Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Cincinnati, College of Medicine 1995
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2012 - 2013
• Recognition
• 

  In the News

  • APR 7, 2017

    Duke Health Blog

    Dukes Short Lung Transplant List Saves CF Patient
• Research
• 

  Selected Grants

  • Cystic Fibrosis Lung Transplant Consortium awarded by Cystic Fibrosis Foundation 2020 - 2022
  • Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
  • A phase III clinical trial to demonstrate the effectiveness and safety of Liposomal Cyclosporine A (L-CsA) inhalation solution delivered via the PARI Investigational eFlow device plus standard of care v. standard of care of BOS in double lung transpl awarded by BREATH Therapeutics 2019 - 2021
  • A phase III clinical trial to demonstrate the effectiveness and safety of Liposomal Cyclosporine A (L-CsA) inhalation solution delivered via the PARI Investigational eFlow device plus standard of care v. standard of care of BOS in single lung transpl awarded by BREATH Therapeutics 2019 - 2021
  • ECP Management of BOS awarded by Washington University in St. Louis 2018 - 2020
  • Cystic Fibrosis Lung Transplant Consortium awarded by Cystic Fibrosis Foundation Therapeutics, Inc. 2017 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zhang, Chen Yang Kevin, Musawir Ahmed, Ella Huszti, Liran Levy, Sarah E. Hunter, Kristen M. Boonstra, Sajad Moshkelgosha, et al. “Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.” J Heart Lung Transplant 39, no. 9 (September 2020): 934–44. https://doi.org/10.1016/j.healun.2020.05.006.
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    • Todd, Jamie L., Megan L. Neely, Heather Kopetskie, Michelle L. Sever, Jerry Kirchner, Courtney W. Frankel, Laurie D. Snyder, et al. “Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.” Am J Respir Crit Care Med 202, no. 4 (August 15, 2020): 576–85. https://doi.org/10.1164/rccm.201910-1915OC.
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    • Permpalung, Nitipong, Tany Thaniyavarn, Jennifer L. Saullo, Sana Arif, Rachel A. Miller, John M. Reynolds, and Barbara D. Alexander. “Oral and Inhaled Ribavirin Treatment for Respiratory Syncytial Virus Infection in Lung Transplant Recipients.” Transplantation 104, no. 6 (June 2020): 1280–86. https://doi.org/10.1097/TP.0000000000002985.
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    • Snyder, Laurie D., John Belperio, Marie Budev, Courtney Frankel, Jerry Kirchner, Tereza Martinu, Megan L. Neely, et al. “Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.” Am J Transplant 20, no. 6 (June 2020): 1489–94. https://doi.org/10.1111/ajt.15957.
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    • Nolley, Eric, Jessica Fleck, Dio Kavalieratos, Mary Amanda Dew, Daniel Dilling, Rebecca Colman, Maria M. Crespo, et al. “Lung Transplant Pulmonologists' Views of Specialty Palliative Care for Lung Transplant Recipients.” J Palliat Med 23, no. 5 (May 2020): 619–26. https://doi.org/10.1089/jpm.2019.0222.
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    • Baker, Arthur W., Eileen K. Maziarz, Christopher J. Arnold, Melissa D. Johnson, Adrienne D. Workman, John M. Reynolds, John R. Perfect, and Barbara D. Alexander. “Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.” Clin Infect Dis 70, no. 1 (January 1, 2020): 30–39. https://doi.org/10.1093/cid/ciz156.
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    • Barac, Yaron D., Benjamin Bryner, Desiree Bonadonna, Cameron Wolfe, John Reynolds, John C. Haney, and Mani A. Daneshmand. “Bilateral pneumonectomy with veno-arterial extracorporeal membrane oxygenation as a bridge to lung transplant.” J Heart Lung Transplant 38, no. 11 (November 2019): 1231–32. https://doi.org/10.1016/j.healun.2019.08.011.
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    • Weigt, S Samuel, Xiaoyan Wang, Vyacheslav Palchevskiy, Xinmin Li, Naman Patel, David J. Ross, John Reynolds, et al. “Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection.” J Heart Lung Transplant 38, no. 8 (August 2019): 845–55. https://doi.org/10.1016/j.healun.2019.05.001.
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    • Todd, Jamie L., Megan L. Neely, C. A. Finlen Copeland, Courtney W. Frankel, John M. Reynolds, and Scott M. Palmer. “Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.” J Heart Lung Transplant 38, no. 2 (February 2019): 184–93. https://doi.org/10.1016/j.healun.2018.10.006.
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    • Messina, Julia A., Cameron R. Wolfe, Marion Hemmersbach-Miller, Carmelo Milano, Jamie L. Todd, John Reynolds, Barbara D. Alexander, Wiley A. Schell, Christina A. Cuomo, and John R. Perfect. “Genomic characterization of recurrent mold infections in thoracic transplant recipients.” Transpl Infect Dis 20, no. 5 (October 2018): e12935. https://doi.org/10.1111/tid.12935.
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    • Philo, Sarah E., Benjamin D. Anderson, Sylvia F. Costa, Nancy Henshaw, Sarah S. Lewis, John M. Reynolds, Jayanthi Jayakumar, Yvonne C. F. Su, and Gregory C. Gray. “Adenovirus Type 21 Outbreak Among Lung Transplant Patients at a Large Tertiary Care Hospital.” Open Forum Infect Dis 5, no. 8 (August 2018): ofy188. https://doi.org/10.1093/ofid/ofy188.
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    • Freischlag, Kyle William, Julia Messina, Brian Ezekian, Michael S. Mulvihill, Andrew Barbas, Carl Berg, Debra Sudan, John Reynolds, Matthew Hartwig, and Stuart Knechtle. “Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.” Transplant Direct 4, no. 5 (May 2018): e349. https://doi.org/10.1097/TXD.0000000000000785.
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    • Gerity, Sandra L., Susan G. Silva, John M. Reynolds, Benson Hoffman, and Marilyn H. Oermann. “Multimedia Education Reduces Anxiety in Lung Transplant Patients.” Prog Transplant 28, no. 1 (March 2018): 83–86. https://doi.org/10.1177/1526924817746910.
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    • Farquhar, Julia M., Patrick J. Smith, Laurie Snyder, Alice L. Gray, John M. Reynolds, and James A. Blumenthal. “Patterns and predictors of pain following lung transplantation.” Gen Hosp Psychiatry 50 (January 2018): 125–30. https://doi.org/10.1016/j.genhosppsych.2017.11.007.
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    • Baker, Arthur W., Sarah S. Lewis, Barbara D. Alexander, Luke F. Chen, Richard J. Wallace, Barbara A. Brown-Elliott, Pamela J. Isaacs, et al. “Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.” Clin Infect Dis 64, no. 7 (April 1, 2017): 902–11. https://doi.org/10.1093/cid/ciw877.
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    • Smith, P. J., S. K. Rivelli, A. M. Waters, A. Hoyle, M. T. Durheim, J. M. Reynolds, M. Flowers, et al. “Delirium affects length of hospital stay after lung transplantation.” J Crit Care 30, no. 1 (February 2015): 126–29. https://doi.org/10.1016/j.jcrc.2014.09.010.
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    • Smith, Patrick J., Sara Rivelli, Alexa Waters, John Reynolds, Amelia Hoyle, Miranda Flowers, R. D. Davis, et al. “Neurocognitive changes after lung transplantation.” Ann Am Thorac Soc 11, no. 10 (December 2014): 1520–27. https://doi.org/10.1513/AnnalsATS.201406-232OC.
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    • Snyder, L. D., A. L. Gray, J. M. Reynolds, G. M. Arepally, A. Bedoya, M. G. Hartwig, R. D. Davis, et al. “Antibody desensitization therapy in highly sensitized lung transplant candidates.” Am J Transplant 14, no. 4 (April 2014): 849–56. https://doi.org/10.1111/ajt.12636.
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    • Todd, Jamie L., Rahil Jain, Elizabeth N. Pavlisko, C Ashley Finlen Copeland, John M. Reynolds, Laurie D. Snyder, and Scott M. Palmer. “Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.” Am J Respir Crit Care Med 189, no. 2 (January 15, 2014): 159–66. https://doi.org/10.1164/rccm.201306-1155OC.
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    • Suzuki, Hidemi, Mark E. Lasbury, Lin Fan, Ragini Vittal, Elizabeth A. Mickler, Heather L. Benson, Rebecca Shilling, et al. “Role of complement activation in obliterative bronchiolitis post-lung transplantation.” J Immunol 191, no. 8 (October 15, 2013): 4431–39. https://doi.org/10.4049/jimmunol.1202242.
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    • Lobo, L. J., J. M. Reynolds, and L. D. Snyder. “Rituximab-associated progressive multifocal leukoencephalopathy after lung transplantation.” The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation 32, no. 7 (July 1, 2013): 752–53.
    • Lobo, Leonard J., John M. Reynolds, and Laurie D. Snyder. “Rituximab-associated progressive multifocal leukoencephalopathy after lung transplantation.” J Heart Lung Transplant 32, no. 7 (July 2013): 752–53. https://doi.org/10.1016/j.healun.2013.04.007.
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    • Shah, Rupal J., Scarlett L. Bellamy, A Russell Localio, Nancy Wickersham, Joshua M. Diamond, Ann Weinacker, Vibha N. Lama, et al. “A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation.” J Heart Lung Transplant 31, no. 9 (September 2012): 942–49. https://doi.org/10.1016/j.healun.2012.05.001.
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    • Diamond, J. M., D. J. Lederer, S. M. Kawut, J. Lee, V. N. Ahya, S. Bellamy, S. M. Palmer, et al. “Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis.” Am J Transplant 11, no. 11 (November 2011): 2517–22. https://doi.org/10.1111/j.1600-6143.2011.03702.x.
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    • Palmer, Scott M., Ajit P. Limaye, Missy Banks, Dianne Gallup, Jeffrey Chapman, E Clinton Lawrence, Jordan Dunitz, et al. “Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial.” Ann Intern Med 152, no. 12 (June 15, 2010): 761–69. https://doi.org/10.7326/0003-4819-152-12-201006150-00003.
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    • Khan, Babar A., Michael Duncan, John Reynolds, and David S. Wilkes. “Nocardia infection in lung transplant recipients.” Clin Transplant 22, no. 5 (September 2008): 562–66. https://doi.org/10.1111/j.1399-0012.2008.00824.x.
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    • Fridell, Jonathan A., Thomas C. Wozniak, John M. Reynolds, John A. Powelson, Edward F. Hollinger, Michael W. Duncan, Aruna Sannuti, and Martin L. Milgrom. “Bilateral sequential lung and simultaneous pancreas transplant: a new approach for the recipient with cystic fibrosis.” J Cyst Fibros 7, no. 4 (July 2008): 280–84. https://doi.org/10.1016/j.jcf.2007.10.006.
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    • Fridell, J. A., T. C. Wozniak, J. A. Powelson, and J. M. Reynolds. “Simultaneous bilateral lung and pancreas transplantation in recipient with cystic fibrosis.” Transplant Proc 40, no. 2 (March 2008): 494–97. https://doi.org/10.1016/j.transproceed.2008.01.010.
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    • Smith, G. N., E. A. Mickler, K. K. Payne, J. Lee, M. Duncan, J. Reynolds, B. Foresman, and D. S. Wilkes. “Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome.” Am J Transplant 7, no. 7 (July 2007): 1856–61. https://doi.org/10.1111/j.1600-6143.2007.01850.x.
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    • Hage, Chadi A., John M. Reynolds, Michelle Durkin, L Joseph Wheat, and Kenneth S. Knox. “Plasmalyte as a cause of false-positive results for Aspergillus galactomannan in bronchoalveolar lavage fluid.” J Clin Microbiol 45, no. 2 (February 2007): 676–77. https://doi.org/10.1128/JCM.01940-06.
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  • Conference Papers

    • Eichenberger, E. M., G. R. Vece, S. Kakoullis, J. M. Steinbrink, J. M. Reynolds, and C. R. Wolfe. “Viremic Hepatitis B Donors: A Case of Why It's Time to Further Expand the Donor Pool for Thoracic Transplant.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S20, 2020. https://doi.org/10.1016/j.healun.2020.01.1148.
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    • Frankel, C. W., H. Kopetskie, M. Sever, M. Cosgrove, J. Kirchner, M. Robien, N. Williams, et al. “Prospective Assessment of Chronic Lung Allograft Dysfunction (CLAD); the Clinical Trials in Organ Transplantation (CTOT) Study Experience.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S303, 2020. https://doi.org/10.1016/j.healun.2020.01.677.
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    • Rozenberg, D., L. G. Singer, M. L. Neely, J. M. Weber, H. A. Kopetskie, M. L. Sever, J. Kirchner, et al. “Agreement between Fried Frailty Phenotype and Cumulative Deficits Frailty Indices: A Prospective Multi-Center Study.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S314, 2020. https://doi.org/10.1016/j.healun.2020.01.707.
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    • Shino, M. Y., R. M. Elashoff, N. Li, J. L. Todd, M. L. Neely, H. Kopetskie, M. Sever, et al. “A Multi-Center Study of BAL CXCR3 Chemokines during Allograft Injury after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S115, 2020. https://doi.org/10.1016/j.healun.2020.01.990.
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    • Todd, J. L., F. L. Kelly, M. L. Neely, K. Keslar, E. N. Pavlisko, S. J. McCall, A. Fletcher, et al. “NanoString Gene Expression Profiling in Chronic Lung Allograft Dysfunction (CLAD).” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S113, 2020. https://doi.org/10.1016/j.healun.2020.01.985.
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    • Zhang, C., P. H. Schneeberger, L. Levy, Y. Lee, E. Huszti, S. E. Hunter, M. Ahmed, et al. “Pulmonary Microbiome Changes in Lung Transplant Recipients with Gastroesophageal Reflux.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S105, 2020. https://doi.org/10.1016/j.healun.2020.01.963.
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    • Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, Richard K. Wood, Deborah Fisher, Matthew G. Hartwig, Jacob Klapper, et al. “Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.” In Dis Esophagus, 32:1–8, 2019. https://doi.org/10.1093/dote/doz039.
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    • Pavlisko, E. N., M. L. Neely, H. Kopetskie, D. Hwang, C. F. Farver, A. V. Arrossi, W. D. Wallace, et al. “Occurrence and Risk Factors for Acute Lung Injury (ALI) and Organizing Pneumonia (OP) after Lung Transplant.” In The Journal of Heart and Lung Transplantation, 38:S56–57. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.124.
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    • Permpalung, N., T. Thaniyavarn, J. H. Saullo, S. Arif, R. A. Miller, J. M. Reynolds, and B. D. Alexander. “Impact of Respiratory Syncytial Virus Infection on Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients.” In The Journal of Heart and Lung Transplantation, 38:S312–13. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.788.
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    • Todd, J. L., M. L. Neely, H. Kopetskie, M. Sever, J. Kirchner, C. W. Frankel, L. D. Snyder, et al. “Acute Rejection (AR) and Lymphocytic Bronchiolitis (LB) in a Multicenter Lung Transplant Cohort.” In The Journal of Heart and Lung Transplantation, 38:S402–3. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.1025.
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    • Wolfe, C. R., S. Sen, M. R. Kappus, J. N. Schroder, M. A. Daneshmand, J. C. Haney, C. A. Milano, J. M. Reynolds, and C. B. Patel. “Hepatitis and Thoracic Transplantation - No More Virus Non-Grata.” In The Journal of Heart and Lung Transplantation, 38:S308–S308. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.775.
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    • Todd, J. L., M. L. Neely, C. Brinkley, F. L. Kelly, C. W. Frankel, J. Kirchner, J. A. Belperio, et al. “Hyaluronan in Acute Rejection After Lung Transplantation.” In Journal of Heart and Lung Transplantation, 37:S441–S441. ELSEVIER SCIENCE INC, 2018.
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    • Todd, J. L., V. Venkat, R. Henao, C. Brinkley, F. L. Kelly, C. W. Frankel, A. Frear, et al. “Bronchoalveolar Lavage Fluid Proteome in Chronic Lung Allograft Dysfunction.” In Journal of Heart and Lung Transplantation, 37:S204–S204. ELSEVIER SCIENCE INC, 2018.
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    • Weigt, S., X. Wang, V. Palchevskiy, N. D. Patel, D. J. Ross, Y. M. Shino, J. M. Reynolds, et al. “Gene Expression Profiling of BAL Cells and PBMC During Lung Allograft Acute Cellular Rejection.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Chen, Dong-Feng, and John M. Reynolds. “P085 Lung re-transplant with repeated mismatch HLA antigens.” In Human Immunology, 78:115–115. Elsevier BV, 2017. https://doi.org/10.1016/j.humimm.2017.06.145.
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    • Weigt, S. S., X. Wang, V. Palchevskiy, N. D. Patel, D. J. Ross, J. M. Reynolds, P. Shah, et al. “Gene Expression Profiling of Bronchoalveolar Lavage Cells During Lung Allograft Acute Rejection.” In Journal of Heart and Lung Transplantation, 36:S187–88. ELSEVIER SCIENCE INC, 2017.
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    • Bates, C. A., C. W. Frankel, A. L. Gray, J. M. Reynolds, S. M. Palmer, and M. L. Neely. “Outcomes In Lung Transplant Recipients With Pulmonary Fibrosis At High Risk Of Death.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Hoffman, B. M., P. J. Smith, K. K. Ingle, G. L. Stonerock, C. Saulino, S. M. Palmer, L. D. Snyder, J. M. Reynolds, and J. A. Blumenthal. “Coping And Clinical Outcomes Among Lung Transplant Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Todd, J. L., M. W. Foster, A. Valente, C. Brinkley, H. A. Ali, J. M. Reynolds, F. L. Kelly, and S. M. Palmer. “Proteomics Of Bronchoalveolar Lavage (bal) Fluid In Bronchiolitis Obliterans Syndrome (bos).” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Reddy, L. S., M. Daneshmand, J. C. Haney, L. Snyder, A. L. Gray, J. M. Reynolds, and M. G. Hartwig. “Does Single Lung Transplantation Change Perfusion in Relation to Native Lung in Pulmonary Fibrosis? Implications in Choosing Laterality.” In The Journal of Heart and Lung Transplantation, 35:S68–S68. Elsevier BV, 2016. https://doi.org/10.1016/j.healun.2016.01.185.
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    • Gray, A. L., Z. Wang, N. Patel, J. M. Reynolds, R. D. Davis, S. M. Palmer, and L. D. Snyder. “Antibody Directed Therapy after Lung Transplant.” In The Journal of Heart and Lung Transplantation, 32:S170–71. Elsevier BV, 2013. https://doi.org/10.1016/j.healun.2013.01.406.
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    • Diamond, J. M., R. Feng, N. J. Meyer, R. Shah, S. M. Kawut, D. J. Lederer, J. C. Lee, et al. “209 Functional TLR4 Polymorphisms Are Associated with Lower Risk of Primary Graft Dysfunction (PGD) after Lung Transplantation.” In The Journal of Heart and Lung Transplantation, 31:S78–S78. Elsevier BV, 2012. https://doi.org/10.1016/j.healun.2012.01.208.
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