Scholars@Duke
John Michael Reynolds

Selected Publications

Limited utility of Epstein-Barr virus (EBV) surveillance for predicting post-transplant lymphoproliferative disorders in adult EBV seropositive lung transplant recipients.

Journal Article J Clin Virol · December 13, 2024 BACKGROUND: EBV DNAemia surveillance, with reduction of immunosuppression at certain viral load (VL) thresholds, is a common practice for mitigating progression from EBV DNAemia to post-transplant lymphoproliferative disorder (PTLD) in lung transplant reci ... Full text Link to item Cite

Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.

Journal Article J Heart Lung Transplant · December 4, 2024 BACKGROUND: Basiliximab induction immunosuppression is increasingly employed in lung transplant recipients despite limited prospective evidence to support its use in this population. We sought to determine the relationship between basiliximab induction and ... Full text Link to item Cite

Donor-derived Mycoplasma and Ureaplasma infections in lung transplant recipients: A prospective study of donor and recipient respiratory tract screening and recipient outcomes.

Journal Article Am J Transplant · December 2024 Mycoplasma hominis and Ureaplasma species are urogenital mollicutes that can cause serious donor-derived infections in lung transplant recipients. Best practices for mollicute screening remain unknown. We conducted a single-center prospective study analyzi ... Full text Link to item Cite

Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.

Journal Article J Heart Lung Transplant · November 2024 Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blo ... Full text Link to item Cite

Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · October 22, 2024 BACKGROUND: Few tools exist for the early identification of patients at risk for chronic lung allograft dysfunction (CLAD). We previously showed hyaluronan (HA), a matrix molecule that regulates lung inflammation and fibrosis, accumulates in bronchoalveola ... Full text Link to item Cite

Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity.

Journal Article Infect Control Hosp Epidemiol · May 24, 2024 This study identified 26 late invasive primary surgical site infection (IP-SSI) within 4-12 months of transplantation among 2073 SOT recipients at Duke University Hospital over the period 2015-2019. Thoracic organ transplants accounted for 25 late IP-SSI. ... Full text Link to item Cite

Short-term outcomes after third-time lung transplantation: A single institution experience.

Journal Article J Heart Lung Transplant · May 2024 BACKGROUND: Reoperative lung transplantation (LTx) survival has improved over time such that a growing number of patients may present for third-time LTx (L3Tx). To understand the safety of L3Tx, we evaluated perioperative outcomes and 3-year survival after ... Full text Link to item Cite

Risk Factors for and Outcomes Following Early Acquisition of Mycobacterium abscessus Complex After Lung Transplantation.

Journal Article Open Forum Infect Dis · May 2024 BACKGROUND: Lung transplant recipients are at increased risk of Mycobacterium abscessus complex (MABC) acquisition and invasive infection. We analyzed risk factors and outcomes of early post-lung transplant MABC acquisition. METHODS: We conducted a retrosp ... Full text Link to item Cite

Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation.

Journal Article Am J Transplant · April 2024 Mollicute infections, caused by Mycoplasma and Ureaplasma species, are serious complications after lung transplantation; however, understanding of the epidemiology and outcomes of these infections remains limited. We conducted a single-center retrospective ... Full text Open Access Link to item Cite

Risk Factors for Invasive Fungal Infection in Lung Transplant Recipients on Universal Antifungal Prophylaxis.

Journal Article Open Forum Infect Dis · February 2024 BACKGROUND: Many centers use universal antifungal prophylaxis after lung transplant, but risk factors for invasive fungal infection (IFI) in this setting are poorly described. METHODS: This retrospective, single-center cohort study including 603 lung trans ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Preemptive immune globulin therapy in sensitized lung transplant recipients.

Journal Article Transpl Immunol · October 2023 BACKGROUND: Sensitized lung transplant recipients are at increased risk of developing donor-specific antibodies, which have been associated with acute and chronic rejection. Perioperative intravenous immune globulin has been used in sensitized individuals ... Full text Link to item Cite

Acid exposure time is sensitive for detecting gastroesophageal reflux disease and is associated with long-term survival after lung transplant.

Journal Article Dis Esophagus · July 27, 2023 Gastroesophageal reflux disease (GERD) is common in patients who have undergone lung transplantation and is associated with poorer outcomes, but guidelines are lacking to direct management strategies in this population. We assessed the diagnostic yield of ... Full text Link to item Cite

Voxelotor as a Treatment of Persistent Hypoxia in the ICU.

Journal Article Chest · July 2023 Hypoxia is encountered frequently in the ICU as a result of a wide range of pathologic characteristics. The oxygen-hemoglobin dissociation curve describes hemoglobin's affinity for a given Po2 and factors affecting uptake and offload. Research in manipulat ... Full text Link to item Cite

Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Journal Article J Heart Lung Transplant · June 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) increases morbidity and mortality for lung transplant recipients. Club cell secretory protein (CCSP), produced by airway club cells, is reduced in the bronchoalveolar lavage fluid (BALF) of lung recipie ... Full text Link to item Cite

Preoperative Optimization for Lung Transplant

Chapter · January 1, 2023 As the definition of lung transplant (LT) candidacy continues to expand, prospective recipients are presenting with increasing complexity and significant medical comorbidities. While patient selection is essential to developing a successful LT program, it ... Full text Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal Article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal Article Am J Transplant · December 2022 Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult ... Full text Open Access Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal Article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Safety of Inhaled Amphotericin B Lipid Complex as Antifungal Prophylaxis in Lung Transplant Recipients.

Journal Article Antimicrob Agents Chemother · June 21, 2022 Inhaled formulations of amphotericin B are the most widely used antifungal prophylactic agents in lung transplant recipients, yet there are limited data on their safety. We performed a single-center retrospective cohort study of 603 consecutive patients wh ... Full text Link to item Cite

Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

Journal Article J Heart Lung Transplant · April 2022 BACKGROUND: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to under ... Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal Article JAMA Surg · January 1, 2022 IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Gastroparesis Following Lung Transplant: A Single Center's Experience

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

COVID-19 in Lung Transplant Recipients: Outcomes and Long-Term Follow Up

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Mycophenolate Induced Colitis in a Lung Transplant Recipient

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2022 Cite

Case Report of Donor Transmitted SARS-CoV-2 Infection During Lung Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal Article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

Expanding donor availability in lung transplantation: A case report of 5000 miles traveled.

Journal Article Am J Transplant · June 2021 We present the case of a 41-year-old female who underwent bilateral lung transplantation after the donor lungs were placed on a normothermic ex vivo lung perfusion and ventilation device and flown nearly 5000 miles from Honolulu, Hawaii to Durham, North Ca ... Full text Link to item Cite

Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Journal Article Transplant Direct · April 2021 BACKGROUND: Acute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate i ... Full text Link to item Cite

COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature.

Journal Article Transplant Rev (Orlando) · January 2021 Severe acute respiratory virus syndrome 2 (SARS-CoV-2) has led to a worldwide pandemic. Early studies in solid organ transplant (SOT) recipients suggested a wide variety of presentations, however, there remains a paucity of robust data in this population. ... Full text Link to item Cite

Lung Transplantation and the Era of the Sensitized Patient.

Journal Article Front Immunol · 2021 Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibod ... Full text Open Access Link to item Cite

Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization.

Journal Article AJR Am J Roentgenol · December 2020 OBJECTIVE. The purpose of this study was to assess the image quality and resource utilization of single-injection, split-bolus, dual-enhancement abdominopelvic CT angiography (hereafter referred to as dual-enhancement CTA) performed for combined vascular a ... Full text Link to item Cite

Depression, Immunosuppressant Levels, and Clinical Outcomes in Postlung Transplant Recipients.

Journal Article Int J Psychiatry Med · November 2020 OBJECTIVE: Posttransplant depression has been linked to increased risk for adverse outcomes in lung transplant patients. Maintaining target serum immunosuppressant levels is also essential for optimal lung transplant clinical outcome and may be a crucial p ... Full text Link to item Cite

Lung transplantation during the COVID-19 pandemic: Safely navigating the new "normal".

Journal Article Am J Transplant · November 2020 In the United States, an overall national decline in organ transplants has accompanied the substantial burden of COVID-19. Amidst significant regional variations in COVID-19, lung transplantation (LTx) remains a critical life-saving operation. Our LTx prac ... Full text Link to item Cite

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.

Journal Article J Heart Lung Transplant · September 2020 BACKGROUND: Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction. Bile acids-putative markers of gastric microaspiration-and inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with chron ... Full text Link to item Cite

Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.

Journal Article Am J Respir Crit Care Med · August 15, 2020 Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute perivascular rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common in lung transplant recipients and increases the risk for c ... Full text Link to item Cite

Oral and Inhaled Ribavirin Treatment for Respiratory Syncytial Virus Infection in Lung Transplant Recipients.

Journal Article Transplantation · June 2020 BACKGROUND: Respiratory syncytial virus (RSV) infection in lung transplant recipients (LTRs) causes mortality rates of 10%-20% despite antiviral therapy. Ribavirin (RBV) has been used to treat RSV-infected LTRs with limited data. METHODS: A retrospective s ... Full text Link to item Cite

Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.

Journal Article Am J Transplant · June 2020 Long-term survival after lung transplant lags behind that of other commonly transplanted organs, reflecting the current incomplete understanding of the mechanisms involved in the development of posttransplant lung injury, rejection, infection, and chronic ... Full text Link to item Cite

Lung Transplant Pulmonologists' Views of Specialty Palliative Care for Lung Transplant Recipients.

Journal Article J Palliat Med · May 2020 Background: Lung transplant recipients with serious illness may benefit from but rarely receive specialty palliative care (SPC) services. Transplant pulmonologists' views of SPC may be key to understanding SPC utilization but have not been well characteriz ... Full text Link to item Cite

NanoString Gene Expression Profiling in Chronic Lung Allograft Dysfunction (CLAD)

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: CLAD, mainly manifest as bronchiolitis obliterans syndrome (BOS), is the leading cause of late death in lung recipients. BOS develops despite routine immunosuppression and its pathogenesis is poorly understood. The histological correlate of BOS is ... Full text Cite

Pulmonary Microbiome Changes in Lung Transplant Recipients with Gastroesophageal Reflux

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The pulmonary microbiome modulates the immune milieu in the lung allograft and is in turn influenced by external factors such as microaspiration of oropharyngeal contents. A potential driver of microaspiration is gastroesophageal reflux disease (G ... Full text Cite

A Multi-Center Study of BAL CXCR3 Chemokines during Allograft Injury after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The occurrence of acute allograft injuries remains one of the most important factors responsible for the development of early chronic lung allograft dysfunction. We and others have previously demonstrated a consistent association between acute lun ... Full text Cite

Agreement between Fried Frailty Phenotype and Cumulative Deficits Frailty Indices: A Prospective Multi-Center Study

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Frailty is gaining increased recognition in the evaluation of lung transplant (LTx) candidates. The Fried Frailty Phenotype (FFP) index has been the most commonly used instrument and is associated with pre- and post-transplant morbidity and mortal ... Full text Cite

Prospective Assessment of Chronic Lung Allograft Dysfunction (CLAD); the Clinical Trials in Organ Transplantation (CTOT) Study Experience

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Diagnosis of CLAD after lung transplantation (LT) requires sustained decline in lung function and exclusion of other etiologies for the decline. The limitations of relying primarily on pulmonary function test (PFT) decline to define CLAD onset for ... Full text Cite

Viremic Hepatitis B Donors: A Case of Why It's Time to Further Expand the Donor Pool for Thoracic Transplant

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 INTRODUCTION: In light of a national shortage of thoracic organs, patients with end stage lung disease need an expanded donor pool. There are approximately 847,000 persons with chronic hepatitis B virus (HBV) in the U.S. Previously, transplantation of HBV ... Full text Cite

Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.

Journal Article Clin Infect Dis · January 1, 2020 BACKGROUND: Lung transplant recipients commonly develop invasive fungal infections (IFIs), but the most effective strategies to prevent IFIs following lung transplantation are not known. METHODS: We prospectively collected clinical data on all patients who ... Full text Link to item Cite

Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation.

Conference Dis Esophagus · December 13, 2019 Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The a ... Full text Link to item Cite

Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection.

Journal Article J Heart Lung Transplant · August 2019 BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Because effective therapies are lacking, early identification and mitigation of risk factors is a pragmatic approach to improve o ... Full text Link to item Cite

Acute Rejection (AR) and Lymphocytic Bronchiolitis (LB) in a Multicenter Lung Transplant Cohort

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Hepatitis and Thoracic Transplantation - No More Virus Non-Grata

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · February 2019 BACKGROUND: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regar ... Full text Link to item Cite

Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Journal Article Transpl Infect Dis · October 2018 Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold dise ... Full text Link to item Cite

Adenovirus Type 21 Outbreak Among Lung Transplant Patients at a Large Tertiary Care Hospital.

Journal Article Open Forum Infect Dis · August 2018 Here we summarize an April 2016, 7-patient cluster of human adenovirus (HAdV) infections in a cardiothoracic surgery intensive care unit. We show that the patients were infected with a single HAdV21b type. Rapid HAdV typing diagnostics and effective antivi ... Full text Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

Hyaluronan in Acute Rejection After Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Bronchoalveolar Lavage Fluid Proteome in Chronic Lung Allograft Dysfunction

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Multimedia Education Reduces Anxiety in Lung Transplant Patients.

Journal Article Prog Transplant · March 2018 CONTEXT: A significant contribution to the success of lung transplantation is the recipient's ability to self-manage a multidrug regimen and follow complex instructions. Effective education has always been an integral component of the process of preparing ... Full text Link to item Cite

Patterns and predictors of pain following lung transplantation.

Journal Article Gen Hosp Psychiatry · 2018 OBJECTIVE: Our objective was to examine variability in pain levels following lung transplantation, and examine individual biopsychosocial factors influencing changes in pain. METHOD: We performed a retrospective study of a cohort of 150 patients transplant ... Full text Link to item Cite

Gene Expression Profiling of BAL Cells and PBMC During Lung Allograft Acute Cellular Rejection

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

P085 Lung re-transplant with repeated mismatch HLA antigens

Conference Human Immunology · September 2017 Full text Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Coping And Clinical Outcomes Among Lung Transplant Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Proteomics Of Bronchoalveolar Lavage (bal) Fluid In Bronchiolitis Obliterans Syndrome (bos)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Outcomes In Lung Transplant Recipients With Pulmonary Fibrosis At High Risk Of Death

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Delirium affects length of hospital stay after lung transplantation.

Journal Article J Crit Care · February 2015 BACKGROUND: Delirium is relatively common after lung transplantation, although its prevalence and prognostic significance have not been systematically studied. The purpose of the present study was to examine pretransplant predictors of delirium and the sho ... Full text Link to item Cite

Neurocognitive changes after lung transplantation.

Journal Article Ann Am Thorac Soc · December 2014 RATIONALE: Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied. OBJECTIVES: To examine the frequency of neuroco ... Full text Link to item Cite

Antibody desensitization therapy in highly sensitized lung transplant candidates.

Journal Article Am J Transplant · April 2014 As HLAs antibody detection technology has evolved, there is now detailed HLA antibody information available on prospective transplant recipients. Determining single antigen antibody specificity allows for a calculated panel reactive antibodies (cPRA) value ... Full text Link to item Cite

Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.

Journal Article Am J Respir Crit Care Med · January 15, 2014 RATIONALE: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain. OBJECTIVES: To evaluate the hypothesis that spirometri ... Full text Link to item Cite

Role of complement activation in obliterative bronchiolitis post-lung transplantation.

Journal Article J Immunol · October 15, 2013 Obliterative bronchiolitis (OB) post-lung transplantation involves IL-17-regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation. However, the specific role of complement activation in lung allograft pat ... Full text Link to item Cite

Rituximab-associated progressive multifocal leukoencephalopathy after lung transplantation.

Journal Article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · July 1, 2013 Cite

Antibody Directed Therapy after Lung Transplant

Conference The Journal of Heart and Lung Transplantation · April 2013 Full text Cite

A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation.

Journal Article J Heart Lung Transplant · September 2012 BACKGROUND: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. METHODS: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products ... Full text Link to item Cite

Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis.

Journal Article Am J Transplant · November 2011 Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI may be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that ele ... Full text Link to item Cite

Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial.

Journal Article Ann Intern Med · June 15, 2010 BACKGROUND: Cytomegalovirus (CMV) is the most prevalent opportunistic infection after lung transplantation. Current strategies do not prevent CMV in most at-risk patients. OBJECTIVE: To determine whether extending prophylaxis with oral valganciclovir from ... Full text Link to item Cite

Bilateral sequential lung and simultaneous pancreas transplant: a new approach for the recipient with cystic fibrosis.

Journal Article J Cyst Fibros · July 2008 UNLABELLED: Cystic fibrosis (CF) is an inherited disorder that presents in childhood as a multisystem disease. Pulmonary failure and pancreatic insufficiency, including CF related diabetes (CFRD) and exocrine insufficiency, are common complications of this ... Full text Link to item Cite

Simultaneous bilateral lung and pancreas transplantation in recipient with cystic fibrosis.

Journal Article Transplant Proc · March 2008 INTRODUCTION: Cystic fibrosis (CF) is an inherited disorder that presents in childhood as a multisystem disease. Pulmonary failure and pancreatic insufficiency, including CF-related diabetes (CFRD) and exocrine insufficiency, are significant causes of morb ... Full text Link to item Cite

Nocardia infection in lung transplant recipients.

Journal Article Clin Transplant · 2008 Nocardia is a well-recognized pathogen in immunocompromised hosts, but the incidence of Nocardia infections in lung transplant recipients is not well defined. A chart review from 1990 to 2007 at Clarian Hospital Lung Transplant Center and Indiana Universit ... Full text Link to item Cite

Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome.

Journal Article Am J Transplant · July 2007 Parenchymal disease in the allograft lung is associated with interstitial remodeling believed to be mediated by matrix metalloproteinases (MMPs). Recent studies suggest high levels of MMP-9 are associated with bronchiolitis obliterans syndrome (BOS) in lun ... Full text Link to item Cite