Scholars@Duke

Lung Transplantation and the Era of the Sensitized Patient.

Publication ,  Journal Article
Young, KA; Ali, HA; Beermann, KJ; Reynolds, JM; Snyder, LD
Published in: Front Immunol
2021
Published version (DOI) Open Access Copy (Duke) Link to item

Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, "sensitized patients" may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies.

Duke Scholars

Katherine Young
Author Katherine Young Medicine, Pulmonary, Allergy, and Critical Care Medicine
Hakim Azfar Ali
Author Hakim Azfar Ali Medicine, Pulmonary, Allergy, and Critical Care Medicine
John Michael Reynolds
Author John Michael Reynolds Medicine, Pulmonary, Allergy, and Critical Care Medicine
Laurie D. Snyder
Author Laurie D. Snyder Medicine, Pulmonary, Allergy, and Critical Care Medicine

Published In

Front Immunol

DOI

10.3389/fimmu.2021.689420

EISSN

1664-3224

Publication Date

2021

Volume

12

Start / End Page

689420

Location

Switzerland

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Lung Transplantation
  • Isoantibodies
  • Immunosuppressive Agents
  • Humans
  • Histocompatibility Testing
 

Citation

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ICMJE
MLA
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Young, K. A., Ali, H. A., Beermann, K. J., Reynolds, J. M., & Snyder, L. D. (2021). Lung Transplantation and the Era of the Sensitized Patient. Front Immunol, 12, 689420. https://doi.org/10.3389/fimmu.2021.689420
Young, Katherine A., Hakim A. Ali, Kristi J. Beermann, John M. Reynolds, and Laurie D. Snyder. “Lung Transplantation and the Era of the Sensitized Patient.” Front Immunol 12 (2021): 689420. https://doi.org/10.3389/fimmu.2021.689420.
Young KA, Ali HA, Beermann KJ, Reynolds JM, Snyder LD. Lung Transplantation and the Era of the Sensitized Patient. Front Immunol. 2021;12:689420.
Young, Katherine A., et al. “Lung Transplantation and the Era of the Sensitized Patient.” Front Immunol, vol. 12, 2021, p. 689420. Pubmed, doi:10.3389/fimmu.2021.689420.
Young KA, Ali HA, Beermann KJ, Reynolds JM, Snyder LD. Lung Transplantation and the Era of the Sensitized Patient. Front Immunol. 2021;12:689420.

Published In

Front Immunol

DOI

10.3389/fimmu.2021.689420

EISSN

1664-3224

Publication Date

2021

Volume

12

Start / End Page

689420

Location

Switzerland

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Lung Transplantation
  • Isoantibodies
  • Immunosuppressive Agents
  • Humans
  • Histocompatibility Testing