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Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Publication ,  Journal Article
Messina, JA; Wolfe, CR; Hemmersbach-Miller, M; Milano, C; Todd, JL; Reynolds, J; Alexander, BD; Schell, WA; Cuomo, CA; Perfect, JR
Published in: Transpl Infect Dis
October 2018

Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold disease (Verruconis gallopava and Aspergillus fumigatus) in thoracic transplant recipients who had the same mold cultured years prior to the invasive disease presentation. The paired isolates from the index and recurrent infections in both patients were compared using whole-genome sequencing to determine if the same strain of mold caused both the index and recurrent infections. In Case 1, the isolates were found to be of the same strain indicating that the initial colonizing isolate identified pre-transplant eventually caused invasive mold disease post-transplant while in Case 2, the 2 isolates were not of the same strain. These results demonstrate the distinct possibility of molds both persisting within the human body for years prior to invasive mold disease or the long-term risk of recurrent, persistent infection with more than one strain. Further studies of long-term molecular epidemiology of IMD and risk factors for mold persistence in transplant recipients are encouraged.

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Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

October 2018

Volume

20

Issue

5

Start / End Page

e12935

Location

Denmark

Related Subject Headings

  • Whole Genome Sequencing
  • Transplant Recipients
  • Surgery
  • Saccharomycetales
  • Recurrence
  • Middle Aged
  • Male
  • Lung Transplantation
  • Invasive Fungal Infections
  • Humans
 

Citation

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Chicago
ICMJE
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Messina, J. A., Wolfe, C. R., Hemmersbach-Miller, M., Milano, C., Todd, J. L., Reynolds, J., … Perfect, J. R. (2018). Genomic characterization of recurrent mold infections in thoracic transplant recipients. Transpl Infect Dis, 20(5), e12935. https://doi.org/10.1111/tid.12935
Messina, Julia A., Cameron R. Wolfe, Marion Hemmersbach-Miller, Carmelo Milano, Jamie L. Todd, John Reynolds, Barbara D. Alexander, Wiley A. Schell, Christina A. Cuomo, and John R. Perfect. “Genomic characterization of recurrent mold infections in thoracic transplant recipients.Transpl Infect Dis 20, no. 5 (October 2018): e12935. https://doi.org/10.1111/tid.12935.
Messina JA, Wolfe CR, Hemmersbach-Miller M, Milano C, Todd JL, Reynolds J, et al. Genomic characterization of recurrent mold infections in thoracic transplant recipients. Transpl Infect Dis. 2018 Oct;20(5):e12935.
Messina, Julia A., et al. “Genomic characterization of recurrent mold infections in thoracic transplant recipients.Transpl Infect Dis, vol. 20, no. 5, Oct. 2018, p. e12935. Pubmed, doi:10.1111/tid.12935.
Messina JA, Wolfe CR, Hemmersbach-Miller M, Milano C, Todd JL, Reynolds J, Alexander BD, Schell WA, Cuomo CA, Perfect JR. Genomic characterization of recurrent mold infections in thoracic transplant recipients. Transpl Infect Dis. 2018 Oct;20(5):e12935.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

October 2018

Volume

20

Issue

5

Start / End Page

e12935

Location

Denmark

Related Subject Headings

  • Whole Genome Sequencing
  • Transplant Recipients
  • Surgery
  • Saccharomycetales
  • Recurrence
  • Middle Aged
  • Male
  • Lung Transplantation
  • Invasive Fungal Infections
  • Humans