Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship in Gastroenterology and Hepatology, Medicine, University of Pennsylvania, School of Medicine 2012 - 2015
  • Internal Medicine Residency, Medicine, University of Pennsylvania, School of Medicine 2009 - 2012
  • M.D., Vanderbilt University, School of Medicine 2009
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2015 - 2020
• Recognition
• 

  Awards & Honors

  • Future Leaders . AGA. 2019
• Research
• 

  Selected Grants

  • A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Patients with Moderately to Severely Active Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis Who Have an Inadequate R awarded by Allakos Inc. 2020 - 2025
  • A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Patients with Active Eosinophilic Esophagitis awarded by Allakos Inc. 2020 - 2025
  • A Phase 3, Multicenter, Open-Label, Extension Study to Evaluate the Efficacy and Safety of AK002 in Patients That Were Previously Enrolled in AK002-016 or AK002-012 Studies and have Eosinophilic Gastritis and/or Eosinophilic Duodenitis awarded by Allakos Inc. 2021 - 2024
  • A Phase 3 Randomized Multicenter Study to Evaluate the Efficacy and Safety of Open-Label Dual Therapy with Oral Vonoprazan 20 mg or Double-Blind Triple Therapy with Oral Vonoprazan 20 mg Compared to Double-Blind Triple Therapy with Oral Lansoprazole awarded by Phathom Pharmaceuticals, Inc. 2020 - 2023
  • A Phase 3, Randomized, Double-Blind, Two-Phase, Multicenter Study toEvaluate the Efficacy and Safety of Vonoprazan 20 mg Compared to Lansoprazole 30 mg for Healing in Patients with Erosive Esophagitis and to Evaluate the Efficacy and Safety of Vonop awarded by Phathom Pharmaceuticals, Inc. 2020 - 2023
  • Eosinophilic Esophagitis (EoE) awarded by Takeda Pharmaceutical Company Limited 2020 - 2022
  • A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients with Gastroesophageal Reflux Disease while receiving Proton Pump Inhibitors awarded by Ironwood Pharmaceuticals, Inc. 2018 - 2021
• 

  External Relationships

  • Medtronic (Covidien)
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Kamal, Afrin N., Priya Kathpalia, Fouad Otaki, Albert J. Bredenoord, Donald O. Castell, John O. Clarke, Gary W. Falk, et al. “Development of quality indicators for the diagnosis and management of achalasia.” Neurogastroenterol Motil, March 15, 2021, e14118. https://doi.org/10.1111/nmo.14118.
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    • Leiman, David A., Jennifer K. Maratt, Gyanprakash A. Ketwaroo, and Gyanprakash A. Quality Committee of the American Gastroenterological Association. “AGA Institute Quality Measure Development for the Diagnosis and Management of COVID-19.” Gastroenterology 160, no. 4 (March 2021): 985–92. https://doi.org/10.1053/j.gastro.2020.11.039.
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    • Leiman, David A., Nancy Y. Yang, and Deborah A. Fisher. “Esophageal and Gastric Motility Changes Following Lung Transplantation.” J Clin Gastroenterol, January 22, 2021. https://doi.org/10.1097/MCG.0000000000001499.
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    • Posner, Shai, Kurren Mehta, Alice Parish, Donna Niedzwiecki, Rajan T. Gupta, Deborah A. Fisher, and David A. Leiman. “Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.” Dysphagia 35, no. 5 (October 2020): 864–70. https://doi.org/10.1007/s00455-020-10113-2.
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    • Posner, Shai, Kurren Mehta, Alice Parish, Donna Niedzwiecki, Rajan T. Gupta, Deborah A. Fisher, and David A. Leiman. “Correction to: Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.” Dysphagia 35, no. 5 (October 2020): 871. https://doi.org/10.1007/s00455-020-10122-1.
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    • Jawitz, Nicole G., Ziad F. Gellad, Li Lin, Richard K. Wood, and David A. Leiman. “Patient, Physician, and Procedure Characteristics Are Independently Predictive of Polyp Detection Rates in Clinical Practice.” Dig Dis Sci, September 7, 2020. https://doi.org/10.1007/s10620-020-06592-w.
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    • Leiman, David A., Nicole G. Jawitz, Li Lin, Richard K. Wood, and Ziad F. Gellad. “Terminal ileum intubation is not associated with colonoscopy quality measures.” J Gastroenterol Hepatol 35, no. 9 (September 2020): 1503–8. https://doi.org/10.1111/jgh.14997.
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    • Leiman, David A. “Increasing Testing for Helicobacter pylori Infection to Improve Quality of Patient Care.” Clin Gastroenterol Hepatol 18, no. 5 (May 2020): 1028–29. https://doi.org/10.1016/j.cgh.2019.09.045.
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    • Sullivan, Brian, Cecelia Zhang, Kara Wegermann, Tzu-Hao Lee, and David A. Leiman. “Standardizing inpatient colonoscopy preparations improves quality and provider satisfaction.” Int J Health Care Qual Assur ahead-of-print, no. ahead-of-print (March 9, 2020). https://doi.org/10.1108/IJHCQA-11-2019-0186.
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    • Mosko, Jeffrey D., David A. Leiman, Gyanprakash A. Ketwaroo, Neil Gupta, and Neil Quality Measures Committee of the American Gastroenterological Association. “Development of Quality Measures for Acute Pancreatitis: A Model for Hospital-Based Measures in Gastroenterology.” Clin Gastroenterol Hepatol 18, no. 2 (February 2020): 272-275.e5. https://doi.org/10.1016/j.cgh.2019.11.033.
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    • Cohen, Seth M., Hui-Jie Lee, David A. Leiman, Nelson Roy, and Stephanie Misono. “Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population.” Otolaryngol Head Neck Surg 161, no. 3 (September 2019): 546–47. https://doi.org/10.1177/0194599819857603.
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    • Sengupta, Neil, and David A. Leiman. “Improving Acute GI Bleeding Management Through Artificial Intelligence: Unnatural Selection?” Dig Dis Sci 64, no. 8 (August 2019): 2061–64. https://doi.org/10.1007/s10620-019-05698-0.
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    • Lloyd, Benjamin R., and David A. Leiman. “An Updated Approach to Evaluation and Treatment of Helicobacter pylori Infection.” South Med J 112, no. 7 (July 2019): 392–98. https://doi.org/10.14423/SMJ.0000000000000997.
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    • Cohen, Seth M., Hui-Jie Lee, David A. Leiman, Nelson Roy, and Stephanie Misono. “Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population.” Otolaryngol Head Neck Surg 160, no. 3 (March 2019): 519–25. https://doi.org/10.1177/0194599818811292.
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    • Sullivan, Brian, Jonathan Glaab, Rajan T. Gupta, Richard Wood, and David A. Leiman. “Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma.” Radiol Case Rep 13, no. 6 (December 2018): 1119–22. https://doi.org/10.1016/j.radcr.2018.08.015.
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    • Leiman, D. A., B. Kochar, S. Posner, C. Fan, A. Patel, O. Shaheen, C. Y. Keller, N. T. Koutlas, S. Eluri, and E. S. Dellon. “A diagnosis of eosinophilic esophagitis is associated with increased life insurance premiums.” Dis Esophagus 31, no. 8 (August 1, 2018). https://doi.org/10.1093/dote/doy008.
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    • Posner, S., J. Zheng, R. K. Wood, R. A. Shimpi, M. G. Hartwig, S. -. C. Chow, and D. A. Leiman. “Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.” Dis Esophagus 31, no. 5 (May 1, 2018). https://doi.org/10.1093/dote/dox157.
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    • Leiman, David, Angela Mills, Frances Shofer, Andrew Weber, Erin Leiman, Brian Riff, James Lewis, and Shivan Mehta. “Glasgow Blatchford Score of limited benefit for low-risk urban patients: a mixed methods study.” Endoscopy International Open 05, no. 10 (October 2017): E950–58. https://doi.org/10.1055/s-0043-117880.
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    • Leiman, D. A., B. P. Riff, S. Morgan, D. C. Metz, G. W. Falk, B. French, C. A. Umscheid, and J. D. Lewis. “Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis.” Dis Esophagus 30, no. 5 (May 1, 2017): 1–9. https://doi.org/10.1093/dote/dow020.
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    • Leiman, D. A., B. P. Riff, S. Morgan, D. C. Metz, G. W. Falk, B. French, C. A. Umscheid, and J. D. Lewis. “Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis.” Dis Esophagus 30, no. 2 (February 1, 2017): 1–8. https://doi.org/10.1111/dote.12535.
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    • Leiman, David A., David C. Metz, Gregory G. Ginsberg, J. T. Howell, Shivan J. Mehta, and Nuzhat A. Ahmad. “A Novel Electronic Medical Record-Based Workflow to Measure and Report Colonoscopy Quality Measures.” Clin Gastroenterol Hepatol 14, no. 3 (March 2016): 333-337.e1. https://doi.org/10.1016/j.cgh.2015.12.001.
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    • Riff, Brian P., David A. Leiman, Bonita Bennett, Douglas L. Fraker, and David C. Metz. “Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression.” Pancreas 45, no. 2 (February 2016): 193–97. https://doi.org/10.1097/MPA.0000000000000376.
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    • Bewtra, Meenakshi, Angelyn O. Fairchild, Erin Gilroy, David A. Leiman, Caroline Kerner, F Reed Johnson, and James D. Lewis. “Inflammatory Bowel Disease Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse.” Am J Gastroenterol 110, no. 12 (December 2015): 1675–81. https://doi.org/10.1038/ajg.2015.321.
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    • Leiman, David A., Amit Raina, and Melissa Grilliot. “An uncommon gastric finding: a budding problem.” Gastrointest Endosc 80, no. 1 (July 2014): 169–70. https://doi.org/10.1016/j.gie.2014.02.017.
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    • Leiman, David A., and Gary R. Lichtenstein. “Therapy of inflammatory bowel disease: what to expect in the next decade.” Curr Opin Gastroenterol 30, no. 4 (July 2014): 385–90. https://doi.org/10.1097/MOG.0000000000000077.
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    • Leiman, D., M. Barlow, K. Carpin, E. M. Piña, and D. Casso. “Medial and lateral pectoral nerve block with liposomal bupivacaine for the management of postsurgical pain after submuscular breast augmentation.” Plastic and Reconstructive Surgery  Global Open 2, no. 12 (January 1, 2014). https://doi.org/10.1097/GOX.0000000000000253.
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    • Barry, Daniel P., Mohammad Asim, David A. Leiman, Thibaut de Sablet, Kshipra Singh, Robert A. Casero, Rupesh Chaturvedi, and Keith T. Wilson. “Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.” Plos One 6, no. 2 (February 28, 2011): e17510. https://doi.org/10.1371/journal.pone.0017510.
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    • Wagnon, Julianne H., David A. Leiman, Gregory D. Ayers, and David A. Schwartz. “Survey of gastroenterologists' awareness and implementation of AGA guidelines on osteoporosis in inflammatory bowel disease patients: are the guidelines being used and what are the barriers to their use?” Inflamm Bowel Dis 15, no. 7 (July 2009): 1082–89. https://doi.org/10.1002/ibd.20857.
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    • Treweek, Shaun, Alex Doney, and David Leiman. “Public attitudes to the storage of blood left over from routine general practice tests and its use in research.” J Health Serv Res Policy 14, no. 1 (January 2009): 13–19. https://doi.org/10.1258/jhsrp.2008.008016.
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    • Leiman, David A., Nancy M. Lorenzi, Jeremy C. Wyatt, Alex S. F. Doney, and S Trent Rosenbloom. “US and Scottish health professionals' attitudes toward DNA biobanking.” J Am Med Inform Assoc 15, no. 3 (May 2008): 357–62. https://doi.org/10.1197/jamia.M2571.
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    • Leiman, David A., Nancy Lorenzi, Jeremy Wyatt, Alex S. F. Doney, and Trent Rosenbloom. “US and Scottish Health Professionals attitudes toward DNA biobanking.” Amia Annu Symp Proc, October 11, 2007, 1027.
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  • Book Sections

    • Leiman, D. A., and D. C. Metz. “Gastroesophageal Reflux Disease.” In Clinical Gastrointestinal Endoscopy E-Book. Elsevier Health Sciences, 2018.
    • Leiman, D. A., and G. W. Falk. “Endoscopic features of eosinophilic esophagitis.” In Eosinophilic Esophagitis, 165–75, 2012. https://doi.org/10.1007/978-1-60761-515-6_13.
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  • Conference Papers

    • Garbarino, Stephanie, Megan von Isenburg, Deborah A. Fisher, and David A. Leiman. “Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review.” In J Clin Gastroenterol, 54:35–42, 2020. https://doi.org/10.1097/MCG.0000000000001156.
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    • Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, Richard K. Wood, Deborah Fisher, Matthew G. Hartwig, Jacob Klapper, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.” In Dis Esophagus, 32:1–8, 2019. https://doi.org/10.1093/dote/doz039.
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