138.Full Text Link to Item
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Yang, Nancy Y., Alice Parish, Shai Posner, Rahul A. Shimpi, Richard K. Wood, R Thomas Finn, Deborah A. Fisher, et al. “Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.” Dis Esophagus, December 27, 2022. https://doi.org/10.1093/dote/doac114.Full Text Link to Item
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Romanoff, Emily, Justin Zhuo, Annsa C. Huang, Deron Amador, Fouad Otaki, Afrin N. Kamal, Priya Kathpalia, and David A. Leiman. “Achalasia Quality Indicator Adherence.” Dig Dis Sci, December 2, 2022. https://doi.org/10.1007/s10620-022-07658-7.Full Text Link to Item
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Simmons, Jordan K., David A. Leiman, Sarita U. Patil, Edward McCoul, Philip G. Chen, Dennis M. Tang, Edward C. Kuan, Elena E. Chang, and Arthur W. Wu. “Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.” Am J Rhinol Allergy 36, no. 6 (November 2022): 804–7. https://doi.org/10.1177/19458924221116162.Full Text Link to Item
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Noujaim, Michael G., William R. Jeck, and David A. Leiman. “A Rare Cause of Confluent Abnormal Esophageal Mucosa.” Gastroenterology 163, no. 4 (October 2022): 830–31. https://doi.org/10.1053/j.gastro.2022.06.033.Full Text Link to Item
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Leiman, David A., Katelyn Madigan, Megan Carlin, Sarah Cantrell, and Deepak Palakshappa. “Food Insecurity in Digestive Diseases.” Gastroenterology 163, no. 3 (September 2022): 547-551.e13. https://doi.org/10.1053/j.gastro.2022.05.040.Full Text Link to Item
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Ketwaroo, Gyanprakash, Carolyn Newberry, Vladimir Kushnir, Sunil G. Sheth, David A. Leiman, and David A. QUALITY COMMITTEE OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION. “AGA Institute Quality Measure Development for Intragastric Balloons in the Management of Obesity.” Gastroenterology 163, no. 2 (August 2022): 350–53. https://doi.org/10.1053/j.gastro.2022.04.022.Full Text Link to Item
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Leiman, David A., Karthik Ravi, Daniel E. Freedberg, and C Prakash Gyawali. “Proton Pump Inhibitor Prescribing and Monitoring Patterns Among Gastroenterology Practitioners.” J Clin Gastroenterol 56, no. 7 (August 1, 2022): 571–75. https://doi.org/10.1097/MCG.0000000000001623.Full Text Link to Item
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Hung, Kenneth W., Jennifer K. Maratt, Won Kyoo Cho, Brijen J. Shah, Chioma I. Anjou, and David A. Leiman. “AGA Institute Quality Measure Development for the Management of Gastric Intestinal Metaplasia With Helicobacter pylori.” Gastroenterology 163, no. 1 (July 2022): 3–7. https://doi.org/10.1053/j.gastro.2022.03.023.Full Text Link to Item
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Song, Erin J., Rena Yadlapati, Joan W. Chen, Alice Parish, Matthew J. Whitson, Karthik Ravi, Amit Patel, et al. “Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation.” Dis Esophagus 35, no. 5 (May 10, 2022). https://doi.org/10.1093/dote/doab078.Full Text Link to Item
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Leiman, David A., Diana M. Cardona, Sonia S. Kupfer, Jonathan Rosenberg, Gregary T. Bocsi, Heather Hampel, and Heather American Gastroenterological Association Quality Committee and the College of American Pathologists Quality Payment Measure Committee. “American Gastroenterological Association Institute and College of American Pathologists Quality Measure Development for Detection of Mismatch Repair Deficiency and Lynch Syndrome Management.” Gastroenterology 162, no. 2 (February 2022): 360–65. https://doi.org/10.1053/j.gastro.2021.09.071.Full Text Link to Item
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Leiman, D. A. “Preface: Quality in Endoscopy Part I.” Techniques and Innovations in Gastrointestinal Endoscopy 24, no. 3 (January 1, 2022): 225. https://doi.org/10.1016/j.tige.2022.04.002.Full Text
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Leiman, D. A. “Preface: Quality in Endoscopy Part II.” Techniques and Innovations in Gastrointestinal Endoscopy 24, no. 4 (January 1, 2022): 315. https://doi.org/10.1016/j.tige.2022.07.003.Full Text
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Dorsey, Y Claire, Erin J. Song, and David A. Leiman. “Beyond the Eckardt Score: Patient-Reported Outcomes Measures in Esophageal Disorders.” Curr Gastroenterol Rep 23, no. 12 (December 1, 2021): 29. https://doi.org/10.1007/s11894-021-00831-4.Full Text Link to Item
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Reddy, Alexander T., Rahul A. Shimpi, Alice Parish, Donna Niedzwiecki, and David A. Leiman. “Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction.” Dig Dis Sci 66, no. 11 (November 2021): 3968–75. https://doi.org/10.1007/s10620-020-06726-0.Full Text Link to Item
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Kamal, Afrin N., Priya Kathpalia, Fouad Otaki, Albert J. Bredenoord, Donald O. Castell, John O. Clarke, Gary W. Falk, et al. “Development of quality indicators for the diagnosis and management of achalasia.” Neurogastroenterol Motil 33, no. 10 (October 2021): e14118. https://doi.org/10.1111/nmo.14118.Full Text Link to Item
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Leiman, David A., Nancy Y. Yang, and Deborah A. Fisher. “Esophageal and Gastric Motility Changes Following Lung Transplantation.” J Clin Gastroenterol 55, no. 8 (September 1, 2021): 730–31. https://doi.org/10.1097/MCG.0000000000001499.Full Text Link to Item
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Jawitz, Nicole G., Ziad F. Gellad, Li Lin, Richard K. Wood, and David A. Leiman. “Patient, Physician, and Procedure Characteristics Are Independently Predictive of Polyp Detection Rates in Clinical Practice.” Dig Dis Sci 66, no. 8 (August 2021): 2570–77. https://doi.org/10.1007/s10620-020-06592-w.Full Text Link to Item
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Leiman, David A., Michael L. Weinstein, and Megan A. Adams. “An Impetus for Change: How COVID-19 Will Transform the Delivery of GI Health Care.” Clin Gastroenterol Hepatol 19, no. 7 (July 2021): 1310–13. https://doi.org/10.1016/j.cgh.2021.03.042.Full Text Link to Item
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Madigan, Katelyn E., David A. Leiman, and Deepak Palakshappa. “Food Insecurity Is an Independent Risk Factor for Depressive Symptoms in Survivors of Digestive Cancers.” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 30, no. 6 (June 2021): 1122–28. https://doi.org/10.1158/1055-9965.epi-20-1683.Full Text
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Leiman, David A., Jennifer K. Maratt, Gyanprakash A. Ketwaroo, and Gyanprakash A. Quality Committee of the American Gastroenterological Association. “AGA Institute Quality Measure Development for the Diagnosis and Management of COVID-19.” Gastroenterology 160, no. 4 (March 2021): 985–92. https://doi.org/10.1053/j.gastro.2020.11.039.Full Text Link to Item
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Posner, Shai, Kurren Mehta, Alice Parish, Donna Niedzwiecki, Rajan T. Gupta, Deborah A. Fisher, and David A. Leiman. “Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.” Dysphagia 35, no. 5 (October 2020): 864–70. https://doi.org/10.1007/s00455-020-10113-2.Full Text Link to Item
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Posner, Shai, Kurren Mehta, Alice Parish, Donna Niedzwiecki, Rajan T. Gupta, Deborah A. Fisher, and David A. Leiman. “Correction to: Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.” Dysphagia 35, no. 5 (October 2020): 871. https://doi.org/10.1007/s00455-020-10122-1.Full Text Link to Item
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Leiman, David A., Nicole G. Jawitz, Li Lin, Richard K. Wood, and Ziad F. Gellad. “Terminal ileum intubation is not associated with colonoscopy quality measures.” J Gastroenterol Hepatol 35, no. 9 (September 2020): 1503–8. https://doi.org/10.1111/jgh.14997.Full Text Open Access Copy Link to Item
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Leiman, David A. “Increasing Testing for Helicobacter pylori Infection to Improve Quality of Patient Care.” Clin Gastroenterol Hepatol 18, no. 5 (May 2020): 1028–29. https://doi.org/10.1016/j.cgh.2019.09.045.Full Text Link to Item
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Sullivan, Brian, Cecelia Zhang, Kara Wegermann, Tzu-Hao Lee, and David A. Leiman. “Standardizing inpatient colonoscopy preparations improves quality and provider satisfaction.” Int J Health Care Qual Assur ahead-of-print, no. ahead-of-print (March 9, 2020). https://doi.org/10.1108/IJHCQA-11-2019-0186.Full Text Open Access Copy Link to Item
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Mosko, Jeffrey D., David A. Leiman, Gyanprakash A. Ketwaroo, Neil Gupta, and Neil Quality Measures Committee of the American Gastroenterological Association. “Development of Quality Measures for Acute Pancreatitis: A Model for Hospital-Based Measures in Gastroenterology.” Clin Gastroenterol Hepatol 18, no. 2 (February 2020): 272-275.e5. https://doi.org/10.1016/j.cgh.2019.11.033.Full Text Link to Item
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Cohen, Seth M., Hui-Jie Lee, David A. Leiman, Nelson Roy, and Stephanie Misono. “Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population.” Otolaryngol Head Neck Surg 161, no. 3 (September 2019): 546–47. https://doi.org/10.1177/0194599819857603.Full Text Link to Item
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Sengupta, Neil, and David A. Leiman. “Improving Acute GI Bleeding Management Through Artificial Intelligence: Unnatural Selection?” Dig Dis Sci 64, no. 8 (August 2019): 2061–64. https://doi.org/10.1007/s10620-019-05698-0.Full Text Link to Item
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Lloyd, Benjamin R., and David A. Leiman. “An Updated Approach to Evaluation and Treatment of Helicobacter pylori Infection.” South Med J 112, no. 7 (July 2019): 392–98. https://doi.org/10.14423/SMJ.0000000000000997.Full Text Link to Item
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Cohen, Seth M., Hui-Jie Lee, David A. Leiman, Nelson Roy, and Stephanie Misono. “Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population.” Otolaryngol Head Neck Surg 160, no. 3 (March 2019): 519–25. https://doi.org/10.1177/0194599818811292.Full Text Link to Item
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Sullivan, Brian, Jonathan Glaab, Rajan T. Gupta, Richard Wood, and David A. Leiman. “Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma.” Radiol Case Rep 13, no. 6 (December 2018): 1119–22. https://doi.org/10.1016/j.radcr.2018.08.015.Full Text Link to Item
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Leiman, D. A., B. Kochar, S. Posner, C. Fan, A. Patel, O. Shaheen, C. Y. Keller, N. T. Koutlas, S. Eluri, and E. S. Dellon. “A diagnosis of eosinophilic esophagitis is associated with increased life insurance premiums.” Dis Esophagus 31, no. 8 (August 1, 2018). https://doi.org/10.1093/dote/doy008.Full Text Link to Item
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Posner, S., J. Zheng, R. K. Wood, R. A. Shimpi, M. G. Hartwig, S. -. C. Chow, and D. A. Leiman. “Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.” Dis Esophagus 31, no. 5 (May 1, 2018). https://doi.org/10.1093/dote/dox157.Full Text Open Access Copy Link to Item
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Leiman, D. A., A. M. Mills, F. S. Shofer, A. T. Weber, E. R. Leiman, B. P. Riff, J. D. Lewis, and S. J. Mehta. “Glasgow Blatchford Score of limited benefit for low-risk urban patients: a mixed methods study.” Endoscopy International Open 5, no. 10 (October 2, 2017): E950–58. https://doi.org/10.1055/s-0043-117880.Full Text Link to Item
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Leiman, D. A., B. P. Riff, S. Morgan, D. C. Metz, G. W. Falk, B. French, C. A. Umscheid, and J. D. Lewis. “Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis.” Dis Esophagus 30, no. 5 (May 1, 2017): 1–9. https://doi.org/10.1093/dote/dow020.Full Text Link to Item
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Leiman, D. A., B. P. Riff, S. Morgan, D. C. Metz, G. W. Falk, B. French, C. A. Umscheid, and J. D. Lewis. “Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis.” Dis Esophagus 30, no. 2 (February 1, 2017): 1–8. https://doi.org/10.1111/dote.12535.Full Text Link to Item
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Leiman, David A., David C. Metz, Gregory G. Ginsberg, J. T. Howell, Shivan J. Mehta, and Nuzhat A. Ahmad. “A Novel Electronic Medical Record-Based Workflow to Measure and Report Colonoscopy Quality Measures.” Clin Gastroenterol Hepatol 14, no. 3 (March 2016): 333-337.e1. https://doi.org/10.1016/j.cgh.2015.12.001.Full Text Link to Item
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Riff, Brian P., David A. Leiman, Bonita Bennett, Douglas L. Fraker, and David C. Metz. “Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression.” Pancreas 45, no. 2 (February 2016): 193–97. https://doi.org/10.1097/MPA.0000000000000376.Full Text Link to Item
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Bewtra, Meenakshi, Angelyn O. Fairchild, Erin Gilroy, David A. Leiman, Caroline Kerner, F Reed Johnson, and James D. Lewis. “Inflammatory Bowel Disease Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse.” Am J Gastroenterol 110, no. 12 (December 2015): 1675–81. https://doi.org/10.1038/ajg.2015.321.Full Text Link to Item
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Leiman, David A., and Gary R. Lichtenstein. “Therapy of inflammatory bowel disease: what to expect in the next decade.” Curr Opin Gastroenterol 30, no. 4 (July 2014): 385–90. https://doi.org/10.1097/MOG.0000000000000077.Full Text Link to Item
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Leiman, David A., Amit Raina, and Melissa Grilliot. “An uncommon gastric finding: a budding problem.” Gastrointest Endosc 80, no. 1 (July 2014): 169–70. https://doi.org/10.1016/j.gie.2014.02.017.Full Text Link to Item
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Leiman, D., M. Barlow, K. Carpin, E. M. Piña, and D. Casso. “Medial and lateral pectoral nerve block with liposomal bupivacaine for the management of postsurgical pain after submuscular breast augmentation.” Plastic and Reconstructive Surgery Global Open 2, no. 12 (January 1, 2014). https://doi.org/10.1097/GOX.0000000000000253.Full Text
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Barry, Daniel P., Mohammad Asim, David A. Leiman, Thibaut de Sablet, Kshipra Singh, Robert A. Casero, Rupesh Chaturvedi, and Keith T. Wilson. “Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.” Plos One 6, no. 2 (February 28, 2011): e17510. https://doi.org/10.1371/journal.pone.0017510.Full Text Link to Item
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Wagnon, Julianne H., David A. Leiman, Gregory D. Ayers, and David A. Schwartz. “Survey of gastroenterologists' awareness and implementation of AGA guidelines on osteoporosis in inflammatory bowel disease patients: are the guidelines being used and what are the barriers to their use?” Inflamm Bowel Dis 15, no. 7 (July 2009): 1082–89. https://doi.org/10.1002/ibd.20857.Full Text Link to Item
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Treweek, Shaun, Alex Doney, and David Leiman. “Public attitudes to the storage of blood left over from routine general practice tests and its use in research.” J Health Serv Res Policy 14, no. 1 (January 2009): 13–19. https://doi.org/10.1258/jhsrp.2008.008016.Full Text Link to Item
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Leiman, David A., Nancy M. Lorenzi, Jeremy C. Wyatt, Alex S. F. Doney, and S Trent Rosenbloom. “US and Scottish health professionals' attitudes toward DNA biobanking.” J Am Med Inform Assoc 15, no. 3 (2008): 357–62. https://doi.org/10.1197/jamia.M2571.Full Text Link to Item
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Leiman, David A., Nancy Lorenzi, Jeremy Wyatt, Alex S. F. Doney, and Trent Rosenbloom. “US and Scottish Health Professionals attitudes toward DNA biobanking.” Amia Annu Symp Proc, October 11, 2007, 1027.Link to Item
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Book Sections
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Leiman, D. A., and D. C. Metz. “Gastroesophageal Reflux Disease.” In Clinical Gastrointestinal Endoscopy E-Book. Elsevier Health Sciences, 2018.
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Leiman, D. A., and G. W. Falk. “Endoscopic features of eosinophilic esophagitis.” In Eosinophilic Esophagitis, 165–75, 2012. https://doi.org/10.1007/978-1-60761-515-6_13.Full Text
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Conference Papers
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Garbarino, Stephanie, Megan von Isenburg, Deborah A. Fisher, and David A. Leiman. “Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review.” In J Clin Gastroenterol, 54:35–42, 2020. https://doi.org/10.1097/MCG.0000000000001156.Full Text Link to Item
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Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, Richard K. Wood, Deborah Fisher, Matthew G. Hartwig, Jacob Klapper, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.” In Dis Esophagus, 32:1–8, 2019. https://doi.org/10.1093/dote/doz039.Full Text Link to Item
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