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Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.

Publication ,  Journal Article
Barac, YD; Jawitz, OK; Hartwig, MG; Klapper, J; Schroder, JN; Daneshmand, MA; Patel, CB; Milano, CA
Published in: Ann Thorac Surg
April 2021

BACKGROUND: Heart transplantation is limited by the supply of donor organs. Previous studies have associated female donor to male recipient with decreased posttransplant survival. We wanted to evaluate whether this risk can be mitigated using higher donor than recipient body mass index (BMI). METHODS: We performed a retrospective analysis of the Organ Procurement and Transplantation Network/United Network of Organ Sharing registry encompassing years 2005 to 2018 for all male adult recipients (>18 years of age) who underwent isolated heart transplantation with grafts from female donors. The association between donor and recipient BMI difference and recipient survival was evaluated using adjusted Cox proportional hazards modeling. RESULTS: A total of 3788 male recipients who received female donor hearts met inclusion criteria for analysis. Maximally selected rank statistics identified donor minus recipient BMI of 1.5 kg/m2 as a meaningful cutoff point in the analysis of recipient survival. Multivariable Cox proportional hazards analysis demonstrated that increasing donor BMI relative to recipient BMI up to this cutoff point was associated with improved survival (hazard ratio per 5-unit difference, 0.87; 95% confidence interval, 0.77-0.99). Above this cutoff point, increasing donor BMI relative to the recipient did not improve survival more than what was achieved by adding 1.5 of BMI difference (hazard ratio per 5-unit difference, 0.97; 95% confidence interval, 0.90-1.04). CONCLUSIONS: Increasing donor BMI relative to recipient BMI up to 1.5 kg/m2 greater than recipient BMI was associated with improved survival. BMI difference may be useful as a simple surrogate for predicted heart mass difference to help mitigate the impact of sex mismatch in heart transplantation.

Duke Scholars

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

April 2021

Volume

111

Issue

4

Start / End Page

1299 / 1307

Location

Netherlands

Related Subject Headings

  • Transplant Recipients
  • Tissue and Organ Procurement
  • Tissue Donors
  • Sex Factors
  • Risk Factors
  • Retrospective Studies
  • Respiratory System
  • Registries
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Barac, Y. D., Jawitz, O. K., Hartwig, M. G., Klapper, J., Schroder, J. N., Daneshmand, M. A., … Milano, C. A. (2021). Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference. Ann Thorac Surg, 111(4), 1299–1307. https://doi.org/10.1016/j.athoracsur.2020.06.109
Barac, Yaron D., Oliver K. Jawitz, Matthew G. Hartwig, Jacob Klapper, Jacob N. Schroder, Mani A. Daneshmand, Chetan B. Patel, and Carmelo A. Milano. “Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.Ann Thorac Surg 111, no. 4 (April 2021): 1299–1307. https://doi.org/10.1016/j.athoracsur.2020.06.109.
Barac YD, Jawitz OK, Hartwig MG, Klapper J, Schroder JN, Daneshmand MA, et al. Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference. Ann Thorac Surg. 2021 Apr;111(4):1299–307.
Barac, Yaron D., et al. “Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference.Ann Thorac Surg, vol. 111, no. 4, Apr. 2021, pp. 1299–307. Pubmed, doi:10.1016/j.athoracsur.2020.06.109.
Barac YD, Jawitz OK, Hartwig MG, Klapper J, Schroder JN, Daneshmand MA, Patel CB, Milano CA. Mitigating the Impact of Using Female Donor Hearts in Male Recipients Using BMI Difference. Ann Thorac Surg. 2021 Apr;111(4):1299–1307.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

April 2021

Volume

111

Issue

4

Start / End Page

1299 / 1307

Location

Netherlands

Related Subject Headings

  • Transplant Recipients
  • Tissue and Organ Procurement
  • Tissue Donors
  • Sex Factors
  • Risk Factors
  • Retrospective Studies
  • Respiratory System
  • Registries
  • Middle Aged
  • Male