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David Asher Leiman

Associate Professor of Medicine
Medicine, Gastroenterology

Selected Publications


Evaluation of the Potential Utility of an Artificial Intelligence Chatbot in Gastroesophageal Reflux Disease Management.

Journal Article Am J Gastroenterol · December 1, 2023 INTRODUCTION: Artificial intelligence chatbots could serve as an information resource for patients and a tool for clinicians. Their ability to respond appropriately to questions regarding gastroesophageal reflux disease is unknown. METHODS: Twenty-three pr ... Full text Link to item Cite

Self-Reported Dysphagia and Psychosocial Health Among Community-Dwelling Older Adults: Results of a National Study.

Journal Article J Gen Intern Med · November 2023 BACKGROUND: The risk of dysphagia increases with age, affecting up to 33% of adults over the age of 65. Older adults with dysphagia are at increased risk for negative physical health outcomes such as aspiration pneumonia and death. However, the relationshi ... Full text Link to item Cite

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound.

Journal Article J Appl Gerontol · September 2023 Objective: Our aim was to evaluate relationships between swallowing difficulty (dysphagia) and social determinants of health (SDOH) in older adults ≥65 years. Method: Cross-sectional analyses were performed in community-dwelling Medicare beneficiaries from ... Full text Link to item Cite

Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?

Journal Article Cancer Epidemiol Biomarkers Prev · September 1, 2023 Proton pump inhibitors (PPI) are a cornerstone of management for many digestive diseases. While chronic PPI use induces physiologic changes including gastric acid suppression and hypergastrinemia, existing data are conflicting on whether this impacts the r ... Full text Link to item Cite

Dysphagia Worsens With Increasing Ineffective Swallows Among Patients With Ineffective Esophageal Motility.

Journal Article J Clin Gastroenterol · August 1, 2023 INTRODUCTION: Ineffective esophageal motility (IEM) is the most common motility disorder identified on esophageal high-resolution manometry (HRM), but patients with this finding may be asymptomatic. Therefore, we aimed to identify specific HRM findings pre ... Full text Link to item Cite

Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.

Journal Article Dis Esophagus · July 27, 2023 Gastroesophageal reflux disease (GERD) is common in patients who have undergone lung transplantation and is associated with poorer outcomes, but guidelines are lacking to direct management strategies in this population. We assessed the diagnostic yield of ... Full text Link to item Cite

Quality Indicators for the Diagnosis and Management of Eosinophilic Esophagitis.

Journal Article Am J Gastroenterol · June 1, 2023 INTRODUCTION: Despite best practice recommendations for managing eosinophilic esophagitis (EoE), variation in care exists. METHODS: We used established methodology for quality indicator development to identify metrics to define quality for the treatment of ... Full text Link to item Cite

AGA Institute Quality Indicator Development and Uses.

Journal Article Clin Gastroenterol Hepatol · June 2023 Full text Link to item Cite

Preoperative dysphagia risk in community-dwelling adults aged ≥50 years: Prevalence and risk factors.

Journal Article Nutr Clin Pract · February 2023 BACKGROUND: Preoperative dysphagia screening is rare. The purpose of this study was to assess the prevalence and potential risk factors of preoperative dysphagia risk in adults preparing for surgery. METHODS: The Eating Assessment Tool (EAT-10), Patient-Ge ... Full text Open Access Link to item Cite

Achalasia Quality Indicator Adherence.

Journal Article Dig Dis Sci · February 2023 BACKGROUND: Quality indicators (QIs) are formal ways to track health care performance and outcomes, guide quality improvement, and identify gaps in care delivery. We developed twelve quality indicators for achalasia management which cover the domains of pa ... Full text Link to item Cite

Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.

Journal Article Am J Rhinol Allergy · November 2022 BACKGROUND: Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher preva ... Full text Link to item Cite

A Rare Cause of Confluent Abnormal Esophageal Mucosa.

Journal Article Gastroenterology · October 2022 Full text Link to item Cite

Food Insecurity in Digestive Diseases.

Journal Article Gastroenterology · September 2022 Full text Link to item Cite

Proton Pump Inhibitor Prescribing and Monitoring Patterns Among Gastroenterology Practitioners.

Journal Article J Clin Gastroenterol · August 1, 2022 GOALS: The aim was to quantify proton pump inhibitor (PPI) practice habits among gastroenterology (GI) practitioners. BACKGROUND: Reports of side effects have prompted patients and practitioners alike to discontinue PPI use. Emerging evidence-based literat ... Full text Link to item Cite

Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation.

Journal Article Dis Esophagus · May 10, 2022 BACKGROUND: Upper endoscopy (EGD) is frequently performed in patients with esophageal complaints following anti-reflux surgery such as fundoplication. Endoscopic evaluation of fundoplication wrap integrity can be challenging. Our primary aim in this pilot ... Full text Link to item Cite

Preface: Quality in Endoscopy Part I

Journal Article Techniques and Innovations in Gastrointestinal Endoscopy · January 1, 2022 Full text Cite

Evaluation of the Potential Utility of an Artificial Intelligence Chatbot in Gastroesophageal Reflux Disease Management.

Journal Article Am J Gastroenterol · December 1, 2023 INTRODUCTION: Artificial intelligence chatbots could serve as an information resource for patients and a tool for clinicians. Their ability to respond appropriately to questions regarding gastroesophageal reflux disease is unknown. METHODS: Twenty-three pr ... Full text Link to item Cite

Self-Reported Dysphagia and Psychosocial Health Among Community-Dwelling Older Adults: Results of a National Study.

Journal Article J Gen Intern Med · November 2023 BACKGROUND: The risk of dysphagia increases with age, affecting up to 33% of adults over the age of 65. Older adults with dysphagia are at increased risk for negative physical health outcomes such as aspiration pneumonia and death. However, the relationshi ... Full text Link to item Cite

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound.

Journal Article J Appl Gerontol · September 2023 Objective: Our aim was to evaluate relationships between swallowing difficulty (dysphagia) and social determinants of health (SDOH) in older adults ≥65 years. Method: Cross-sectional analyses were performed in community-dwelling Medicare beneficiaries from ... Full text Link to item Cite

Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?

Journal Article Cancer Epidemiol Biomarkers Prev · September 1, 2023 Proton pump inhibitors (PPI) are a cornerstone of management for many digestive diseases. While chronic PPI use induces physiologic changes including gastric acid suppression and hypergastrinemia, existing data are conflicting on whether this impacts the r ... Full text Link to item Cite

Dysphagia Worsens With Increasing Ineffective Swallows Among Patients With Ineffective Esophageal Motility.

Journal Article J Clin Gastroenterol · August 1, 2023 INTRODUCTION: Ineffective esophageal motility (IEM) is the most common motility disorder identified on esophageal high-resolution manometry (HRM), but patients with this finding may be asymptomatic. Therefore, we aimed to identify specific HRM findings pre ... Full text Link to item Cite

Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.

Journal Article Dis Esophagus · July 27, 2023 Gastroesophageal reflux disease (GERD) is common in patients who have undergone lung transplantation and is associated with poorer outcomes, but guidelines are lacking to direct management strategies in this population. We assessed the diagnostic yield of ... Full text Link to item Cite

Quality Indicators for the Diagnosis and Management of Eosinophilic Esophagitis.

Journal Article Am J Gastroenterol · June 1, 2023 INTRODUCTION: Despite best practice recommendations for managing eosinophilic esophagitis (EoE), variation in care exists. METHODS: We used established methodology for quality indicator development to identify metrics to define quality for the treatment of ... Full text Link to item Cite

AGA Institute Quality Indicator Development and Uses.

Journal Article Clin Gastroenterol Hepatol · June 2023 Full text Link to item Cite

Preoperative dysphagia risk in community-dwelling adults aged ≥50 years: Prevalence and risk factors.

Journal Article Nutr Clin Pract · February 2023 BACKGROUND: Preoperative dysphagia screening is rare. The purpose of this study was to assess the prevalence and potential risk factors of preoperative dysphagia risk in adults preparing for surgery. METHODS: The Eating Assessment Tool (EAT-10), Patient-Ge ... Full text Open Access Link to item Cite

Achalasia Quality Indicator Adherence.

Journal Article Dig Dis Sci · February 2023 BACKGROUND: Quality indicators (QIs) are formal ways to track health care performance and outcomes, guide quality improvement, and identify gaps in care delivery. We developed twelve quality indicators for achalasia management which cover the domains of pa ... Full text Link to item Cite

Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.

Journal Article Am J Rhinol Allergy · November 2022 BACKGROUND: Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher preva ... Full text Link to item Cite

A Rare Cause of Confluent Abnormal Esophageal Mucosa.

Journal Article Gastroenterology · October 2022 Full text Link to item Cite

Food Insecurity in Digestive Diseases.

Journal Article Gastroenterology · September 2022 Full text Link to item Cite

Proton Pump Inhibitor Prescribing and Monitoring Patterns Among Gastroenterology Practitioners.

Journal Article J Clin Gastroenterol · August 1, 2022 GOALS: The aim was to quantify proton pump inhibitor (PPI) practice habits among gastroenterology (GI) practitioners. BACKGROUND: Reports of side effects have prompted patients and practitioners alike to discontinue PPI use. Emerging evidence-based literat ... Full text Link to item Cite

Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation.

Journal Article Dis Esophagus · May 10, 2022 BACKGROUND: Upper endoscopy (EGD) is frequently performed in patients with esophageal complaints following anti-reflux surgery such as fundoplication. Endoscopic evaluation of fundoplication wrap integrity can be challenging. Our primary aim in this pilot ... Full text Link to item Cite

Preface: Quality in Endoscopy Part I

Journal Article Techniques and Innovations in Gastrointestinal Endoscopy · January 1, 2022 Full text Cite

Preface: Quality in Endoscopy Part II

Journal Article Techniques and Innovations in Gastrointestinal Endoscopy · January 1, 2022 Full text Cite

Beyond the Eckardt Score: Patient-Reported Outcomes Measures in Esophageal Disorders.

Journal Article Curr Gastroenterol Rep · December 1, 2021 PURPOSE OF REVIEW: To provide an overview of patient reported outcome measures (PROMs) and summarize their role in assessing undifferentiated dysphagia and common esophageal disorders, including achalasia, eosinophilic esophagitis (EoE), and gastroesophage ... Full text Link to item Cite

Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction.

Journal Article Dig Dis Sci · November 2021 BACKGROUND: Esophagogastric junction outflow obstruction (EGJOO) is a common but nonspecific motility pattern identified by esophageal high-resolution manometry (HRM). Functional luminal impedance planimetry (FLIP) provides information regarding lower esop ... Full text Link to item Cite

Development of quality indicators for the diagnosis and management of achalasia.

Journal Article Neurogastroenterol Motil · October 2021 BACKGROUND: The management of achalasia has improved due to diagnostic and therapeutic innovations. However, variability in care delivery remains and no established measures defining quality of care for this population exist. We aimed to use formal methodo ... Full text Link to item Cite

Patient, Physician, and Procedure Characteristics Are Independently Predictive of Polyp Detection Rates in Clinical Practice.

Journal Article Dig Dis Sci · August 2021 BACKGROUND: Variability in colon polyp detection impacts patient outcomes. However, the relative influence of physician, patient, and procedure-specific factors on polyp detection is unclear. Therefore, determining how these factors contribute to adenoma a ... Full text Link to item Cite

Food Insecurity Is an Independent Risk Factor for Depressive Symptoms in Survivors of Digestive Cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2021 BACKGROUND: Colorectal and other digestive cancer survivors are at increased risk of depression, which can negatively affect health outcomes. Food insecurity (FI), the lack of consistent access to enough food, can also contribute to these health complicati ... Full text Link to item Cite

Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.

Journal Article Dysphagia · October 2020 Gastroesophageal reflux disease and esophageal dysmotility are common in patients with advanced lung disease (ALD) and are associated with worse outcomes. Assessing esophageal function in these patients is relevant for determining pulmonary transplant elig ... Full text Link to item Cite

Correction to: Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.

Journal Article Dysphagia · October 2020 The original version of this article unfortunately contained a mistake. The shared first authorship information was missing in the published article. It has been given below. The first authorship is shared between Dr. Shai Posner and Kurren Mehta. ... Full text Link to item Cite

Terminal ileum intubation is not associated with colonoscopy quality measures.

Journal Article J Gastroenterol Hepatol · September 2020 BACKGROUND AND AIM: Intubation of the terminal ileum (TI) demonstrates a complete colonoscopy, but its clinical value during screening exams is unknown. We aimed to determine whether TI intubation during screening colonoscopy is associated with colonoscopy ... Full text Open Access Link to item Cite

Standardizing inpatient colonoscopy preparations improves quality and provider satisfaction.

Journal Article Int J Health Care Qual Assur · March 9, 2020 PURPOSE: Inpatient colonoscopy bowel preparation quality is frequently suboptimal. This quality improvement (QI) intervention is focused on regimenting this process to impact important outcomes. DESIGN/METHODOLOGY/APPROACH: Define, Measure, Analyze, Improv ... Full text Open Access Link to item Cite

Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review.

Conference J Clin Gastroenterol · January 2020 GOALS: Awareness of functional esophagogastric junction outflow obstruction (fEGJOO) has increased, but because there is no consensus on its management, we performed a systematic review of the literature to explore treatment strategies and outcomes. BACKGR ... Full text Link to item Cite

Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.

Conference Dis Esophagus · December 13, 2019 Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The a ... Full text Link to item Cite

An Updated Approach to Evaluation and Treatment of Helicobacter pylori Infection.

Journal Article South Med J · July 2019 Helicobacter pylori is a chronic bacterial infection that can lead to peptic ulcer disease, chronic gastritis, and gastric cancer. Its prevalence in the United States is lower than in most of the world, although specific populations are at particular risk ... Full text Link to item Cite

Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population.

Journal Article Otolaryngol Head Neck Surg · March 2019 OBJECTIVES: To examine the relationship between community-acquired pneumonia (CAP) and proton pump inhibitor (PPI) treatment among patients with laryngeal/voice disorders. STUDY DESIGN: Retrospective cohort analysis. SETTING: Large national administrative ... Full text Link to item Cite

Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma.

Journal Article Radiol Case Rep · December 2018 Lymphogranuloma venereum is a sexually transmitted infection caused by serotypes L1-3 of Chlamydia trachomatis and may present as hemorrhagic proctocolitis. The diagnosis of an active infection is difficult to establish, as confirmatory testing can be unre ... Full text Link to item Cite

A diagnosis of eosinophilic esophagitis is associated with increased life insurance premiums.

Journal Article Dis Esophagus · August 1, 2018 Eosinophilic esophagitis (EoE) is a chronic disease that can be diagnosed at any age, but is not associated with malignancy and does not shorten lifespan. It remains unknown whether an EoE diagnosis affects insurability or insurance premium costs. We there ... Full text Link to item Cite

Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.

Journal Article Dis Esophagus · May 1, 2018 Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testi ... Full text Open Access Link to item Cite

Gastroesophageal Reflux Disease

Chapter · January 17, 2018 Cite

Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis.

Journal Article Dis Esophagus · May 1, 2017 In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective. However, in some patients, especially those with nonerosive reflux disease or atypical GERD symptoms, acid-su ... Full text Link to item Cite

Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis.

Journal Article Dis Esophagus · February 1, 2017 In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective. However, in some patients, especially those with non-erosive reflux disease or atypical GERD symptoms, acid s ... Full text Link to item Cite

Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression.

Journal Article Pancreas · February 2016 OBJECTIVES: Zollinger-Ellison syndrome (ZES) is characterized by hypergastrinemia and gastric acid hypersecretion resulting in peptic ulcer disease, diarrhea, and weight loss. Acid secretion can be controlled with medication, and biochemical cure is possib ... Full text Link to item Cite

Inflammatory Bowel Disease Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse.

Journal Article Am J Gastroenterol · December 2015 OBJECTIVES: Biomarkers, endoscopy and imaging tests can identify patients at increased risk for early recurrence of symptomatic inflammatory bowel disease (IBD). However, patients may be unwilling to accept additional medical therapy risks related to thera ... Full text Link to item Cite

An uncommon gastric finding: a budding problem.

Journal Article Gastrointest Endosc · July 2014 Full text Link to item Cite

Therapy of inflammatory bowel disease: what to expect in the next decade.

Journal Article Curr Opin Gastroenterol · July 2014 PURPOSE OF REVIEW: The increased understanding of the molecular mechanisms that are responsible for inflammatory bowel disease (IBD) has led to a wide range of potential therapeutic targets for this condition. Physicians treating individuals with Crohn's d ... Full text Link to item Cite

Medial and lateral pectoral nerve block with liposomal bupivacaine for the management of postsurgical pain after submuscular breast augmentation

Journal Article Plastic and Reconstructive Surgery - Global Open · January 1, 2014 Summary: This report describes an ultrasound-guided medial and lateral pectoralis nerve block using liposome bupivacaine, performed before the surgical incision, in a patient undergoing submuscular breast augmentation. The anatomic basis and technique are ... Full text Cite

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.

Journal Article PLoS One · February 28, 2011 Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by antibioti ... Full text Link to item Cite

Survey of gastroenterologists' awareness and implementation of AGA guidelines on osteoporosis in inflammatory bowel disease patients: are the guidelines being used and what are the barriers to their use?

Journal Article Inflamm Bowel Dis · July 2009 BACKGROUND: The American Gastroenterology Association (AGA) published guidelines to assist clinicians in the evaluation and management of osteoporosis in inflammatory bowel disease (IBD) patients. Two studies suggest that when clinicians utilized the guide ... Full text Link to item Cite

Public attitudes to the storage of blood left over from routine general practice tests and its use in research.

Journal Article J Health Serv Res Policy · January 2009 OBJECTIVE: There is increasing international interest in DNA biobanks but relatively little evidence concerning appropriate recruitment methods for these repositories of genetic information linked to patient-specific phenotypic data. To this end, our study ... Full text Link to item Cite

US and Scottish health professionals' attitudes toward DNA biobanking.

Journal Article J Am Med Inform Assoc · 2008 BACKGROUND: The authors define a DNA biobank as a repository of genetic information correlated with patient medical records. DNA biobanks may assist in the research and identification of genetic factors influencing disease and drug interactions, but may ra ... Full text Link to item Cite

US and Scottish Health Professionals attitudes toward DNA biobanking.

Journal Article AMIA Annu Symp Proc · October 11, 2007 The authors used a fifteen item survey to canvass 200 health care professionals in the United States and Scotland about their attitudes toward the potential utility of a DNA biobank. Results indicate a broadly favorable opinion in both locations. This find ... Link to item Cite