Scholars@Duke
Jacob A Klapper

Jacob A Klapper

Associate Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery

Selected Publications

Transfusions in Lung Transplantation: Reply.

Journal Article Anesthesiology · December 1, 2024 Full text Link to item Cite

Commentary: Mission accomplished.

Journal Article J Thorac Cardiovasc Surg · August 28, 2024 Full text Link to item Cite

The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding.

Journal Article J Cardiothorac Surg · July 25, 2024 BACKGROUND: Lung transplantation (LT) represents a high-risk procedure for end-stage lung diseases. This study describes the outcomes of patients undergoing LT that require massive transfusions as defined by the universal definition of perioperative bleedi ... Full text Link to item Cite

Short-term outcomes after third-time lung transplantation: A single institution experience.

Journal Article J Heart Lung Transplant · May 2024 BACKGROUND: Reoperative lung transplantation (LTx) survival has improved over time such that a growing number of patients may present for third-time LTx (L3Tx). To understand the safety of L3Tx, we evaluated perioperative outcomes and 3-year survival after ... Full text Link to item Cite

Efforts to improve the billing accuracy of robotic-assisted thoracic surgery through education, updated procedure cards, and electronic medical record system changes.

Journal Article BMJ Open Qual · April 22, 2024 Precise medical billing is essential for decreasing hospital liability, upholding environmental stewardship and ensuring fair costs for patients. We instituted a multifaceted approach to improve the billing accuracy of our robotic-assisted thoracic surgery ... Full text Link to item Cite

Computed Tomography Volumetrics for Size Matching in Lung Transplantation for Restrictive Disease.

Journal Article Ann Thorac Surg · February 2024 BACKGROUND: There is no consensus on the optimal allograft sizing strategy for lung transplantation in restrictive lung disease. Current methods that are based on predicted total lung capacity (pTLC) ratios do not account for the diminutive recipient chest ... Full text Link to item Cite

Impact of simultaneous heart procurement on outcomes of donation after circulatory death lung transplantation.

Journal Article Am J Transplant · January 2024 Donation after circulatory death (DCD) heart procurement is done using either direct procurement (DP) or thoracoabdominal normothermic machine perfusion (TA-NRP). Both approaches could impact lung transplant outcomes with combined heart and lung procuremen ... Full text Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.

Journal Article Dis Esophagus · July 27, 2023 Gastroesophageal reflux disease (GERD) is common in patients who have undergone lung transplantation and is associated with poorer outcomes, but guidelines are lacking to direct management strategies in this population. We assessed the diagnostic yield of ... Full text Link to item Cite

Commentary: Experience fills the void.

Journal Article J Thorac Cardiovasc Surg · April 2023 Full text Link to item Cite

A Randomized, Multicenter, Blinded Pilot Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs.

Conference Pulm Ther · March 2023 INTRODUCTION: Normothermic ex vivo lung perfusion (EVLP) is used to evaluate and condition donor lungs for transplantation. The objective of this study was to determine whether administration of exogenous nitric oxide during EVLP contributes to improvement ... Full text Link to item Cite

Same-teams versus different-teams for long distance lung procurement: A cost analysis.

Journal Article J Thorac Cardiovasc Surg · March 2023 OBJECTIVE: In an era of broader lung sharing, different-team transplantation (DT, procuring team from nonrecipient center) may streamline procurement logistics; however, safety and cost implications of DT remain unclear. To understand whether DT represents ... Full text Link to item Cite

Textbook Outcome: Definition and Analysis of a Novel Quality Measure in Lung Transplantation.

Journal Article Ann Surg · February 1, 2023 OBJECTIVE: To define textbook outcome (TO) for lung transplantation (LTx) using a contemporary cohort from a high-volume institution. SUMMARY BACKGROUND DATA: TO is a standardized, composite quality measure based on multiple postoperative endpoints represe ... Full text Link to item Cite

Preoperative Optimization for Lung Transplant

Chapter · January 1, 2023 As the definition of lung transplant (LT) candidacy continues to expand, prospective recipients are presenting with increasing complexity and significant medical comorbidities. While patient selection is essential to developing a successful LT program, it ... Full text Cite

Commentary: Something gained, nothing wasted.

Journal Article J Thorac Cardiovasc Surg · December 2022 Full text Link to item Cite

Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension.

Journal Article J Heart Lung Transplant · November 2022 BACKGROUND: Planned venoarterial extracorporeal membrane oxygenation (VA ECMO) is increasingly used during bilateral orthotopic lung transplantation (BOLT) and may be superior to off-pump support for patients without pulmonary hypertension. In this single- ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Commentary: Good bad times.

Journal Article J Thorac Cardiovasc Surg · August 2022 Full text Link to item Cite

Lung Transplantation After Ex Vivo Lung Perfusion Early Outcomes From a US National Registry.

Journal Article Ann Surg · May 1, 2022 OBJECTIVE: The objective of this study was to examine early lung transplant outcomes following EVLP using a large national transplant registry. SUMMARY OF BACKGROUND DATA: Lung transplantation in the United States continues to be constrained by a limited s ... Full text Link to item Cite

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Journal Article Clin Transplant · April 2022 INTRO: Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to 1-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility ... Full text Link to item Cite

Factors associated with short- versus long-term survival after lung transplant.

Journal Article J Thorac Cardiovasc Surg · March 2022 OBJECTIVE: A small but growing proportion of lung transplant recipients survive longer than a decade post-transplant. The aim of this study was to identify factors associated with survival beyond a decade after lung transplant. METHODS: We queried the Unit ... Full text Link to item Cite

Commentary: Heroic tales from a national tragedy.

Journal Article J Thorac Cardiovasc Surg · March 2022 Full text Link to item Cite

Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis.

Journal Article Ann Thorac Surg · March 2022 BACKGROUND: There is clinical equipoise regarding the perioperative and long-term outcomes of autoimmune myasthenia gravis (MG) patients undergoing open vs minimally invasive thymectomy, particularly for nonthymomatous MG. This analysis utilizes multicente ... Full text Link to item Cite

Commentary: In the aftermath, what awaits us?

Journal Article J Thorac Cardiovasc Surg · March 2022 Full text Link to item Cite

Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · February 2022 OBJECTIVES: Pembrolizumab is a programmed death receptor-1 masking antibody approved for metastatic non-small cell lung cancer. This Phase 2 study (NCT02818920) of neoadjuvant pembrolizumab in non-small cell lung cancer had a primary end point of safety an ... Full text Link to item Cite

Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis.

Journal Article Am J Transplant · February 2022 Ex vivo lung perfusion (EVLP) is a novel lung preservation strategy that facilitates the use of marginal allografts; however, it is more expensive than static cold storage (SCS). To understand how preservation method might affect postoperative costs, we co ... Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal Article JAMA Surg · January 1, 2022 IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Gastroparesis Following Lung Transplant: A Single Center's Experience

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Textbook Outcome in Lung Transplantation: Planned VA ECMO versus Off-Pump.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Lung transplantation using allografts with more than 8 hours of ischemic time: A single-institution experience.

Conference J Heart Lung Transplant · November 2021 BACKGROUND: Six hours was historically regarded as the limit of acceptable ischemic time for lung allografts. However, broader sharing of donor lungs often necessitates use of allografts with ischemic time >6 hours. We characterized the association between ... Full text Link to item Cite

Lung retransplantation in the modern era.

Journal Article J Thorac Dis · November 2021 Chronic lung allograft dysfunction remains the leading cause of long-term morbidity and mortality for lung transplant recipients. Lung retransplantation currently represents the only therapeutic option for patients for refractory allograft dysfunction. How ... Full text Link to item Cite

Blood product transfusion and lung transplant outcomes: A systematic review.

Journal Article Clinical transplantation · October 2021 The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and aft ... Full text Cite

Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival.

Journal Article Clin Transplant · September 2021 BACKGROUND: Organ procurement organizations (OPOs) vary in willingness to pursue and utilize non-ideal donor lungs; implications of these practices for lung transplant (LTx) recipients remain unclear. We examined associations between OPO-level behavior tow ... Full text Link to item Cite

Commentary: A testament to longevity.

Journal Article J Thorac Cardiovasc Surg · June 2021 Full text Link to item Cite

Expanding donor availability in lung transplantation: A case report of 5000 miles traveled.

Journal Article Am J Transplant · June 2021 We present the case of a 41-year-old female who underwent bilateral lung transplantation after the donor lungs were placed on a normothermic ex vivo lung perfusion and ventilation device and flown nearly 5000 miles from Honolulu, Hawaii to Durham, North Ca ... Full text Link to item Cite

Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.

Journal Article Ann Thorac Surg · April 2021 BACKGROUND: Heart transplantation is limited by the supply of donor organs. Previous studies have associated female donor to male recipient with decreased posttransplant survival. We wanted to evaluate whether this risk can be mitigated using higher donor ... Full text Link to item Cite

Safety and efficacy of an implantable device for management of gastroesophageal reflux in lung transplant recipients.

Journal Article J Thorac Dis · April 2021 BACKGROUND: Magnetic sphincter augmentation (MSA) is a promising minimally invasive surgical technique for management of gastroesophageal reflux disease (GERD); however, device implantation after transplantation has not been studied and may be concerning i ... Full text Link to item Cite

Dual Procurement of Lung and Heart Allografts Does Not Negatively Affect Lung Transplant Outcomes.

Journal Article J Surg Res · March 2021 BACKGROUND: The data that exists regarding multiorgan procurement outcomes is conflicted. Given the increasing demand for pulmonary allografts, it is critical to assess the impact of dual procurement on lung transplant recipient outcomes. METHODS: The Unit ... Full text Link to item Cite

Predictors of nonuse of donation after circulatory death lung allografts.

Journal Article J Thorac Cardiovasc Surg · February 2021 OBJECTIVE: Despite growing evidence of comparable outcomes in recipients of donation after circulatory death and donation after brain death donor lungs, donation after circulatory death allografts continue to be underused nationally. We examined predictors ... Full text Link to item Cite

Commentary: The Field Moves Forward.

Journal Article Semin Thorac Cardiovasc Surg · 2021 Full text Link to item Cite

Center volume and primary graft dysfunction in patients undergoing lung transplantation in the United States - a cohort study.

Journal Article Transpl Int · January 2021 Lung transplantation primary graft dysfunction (PGD) is common and portends poor outcomes. We examined the association of lung transplant center volume with PGD and the risk of mortality. The United Network for Organ Sharing transplant registry was queried ... Full text Link to item Cite

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality.

Journal Article Curr Transplant Rep · 2021 PURPOSE OF REVIEW: We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality. RECENT FINDINGS: The number of ... Full text Link to item Cite

Inhaled Selective Pulmonary Vasodilators for Adult Lung Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Commentary: Is Our Fate With the Birds?

Journal Article Semin Thorac Cardiovasc Surg · 2021 Full text Link to item Cite

Commentary: An ingenious solution born out of necessity

Journal Article JTCVS Techniques · December 1, 2020 Full text Cite

Commentary: When the field just moves on

Journal Article JTCVS Open · December 1, 2020 Full text Cite

Predictors of Older Donor Lung Use: Are We Too Good at Saying No?

Journal Article Ann Thorac Surg · November 2020 BACKGROUND: Patterns of use of older donor lungs within this previously underused donor population are poorly characterized. This study examined factors associated with the use of older donor lung allografts and factors associated with survival in recipien ... Full text Link to item Cite

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

Journal Article J Cardiothorac Vasc Anesth · November 2020 OBJECTIVES: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product require ... Full text Link to item Cite

Lung transplantation during the COVID-19 pandemic: Safely navigating the new "normal".

Journal Article Am J Transplant · November 2020 In the United States, an overall national decline in organ transplants has accompanied the substantial burden of COVID-19. Amidst significant regional variations in COVID-19, lung transplantation (LTx) remains a critical life-saving operation. Our LTx prac ... Full text Link to item Cite

Black mold takes hold and story told.

Journal Article Med Mycol Case Rep · September 2020 We present a case of an invasive Curvularia infection in a patient who developed following bilateral orthotopic lung transplantation despite receiving post-transplant antifungal prophylaxis. This infection presented as mold colonies studding the interior s ... Full text Link to item Cite

Increased Calculated Panel Reactive Antigen Is Associated With Increased Waitlist Time and Mortality in Lung Transplantation.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Sensitized candidates with unacceptable antigens are a group that demands special attention in organ transplantation. Calculated panel reactive antigen (cPRA) is not used to modify allocation priorities in lung transplantation. The impact of cP ... Full text Link to item Cite

Commentary: Let's just celebrate this win.

Journal Article J Thorac Cardiovasc Surg · July 13, 2020 Full text Link to item Cite

Disparities in guideline-concordant treatment for node-positive, non-small cell lung cancer following surgery.

Conference J Thorac Cardiovasc Surg · July 2020 OBJECTIVES: To examine guideline concordance across a national sample and determine the relationship between socioeconomic factors, use of recommended postoperative adjuvant therapy, and outcomes for patients with resected pN1 or pN2 non-small cell lung ca ... Full text Link to item Cite

Anticoagulation Strategies in the Perioperative Period for Lung Transplant.

Journal Article Ann Thorac Surg · July 2020 Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to re ... Full text Link to item Cite

Constrictive Pericarditis After Lung Transplantation.

Journal Article Transplantation · May 2020 BACKGROUND: Constrictive pericarditis is a rare, but increasingly recognized long-term postoperative complication of lung transplantation. Heightened clinical suspicion, improved diagnostic imaging, and effective surgical treatment of the disease have led ... Full text Link to item Cite

Variability in donor organ offer acceptance and lung transplantation survival.

Journal Article J Heart Lung Transplant · April 2020 BACKGROUND: Lung transplantation offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the offer for a matched candidate on their waitlist. The degree to which variability in ... Full text Link to item Cite

Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Transfusion during lung transplantation (LT) is linked to primary graft dysfunction (PGD) and worsened outcomes. Goal-directed protocols have improved outcomes in cardiac surgical populations and decreased transfusions in LT on cardiopulmonary byp ... Full text Cite

Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Blood transfusion during lung transplantation (LT) surgery is common. There is little evidence to identify potential candidates for transfusion-free LT surgery. We describe patient and procedural characteristics of LT patients in the era of ECMO a ... Full text Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.

Conference Dis Esophagus · December 13, 2019 Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The a ... Full text Link to item Cite

Impact of Donor Brain Death Duration on Outcomes After Lung Transplantation.

Journal Article Ann Thorac Surg · November 2019 BACKGROUND: Donor brain death duration (BDD) may impact posttransplant graft function and survival in lung transplant. METHODS: We queried the 2007 to 2018 United Network for Organ Sharing Registry for adult recipients undergoing first-time isolated lung t ... Full text Link to item Cite

Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry.

Journal Article Transpl Int · November 2019 The association of donor and recipient age with survival following adult heart transplantation has not been well characterized. The purpose of this study was to examine the impact of the relationship between donor and recipient age on post-transplant survi ... Full text Link to item Cite

Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation.

Journal Article Ann Thorac Surg · October 2019 Magnetic sphincter augmentation with the LINX Reflux Management System (Torax Medical, St. Paul, MN) is a recently introduced surgical option with comparable therapeutic efficacy for medically refractory gastroesophageal reflux disease. An appropriately si ... Full text Link to item Cite

Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors: UNOS Registry Propensity-Matched Analysis.

Journal Article J Am Heart Assoc · September 3, 2019 Background The transplantation of hearts from traumatically brain-injured (TBI) donors has been associated with inferior long-term survival in single-center analyses. However, in a more recent analysis, death caused by cerebrovascular accident was associat ... Full text Link to item Cite

Commentary: Failing grades.

Journal Article J Thorac Cardiovasc Surg · September 2019 Full text Link to item Cite

Single lung transplantation in patients with severe secondary pulmonary hypertension.

Journal Article J Heart Lung Transplant · September 2019 BACKGROUND: The optimal transplant strategy for patients with end-stage lung disease complicated by secondary pulmonary hypertension (PH) is controversial. The aim of this study is to define the role of single lung transplantation in this population. METHO ... Full text Link to item Cite

Challenging 30-day mortality as a site-specific quality metric in non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2019 OBJECTIVE: The objective of this project was to assess the best measure for postoperative outcomes by comparing 30-day and 90-day mortality rates after surgery for non-small cell lung cancer using the National Cancer Database. Secondarily, hospital perform ... Full text Link to item Cite

Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.

Journal Article J Cardiothorac Vasc Anesth · July 2019 OBJECTIVES: To analyze the perioperative management of veno-venous extracorporeal membrane oxygenation (VV ECMO) in patients undergoing major noncardiac surgical procedures, which is poorly described in the literature. In doing so, perioperative challenges ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Center Variability in Organ Offer Acceptance and Waitlist Mortality in Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Time from Lung Transplant Donor Brain Death to Cross Clamp: An Analysis of the UNOS Registry

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Mitigating the Impact of Gender Mismatch in Heart Transplantation Using BMI and BSA Ratios

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Heart Transplantation Survival and the Use of Traumatically Brain-Injured Donors

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

Journal Article J Heart Lung Transplant · March 2019 BACKGROUND: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-r ... Full text Link to item Cite

A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer.

Journal Article Ann Surg · January 2019 OBJECTIVE: The objective of this study was to compare the long-term survival of open versus thoracoscopic (VATS) lobectomy for early stage non-small-cell lung cancer (NSCLC). BACKGROUND: Data from national studies on long-term survival for VATS versus open ... Full text Link to item Cite

Implications of blood group on lung transplantation rates: A propensity-matched registry analysis.

Journal Article J Heart Lung Transplant · January 2019 BACKGROUND: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudice ... Full text Link to item Cite

Just buckle up.

Journal Article J Thorac Cardiovasc Surg · August 2018 Full text Link to item Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2018 Link to item Cite

Single Lung Transplantation in Patients with Severe Secondary Pulmonary Hypertension

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Neurological Sequelae and Clinical Outcomes After Lung Transplantation.

Journal Article Transplant Direct · April 2018 BACKGROUND: Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant recipients. METHODS: We co ... Full text Open Access Link to item Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion During Ex Vivo Lung Perfusion

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · March 2018 BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer. METHODS: From 2013 to 2017, posto ... Full text Link to item Cite

A Minimally Invasive Approach for Placing Sew-On Epicardial Leads in the Child.

Journal Article Innovations (Phila) · 2018 Traditionally, pacing leads are placed transvenously, although smaller pediatric patients who require permanent pacemakers may benefit from delaying tranvenous lead placement until they are larger. Alternative, minimally invasive atrioventricular pacing op ... Full text Link to item Cite

With age comes…a missed opportunity?

Journal Article J Thorac Cardiovasc Surg · December 2017 Full text Link to item Cite

Esophageal Perforation: A Common Clinical Problem with Many Different Management Options.

Journal Article Am Surg · August 1, 2017 Esophageal perforation is a complex clinical entity that has multiple etiologies and variability in presentation, making it challenging to diagnose and treat. The mortality of esophageal perforation has improved because therapies have evolved. Whereas prim ... Link to item Cite

Alternatives to Lobectomy for High-Risk Patients With Early-Stage Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · April 2017 The standard of care for the surgical management of non-small cell lung cancer remains a lobectomy. For patients with limited pulmonary reserve, lesser resections or nonoperative therapies may be indicated. The purpose of this review is to evaluate the out ... Full text Link to item Cite

A Unique Strategy for Lung Isolation During Tracheobronchoplasty.

Journal Article J Cardiothorac Vasc Anesth · April 2017 Full text Link to item Cite

Lung Donation After Death Resulting From a Stanford Type A Aortic Dissection.

Journal Article Ann Thorac Surg · March 2017 The number of lung transplantations performed in the United States has increased at a modest pace over the past decades and reached an all-time high of 2,052 in 2015. However, the transplant wait list mortality remains unacceptably high with approximately ... Full text Link to item Cite

Tough problem, creative solution.

Journal Article J Thorac Cardiovasc Surg · February 2017 Full text Link to item Cite

Intralobar Pulmonary Sequestration With Aneurysmal Feeding Vessel: Use of Hybrid Surgical Management.

Journal Article Ann Thorac Surg · December 2016 We describe the endovascular exclusion and surgical resection of an intralobar pulmonary sequestration supplied by an aneurysmal feeding vessel from the aorta. Pulmonary sequestration is a rare congenital anomaly, and the presence of an aneurysmal feeding ... Full text Link to item Cite

VATS versus open surgery for lung cancer resection: moving toward a minimally invasive approach.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · February 2015 The use of video-assisted thoracoscopic surgery (VATS) has become the standard approach for the surgical resection of early-stage lung cancer. Although no large prospective, randomized, controlled trial has compared VATS lobectomy with thoracotomy, well-de ... Full text Cite

Pathologic staging of the mediastinum: when and how?

Journal Article J Thorac Cardiovasc Surg · October 2014 Full text Link to item Cite

Outcomes after pneumonectomy for benign disease: the impact of urgent resection.

Journal Article J Am Coll Surg · September 2014 BACKGROUND: Pneumonectomy for benign disease is often complicated by inflammatory processes that obscure operative planes. We reviewed our experience to evaluate the impact of requiring urgent or emergent pneumonectomy on outcomes. STUDY DESIGN: All pneumo ... Full text Link to item Cite

Surgical management of melanoma brain metastases in patients treated with immunotherapy.

Journal Article J Neurosurg · July 2011 OBJECT: Despite the increasing use of immunotherapy in the treatment of metastatic melanoma, the effects of this therapy on the management of patients with associated brain metastases are not completely defined. The authors undertook this study to determin ... Full text Link to item Cite

Thoracic metastasectomy for adoptive immunotherapy of melanoma: a single-institution experience.

Journal Article J Thorac Cardiovasc Surg · December 2010 OBJECTIVES: Although refractory to chemotherapy, metastatic melanoma may respond to adoptive immunotherapy. As novel treatments evolve, surgeons may be asked to perform metastasectomy not only for palliation or potential cure but also for isolation of tumo ... Full text Link to item Cite

Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL.

Journal Article J Immunother · October 2010 Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate objective tumor regression in 49% to 72% of patients with many long-term durable responses. To undergo treatment a patient must have (1) a resectable tumor from which (2) TIL can b ... Full text Link to item Cite

Liver resection for metastatic melanoma with postoperative tumor-infiltrating lymphocyte therapy.

Journal Article Ann Surg Oncol · January 2010 BACKGROUND: Patients with metastatic melanoma to the liver (MML) have a median survival of 4 to 6 months. This study evaluated patients who underwent liver resection with intent to receive postoperative tumor-infiltrating lymphocyte (TIL) therapy. METHODS: ... Full text Link to item Cite

Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma.

Journal Article J Immunother · October 2009 A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that r ... Full text Link to item Cite

Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy.

Journal Article J Immunol Methods · June 30, 2009 Adoptive cell therapy (ACT) for metastatic melanoma involves the ex vivo expansion and reinfusion of tumor infiltrating lymphocytes (TIL) obtained from resected specimens. With an overall objective response rate of 56%, this T-cell immunotherapy provides a ... Full text Link to item Cite

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.

Journal Article J Clin Oncol · November 10, 2008 PURPOSE: The two approved treatments for patients with metastatic melanoma, interleukin (IL)-2 and dacarbazine, mediate objective response rates of 12% to 15%. We previously reported that adoptive cell therapy (ACT) with autologous antitumor lymphocytes in ... Full text Link to item Cite

Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.

Journal Article Clin Cancer Res · September 1, 2008 PURPOSE: To identify prognostic factors associated with survival beyond 4 years and overall response in patients with metastatic melanoma treated with high-dose bolus i.v. interleukin-2 (IL-2) given either alone or in combination with a variety of melanoma ... Full text Link to item Cite

High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

Journal Article Cancer · July 15, 2008 BACKGROUND: The treatment of metastatic renal cell carcinoma (RCC) with high-dose interleukin-2 (HD IL-2) has resulted in durable tumor regression in a minority of patients. The current study presents the authors' 20-year experience administering this immu ... Full text Link to item Cite

Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade.

Journal Article Clin Cancer Res · November 15, 2007 PURPOSE: CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma ... Full text Link to item Cite