Voxelotor as a Treatment of Persistent Hypoxia in the ICU.
Publication
, Journal Article
Al-Qudsi, O; Reynolds, JM; Haney, JC; Welsby, IJ
Published in: Chest
July 2023
Hypoxia is encountered frequently in the ICU as a result of a wide range of pathologic characteristics. The oxygen-hemoglobin dissociation curve describes hemoglobin's affinity for a given Po2 and factors affecting uptake and offload. Research in manipulating this relationship between hemoglobin and oxygen is sparing. Voxelotor is a hemoglobin oxygen-affinity modulator that is approved by the US Food and Drug Association for use in the management of sickle cell disease. We present two patients without sickle cell disease who underwent treatment with this novel agent to assist with chronic hypoxia and weaning of mechanical support.
Duke Scholars
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Published In
Chest
DOI
EISSN
1931-3543
Publication Date
July 2023
Volume
164
Issue
1
Start / End Page
e1 / e4
Location
United States
Related Subject Headings
- Respiratory System
- Oxygen
- Intensive Care Units
- Hypoxia
- Humans
- Hemoglobins
- Anemia, Sickle Cell
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Al-Qudsi, O., Reynolds, J. M., Haney, J. C., & Welsby, I. J. (2023). Voxelotor as a Treatment of Persistent Hypoxia in the ICU. Chest, 164(1), e1–e4. https://doi.org/10.1016/j.chest.2023.01.036
Al-Qudsi, Omar, John M. Reynolds, John C. Haney, and Ian J. Welsby. “Voxelotor as a Treatment of Persistent Hypoxia in the ICU.” Chest 164, no. 1 (July 2023): e1–4. https://doi.org/10.1016/j.chest.2023.01.036.
Al-Qudsi O, Reynolds JM, Haney JC, Welsby IJ. Voxelotor as a Treatment of Persistent Hypoxia in the ICU. Chest. 2023 Jul;164(1):e1–4.
Al-Qudsi, Omar, et al. “Voxelotor as a Treatment of Persistent Hypoxia in the ICU.” Chest, vol. 164, no. 1, July 2023, pp. e1–4. Pubmed, doi:10.1016/j.chest.2023.01.036.
Al-Qudsi O, Reynolds JM, Haney JC, Welsby IJ. Voxelotor as a Treatment of Persistent Hypoxia in the ICU. Chest. 2023 Jul;164(1):e1–e4.
Published In
Chest
DOI
EISSN
1931-3543
Publication Date
July 2023
Volume
164
Issue
1
Start / End Page
e1 / e4
Location
United States
Related Subject Headings
- Respiratory System
- Oxygen
- Intensive Care Units
- Hypoxia
- Humans
- Hemoglobins
- Anemia, Sickle Cell
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences