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Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.

Publication ,  Journal Article
Simmons, JK; Leiman, DA; Patil, SU; McCoul, E; Chen, PG; Tang, DM; Kuan, EC; Chang, EE; Wu, AW
Published in: Am J Rhinol Allergy
November 2022

BACKGROUND: Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher prevalence of EoE may exist in patients with CRS. OBJECTIVES: We aimed to expand the base of evidence across geographic regions and investigate the association between EoE and CRS, including CRS with nasal polyposis (CRSwNP). METHODS: Quantitative data detailing the prevalence of CRS, CRSwNP, and EoE were pooled from 6 large academic institutions spread across the United States using Epic electronic medical record system. One-way analysis of variance was then used to analyze the data. RESULTS: The mean prevalence of EoE in our general population sample of over 26 million individual records was 0.058% (range, 0.013%-0.103%). The mean prevalence of EoE in our sub-populations of individual with diagnoses of CRS and CRSwNP was 0.43% (F(1,12)  =  [8.194], P  =  .01) and 0.84% (F(1,12)  =  [23.61], P < .01) respectively. CONCLUSION: This study reveals an 8-fold greater prevalence of concurrent EoE in patients with CRS. Importantly, this is the first study to describe the association of EoE and the CRSwNP subtype, and we demonstrate a 14-fold greater prevalence of EoE in patients with CRSwNP.

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Published In

Am J Rhinol Allergy

DOI

EISSN

1945-8932

Publication Date

November 2022

Volume

36

Issue

6

Start / End Page

804 / 807

Location

United States

Related Subject Headings

  • Sinusitis
  • Rhinitis
  • Prevalence
  • Otorhinolaryngology
  • Nasal Polyps
  • Humans
  • Gastritis
  • Eosinophilic Esophagitis
  • Eosinophilia
  • Enteritis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Simmons, J. K., Leiman, D. A., Patil, S. U., McCoul, E., Chen, P. G., Tang, D. M., … Wu, A. W. (2022). Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis. Am J Rhinol Allergy, 36(6), 804–807. https://doi.org/10.1177/19458924221116162
Simmons, Jordan K., David A. Leiman, Sarita U. Patil, Edward McCoul, Philip G. Chen, Dennis M. Tang, Edward C. Kuan, Elena E. Chang, and Arthur W. Wu. “Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.Am J Rhinol Allergy 36, no. 6 (November 2022): 804–7. https://doi.org/10.1177/19458924221116162.
Simmons JK, Leiman DA, Patil SU, McCoul E, Chen PG, Tang DM, et al. Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis. Am J Rhinol Allergy. 2022 Nov;36(6):804–7.
Simmons, Jordan K., et al. “Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis.Am J Rhinol Allergy, vol. 36, no. 6, Nov. 2022, pp. 804–07. Pubmed, doi:10.1177/19458924221116162.
Simmons JK, Leiman DA, Patil SU, McCoul E, Chen PG, Tang DM, Kuan EC, Chang EE, Wu AW. Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis. Am J Rhinol Allergy. 2022 Nov;36(6):804–807.

Published In

Am J Rhinol Allergy

DOI

EISSN

1945-8932

Publication Date

November 2022

Volume

36

Issue

6

Start / End Page

804 / 807

Location

United States

Related Subject Headings

  • Sinusitis
  • Rhinitis
  • Prevalence
  • Otorhinolaryngology
  • Nasal Polyps
  • Humans
  • Gastritis
  • Eosinophilic Esophagitis
  • Eosinophilia
  • Enteritis