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Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.

Publication ,  Conference
Posner, S; Finn, RT; Shimpi, RA; Wood, RK; Fisher, D; Hartwig, MG; Klapper, J; Reynolds, J; Niedzwiecki, D; Parish, A; Leiman, DA
Published in: Dis Esophagus
December 13, 2019

Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The aim of this study was to describe the changes in esophageal function occurring after lung transplantation. A retrospective cohort study was performed on lung transplant candidates evaluated at a tertiary care center between 2015 and 2016. A total of 76 patients who underwent lung transplantation had high-resolution manometry and ambulatory pH-metry before and after transplant. Demographic data, esophageal function testing results, and clinical outcomes such as pulmonary function testing were collected and analyzed using appropriate statistical tests and multivariable regression. Of the 76 patients, 59 (78%) received a bilateral transplant. There was a significant increase in esophageal contractility posttransplant, with an increase in median distal contractile integral from 1470 to 2549 mmHg cm s (P < 0.01). There were 19 patients with Jackhammer esophagus posttransplant, including 15 patients with normal motility pretransplant. Nine patients with ineffective or fragmented peristalsis pretransplant had normal manometry posttransplant. Abnormal pH-metry was observed in 35 (46%) patients pretransplant and 29 (38%) patients posttransplant (P = 0.33). Patients with gastroesophageal reflux disease posttransplant had less improvement in pulmonary function at one year, as measured by forced expiratory volume (P = 0.04). These results demonstrate that esophageal contractility increases significantly after lung transplantation, with an associated change in motility classification. In comparison, gastroesophageal reflux does not worsen, but is associated with worse pulmonary function, posttransplant.

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Published In

Dis Esophagus

DOI

EISSN

1442-2050

Publication Date

December 13, 2019

Volume

32

Issue

10

Start / End Page

1 / 8

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Postoperative Period
  • Peristalsis
  • Middle Aged
  • Manometry
  • Male
  • Lung Transplantation
  • Lung Diseases
  • Lung
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Posner, S., Finn, R. T., Shimpi, R. A., Wood, R. K., Fisher, D., Hartwig, M. G., … Leiman, D. A. (2019). Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. In Dis Esophagus (Vol. 32, pp. 1–8). United States. https://doi.org/10.1093/dote/doz039
Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, Richard K. Wood, Deborah Fisher, Matthew G. Hartwig, Jacob Klapper, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.” In Dis Esophagus, 32:1–8, 2019. https://doi.org/10.1093/dote/doz039.
Posner S, Finn RT, Shimpi RA, Wood RK, Fisher D, Hartwig MG, et al. Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. In: Dis Esophagus. 2019. p. 1–8.
Posner, Shai, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.Dis Esophagus, vol. 32, no. 10, 2019, pp. 1–8. Pubmed, doi:10.1093/dote/doz039.
Posner S, Finn RT, Shimpi RA, Wood RK, Fisher D, Hartwig MG, Klapper J, Reynolds J, Niedzwiecki D, Parish A, Leiman DA. Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. Dis Esophagus. 2019. p. 1–8.
Journal cover image

Published In

Dis Esophagus

DOI

EISSN

1442-2050

Publication Date

December 13, 2019

Volume

32

Issue

10

Start / End Page

1 / 8

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Postoperative Period
  • Peristalsis
  • Middle Aged
  • Manometry
  • Male
  • Lung Transplantation
  • Lung Diseases
  • Lung
  • Humans