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Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization.

Publication ,  Journal Article
Schwartz, FR; Khawaja, RDA; Marin, D; Patel, BN; Gray, AL; Reynolds, JM; Koweek, LH
Published in: AJR Am J Roentgenol
December 2020

OBJECTIVE. The purpose of this study was to assess the image quality and resource utilization of single-injection, split-bolus, dual-enhancement abdominopelvic CT angiography (hereafter referred to as dual-enhancement CTA) performed for combined vascular and solid organ assessment compared with those of single-injection, single-enhancement abdominopelvic CT angiography (hereafter referred to as single-enhancement CTA) for vascular assessment in combination with additional examinations (CT, MRI, and US) performed to assess for malignancy in lung transplant candidates. MATERIALS AND METHODS. We retrospectively reviewed 100 patients who underwent abdominopelvic CTA examinations before lung transplant. Cohort A (n = 50) underwent dual-enhancement CTA and cohort B (n = 50) underwent single-enhancement CTA. Contrast opacification of the vasculature was assessed along the abdominal aorta through the right femoral artery. Solid organ enhancement was assessed in the right lobe of the liver and the right renal cortex. Measurements of mean radiation dose, contrast exposure, and cost of the studies (in U.S. dollars) were compared. RESULTS. Mean (± SD) vascular enhancement on dual-enhancement CTA and single-enhancement CTA was 334.2 ± 26.5 HU (coefficient of variation, 8.3%) and 340.0 ± 21.6 HU (coefficient of variation, 6.5%) (p = 0.23), respectively. For dual-enhancement CTA and single-enhancement CTA, mean liver enhancement was 125.8 ± 30.5 HU and 60.4 ± 6.9 HU (p < 0.01), respectively, whereas mean renal cortical enhancement was 260.3 ± 62.2 HU and 133.4 ± 38.6 HU (p < 0.01), respectively. The mean IV contrast volume was 150 mL for dual-enhancement CTA and 75 mL for single-enhancement CTA. Cohort A underwent six additional imaging studies (one of which was a CT colonography study with an effective dose of 19.0 mSv) at a total cost of $9840 per patient. Cohort B underwent 44 additional imaging studies (mean effective dose, 12.7 ± 6.5 mSv) at a total cost of $12,846 per patient (resulting in a 30.6% reduction in cost for dual-enhancement CTA studies; p < 0.0001). CONCLUSION. Dual-enhancement abdominopelvic CTA allows combined vascular and abdominopelvic solid organ assessment with improved image quality and a lower cost compared with traditional imaging pathways.

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Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2020

Volume

215

Issue

6

Start / End Page

1520 / 1527

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Radiography, Abdominal
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung Transplantation
  • Iopamidol
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schwartz, F. R., Khawaja, R. D. A., Marin, D., Patel, B. N., Gray, A. L., Reynolds, J. M., & Koweek, L. H. (2020). Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization. AJR Am J Roentgenol, 215(6), 1520–1527. https://doi.org/10.2214/AJR.19.22335
Schwartz, Fides Regina, Ranish Deedar Ali Khawaja, Daniele Marin, Bhavik N. Patel, Alice L. Gray, John M. Reynolds, and Lynne Hurwitz Koweek. “Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization.AJR Am J Roentgenol 215, no. 6 (December 2020): 1520–27. https://doi.org/10.2214/AJR.19.22335.
Schwartz FR, Khawaja RDA, Marin D, Patel BN, Gray AL, Reynolds JM, et al. Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization. AJR Am J Roentgenol. 2020 Dec;215(6):1520–7.
Schwartz, Fides Regina, et al. “Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization.AJR Am J Roentgenol, vol. 215, no. 6, Dec. 2020, pp. 1520–27. Pubmed, doi:10.2214/AJR.19.22335.
Schwartz FR, Khawaja RDA, Marin D, Patel BN, Gray AL, Reynolds JM, Koweek LH. Split-Bolus, Single-Acquisition, Dual-Phase Abdominopelvic CT Angiography for the Evaluation of Lung Transplant Candidates: Image Quality and Resource Utilization. AJR Am J Roentgenol. 2020 Dec;215(6):1520–1527.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2020

Volume

215

Issue

6

Start / End Page

1520 / 1527

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Radiography, Abdominal
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung Transplantation
  • Iopamidol
  • Humans