Jacob A Klapper
Associate Professor of Surgery
Current Appointments & Affiliations
- Associate Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2021
Contact Information
- Background
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Education, Training, & Certifications
- Masters in Clinical Research, Clinical Research, Medical University of South Carolina, College of Medicine 2014 - 2016
- Cardiothoracic Surgery Fellow, Surgery, Duke University 2011 - 2014
- General Surgery Resident, General Surgery, Indiana University at Indianapolis 2003 - 2011
- M.D., Indiana University, School of Medicine 2003
- B.A., Colgate University 1998
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Previous Appointments & Affiliations
- Assistant Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2021
- Assistant Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2016 - 2020
- Research
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Selected Grants
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External Relationships
- Up To Date Inc/Wolters Kluwer Health
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Prabhu, Neel K., Megan K. Wong, Jacob A. Klapper, John C. Haney, Maciej A. Mazurowski, Joseph G. Mammarappallil, and Matthew G. Hartwig. “Computed Tomography Volumetrics for Size Matching in Lung Transplantation for Restrictive Disease.” Ann Thorac Surg, April 7, 2023. https://doi.org/10.1016/j.athoracsur.2023.03.033.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Experience fills the void.” J Thorac Cardiovasc Surg 165, no. 4 (April 2023): 1602–3. https://doi.org/10.1016/j.jtcvs.2022.02.036.Full Text Link to Item
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Halpern, Samantha E., Dimitrios Moris, Jared N. Gloria, Brian I. Shaw, John C. Haney, Jacob A. Klapper, Andrew S. Barbas, and Matthew G. Hartwig. “Textbook Outcome: Definition and Analysis of a Novel Quality Measure in Lung Transplantation.” Ann Surg 277, no. 2 (February 1, 2023): 350–57. https://doi.org/10.1097/SLA.0000000000004916.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Something gained, nothing wasted.” J Thorac Cardiovasc Surg 164, no. 6 (December 2022): 1660. https://doi.org/10.1016/j.jtcvs.2022.02.013.Full Text Link to Item
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Halpern, Samantha E., Mary C. Wright, Gabrielle Madsen, Bryan Chow, Chelsea S. Harris, John C. Haney, Jacob A. Klapper, Brandi A. Bottiger, and Matthew G. Hartwig. “Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension.” J Heart Lung Transplant 41, no. 11 (November 2022): 1628–37. https://doi.org/10.1016/j.healun.2022.07.015.Full Text Link to Item
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Eichenberger, Emily M., Amanda C. Coniglio, Carmelo Milano, Jacob Schroder, Benjamin S. Bryner, Philip J. Spencer, John C. Haney, et al. “Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.” J Heart Lung Transplant 41, no. 10 (October 2022): 1376–81. https://doi.org/10.1016/j.healun.2022.06.018.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Good bad times.” J Thorac Cardiovasc Surg 164, no. 2 (August 2022): 449. https://doi.org/10.1016/j.jtcvs.2021.09.005.Full Text Link to Item
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Olaso, Danae G., Samantha E. Halpern, Madison K. Krischak, Sandra Au, Ian R. Jamieson, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Same-teams versus different-teams for long distance lung procurement: A cost analysis.” J Thorac Cardiovasc Surg, June 10, 2022. https://doi.org/10.1016/j.jtcvs.2022.05.040.Full Text Link to Item
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Jawitz, Oliver K., Vignesh Raman, David Becerra, Julie Doberne, Ashley Y. Choi, Samantha E. Halpern, Jacob A. Klapper, and Matthew G. Hartwig. “Lung Transplantation After Ex Vivo Lung Perfusion Early Outcomes From a US National Registry.” Ann Surg 275, no. 5 (May 1, 2022): 1006–12. https://doi.org/10.1097/SLA.0000000000004233.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Modern analytics: Good for surgery, bad for baseball.” J Thorac Cardiovasc Surg 163, no. 4 (April 2022): 1517. https://doi.org/10.1016/j.jtcvs.2021.01.084.Full Text Link to Item
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Krischak, Madison K., Sandra Au, Samantha E. Halpern, Danae G. Olaso, Dimitrios Moris, Laurie D. Snyder, Andrew S. Barbas, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Textbook surgical outcome in lung transplantation: Analysis of a US national registry.” Clin Transplant 36, no. 4 (April 2022): e14588. https://doi.org/10.1111/ctr.14588.Full Text Link to Item
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Jawitz, Oliver K., Vignesh Raman, David Becerra, Jacob Klapper, and Matthew G. Hartwig. “Factors associated with short- versus long-term survival after lung transplant.” J Thorac Cardiovasc Surg 163, no. 3 (March 2022): 853-860.e2. https://doi.org/10.1016/j.jtcvs.2020.09.097.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Heroic tales from a national tragedy.” J Thorac Cardiovasc Surg 163, no. 3 (March 2022): 1082–83. https://doi.org/10.1016/j.jtcvs.2020.11.119.Full Text Link to Item
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Klapper, Jacob A. “Commentary: In the aftermath, what awaits us?” J Thorac Cardiovasc Surg 163, no. 3 (March 2022): 870–71. https://doi.org/10.1016/j.jtcvs.2021.06.058.Full Text Link to Item
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Raja, Shruti M., Jeffrey T. Guptill, Alec McConnell, Hussein R. Al-Khalidi, Matthew G. Hartwig, and Jacob A. Klapper. “Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis.” Ann Thorac Surg 113, no. 3 (March 2022): 904–10. https://doi.org/10.1016/j.athoracsur.2021.06.071.Full Text Link to Item
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Halpern, Samantha E., Samuel J. Kesseli, Sandra Au, Madison K. Krischak, Danae G. Olaso, Haley Smith, Greg Tipton, et al. “Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis.” Am J Transplant 22, no. 2 (February 2022): 552–64. https://doi.org/10.1111/ajt.16794.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Respect idiopathic pulmonary hypertension…or urine trouble.” J Thorac Cardiovasc Surg 163, no. 2 (February 2022): 536–37. https://doi.org/10.1016/j.jtcvs.2021.06.007.Full Text Link to Item
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Tong, Betty C., Lin Gu, Xiaofei Wang, Dennis A. Wigle, Joseph D. Phillips, David H. Harpole, Jacob A. Klapper, Thomas Sporn, Neal E. Ready, and Thomas A. D’Amico. “Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.” J Thorac Cardiovasc Surg 163, no. 2 (February 2022): 427–36. https://doi.org/10.1016/j.jtcvs.2021.02.099.Full Text Link to Item
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Ghadimi, Kamrouz, Jhaymie Cappiello, Mary Cooter-Wright, John C. Haney, John M. Reynolds, Brandi A. Bottiger, Jacob A. Klapper, Jerrold H. Levy, Matthew G. Hartwig, and Matthew G. INSPIRE-FLO Investigators. “Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.” Jama Surg 157, no. 1 (January 1, 2022): e215856. https://doi.org/10.1001/jamasurg.2021.5856.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Artificial Organs: The Fits, The Starts, and Maybe the Future?” Semin Thorac Cardiovasc Surg 34, no. 2 (2022): 762. https://doi.org/10.1053/j.semtcvs.2021.04.042.Full Text Link to Item
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Rucker, A Justin, Joseph R. Nellis, Jacob A. Klapper, and Matthew G. Hartwig. “Lung retransplantation in the modern era.” J Thorac Dis 13, no. 11 (November 2021): 6587–93. https://doi.org/10.21037/jtd-2021-25.Full Text Link to Item
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Klapper, Jacob A., Anne C. Hicks, Leila Ledbetter, Jessica Poisson, Matthew G. Hartwig, Nazish Hashmi, Ian Welsby, and Brandi A. Bottiger. “Blood product transfusion and lung transplant outcomes: A systematic review.” Clin Transplant 35, no. 10 (October 2021): e14404. https://doi.org/10.1111/ctr.14404.Full Text Link to Item
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Halpern, Samantha E., Oliver K. Jawitz, Vignesh Raman, Ashley Y. Choi, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival.” Clin Transplant 35, no. 9 (September 2021): e14414. https://doi.org/10.1111/ctr.14414.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Organ selection and your financial advisor… more in common than you might think.” J Thorac Cardiovasc Surg 162, no. 2 (August 2021): 500. https://doi.org/10.1016/j.jtcvs.2020.08.071.Full Text Link to Item
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Klapper, Jacob, Chadrick Denlinger, and Robert M. Sade. “Smoking Relapse After Lung Transplantation: Is a Second Transplant Justified?” Ann Thorac Surg 112, no. 2 (August 2021): 373–78. https://doi.org/10.1016/j.athoracsur.2021.03.103.Full Text Link to Item
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Fitch, Zachary W., Julie Doberne, John M. Reynolds, Ian Jamieson, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Expanding donor availability in lung transplantation: A case report of 5000 miles traveled.” Am J Transplant 21, no. 6 (June 2021): 2269–72. https://doi.org/10.1111/ajt.16556.Full Text Link to Item
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Klapper, Jacob A. “Commentary: A testament to longevity.” J Thorac Cardiovasc Surg 161, no. 6 (June 2021): 1960. https://doi.org/10.1016/j.jtcvs.2020.02.118.Full Text Link to Item
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Nellis, Joseph R., Mohammed K. Alsarraj, Jude S. Sauer, Jacob A. Klapper, Salim F. Idriss, and Joseph W. Turek. “A minimally invasive approach for atrial and ventricular sew-on epicardial lead placement.” Jtcvs Tech 7 (June 2021): 245–48. https://doi.org/10.1016/j.xjtc.2021.02.025.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Perceived versus real threat…and the nuclear option.” J Thorac Cardiovasc Surg 161, no. 5 (May 2021): 1637–38. https://doi.org/10.1016/j.jtcvs.2020.03.087.Full Text Link to Item
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Barac, Yaron D., Oliver K. Jawitz, Matthew G. Hartwig, Jacob Klapper, Jacob N. Schroder, Mani A. Daneshmand, Chetan B. Patel, and Carmelo A. Milano. “Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.” Ann Thorac Surg 111, no. 4 (April 2021): 1299–1307. https://doi.org/10.1016/j.athoracsur.2020.06.109.Full Text Link to Item
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Halpern, Samantha E., Aryaman Gupta, Oliver K. Jawitz, Ashley Y. Choi, Hai V. Salfity, Jacob A. Klapper, and Matthew G. Hartwig. “Safety and efficacy of an implantable device for management of gastroesophageal reflux in lung transplant recipients.” J Thorac Dis 13, no. 4 (April 2021): 2116–27. https://doi.org/10.21037/jtd-20-3276.Full Text Link to Item
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Contreras, Fabian Jimenez, Oliver K. Jawitz, Vignesh Raman, Ashley Y. Choi, Matthew G. Hartwig, and Jacob A. Klapper. “Dual Procurement of Lung and Heart Allografts Does Not Negatively Affect Lung Transplant Outcomes.” J Surg Res 259 (March 2021): 106–13. https://doi.org/10.1016/j.jss.2020.11.036.Full Text Link to Item
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Choi, Ashley Y., Oliver K. Jawitz, Vignesh Raman, Michael S. Mulvihill, Samantha E. Halpern, Yaron D. Barac, Jacob A. Klapper, and Matthew G. Hartwig. “Predictors of nonuse of donation after circulatory death lung allografts.” The Journal of Thoracic and Cardiovascular Surgery 161, no. 2 (February 2021): 458-466.e3. https://doi.org/10.1016/j.jtcvs.2020.04.111.Full Text
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Jawitz, Oliver K., Vignesh Raman, Benjamin S. Bryner, Jacob Klapper, and Matthew G. Hartwig. “Center volume and primary graft dysfunction in patients undergoing lung transplantation in the United States - a cohort study.” Transpl Int 34, no. 1 (January 2021): 194–203. https://doi.org/10.1111/tri.13784.Full Text Link to Item
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Klapper, Jacob A. “Commentary: The Field Moves Forward.” Semin Thorac Cardiovasc Surg 33, no. 2 (2021): 416. https://doi.org/10.1053/j.semtcvs.2020.07.010.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Is Our Fate With the Birds?” Semin Thorac Cardiovasc Surg 33, no. 4 (2021): 1122. https://doi.org/10.1053/j.semtcvs.2021.03.012.Full Text Link to Item
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Nasir, Basil S., Jacob Klapper, and Matthew Hartwig. “Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality.” Curr Transplant Rep 8, no. 2 (2021): 140–50. https://doi.org/10.1007/s40472-021-00323-4.Full Text Link to Item
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Klapper, J. A. “Commentary: An ingenious solution born out of necessity.” Jtcvs Techniques 4 (December 1, 2020): 401. https://doi.org/10.1016/j.xjtc.2020.08.069.Full Text
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Klapper, J. A. “Commentary: When the field just moves on.” Jtcvs Open 4 (December 1, 2020): 103–4. https://doi.org/10.1016/j.xjon.2020.09.006.Full Text
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Choi, Ashley Y., Oliver K. Jawitz, Vignesh Raman, Samantha E. Halpern, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Predictors of Older Donor Lung Use: Are We Too Good at Saying No?” Ann Thorac Surg 110, no. 5 (November 2020): 1683–90. https://doi.org/10.1016/j.athoracsur.2020.04.050.Full Text Link to Item
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Bottiger, Brandi A., Jacob Klapper, Angela Pollak, and Ian Welsby. “When Therapy Is Confounded With Approach: Retrospective Studies of Transfusion-Related Outcomes After Lung Transplantation.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3021–23. https://doi.org/10.1053/j.jvca.2020.07.064.Full Text Link to Item
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Halpern, Samantha E., Danae G. Olaso, Madison K. Krischak, John M. Reynolds, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Lung transplantation during the COVID-19 pandemic: Safely navigating the new "normal".” Am J Transplant 20, no. 11 (November 2020): 3094–3105. https://doi.org/10.1111/ajt.16304.Full Text Link to Item
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Seay, Theresa, Nicole Guinn, Yasmin Maisonave, Matt Fuller, Jessica Poisson, Angela Pollak, Ben Bryner, et al. “The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3024–32. https://doi.org/10.1053/j.jvca.2020.05.043.Full Text Link to Item
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Raman, Vignesh, John K. Christopher, Oliver K. Jawitz, and Jacob A. Klapper. “Robot- vs Video-Assisted Thoracoscopic Lobectomy for Early Lung Cancer.” Jnci Cancer Spectr 4, no. 5 (October 2020): pkaa031. https://doi.org/10.1093/jncics/pkaa031.Full Text Link to Item
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Rolfe, Robert, Wiley A. Schell, Becky Smith, Jacob Klapper, John R. Perfect, and Julia A. Messina. “Black mold takes hold and story told.” Med Mycol Case Rep 29 (September 2020): 12–14. https://doi.org/10.1016/j.mmcr.2020.05.005.Full Text Link to Item
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Barac, Yaron D., Mike S. Mulvihill, Oliver Jawitz, Jacob Klapper, John Haney, Mani Daneshmand, Basil Nasir, Dongfeng Chen, Carmelo A. Milano, and Matthew G. Hartwig. “Increased Calculated Panel Reactive Antigen Is Associated With Increased Waitlist Time and Mortality in Lung Transplantation.” Ann Thorac Surg 110, no. 2 (August 2020): 414–23. https://doi.org/10.1016/j.athoracsur.2020.02.061.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Innovation…or disruption and the delayed acknowledgement of a new reality.” J Thorac Cardiovasc Surg 160, no. 2 (August 2020): 583–84. https://doi.org/10.1016/j.jtcvs.2019.10.170.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Let's just celebrate this win.” J Thorac Cardiovasc Surg 161, no. 1 (July 13, 2020): e43. https://doi.org/10.1016/j.jtcvs.2020.06.103.Full Text Link to Item
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Barac, Yaron D., Jacob Klapper, Angela Pollack, Jessica Poisson, Ian Welsby, M. G. Hartwig, and Brandi Bottiger. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant.” Ann Thorac Surg 110, no. 1 (July 2020): e23–25. https://doi.org/10.1016/j.athoracsur.2019.11.056.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Admission is not absolution-The burden of proof remains.” J Thorac Cardiovasc Surg 159, no. 6 (June 2020): 2570. https://doi.org/10.1016/j.jtcvs.2019.10.020.Full Text Link to Item
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Armstrong, Jenna L., Charles M. Wojnarski, Ashley Y. Choi, Matthew G. Hartwig, Jacob A. Klapper, John C. Haney, Carmelo A. Milano, and Mani A. Daneshmand. “Constrictive Pericarditis After Lung Transplantation.” Transplantation 104, no. 5 (May 2020): 1081–84. https://doi.org/10.1097/TP.0000000000002943.Full Text Link to Item
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Mulvihill, Michael S., Hui J. Lee, Jeremy Weber, Ashley Y. Choi, Morgan L. Cox, Babatunde A. Yerokun, Muath A. Bishawi, Jacob Klapper, Maragatha Kuchibhatla, and Matthew G. Hartwig. “Variability in donor organ offer acceptance and lung transplantation survival.” J Heart Lung Transplant 39, no. 4 (April 2020): 353–62. https://doi.org/10.1016/j.healun.2019.12.010.Full Text Link to Item
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VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.Full Text Open Access Copy Link to Item
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Jawitz, Oliver K., Vignesh Raman, Jacob Klapper, Matthew Hartwig, Chetan B. Patel, and Carmelo Milano. “Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry.” Transpl Int 32, no. 11 (November 2019): 1194–1202. https://doi.org/10.1111/tri.13481.Full Text Link to Item
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Jawitz, Oliver K., Vignesh Raman, Yaron Barac, Michael S. Mulvihill, Carrie Moore, Ashley Y. Choi, Matthew Hartwig, and Jacob Klapper. “Impact of Donor Brain Death Duration on Outcomes After Lung Transplantation.” Ann Thorac Surg 108, no. 5 (November 2019): 1519–26. https://doi.org/10.1016/j.athoracsur.2019.05.026.Full Text Link to Item
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Alnasser, Saleh A., Hai V. Salfity, Jacob A. Klapper, and Matthew G. Hartwig. “Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation.” Ann Thorac Surg 108, no. 4 (October 2019): e225–27. https://doi.org/10.1016/j.athoracsur.2019.02.014.Full Text Link to Item
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Barac, Yaron D., Oliver K. Jawitz, Jacob Klapper, Jacob Schroder, Mani A. Daneshmand, Chet Patel, Matt G. Hartwig, Nancy K. Sweitzer, and Carmelo A. Milano. “Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors: UNOS Registry Propensity-Matched Analysis.” J Am Heart Assoc 8, no. 17 (September 3, 2019): e012894. https://doi.org/10.1161/JAHA.119.012894.Full Text Link to Item
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Klapper, Jacob A. “Commentary: Failing grades.” J Thorac Cardiovasc Surg 158, no. 3 (September 2019): 965. https://doi.org/10.1016/j.jtcvs.2019.03.037.Full Text Link to Item
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Nasir, Basil S., Michael S. Mulvihill, Yaron D. Barac, Muath Bishawi, Morgan L. Cox, Dominick J. Megna, John C. Haney, Jacob A. Klapper, Mani A. Daneshmand, and Matthew G. Hartwig. “Single lung transplantation in patients with severe secondary pulmonary hypertension.” J Heart Lung Transplant 38, no. 9 (September 2019): 939–48. https://doi.org/10.1016/j.healun.2019.06.014.Full Text Link to Item
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Moore, Carrie B., Morgan L. Cox, Michael S. Mulvihill, Jacob Klapper, Thomas A. D’Amico, and Matthew G. Hartwig. “Challenging 30-day mortality as a site-specific quality metric in non-small cell lung cancer.” J Thorac Cardiovasc Surg 158, no. 2 (August 2019): 570-578.e3. https://doi.org/10.1016/j.jtcvs.2019.02.123.Full Text Link to Item
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Fierro, Michael A., Benjamin Dunne, David N. Ranney, Mani A. Daneshmand, John C. Haney, Jacob A. Klapper, Matthew G. Hartwig, Desiree Bonadonna, Michael W. Manning, and Raquel R. Bartz. “Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.” J Cardiothorac Vasc Anesth 33, no. 7 (July 2019): 1855–62. https://doi.org/10.1053/j.jvca.2019.01.055.Full Text Link to Item
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Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.Full Text Link to Item
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Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.Full Text Open Access Copy Link to Item
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Cox, Morgan L., Michael S. Mulvihill, Ashley Y. Choi, Muath Bishawi, Asishana A. Osho, John C. Haney, Mani Daneshmand, Jacob A. Klapper, Cameron R. Wolfe, and Matthew Hartwig. “Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.” J Heart Lung Transplant 38, no. 3 (March 2019): 295–305. https://doi.org/10.1016/j.healun.2018.12.012.Full Text Link to Item
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Barac, Yaron D., Mike S. Mulvihill, Morgan L. Cox, Muath Bishawi, Jacob Klapper, John Haney, Mani Daneshmand, and Matthew G. Hartwig. “Implications of blood group on lung transplantation rates: A propensity-matched registry analysis.” J Heart Lung Transplant 38, no. 1 (January 2019): 73–82. https://doi.org/10.1016/j.healun.2018.09.013.Full Text Link to Item
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Yang, Chi-Fu Jeffrey, Arvind Kumar, Jacob A. Klapper, Matthew G. Hartwig, Betty C. Tong, David H. Harpole, Mark F. Berry, and Thomas A. D’Amico. “A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer.” Ann Surg 269, no. 1 (January 2019): 163–71. https://doi.org/10.1097/SLA.0000000000002342.Full Text Link to Item
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Klapper, Jacob A. “Just buckle up.” J Thorac Cardiovasc Surg 156, no. 2 (August 2018): 806–7. https://doi.org/10.1016/j.jtcvs.2018.04.017.Full Text Link to Item
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Smith, Patrick J., Gregory L. Stonerock, Krista K. Ingle, Caroline K. Saulino, Benson Hoffman, Brian Wasserman, James A. Blumenthal, et al. “Neurological Sequelae and Clinical Outcomes After Lung Transplantation.” Transplant Direct 4, no. 4 (April 2018): e353. https://doi.org/10.1097/TXD.0000000000000766.Full Text Open Access Copy Link to Item
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Yang, Chi-Fu Jeffrey, Frances McSherry, Nicholas R. Mayne, Xiaofei Wang, Mark F. Berry, Betty Tong, David H. Harpole, et al. “Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.” Ann Thorac Surg 105, no. 3 (March 2018): 924–29. https://doi.org/10.1016/j.athoracsur.2017.09.030.Full Text Link to Item
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Nellis, Joseph R., Zachary W. Fitch, Ashley Y. Choi, James M. Meza, Zebulon Z. Spector, Nicholas H. Von Bergen, Jose E. Torres, Jacob A. Klapper, Jude S. Sauer, and Joseph W. Turek. “A Minimally Invasive Approach for Placing Sew-On Epicardial Leads in the Child.” Innovations (Phila) 13, no. 6 (2018): 455–57. https://doi.org/10.1097/IMI.0000000000000568.Full Text Link to Item
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Klapper, Jacob A. “With age comes…a missed opportunity?” J Thorac Cardiovasc Surg 154, no. 6 (December 2017): 2134. https://doi.org/10.1016/j.jtcvs.2017.07.062.Full Text Link to Item
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Klapper, Jacob A. “Like a phoenix: The rise of an extracorporeal membrane oxygenation program.” J Thorac Cardiovasc Surg 154, no. 5 (November 2017): 1810. https://doi.org/10.1016/j.jtcvs.2017.07.014.Full Text Link to Item
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Felmly, Lloyd M., Hyejin Kwon, Chadrick E. Denlinger, and Jacob A. Klapper. “Esophageal Perforation: A Common Clinical Problem with Many Different Management Options.” Am Surg 83, no. 8 (August 1, 2017): 911–17.Link to Item
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Klapper, Jacob A., and Matthew G. Hartwig. “Robotic esophagectomy: a better way or just another way?” J Thorac Dis 9, no. 8 (August 2017): 2328–31. https://doi.org/10.21037/jtd.2017.08.57.Full Text Link to Item
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Klapper, Jacob A., Scott A. Hittinger, and Chadrick E. Denlinger. “Alternatives to Lobectomy for High-Risk Patients With Early-Stage Non-Small Cell Lung Cancer.” Ann Thorac Surg 103, no. 4 (April 2017): 1330–39. https://doi.org/10.1016/j.athoracsur.2016.11.045.Full Text Link to Item
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McLaurin, Sam, George B. Whitener, Toby Steinburg, Alan Finley, Timothy Heinke, Eric Nelson, G. J. Guldan Iii, Jacob Klapper, Peter Slinger, and James H. Abernathy. “A Unique Strategy for Lung Isolation During Tracheobronchoplasty.” J Cardiothorac Vasc Anesth 31, no. 2 (April 2017): 731–37. https://doi.org/10.1053/j.jvca.2016.11.027.Full Text Link to Item
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Denlinger, Chadrick E., Bradley LeNoir, Timothy P. Whelan, Luca Paoletti, and Jacob A. Klapper. “Lung Donation After Death Resulting From a Stanford Type A Aortic Dissection.” Ann Thorac Surg 103, no. 3 (March 2017): e273–75. https://doi.org/10.1016/j.athoracsur.2016.08.046.Full Text Link to Item
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Klapper, Jacob A., and Matthew G. Hartwig. “Tough problem, creative solution.” J Thorac Cardiovasc Surg 153, no. 2 (February 2017): 476. https://doi.org/10.1016/j.jtcvs.2016.10.038.Full Text Link to Item
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Hewett, Lara, Jennie Kwon, Joshua D. Adams, Chadrick E. Denlinger, and Jacob A. Klapper. “Intralobar Pulmonary Sequestration With Aneurysmal Feeding Vessel: Use of Hybrid Surgical Management.” Ann Thorac Surg 102, no. 6 (December 2016): e533–35. https://doi.org/10.1016/j.athoracsur.2016.05.043.Full Text Link to Item
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Klapper, Jacob A. “The necessity of self-promotion: A key component to early practice building.” J Thorac Cardiovasc Surg 151, no. 6 (June 2016): 1462–64. https://doi.org/10.1016/j.jtcvs.2016.02.012.Full Text Link to Item
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Klapper, Jacob, and Thomas A. D’Amico. “VATS versus open surgery for lung cancer resection: moving toward a minimally invasive approach.” J Natl Compr Canc Netw 13, no. 2 (February 2015): 162–64. https://doi.org/10.6004/jnccn.2015.0023.Full Text Link to Item
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Klapper, Jacob A., and Chadrick E. Denlinger. “Pathologic staging of the mediastinum: when and how?” J Thorac Cardiovasc Surg 148, no. 4 (October 2014): 1177–78. https://doi.org/10.1016/j.jtcvs.2014.09.001.Full Text Link to Item
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Klapper, Jacob, Sameer Hirji, Matthew G. Hartwig, Thomas A. D’Amico, David H. Harpole, Mark W. Onaitis, and Mark F. Berry. “Outcomes after pneumonectomy for benign disease: the impact of urgent resection.” J Am Coll Surg 219, no. 3 (September 2014): 518–24. https://doi.org/10.1016/j.jamcollsurg.2014.01.062.Full Text Link to Item
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Lonser, Russell R., Debbie K. Song, Jacob Klapper, Marygrace Hagan, Sungyoung Auh, P Benjamin Kerr, Deborah E. Citrin, John D. Heiss, Kevin Camphausen, and Steven A. Rosenberg. “Surgical management of melanoma brain metastases in patients treated with immunotherapy.” J Neurosurg 115, no. 1 (July 2011): 30–36. https://doi.org/10.3171/2011.3.JNS091107.Full Text Link to Item
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Klapper, Jacob A., Jeremy L. Davis, R Taylor Ripley, Franz O. Smith, Dao M. Nguyen, King F. Kwong, Leandro Mercedes, et al. “Thoracic metastasectomy for adoptive immunotherapy of melanoma: a single-institution experience.” J Thorac Cardiovasc Surg 140, no. 6 (December 2010): 1276–82. https://doi.org/10.1016/j.jtcvs.2010.05.020.Full Text Link to Item
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Goff, Stephanie L., Franz O. Smith, Jacob A. Klapper, Richard Sherry, John R. Wunderlich, Seth M. Steinberg, Donald White, Steven A. Rosenberg, Mark E. Dudley, and James C. Yang. “Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL.” J Immunother 33, no. 8 (October 2010): 840–47. https://doi.org/10.1097/CJI.0b013e3181f05b91.Full Text Link to Item
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Ripley, R Taylor, Jeremy L. Davis, Jacob A. Klapper, Aarti Mathur, Udai Kammula, Richard E. Royal, James C. Yang, et al. “Liver resection for metastatic melanoma with postoperative tumor-infiltrating lymphocyte therapy.” Ann Surg Oncol 17, no. 1 (January 2010): 163–70. https://doi.org/10.1245/s10434-009-0677-0.Full Text Link to Item
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Smith, Franz O., Jacob A. Klapper, John R. Wunderlich, Steven A. Rosenberg, and Mark E. Dudley. “Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma.” J Immunother 32, no. 8 (October 2009): 870–74. https://doi.org/10.1097/CJI.0b013e3181b36b69.Full Text Link to Item
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Klapper, Jacob A., Armen A. Thomasian, Douglas M. Smith, Gayle C. Gorgas, John R. Wunderlich, Franz O. Smith, Brian S. Hampson, Steven A. Rosenberg, and Mark E. Dudley. “Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy.” J Immunol Methods 345, no. 1–2 (June 30, 2009): 90–99. https://doi.org/10.1016/j.jim.2009.04.009.Full Text Link to Item
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Dudley, Mark E., James C. Yang, Richard Sherry, Marybeth S. Hughes, Richard Royal, Udai Kammula, Paul F. Robbins, et al. “Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.” J Clin Oncol 26, no. 32 (November 10, 2008): 5233–39. https://doi.org/10.1200/JCO.2008.16.5449.Full Text Link to Item
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Smith, Franz O., Stephanie G. Downey, Jacob A. Klapper, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, et al. “Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.” Clin Cancer Res 14, no. 17 (September 1, 2008): 5610–18. https://doi.org/10.1158/1078-0432.CCR-08-0116.Full Text Link to Item
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Klapper, Jacob A., Stephanie G. Downey, Franz O. Smith, James C. Yang, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, Richard E. Royal, Seth M. Steinberg, and Steven Rosenberg. “High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.” Cancer 113, no. 2 (July 15, 2008): 293–301. https://doi.org/10.1002/cncr.23552.Full Text Link to Item
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Downey, Stephanie G., Jacob A. Klapper, Franz O. Smith, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, et al. “Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade.” Clin Cancer Res 13, no. 22 Pt 1 (November 15, 2007): 6681–88. https://doi.org/10.1158/1078-0432.CCR-07-0187.Full Text Link to Item
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Smith, Franz O., Stephanie L. Goff, Jacob A. Klapper, Catherine Levy, Tamika Allen, Sharon A. Mavroukakis, and Steven A. Rosenberg. “Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody.” J Immunother 30, no. 1 (January 2007): 130. https://doi.org/10.1097/01.cji.0000211334.06762.89.Full Text Link to Item
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Book Sections
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Klapper, J. A., and C. E. Denlinger. “Biological basis of esophageal adenocarcinoma.” In Modern Thoracic Oncology, 3–3:63–67, 2018.
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Klapper, J. A., B. Gulack, and M. G. Hartwig. “Reflux and aspiration: Their presumed role in chronic cough and the development of end-stage lung disease.” In Reflux Aspiration and Lung Disease, 213–23, 2018. https://doi.org/10.1007/978-3-319-90525-9_18.Full Text
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Conference Papers
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Hartwig, M. G., J. A. Klapper, N. Poola, A. Banga, P. G. Sanchez, J. S. Murala, and J. L. Potenziano. “A Randomized, Multicenter, Blinded Pilot Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs.” In Pulmonary Therapy, 9:151–63, 2023. https://doi.org/10.1007/s41030-022-00209-5.Full Text
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Halpern, Samantha E., Sandra Au, Samuel J. Kesseli, Madison K. Krischak, Danae G. Olaso, Brandi A. Bottiger, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Lung transplantation using allografts with more than 8 hours of ischemic time: A single-institution experience.” In J Heart Lung Transplant, 40:1463–71, 2021. https://doi.org/10.1016/j.healun.2021.05.008.Full Text Link to Item
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Bottiger, B., J. Klapper, M. Cooter, H. Salfity, A. Pollak, K. Ghadimi, J. Reynolds, J. Haney, M. Hartwig, and M. Stafford-Smith. “Perioperative Acute Kidney Injury after Sequential Bilateral Lung Transplant: Comparing Intraoperative Elective VA ECMO to an "Off Pump" Strategy.” In Journal of Heart and Lung Transplantation, 40:S167–S167, 2021.Link to Item
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Ghadimi, K., J. Cappiello, M. Cooter, J. Haney, J. Reynolds, B. A. Bottiger, J. Klapper, B. McLendon-Arvik, J. H. Levy, and M. G. Hartwig. “Inhaled Selective Pulmonary Vasodilators for Adult Lung Transplantation.” In Journal of Heart and Lung Transplantation, 40:S75–S75, 2021.Link to Item
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Salfity, H. V., B. Bottiger, M. Cooter, J. Poisson, L. Zaffiri, M. G. Hartwig, J. Haney, I. Welsby, and J. A. Klapper. “Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump.” In Journal of Heart and Lung Transplantation, 40:S331–S331, 2021.Link to Item
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Farrow, Norma E., Selena J. An, Paul J. Speicher, David H. Harpole, Thomas A. D’Amico, Jacob A. Klapper, Matthew G. Hartwig, and Betty C. Tong. “Disparities in guideline-concordant treatment for node-positive, non-small cell lung cancer following surgery.” In J Thorac Cardiovasc Surg, 160:261-271.e1, 2020. https://doi.org/10.1016/j.jtcvs.2019.10.102.Full Text Link to Item
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Najmeh, S., J. Klapper, J. Poisson, M. Fuller, L. Zaffiri, J. Haney, M. Hartwig, et al. “Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S317, 2020. https://doi.org/10.1016/j.healun.2020.01.715.Full Text
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Pollak, A. L., J. Poisson, M. Cooter, Y. D. Barac, B. Bryner, J. Haney, M. G. Hartwig, et al. “Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S330, 2020. https://doi.org/10.1016/j.healun.2020.01.349.Full Text
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Halpern, S. E., A. McConnell, S. Peskoe, V. Raman, O. K. Jawitz, A. Y. Choi, J. C. Haney, J. A. Klapper, and M. G. Hartwig. “Risk Aversion in Lung Transplantation: Organ Procurement Organizations Differ in Willingness to Pursue Non-Ideal Donor Organs.” In American Journal of Transplantation, 20:527–28, 2020.Link to Item
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Kakoullis, S. A., E. M. Eichenberger, J. M. Steinbrink, E. Maziarz, H. Ali, H. Berry, J. Haney, J. Klapper, J. M. Reynolds, and C. R. Wolfe. “Viremic Hepatitis C (HCV) Donors a Viable Option for Lung Transplant Recipients Treated with Real World Delayed Therapy.” In American Journal of Transplantation, 20:522–23, 2020.Link to Item
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Kram, Shawn, Mary Tatum, Ehimemem Iboaya, and Jacob Klapper. “NONENTERAL ADMINISTRATION OF PRE-GABALIN FOR WITHDRAWAL IN A SURGICAL CRITICALLY ILL PATIENT.” In Critical Care Medicine, Vol. 48, 2020.Link to Item
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Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, Richard K. Wood, Deborah Fisher, Matthew G. Hartwig, Jacob Klapper, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.” In Dis Esophagus, 32:1–8, 2019. https://doi.org/10.1093/dote/doz039.Full Text Link to Item
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Yang, Nancy, Shai Posner, Raymond T. Finn, Alice Parish, Rahul A. Shimpi, Richard K. Wood, Deborah A. Fisher, et al. “IDENTIFYING GASTROESOPHAGEAL REFLUX DISEASE POST-LUNG TRANSPLANT IS NOT IMPROVED WITH INTRALUMINAL IMPEDANCE VERSUS PH-METRY.” In Gastroenterology, 156:S297–98. W B SAUNDERS CO-ELSEVIER INC, 2019.Link to Item
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Choi, A. Y., M. S. Mulvihill, J. Weber, H. Lee, M. Cox, B. Yerokun, M. Kuchibhatla, J. A. Klapper, and M. G. Hartwig. “Center Variability in Organ Offer Acceptance and Waitlist Mortality in Lung Transplantation.” In American Journal of Transplantation, 19:397–98. WILEY, 2019.Link to Item
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Barac, Y. D., J. Klapper, J. Poisson, L. Zaffiri, A. Pollack, T. Seay, O. Jawitz, et al. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant: 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal.” In The Journal of Heart and Lung Transplantation, 38:S419–S419. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.1069.Full Text
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Barac, Y. D., M. Mulvihill, O. Jawitz, J. Haney, J. Klapper, M. Daneshmand, and M. Hartwig. “High Calculated Panel Reactive Antigen (cPRA) is Associated with Decreased Rates of Transplantation and Increased Waitlist Mortality in Lung Transplantation: A UNOS/OPTN Registry Analysis.” In The Journal of Heart and Lung Transplantation, 38:S148–S148. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.353.Full Text
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Barac, Y. D., O. Jawitz, J. Klapper, J. Schroder, M. Daneshmand, C. Patel, C. Milano, and M. Hartwig. “Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors.” In The Journal of Heart and Lung Transplantation, 38:S186–S186. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.449.Full Text
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Barac, Y. D., O. Jawitz, V. Raman, M. Hartwig, J. Klapper, J. Schroder, M. Daneshmand, C. Patel, and C. Milano. “Mitigating the Impact of Gender Mismatch in Heart Transplantation Using BMI and BSA Ratios.” In The Journal of Heart and Lung Transplantation, 38:S161–S161. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.384.Full Text
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Choi, A. Y., M. S. Mulvihill, J. Weber, H. Lee, M. L. Cox, B. A. Yerokun, M. Kuchibhatla, J. A. Klapper, and M. G. Hartwig. “Center Variability in Organ Offer Acceptance and Waitlist Mortality in Lung Transplantation.” In The Journal of Heart and Lung Transplantation, 38:S103–4. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.243.Full Text
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Jawitz, O. K., V. Raman, Y. Barac, M. Mulvihill, C. Moore, A. Choi, M. Hartwig, and J. Klapper. “Time from Lung Transplant Donor Brain Death to Cross Clamp: An Analysis of the UNOS Registry.” In The Journal of Heart and Lung Transplantation, 38:S190–S190. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.459.Full Text
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Yang, Nancy, Shai Posner, Alice Parish, Rahul Shimpi, Richard Wood, Thomas Finn, Deborah Fisher, et al. “Gastric Emptying Is Not Associated With Esophageal Motility Pattern or Patient Outcomes After Lung Transplantation.” In American Journal of Gastroenterology, 113:S227–S227. NATURE PUBLISHING GROUP, 2018.Link to Item
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Davis, R., Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, and A. Barbas. “CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion.” In American Journal of Transplantation, 18:505–505. WILEY, 2018.Link to Item
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Barc, Y., M. Mulvihill, M. Cox, M. Bishawi, J. Klapper, J. Haney, M. Daneshmand, and M. Hartwig. “Blood Group O is Associated with Decreased Rates of Transplantation and Increased Waitlist Mortality in Lung Transplantation: A Propensity-Matched Registry Analysis.” In The Journal of Heart and Lung Transplantation, 37:S167–S167. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.405.Full Text
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Bottiger, B., J. Klapper, V. Esposito, N. Hashmi, M. Berger, and P. Smith. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” In The Journal of Heart and Lung Transplantation, 37:S252–53. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.628.Full Text
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Cox, M. L., M. S. Mulvihill, M. Bishawi, A. A. Osho, J. Klapper, J. C. Haney, M. A. Daneshmand, and M. G. Hartwig. “Implications of the Refusal of Increased Risk Donor Offers on Waitlist Survival in Lung Transplantation.” In The Journal of Heart and Lung Transplantation, 37:S200–S200. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.486.Full Text
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Davis, R., Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, and A. Barbas. “CXCR4 Inhibition Improves Donor Leukocyte Depletion During Ex Vivo Lung Perfusion.” In The Journal of Heart and Lung Transplantation, 37:S221–S221. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.546.Full Text
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Nasir, B. S., M. S. Mulvihill, M. Bishawi, M. L. Cox, D. J. Megna, J. C. Haney, J. A. Klapper, M. A. Daneshmand, and M. G. Hartwig. “Single Lung Transplantation in Patients with Severe Secondary Pulmonary Hypertension.” In The Journal of Heart and Lung Transplantation, 37:S456–S456. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.1187.Full Text
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