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Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?

Publication ,  Journal Article
Richman, CM; Leiman, DA
Published in: Cancer Epidemiol Biomarkers Prev
September 1, 2023

Proton pump inhibitors (PPI) are a cornerstone of management for many digestive diseases. While chronic PPI use induces physiologic changes including gastric acid suppression and hypergastrinemia, existing data are conflicting on whether this impacts the risk of gastric cancer among PPI users. Sassano and colleagues utilized pooled case-control data from five studies in the Stomach cancer Pooling (StoP) Project to investigate the association between PPI use and histologically confirmed gastric cancer. Short-term PPI use (6 months) was associated with increased risk of gastric cancer, but no association was found between long-term PPI use (3 years or more) and gastric cancer. Although the authors relied on patient-reported PPI use data, and data related to Helicobacter pylori infection and eradication rates were missing, no histologic gastric cancer subtypes in this international case-control study were associated with any PPI use. Currently reported findings provide patients and clinicians with reassuring observations that long-term PPI use does not significantly increase gastric cancer risk. The relationship identified among short-term PPI users may reflect reverse causality. Our understanding will be furthered by additional assessment of potential confounders, including comorbid conditions, PPI metabolism, and social determinants of health. See related article by Sassano et al., p. 1174.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

September 1, 2023

Volume

32

Issue

9

Start / End Page

1127 / 1129

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Proton Pump Inhibitors
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Epidemiology
  • Case-Control Studies
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Richman, C. M., & Leiman, D. A. (2023). Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk? Cancer Epidemiol Biomarkers Prev, 32(9), 1127–1129. https://doi.org/10.1158/1055-9965.EPI-23-0809
Richman, Courtney M., and David A. Leiman. “Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?Cancer Epidemiol Biomarkers Prev 32, no. 9 (September 1, 2023): 1127–29. https://doi.org/10.1158/1055-9965.EPI-23-0809.
Richman CM, Leiman DA. Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk? Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1127–9.
Richman, Courtney M., and David A. Leiman. “Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?Cancer Epidemiol Biomarkers Prev, vol. 32, no. 9, Sept. 2023, pp. 1127–29. Pubmed, doi:10.1158/1055-9965.EPI-23-0809.
Richman CM, Leiman DA. Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk? Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1127–1129.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

September 1, 2023

Volume

32

Issue

9

Start / End Page

1127 / 1129

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Proton Pump Inhibitors
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Epidemiology
  • Case-Control Studies
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences