Ian James Welsby
Professor of Anesthesiology
As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.
Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.
My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations.
In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice.
Current Research Interests
Elucidating factors predisposing to thrombotic or hemorrhagic complications and adverse outcomes related to transfusion after cardiac surgery. Utilizing outcomes data after cardiac surgery to optimize transfusion safety in this patient group.
The clinical implications of the generation of antibodies to the composite heparin/platelet factor 4 antigen and the management of heparin induced thrombocytopenia (HIT), in collaboration with Dr TL Ortel, Duke Hematology, and exploring alternative anticoagulant regimens to improve anticoagulation during and after cardiac surgery for patients with HIT.
Improving the outcome associated with blood product transfusion in the cardiac surgical patient by developing techniques of microparticle elimination prior to RBC transfusion and autologous platelet harvest during cardiac surgery.
Current Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2018
- Professor of Medicine, Medicine, Hematology, Medicine 2019
Contact Information
- 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
- Box 3094 Med Ctr, Durham, NC 27710
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ian.welsby@duke.edu
(919) 681-6752
- Background
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Education, Training, & Certifications
- Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom) 1995
- Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom) 1995
- Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom) 1994 - 1995
- Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom) 1993 - 1994
- Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom) 1992 - 1993
- Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom) 1992
- Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom) 1991 - 1992
- House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom) 1991
- House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom) 1990 - 1991
- M.B.B.S., University College London (United Kingdom) 1990
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Previous Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2014 - 2018
- Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2009 - 2014
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2003 - 2009
- Associate in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2000 - 2003
- Instructor, Temporary in the Department of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2000
- Visiting Associate in the Department of Anesthesiology, Part-time, Anesthesiology, Critical Care Medicine, Anesthesiology 1996 - 1997
- Instructor, Temporary of Anesthesiology, Anesthesiology, Critical Care Medicine, Anesthesiology 1996
- Recognition
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In the News
- Research
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Selected Grants
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- Cerus/BARDA CLI 00125 ReCePI study awarded by Cerus Corporation 2019 - 2024
- A Phase 2b Open-Label, Single Arm Study to Evaluate the Efficacy of Voxelotor for Improving Oxygen Saturation and Reducing Ventilatory Support Requirements in Adult Patients with New or Increased Oxygen Requirement. awarded by Global Blood Therapeutics, Inc. 2022 - 2024
- Clinical Study of a Method Comparison of Plasma Low in Mechanical Circulatory Support(MCS) procedures awarded by HemoCue AB 2022 - 2023
- Aridis 301 awarded by Aridis Pharmaceuticals Inc. 2019 - 2023
- CytoSorbents REFRESH II awarded by CytoSorbents Corporation 2018 - 2022
- Single cell RNA-Seq of stored RBC to detect Autologous Blood Transfusion awarded by Partnership for Clean Competition 2021 - 2022
- HEMCS-037 Qstat Multi-site Precision Study awarded by HemoSonics, LLC 2021 - 2022
- Rejuvenated RBC in Healthy Subjects awarded by Biomet Biologics, LLC 2017 - 2021
- Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications awarded by Mayo Clinic 2014 - 2020
- ARrest RESpiraTory failure due to PNEUMONIA Phase 1 awarded by Stanford University 2020
- Aridis AR-105 Aerucin awarded by Aridis Pharmaceuticals Inc. 2018 - 2019
- Detect autologous transfusion by novel separation and characterization of RBC storage exosomes awarded by Partnership for Clean Competition 2018 - 2019
- A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiac Surgery with Cardiopulmonary Bypass awarded by Grifols USA, LLC 2014 - 2019
- Rejuvesol Ex Vivo ECMO awarded by Biomet Biologics, LLC 2016 - 2019
- 14-505-Andexanet Alfa in Patients Receiving a Factor Xa Inhibitor Who Have Acute Major Bleeding awarded by Portola Pharmaceuticals 2015 - 2019
- Evaluation of Quantra System in Adult Patients Undergoing Major Surgical Procedures awarded by HemoSonics, LLC 2017 - 2018
- In Vitro Removal of Rejuvesol from Rejuvenated Units by Cell Saver awarded by Biomet Biologics, LLC 2016 - 2018
- Rejuvesol Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions awarded by Biomet Biologics, LLC 2016 - 2017
- LIPS-A: Lung Injury Prevention Study with Aspirin awarded by Mayo Clinic 2011 - 2016
- Clinical Significance of protamine/heparin antibodies after CPB awarded by National Institutes of Health 2011 - 2014
- Thrombosis and Hemostasis Centers Research and Prevention Network awarded by Centers for Disease Control and Prevention 2002 - 2013
- Rare Thrombotic Diseases Clinical Research Network awarded by National Institutes of Health 2004 - 2010
- Integrated Program for Persons with Hemostatic Disorders awarded by Centers for Disease Control 2001 - 2007
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External Relationships
- Anesthesia Labs
- Bio Products Laboratory USA
- Global Blood Therapeutics now bought by Pfizer
- Hemosonics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Milling, Truman J., Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew Demchuk, John W. Eikelboom, Peter Verhamme, et al. “Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors.” Circulation 147, no. 13 (March 28, 2023): 1026–38. https://doi.org/10.1161/CIRCULATIONAHA.121.057844.Full Text Link to Item
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Krom, Russell J., Ian J. Welsby, Matthew Fuller, Andrew S. Barbas, Qimeng Gao, Imran J. Anwar, and W Jonathan Dunkman. “Incidence of Postreperfusion Hyperfibrinolysis in Liver Transplantation by Donor Type and Observed Treatment Strategies.” Anesth Analg 136, no. 3 (March 1, 2023): 518–23. https://doi.org/10.1213/ANE.0000000000006302.Full Text Open Access Copy Link to Item
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Cutrone, Michael H., Ian J. Welsby, and Kamrouz Ghadimi. “Targeting Chemoprophylaxis in Venous Thromboembolism Using Biomarker Guidance.” Jama Surg 158, no. 2 (February 1, 2023): 220–21. https://doi.org/10.1001/jamasurg.2022.5333.Full Text Link to Item
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Moront, Michael George, Michael K. Woodward, Michael K. Essandoh, Edwin G. Avery, T Brett Reece, Marek Brzezinski, Bruce Spiess, et al. “A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Antithrombin Supplementation in Patients at Risk for Antithrombin Deficiency After Cardiac Surgery.” Anesth Analg 135, no. 4 (October 1, 2022): 757–68. https://doi.org/10.1213/ANE.0000000000006145.Full Text Link to Item
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Smith, Mark M., Darrell R. Schroeder, James A. Nelson, William J. Mauermann, Ian J. Welsby, Alberto Pochettino, Beth L. Montonye, Chalailak Assawakawintip, and Gregory A. Nuttall. “Prothrombin Complex Concentrate vs Plasma for Post-Cardiopulmonary Bypass Coagulopathy and Bleeding: A Randomized Clinical Trial.” Jama Surg 157, no. 9 (September 1, 2022): 757–64. https://doi.org/10.1001/jamasurg.2022.2235.Full Text Link to Item
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Brockbank, Benjamin H., Mary Cooter Wright, Jhaymie Cappiello, Brittany A. Zwischenberger, Ian J. Welsby, Jerrold H. Levy, and Negmeldeen Mamoun. “Heated Humidified Breathing Circuit Rewarming in Hypothermic Patients Post-Cardiopulmonary Bypass-Pilot Study.” J Cardiothorac Vasc Anesth 36, no. 4 (April 2022): 1007–13. https://doi.org/10.1053/j.jvca.2021.06.020.Full Text Link to Item
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Corwin, Howard L., Aryeh Shander, Bruce Speiss, Manuel Muñoz, David Faraoni, Domenico Calcaterra, Ian Welsby, et al. “Management of Perioperative Iron Deficiency in Cardiac Surgery: A Modified RAND Delphi Study.” Ann Thorac Surg 113, no. 1 (January 2022): 316–23. https://doi.org/10.1016/j.athoracsur.2020.11.031.Full Text Link to Item
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Vestal, Mark L., Kimberly Hodulik, Jennifer Mando-Vandrick, Michael L. James, Thomas L. Ortel, Matthew Fuller, Maria Notini, Mark Friedland, and Ian J. Welsby. “Andexanet alfa and four-factor prothrombin complex concentrate for reversal of apixaban and rivaroxaban in patients diagnosed with intracranial hemorrhage.” J Thromb Thrombolysis 53, no. 1 (January 2022): 167–75. https://doi.org/10.1007/s11239-021-02495-3.Full Text Link to Item
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Oyedeji, Charity I., and Ian J. Welsby. “Optimizing management of sickle cell disease in patients undergoing surgery.” Hematology Am Soc Hematol Educ Program 2021, no. 1 (December 10, 2021): 405–10. https://doi.org/10.1182/hematology.2021000274.Full Text Link to Item
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Isaacs, James, Ian J. Welsby, Jacob N. Schroder, and Oluwatoyosi A. Onwuemene. “Activated Coagulation Time and Hepcon Protamine Titration Device to Manage Unfractionated Heparin During Cardiopulmonary Bypass in a Hemophilia A Patient on Emicizumab.” J Cardiothorac Vasc Anesth 35, no. 11 (November 2021): 3299–3302. https://doi.org/10.1053/j.jvca.2020.08.058.Full Text Open Access Copy Link to Item
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Klapper, Jacob A., Anne C. Hicks, Leila Ledbetter, Jessica Poisson, Matthew G. Hartwig, Nazish Hashmi, Ian Welsby, and Brandi A. Bottiger. “Blood product transfusion and lung transplant outcomes: A systematic review.” Clin Transplant 35, no. 10 (October 2021): e14404. https://doi.org/10.1111/ctr.14404.Full Text Link to Item
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Faraoni, David, and Ian J. Welsby. “A Step toward Combined Platelet and Erythrocyte Recovery.” Anesthesiology 135, no. 2 (August 1, 2021): 200–202. https://doi.org/10.1097/ALN.0000000000003846.Full Text Link to Item
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Thomas, Tiffany, Francesca Cendali, Xiaoyun Fu, Fabia Gamboni, Evan J. Morrison, Jonathan Beirne, Travis Nemkov, et al. “Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.” Transfusion 61, no. 6 (June 2021): 1867–83. https://doi.org/10.1111/trf.16402.Full Text Link to Item
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Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.Full Text Link to Item
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Levitt, Joseph E., Emir Festic, Manisha Desai, Haley Hedlin, Kenneth W. Mahaffey, Angela J. Rogers, Ognjen Gajic, Michael A. Matthay, and Michael A. ARREST Pneumonia Clinical Trial Investigators. “The ARREST Pneumonia Clinical Trial. Rationale and Design.” Annals of the American Thoracic Society 18, no. 4 (April 2021): 698–708. https://doi.org/10.1513/annalsats.202009-1115sd.Full Text
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Evans, Brooke A., Andrea K. Ansari, Reed W. Kamyszek, Michele Salvagno, John Welsby, Matthew Fuller, and Ian Welsby. “Modulation of red blood cell oxygen affinity with a novel allosteric modifier of hemoglobin is additive to the Bohr effect.” Blood Cells, Molecules & Diseases 87 (March 2021): 102520. https://doi.org/10.1016/j.bcmd.2020.102520.Full Text
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Evans, Brooke A., Reed W. Kamyszek, Mark Piegore, Keaton Stoner, Matthew Fuller, Ian J. Welsby, and Micah Mooberry. “Global sources of cryoprecipitate demonstrate variability in coagulant factor levels and functional hemostasis.” Blood Coagul Fibrinolysis 32, no. 2 (March 1, 2021): 87–102. https://doi.org/10.1097/MBC.0000000000000982.Full Text Link to Item
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Welsby, Ian J., Philip J. Norris, William J. Mauermann, Mihai V. Podgoreanu, Chelsea M. Conn, Laurie Meade, Tamara Cannon, et al. “Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles.” Anesthesiology 134, no. 3 (March 1, 2021): 395–404. https://doi.org/10.1097/ALN.0000000000003689.Full Text Link to Item
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Moreno-Duarte, Ingrid, Mary Cooter, Oluwatoyosi A. Onwuemene, Kamrouz Ghadimi, and Ian J. Welsby. “Clinical outcomes of cardiac surgery patients undergoing therapeutic plasma exchange for heparin-induced thrombocytopenia.” Vox Sang 116, no. 2 (February 2021): 217–24. https://doi.org/10.1111/vox.13008.Full Text Link to Item
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Daughety, Molly M., Andrew Morgan, Erin Frost, Chester Kao, Joyce Hwang, Rachel Tobin, Bhavik Patel, Matthew Fuller, Ian Welsby, and Thomas L. Ortel. “COVID-19 associated coagulopathy: Thrombosis, hemorrhage and mortality rates with an escalated-dose thromboprophylaxis strategy.” Thromb Res 196 (December 2020): 483–85. https://doi.org/10.1016/j.thromres.2020.10.004.Full Text Link to Item
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Bottiger, Brandi A., Jacob Klapper, Angela Pollak, and Ian Welsby. “When Therapy Is Confounded With Approach: Retrospective Studies of Transfusion-Related Outcomes After Lung Transplantation.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3021–23. https://doi.org/10.1053/j.jvca.2020.07.064.Full Text Link to Item
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Kamyszek, Reed W., Matthew W. Foster, Brooke A. Evans, Keaton Stoner, Jessica Poisson, Amudan J. Srinivasan, J Will Thompson, M Arthur Moseley, Micah J. Mooberry, and Ian J. Welsby. “The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.” Blood Transfus 18, no. 6 (November 2020): 454–64. https://doi.org/10.2450/2020.0077-20.Full Text Link to Item
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Barac, Yaron D., Jacob Klapper, Angela Pollack, Jessica Poisson, Ian Welsby, M. G. Hartwig, and Brandi Bottiger. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant.” Ann Thorac Surg 110, no. 1 (July 2020): e23–25. https://doi.org/10.1016/j.athoracsur.2019.11.056.Full Text Link to Item
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Evans, Brooke A., Andrea K. Ansari, Amudan J. Srinivasan, Reed W. Kamyszek, Keaton C. Stoner, Matthew Fuller, Jessica L. Poisson, and Ian J. Welsby. “Rejuvenation solution as an adjunct cold storage solution maintains physiological haemoglobin oxygen affinity during early-storage period of red blood cells.” Vox Sang 115, no. 5 (July 2020): 388–94. https://doi.org/10.1111/vox.12910.Full Text Link to Item
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Lopez Domowicz, Denise A., Ian Welsby, Charles R. Esther, Hongmei Zhu, Robert D. Marek, Grace Lee, Nirmish Shah, Jessica L. Poisson, and Tim J. McMahon. “Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.” Blood Transfus 18, no. 3 (May 2020): 200–207. https://doi.org/10.2450/2020.0237-19.Full Text Link to Item
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Ansari, Andrea, Julien Cobert, Neelima Navuluri, George Cheng, John C. Haney, and Ian Welsby. “Intrapulmonary Activated Factor VII for Hemoptysis Complicating Pulmonary Thromboendarterectomy.” Ann Thorac Surg 109, no. 4 (April 2020): e243–45. https://doi.org/10.1016/j.athoracsur.2019.06.102.Full Text Link to Item
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Groves, Danja S., Ian J. Welsby, Bhiken I. Naik, Kenichi Tanaka, Jennifer N. Hauck, Charles S. Greenberg, Deborah A. Winegar, and Francesco Viola. “Multicenter Evaluation of the Quantra QPlus System in Adult Patients Undergoing Major Surgical Procedures.” Anesth Analg 130, no. 4 (April 2020): 899–909. https://doi.org/10.1213/ANE.0000000000004659.Full Text Link to Item
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Sun, Gina H., Claudia Bruguera, Siavash Saadat, David Moss, Roman Schumann, Ian J. Welsby, Ethan Y. Brovman, and Frederick C. Cobey. “ABO Blood Group and Transfusions In the Intraoperative and Postoperative Period After LVAD Implantation.” J Cardiothorac Vasc Anesth 34, no. 4 (April 2020): 906–11. https://doi.org/10.1053/j.jvca.2019.09.015.Full Text Link to Item
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Noubouossie, Denis F., Michael W. Henderson, Micah Mooberry, Anton Ilich, Patrick Ellsworth, Mark Piegore, Sarah C. Skinner, et al. “Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways.” Blood 135, no. 10 (March 5, 2020): 755–65. https://doi.org/10.1182/blood.2019001643.Full Text Link to Item
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Raphael, Jacob, C David Mazer, Andrew Wilkey, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, et al. “Corrigendum to 'Society of Cardiovascular Anesthesiologists (SCA) Clinical Practice Improvement (CPI) Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients' [Journal of Cardiothoracic and Vascular Anesthesia 33 (2019) 2887-2899].” J Cardiothorac Vasc Anesth 34, no. 3 (March 2020): 840–41. https://doi.org/10.1053/j.jvca.2019.11.004.Full Text Link to Item
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Barac, Yaron D., Adam Nevo, Oliver Jawitz, Nazish K. Hashmi, Peter Henkel, Laura J. Blue, Joseph Kelly, et al. “Prothrombin Complex Concentrate Use in Durable and Short-Term Left Ventricular Assist Device Implantation.” Asaio J 66, no. 1 (January 2020): e8–10. https://doi.org/10.1097/MAT.0000000000000937.Full Text Link to Item
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Raphael, Jacob, C David Mazer, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, Philip E. Roman, et al. “Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients.” J Cardiothorac Vasc Anesth 33, no. 11 (November 2019): 2887–99. https://doi.org/10.1053/j.jvca.2019.04.003.Full Text Link to Item
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Raphael, Jacob, C David Mazer, Sudhakar Subramani, Andrew Schroeder, Mohamed Abdalla, Renata Ferreira, Philip E. Roman, et al. “Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients.” Anesth Analg 129, no. 5 (November 2019): 1209–21. https://doi.org/10.1213/ANE.0000000000004355.Full Text Link to Item
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Gehrke, Sarah, Nirmish Shah, Fabia Gamboni, Reed Kamyszek, Amudan J. Srinivasan, Alan Gray, Matthew Landrigan, Ian Welsby, and Angelo D’Alessandro. “Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.” Transfusion 59, no. 10 (October 2019): 3102–12. https://doi.org/10.1111/trf.15467.Full Text Link to Item
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Kamyszek, Reed W., Jay S. Raval, Amudan J. Srinivasan, Andrea K. Ansari, Brooke A. Evans, Marian A. Rollins-Raval, Jessica L. Poisson, Nirmish R. Shah, and Ian J. Welsby. “Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.” Transfusion 59, no. 8 (August 2019): 2622–28. https://doi.org/10.1111/trf.15386.Full Text Link to Item
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Hashmi, Nazish K., Kamrouz Ghadimi, Amudan J. Srinivasan, Yi-Ju Li, Robert D. Raiff, Jeffrey G. Gaca, Adam G. Root, et al. “Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis.” Vox Sang 114, no. 4 (May 2019): 374–85. https://doi.org/10.1111/vox.12774.Full Text Link to Item
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Culp-Hill, Rachel, Amudan J. Srinivasan, Sarah Gehrke, Reed Kamyszek, Andrea Ansari, Nirmish Shah, Ian Welsby, and Angelo D’Alessandro. “Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.” Transfusion 58, no. 12 (December 2018): 2797–2806. https://doi.org/10.1111/trf.14931.Full Text Link to Item
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Gehrke, Sarah, Amudan J. Srinivasan, Rachel Culp-Hill, Julie A. Reisz, Andrea Ansari, Alan Gray, Matthew Landrigan, Ian Welsby, and Angelo D’Alessandro. “Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.” Transfusion 58, no. 8 (August 2018): 1980–91. https://doi.org/10.1111/trf.14623.Full Text Link to Item
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Washam, Jeffrey B., Babatunde Yerokun, Chetan B. Patel, Ian J. Welsby, Carmelo A. Milano, and Adam D. DeVore. “Cangrelor use prior to left ventricular assist device surgery: a case series.” J Thromb Thrombolysis 46, no. 2 (August 2018): 131–33. https://doi.org/10.1007/s11239-018-1691-5.Full Text Link to Item
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Heath, Michele, Julie Walker, Atilio Barbeito, Adam Williams, Ian Welsby, Cory Maxwell, Mani Daneshmand, John Haney, and Maureane Hoffman. “Differentiating between cold agglutinins and rouleaux: a case series of seven patients.” Perfusion 33, no. 2 (March 2018): 164–69. https://doi.org/10.1177/0267659117727593.Full Text Link to Item
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Ghadimi, Kamrouz, and Ian J. Welsby. “Pro: Factor Concentrates are Essential for Hemostasis in Complex Cardiac Surgery.” J Cardiothorac Vasc Anesth 32, no. 1 (February 2018): 558–64. https://doi.org/10.1053/j.jvca.2017.05.042.Full Text Link to Item
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Sun, Gina H., Visal Patel, Ingrid Moreno-Duarte, Farhad Zahedi, Eric Ursprung, Greg Couper, Fred Y. Chen, et al. “Intraoperative Administration of 4-Factor Prothrombin Complex Concentrate Reduces Blood Requirements in Cardiac Transplantation.” J Cardiothorac Vasc Anesth 32, no. 1 (February 2018): 161–67. https://doi.org/10.1053/j.jvca.2017.08.011.Full Text Link to Item
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Hobbs, Juliann C., Ian J. Welsby, Cynthia L. Green, Ishwori B. Dhakal, and Samuel S. Wellman. “Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.” J Arthroplasty 33, no. 1 (January 2018): 55–60. https://doi.org/10.1016/j.arth.2017.08.020.Full Text Link to Item
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Srinivasan, Amudan J., Kyle Kausch, Collin Inglut, Alan Gray, Matthew Landrigan, Jessica L. Poisson, Jacob N. Schroder, and Ian J. Welsby. “Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells.” Semin Thorac Cardiovasc Surg 30, no. 2 (2018): 134–41. https://doi.org/10.1053/j.semtcvs.2018.02.009.Full Text Link to Item
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Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.Full Text Open Access Copy Link to Item
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Levy, Jerrold H., Kamrouz Ghadimi, Quintin J. Quinones, Raquel R. Bartz, and Ian Welsby. “Adjuncts to Blood Component Therapies for the Treatment of Bleeding in the Intensive Care Unit.” Transfus Med Rev 31, no. 4 (October 2017): 258–63. https://doi.org/10.1016/j.tmrv.2017.04.001.Full Text Link to Item
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Warner, Matthew A., Ian J. Welsby, Phillip J. Norris, Christopher C. Silliman, Sarah Armour, Erica D. Wittwer, Paula J. Santrach, et al. “Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery.” Bmj Open 7, no. 8 (August 18, 2017): e016398. https://doi.org/10.1136/bmjopen-2017-016398.Full Text Link to Item
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Esper, S. A., I. J. Welsby, K. Subramaniam, W. John Wallisch, J. H. Levy, J. H. Waters, D. J. Triulzi, J. W. A. Hayanga, and G. J. Schears. “Adult extracorporeal membrane oxygenation: an international survey of transfusion and anticoagulation techniques.” Vox Sang 112, no. 5 (July 2017): 443–52. https://doi.org/10.1111/vox.12514.Full Text Link to Item
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Srinivasan, Amudan J., Clare Morkane, Daniel S. Martin, and Ian J. Welsby. “Should modulation of p50 be a therapeutic target in the critically ill?” Expert Rev Hematol 10, no. 5 (May 2017): 449–58. https://doi.org/10.1080/17474086.2017.1313699.Full Text Link to Item
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Waldron, Nathan H., Torijaun Dallas, Loretta Erhunmwunsee, Tracy Y. Wang, Mark F. Berry, and Ian J. Welsby. “Bleeding risk associated with eptifibatide (Integrilin) bridging in thoracic surgery patients.” J Thromb Thrombolysis 43, no. 2 (February 2017): 194–202. https://doi.org/10.1007/s11239-016-1441-5.Full Text Link to Item
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Ahmadzia, H. K., E. L. Lockhart, S. M. Thomas, I. J. Welsby, M. R. Hoffman, A. H. James, A. P. Murtha, G. K. Swamy, and C. A. Grotegut. “Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect?” J Neonatal Perinatal Med 10, no. 1 (2017): 1–7. https://doi.org/10.3233/NPM-16139.Full Text Open Access Copy Link to Item
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Welsby, I. J., E. F. Krakow, J. A. Heit, E. C. Williams, G. M. Arepally, S. Bar-Yosef, D. F. Kong, et al. “The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery.” J Thromb Haemost 15, no. 1 (January 2017): 57–65. https://doi.org/10.1111/jth.13533.Full Text Link to Item
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Ghadimi, K., J. H. Levy, and I. J. Welsby. “Perioperative management of the bleeding patient.” Br J Anaesth 117, no. suppl 3 (December 2016): iii18–30. https://doi.org/10.1093/bja/aew358.Full Text Link to Item
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Jooste, Edmund H., Kelly A. Machovec, Lisa M. Einhorn, Warwick A. Ames, Hercilia M. Homi, Robert D. B. Jaquiss, Andrew J. Lodge, Jerrold H. Levy, and Ian J. Welsby. “3-Factor Prothrombin Complex Concentrates in Infants With Refractory Bleeding After Cardiac Surgery.” J Cardiothorac Vasc Anesth 30, no. 6 (December 2016): 1627–31. https://doi.org/10.1053/j.jvca.2016.01.029.Full Text Link to Item
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Keenan, Jeffrey E., Hanghang Wang, Brian C. Gulack, Asvin M. Ganapathi, Nicholas D. Andersen, Brian R. Englum, Yamini Krishnamurthy, Jerrold H. Levy, Ian J. Welsby, and G Chad Hughes. “Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? A propensity-matched comparison in hemiarch replacement.” J Thorac Cardiovasc Surg 152, no. 6 (December 2016): 1559-1569.e2. https://doi.org/10.1016/j.jtcvs.2016.08.014.Full Text Link to Item
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Fierro, Michael A., and Ian J. Welsby. “Identification of Severe Mitral Stenosis Using Real-Time Three-Dimensional Transesophageal Echocardiography During an Left Ventricular Assist Device Insertion.” Anesth Analg 123, no. 5 (November 2016): 1089–93. https://doi.org/10.1213/ANE.0000000000001551.Full Text Link to Item
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Klinger, Rebecca Y., Mary Cooter, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Thomas L. Ortel, Ian J. Welsby, et al. “Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.” Can J Anaesth 63, no. 11 (November 2016): 1223–32. https://doi.org/10.1007/s12630-016-0704-0.Full Text Link to Item
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Connolly, Stuart J., Truman J. Milling, John W. Eikelboom, C Michael Gibson, John T. Curnutte, Alex Gold, Michele D. Bronson, et al. “Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors.” N Engl J Med 375, no. 12 (September 22, 2016): 1131–41. https://doi.org/10.1056/NEJMoa1607887.Full Text Link to Item
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Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.Full Text Link to Item
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Ghadimi, Kamrouz, and Ian J. Welsby. “New reversal agent for factor Xa inhibitors shows promise.” Evid Based Med 21, no. 3 (June 2016): 96. https://doi.org/10.1136/ebmed-2016-110390.Full Text Link to Item
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Hanna, Jennifer M., Jeffrey E. Keenan, Hanghang Wang, Nicholas D. Andersen, Jeffrey G. Gaca, Frederick W. Lombard, Ian J. Welsby, and G Chad Hughes. “Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 151, no. 2 (February 2016): 376–82. https://doi.org/10.1016/j.jtcvs.2015.08.079.Full Text Link to Item
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Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.Full Text Open Access Copy Link to Item
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Schechter, Matthew A., Asad A. Shah, Brian R. Englum, Judson B. Williams, Asvin M. Ganapathi, John D. Davies, Ian J. Welsby, and G Chad Hughes. “Prolonged postoperative respiratory support after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor?” J Crit Care 31, no. 1 (February 2016): 125–29. https://doi.org/10.1016/j.jcrc.2015.10.021.Full Text Link to Item
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Heath, Michele, Atilio Barbeito, Ian Welsby, Cory Maxwell, Alexander Iribarne, and Karthik Raghunathan. “Using Zero-Balance Ultrafiltration With Dialysate as a Replacement Solution for Toxin and Eptifibatide Removal on a Dialysis-Dependent Patient During Cardiopulmonary Bypass.” J Cardiothorac Vasc Anesth 30, no. 1 (January 2016): 162–68. https://doi.org/10.1053/j.jvca.2014.12.007.Full Text Link to Item
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Welsby, Ian J., and Jessica L. Poisson. “Perioperative Removal of Autologous Platelets.” Ann Thorac Surg 100, no. 5 (November 2015): 1970. https://doi.org/10.1016/j.athoracsur.2015.04.014.Full Text Link to Item
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Bartz, Raquel R., Renata G. Ferreira, Jacob N. Schroder, John Davies, Wen-Wei Liu, Andre Camara, and Ian J. Welsby. “Prolonged pulmonary support after cardiac surgery: incidence, risk factors and outcomes: a retrospective cohort study.” J Crit Care 30, no. 5 (October 2015): 940–44. https://doi.org/10.1016/j.jcrc.2015.04.125.Full Text Link to Item
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Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.Full Text Open Access Copy Link to Item
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Shah, Nirmish, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, and Vance G. Nielsen. “Sickle cell disease is associated with iron mediated hypercoagulability.” J Thromb Thrombolysis 40, no. 2 (August 2015): 182–85. https://doi.org/10.1007/s11239-015-1230-6.Full Text Link to Item
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Dallas, Torijaun, Ian Welsby, Brandi Bottiger, Carmelo Milano, Mani Daneshmand, and Nicole Guinn. “Bloodless Orthotopic Heart Transplantation in a Jehovah's Witness.” A a Case Rep 4, no. 10 (May 15, 2015): 140–42. https://doi.org/10.1213/XAA.0000000000000067.Full Text Link to Item
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Welsby, Ian J., and Yi-Ju Li. “Invited commentary.” Ann Thorac Surg 99, no. 3 (March 2015): 768–69. https://doi.org/10.1016/j.athoracsur.2014.11.006.Full Text Link to Item
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Hirji, Sameer A., John C. Haney, Ian Welsby, Frederick W. Lombard, and Mark F. Berry. “Hyperbaric oxygen therapy for treatment of neurologic sequela after atrioesophageal fistula.” Ann Thorac Surg 99, no. 2 (February 2015): 681–82. https://doi.org/10.1016/j.athoracsur.2014.04.058.Full Text Link to Item
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Schechter, Matthew A., Chetan B. Patel, Laura J. Blue, Ian Welsby, Joseph G. Rogers, Jacob N. Schroder, and Carmelo A. Milano. “Improved early survival with a nonsternotomy approach for continuous-flow left ventricular assist device replacement.” Ann Thorac Surg 99, no. 2 (February 2015): 561–66. https://doi.org/10.1016/j.athoracsur.2014.08.032.Full Text Link to Item
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Welsby, Ian, and Thomas L. Ortel. “Is it time for individualized thromboprophylaxis regimens in the ICU?” Crit Care Med 43, no. 2 (February 2015): 500–501. https://doi.org/10.1097/CCM.0000000000000784.Full Text Link to Item
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Cronin, Brett, Timothy Maus, Victor Pretorius, Liem Nguyen, Desmond Johnson, Julio Ovando, William Auger, et al. “Case 13--2014: Management of pulmonary hemorrhage after pulmonary endarterectomy with venovenous extracorporeal membrane oxygenation without systemic anticoagulation.” J Cardiothorac Vasc Anesth 28, no. 6 (December 2014): 1667–76. https://doi.org/10.1053/j.jvca.2014.07.018.Full Text Link to Item
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Welsby, Ian J., Barbara Phillips-Bute, Joseph P. Mathew, Mark F. Newman, Richard Becker, Sunil Rao, Carmelo A. Milano, and Mark Stafford-Smith. “ABO blood group influences transfusion and survival after cardiac surgery.” J Thromb Thrombolysis 38, no. 3 (October 2014): 402–8. https://doi.org/10.1007/s11239-013-1045-2.Full Text Link to Item
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Zhou, Shan, and Ian Welsby. “Is ABO blood group truly a risk factor for thrombosis and adverse outcomes?” World J Cardiol 6, no. 9 (September 26, 2014): 985–92. https://doi.org/10.4330/wjc.v6.i9.985.Full Text Link to Item
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Heath, Michele, Karthik Raghunathan, Ian Welsby, and Cory Maxwell. “Using Zero Balance Ultrafiltration with Dialysate as a Replacement Fluid for Hyperkalemia during Cardiopulmonary Bypass.” J Extra Corpor Technol 46, no. 3 (September 2014): 262–66.Link to Item
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Fontes, Monique T., David L. McDonagh, Barbara Phillips-Bute, Ian J. Welsby, Mihai V. Podgoreanu, Manuel L. Fontes, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group (NORG) of the Duke Heart Center. “Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction.” J Cardiothorac Vasc Anesth 28, no. 3 (June 2014): 462–66. https://doi.org/10.1053/j.jvca.2013.03.034.Full Text Link to Item
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Alberts, Melissa, Nicholas Bandarenko, Jeffrey Gaca, Evelyn Lockhart, Carmelo Milano, Stanlin Alexander, Dean Linder, Frederick W. Lombard, and Ian J. Welsby. “Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion.” Transfusion 54, no. 5 (May 2014): 1348–57. https://doi.org/10.1111/trf.12463.Full Text Link to Item
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Pathak, Vikas, Ian Welsby, Kamran Mahmood, Momen Wahidi, Neil MacIntyre, and Scott Shofer. “Ventilation and anesthetic approaches for rigid bronchoscopy.” Ann Am Thorac Soc 11, no. 4 (May 2014): 628–34. https://doi.org/10.1513/AnnalsATS.201309-302FR.Full Text Link to Item
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Esper, Stephen A., Jerrold H. Levy, Jonathan H. Waters, and Ian J. Welsby. “Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion.” Anesth Analg 118, no. 4 (April 2014): 731–43. https://doi.org/10.1213/ANE.0000000000000115.Full Text Link to Item
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Roman, Philip E. F., Adam D. DeVore, and Ian J. Welsby. “Techniques and applications of perioperative therapeutic plasma exchange.” Curr Opin Anaesthesiol 27, no. 1 (February 2014): 57–64. https://doi.org/10.1097/ACO.0000000000000037.Full Text Link to Item
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Lee, Grace M., Ian J. Welsby, Barbara Phillips-Bute, Thomas L. Ortel, and Gowthami M. Arepally. “High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass.” Blood 121, no. 15 (April 11, 2013): 2828–35. https://doi.org/10.1182/blood-2012-11-469130.Full Text Link to Item
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Firstenberg, Michael S., Cornelius M. Dyke, Dominick J. Angiolillo, Chandrashekar Ramaiahm, Matthew Price, Miroslav Brtko, Ian Welsby, et al. “Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery.” Heart Surg Forum 16, no. 2 (April 2013): E60–69. https://doi.org/10.1532/HSF98.20121103.Full Text Link to Item
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Andersen, Nicholas D., Syamal D. Bhattacharya, Judson B. Williams, Emil L. Fosbol, Evelyn L. Lockhart, Mayur B. Patel, Jeffrey G. Gaca, Ian J. Welsby, and G Chad Hughes. “Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations.” Ann Thorac Surg 93, no. 6 (June 2012): 1921–28. https://doi.org/10.1016/j.athoracsur.2012.02.037.Full Text Link to Item
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Machovec, Kelly A., Deepu S. Ushakumari, Ian J. Welsby, and Vance G. Nielsen. “The procoagulant properties of purified fibrinogen concentrate are enhanced by carbon monoxide releasing molecule-2.” Thromb Res 129, no. 6 (June 2012): 793–96. https://doi.org/10.1016/j.thromres.2011.08.005.Full Text Link to Item
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Welsby, Ian J., and Barbara Phillips-Bute. “Invited commentary.” Ann Thorac Surg 93, no. 3 (March 2012): 883. https://doi.org/10.1016/j.athoracsur.2011.11.045.Full Text Link to Item
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Angiolillo, Dominick J., Michael S. Firstenberg, Matthew J. Price, Pradyumna E. Tummala, Martin Hutyra, Ian J. Welsby, Michele D. Voeltz, et al. “Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial.” Jama 307, no. 3 (January 18, 2012): 265–74. https://doi.org/10.1001/jama.2011.2002.Full Text Link to Item
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Ceppa, Duykhanh P., Ian J. Welsby, Tracy Y. Wang, Mark W. Onaitis, Betty C. Tong, David H. Harpole, Thomas A. D’Amico, and Mark F. Berry. “Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.” Ann Thorac Surg 92, no. 6 (December 2011): 1971–76. https://doi.org/10.1016/j.athoracsur.2011.07.052.Full Text Link to Item
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Cobey, Fred, Bryan L. Balmadrid, Daniel M. Wild, Donald Glower, and Ian J. Welsby. “An unusual cause of massive gastrointestinal bleeding after transesophageal echocardiography.” J Cardiothorac Vasc Anesth 25, no. 4 (August 2011): 678–79. https://doi.org/10.1053/j.jvca.2010.04.007.Full Text Link to Item
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Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.” Ann Thorac Surg 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.Full Text Link to Item
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Williams, Judson B., Barbara Phillips-Bute, Syamal D. Bhattacharya, Asad A. Shah, Nicholas D. Andersen, Burak Altintas, Brian Lima, Peter K. Smith, G Chad Hughes, and Ian J. Welsby. “Predictors of massive transfusion with thoracic aortic procedures involving deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 141, no. 5 (May 2011): 1283–88. https://doi.org/10.1016/j.jtcvs.2010.07.098.Full Text Link to Item
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Welsby, Ian, Barbara Phillips-Bute, and Mark Stafford-Smith. “Alternate analysis strategies for retrospective assessment of outcomes with a male donor-only plasma policy.” Transfusion 51, no. 2 (February 2011): 444–45. https://doi.org/10.1111/j.1537-2995.2010.02952.x.Full Text Link to Item
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Chudasama, Shalini L., Benjamin Espinasse, Fred Hwang, Rui Qi, Manali Joglekar, Galyna Afonina, Mark R. Wiesner, Ian J. Welsby, Thomas L. Ortel, and Gowthami M. Arepally. “Heparin modifies the immunogenicity of positively charged proteins.” Blood 116, no. 26 (December 23, 2010): 6046–53. https://doi.org/10.1182/blood-2010-06-292938.Full Text Link to Item
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Welsby, Ian J., Marla Troughton, Barbara Phillips-Bute, Rebecca Ramsey, Mary Lee Campbell, Nicholas Bandarenko, Joseph P. Mathew, Mark Stafford-Smith, and Mark Cardiothoracic Anesthesiology Research Endeavors. “The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery.” J Thorac Cardiovasc Surg 140, no. 6 (December 2010): 1353–60. https://doi.org/10.1016/j.jtcvs.2009.12.035.Full Text Link to Item
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Achneck, Hardean E., Bantayehu Sileshi, Amar Parikh, Carmelo A. Milano, Ian J. Welsby, and Jeffrey H. Lawson. “Pathophysiology of bleeding and clotting in the cardiac surgery patient: from vascular endothelium to circulatory assist device surface.” Circulation 122, no. 20 (November 16, 2010): 2068–77. https://doi.org/10.1161/CIRCULATIONAHA.110.936773.Full Text Link to Item
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Welsby, Ian J., Evelyn Lockhart, Barbara Phillips-Bute, Mary Lee Campbell, Joseph P. Mathew, Mark F. Newman, Eric Peterson, Carmelo A. Milano, and Carmelo A. Mark Stafford-Smith for members of the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.), Department of Anesthesiology, Duke University Medical Center. “Storage age of transfused platelets and outcomes after cardiac surgery.” Transfusion 50, no. 11 (November 2010): 2311–17. https://doi.org/10.1111/j.1537-2995.2010.02747.x.Full Text Link to Item
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Welsby, Ian, Jennifer Crow, Nicholas Bandarenko, George Lappas, Barbara Phillips-Bute, and Mark Stafford-Smith. “A clinical prediction tool to estimate the number of units of red blood cells needed in primary elective coronary artery bypass surgery.” Transfusion 50, no. 11 (November 2010): 2337–43. https://doi.org/10.1111/j.1537-2995.2010.02711.x.Full Text Link to Item
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Stafford-Smith, Mark, Evelyn Lockhart, Nicholas Bandarenko, and Ian Welsby. “Many, but not all, outcome studies support exclusion of female plasma from the blood supply.” Expert Rev Hematol 3, no. 5 (October 2010): 551–58. https://doi.org/10.1586/ehm.10.57.Full Text Link to Item
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Berry, Mark F., Matthew Williams, Ian Welsby, and Shu Lin. “Cardiac angiosarcoma presenting with right coronary artery pseudoaneurysm.” J Cardiothorac Vasc Anesth 24, no. 4 (August 2010): 633–35. https://doi.org/10.1053/j.jvca.2009.04.002.Full Text Link to Item
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Hudson, Christopher C. C., Ian J. Welsby, Barbara Phillips-Bute, Joseph P. Mathew, Andrew Lutz, G. Chad Hughes, Mark Stafford-Smith, and Mark Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Group. “Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients.” Can J Anaesth 57, no. 6 (June 2010): 565–72. https://doi.org/10.1007/s12630-010-9294-4.Full Text Link to Item
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Welsby, Ian J., Mihai V. Podgoreanu, Barbara Phillips-Bute, Richard Morris, Joseph P. Mathew, Peter K. Smith, Mark F. Newman, Debra A. Schwinn, Mark Stafford-Smith, and Mark Perioperative Genetics and Safety Outcomes Study Investigative Team. “Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.” J Cardiothorac Vasc Anesth 24, no. 3 (June 2010): 427–33. https://doi.org/10.1053/j.jvca.2009.10.030.Full Text Link to Item
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Welsby, Ian J., John Um, Carmelo A. Milano, Thomas L. Ortel, and Gowthami Arepally. “Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia.” Anesth Analg 110, no. 1 (January 1, 2010): 30–35. https://doi.org/10.1213/ANE.0b013e3181c3c1cd.Full Text Link to Item
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Balsara, Keki R., Steven T. Morozowich, Shu S. Lin, Robert D. Davis, Barbara G. Phillips-Bute, Matthew Hartwig, James Z. Appel, and Ian J. Welsby. “Aprotinin's effect on blood product transfusion in off-pump bilateral lung transplantation.” Interact Cardiovasc Thorac Surg 8, no. 1 (January 2009): 45–48. https://doi.org/10.1510/icvts.2008.178749.Full Text Link to Item
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Shaw, Andrew D., Mark Stafford-Smith, William D. White, Barbara Phillips-Bute, Madhav Swaminathan, Carmelo Milano, Ian J. Welsby, et al. “The effect of aprotinin on outcome after coronary-artery bypass grafting.” N Engl J Med 358, no. 8 (February 21, 2008): 784–93. https://doi.org/10.1056/NEJMoa0707768.Full Text Link to Item
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Welsby, Ian J., Robert Jones, John Pylman, Jonathan B. Mark, Charles S. Brudney, Barbara Phillips-Bute, Joseph P. Mathew, Mary Lee Campbell, Mark Stafford-Smith, and Mark Cardiothoracic Anesthesiology Research Endeavours (C.A.R.E.), Department of Anesthesiology, Duke University Medical Center. “ABO blood group and bleeding after coronary artery bypass graft surgery.” Blood Coagul Fibrinolysis 18, no. 8 (December 2007): 781–85. https://doi.org/10.1097/MBC.0b013e3282f1029c.Full Text Link to Item
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Schroder, Jacob N., Mani A. Daneshmand, Nestor R. Villamizar, Rebecca P. Petersen, Laura J. Blue, Ian J. Welsby, Andrew J. Lodge, Thomas L. Ortel, Joseph G. Rogers, and Carmelo A. Milano. “Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients.” Ann Thorac Surg 84, no. 3 (September 2007): 841–45. https://doi.org/10.1016/j.athoracsur.2007.03.049.Full Text Link to Item
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Krakow, Elizabeth F., Ranjit Goudar, Elizabeth Petzold, Shayela Suvarna, Michael Last, Ian J. Welsby, Thomas L. Ortel, and Gowthami M. Arepally. “Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies.” Am J Clin Pathol 128, no. 1 (July 2007): 150–55. https://doi.org/10.1309/RFQK57F5QMURQ1HY.Full Text Link to Item
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Welsby, Ian J., and Thomas L. Ortel. “Invited commentary.” Ann Thorac Surg 84, no. 1 (July 2007): 168–69. https://doi.org/10.1016/j.athoracsur.2007.04.021.Full Text Link to Item
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Welsby, Ian J., Wilbert L. Jones, Gowthami Arepally, Fellery De Lange, Kenji Yoshitani, Barbara Phillips-Bute, Hilary P. Grocott, Richard Becker, and G Burkhard Mackensen. “Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat.” Anesthesiology 106, no. 2 (February 2007): 295–301. https://doi.org/10.1097/00000542-200702000-00018.Full Text Link to Item
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Morozowich, Steven T., Brian S. Donahue, and Ian J. Welsby. “Genetics of coagulation: considerations for cardiac surgery.” Semin Cardiothorac Vasc Anesth 10, no. 4 (December 2006): 297–313. https://doi.org/10.1177/1089253206294345.Full Text Link to Item
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Welsby, Ian J., Kuiran Jiao, Thomas L. Ortel, Charles S. Brudney, Anthony M. Roche, Elliott Bennett-Guerrero, and Tong J. Gan. “The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery.” J Cardiothorac Vasc Anesth 20, no. 4 (August 2006): 531–35. https://doi.org/10.1053/j.jvca.2005.04.013.Full Text Link to Item
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Podgoreanu, M. V., W. D. White, R. W. Morris, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, H. P. Grocott, et al. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.” Circulation 114, no. 1 Suppl (July 4, 2006): I275–81. https://doi.org/10.1161/CIRCULATIONAHA.105.001032.Full Text Link to Item
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Lombard, Frederick W., Ian J. Welsby, Michael J. Alexander, and Cecil O. Borel. “Thromboelastography detects inadequate response to abciximab therapy during stent-assisted cerebral aneurysm coil embolization complicated by stroke.” Neurocrit Care 4, no. 1 (2006): 32–34. https://doi.org/10.1385/NCC:4:1:032.Full Text Link to Item
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Bennett-Guerrero, Elliott, Thomas F. Slaughter, William D. White, Ian J. Welsby, Charles S. Greenberg, Habib El-Moalem, and Thomas L. Ortel. “Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery.” J Thorac Cardiovasc Surg 130, no. 6 (December 2005): 1567–72. https://doi.org/10.1016/j.jtcvs.2005.07.052.Full Text Link to Item
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Welsby, I. J., D. M. Monroe, J. H. Lawson, and M. Hoffmann. “Recombinant activated factor VII and the anaesthetist.” Anaesthesia 60, no. 12 (December 2005): 1203–12. https://doi.org/10.1111/j.1365-2044.2005.04376.x.Full Text Link to Item
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Welsby, Ian J., and Mark Stafford-Smith. “Protamine contributes to myocardial ischemia.” Anesthesiology 103, no. 3 (September 2005): 669. https://doi.org/10.1097/00000542-200509000-00040.Full Text Link to Item
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Sreeram, Gautam M., Ian J. Welsby, Ajeet D. Sharma, Barbara Phillips-Bute, Peter K. Smith, and Thomas F. Slaughter. “Infectious complications after cardiac surgery: lack of association with fresh frozen plasma or platelet transfusions.” J Cardiothorac Vasc Anesth 19, no. 4 (August 2005): 430–34. https://doi.org/10.1053/j.jvca.2005.05.001.Full Text Link to Item
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Stafford-Smith, Mark, Edward A. Lefrak, Anjum G. Qazi, Ian J. Welsby, Linda Barber, Andreas Hoeft, Alejandro Dorenbaum, et al. “Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass.” Anesthesiology 103, no. 2 (August 2005): 229–40. https://doi.org/10.1097/00000542-200508000-00005.Full Text Link to Item
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Patteril, Mathew, Mark Stafford-Smith, John G. Toffaletti, Barbara Phillips Bute, Carmelo A. Milano, and Ian J. Welsby. “Changing systems for measuring activated clotting times: impact on the clinical practice of heparin anticoagulation during cardiac surgery.” Clin Chim Acta 356, no. 1–2 (June 2005): 218–24. https://doi.org/10.1016/j.cccn.2005.01.019.Full Text Link to Item
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Welsby, I. J., M. V. Podgoreanu, B. Phillips-Bute, J. P. Mathew, P. K. Smith, M. F. Newman, D. A. Schwinn, M. Stafford-Smith, and M. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “Genetic factors contribute to bleeding after cardiac surgery.” J Thromb Haemost 3, no. 6 (June 2005): 1206–12. https://doi.org/10.1111/j.1538-7836.2005.01337.x.Full Text Link to Item
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Welsby, Ian J., Mark F. Newman, Barbara Phillips-Bute, Robert H. Messier, Emil D. Kakkis, and Mark Stafford-Smith. “Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery.” Anesthesiology 102, no. 2 (February 2005): 308–14. https://doi.org/10.1097/00000542-200502000-00011.Full Text Link to Item
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Jain, U., I. J. Welsby, and M. Stafford-Smith. “Protamine contributes to myocardial ischemia [3] (multiple letters).” Anesthesiology 103, no. 3 (January 1, 2005): 669–70. https://doi.org/10.1097/00000542-200509000-00039.Full Text
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Mathew, Joseph P., Stanton K. Shernan, William D. White, Jane C. K. Fitch, John C. Chen, Leonard Bell, and Mark F. Newman. “Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery.” Stroke 35, no. 10 (October 2004): 2335–39. https://doi.org/10.1161/01.STR.0000141938.00524.83.Full Text Link to Item
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Welsby, Ian J., and Mark Stafford-Smith. “Monitoring direct thrombin inhibitors: time for standardization.” Anesthesiology 101, no. 4 (October 2004): 1048–49. https://doi.org/10.1097/00000542-200410000-00056.Full Text Link to Item
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Bar-Yosef, Shahar, Joseph P. Mathew, Mark F. Newman, Kevin P. Landolfo, Hilary P. Grocott, and Hilary P. Neurological Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. “Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study.” Anesth Analg 99, no. 3 (September 2004): 641–46. https://doi.org/10.1213/01.ANE.0000130354.90659.63.Full Text Link to Item
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Smigla, Greg R., D Scott Lawson, Ian R. Shearer, James Jaggers, Carmelo Milano, and Ian Welsby. “An ultrafiltration technique for directly reinfusing residual cardiopulmonary bypass blood.” J Extra Corpor Technol 36, no. 3 (September 2004): 231–34.Link to Item
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MacKensen, G Burkhard, Madhav Swaminathan, Lian K. Ti, Hilary P. Grocott, Barbara G. Phillips-Bute, Joseph P. Mathew, Mark F. Newman, et al. “Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG.” Ann Thorac Surg 78, no. 2 (August 2004): 520–26. https://doi.org/10.1016/j.athoracsur.2004.02.106.Full Text Link to Item
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Mathew, Joseph P., Manuel L. Fontes, Iulia C. Tudor, James Ramsay, Peter Duke, C David Mazer, Paul G. Barash, et al. “A multicenter risk index for atrial fibrillation after cardiac surgery.” Jama 291, no. 14 (April 14, 2004): 1720–29. https://doi.org/10.1001/jama.291.14.1720.Full Text Link to Item
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Djaiani, George, Barbara Phillips-Bute, Mihai Podgoreanu, Robert H. Messier, Joseph P. Mathew, Fiona Clements, and Mark F. Newman. “The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery.” Anesth Analg 98, no. 3 (March 2004): 585–89. https://doi.org/10.1213/01.ane.0000099721.67426.de.Full Text Link to Item
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Lombard, Frederick W., Ian J. Welsby, and John V. Booth. “Systemic air embolism during off-pump coronary artery bypass surgery.” J Cardiothorac Vasc Anesth 17, no. 3 (June 2003): 403–4. https://doi.org/10.1016/s1053-0770(03)00068-5.Full Text Link to Item
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Mathew, Joseph P., Hilary P. Grocott, Barbara Phillips-Bute, Mark Stafford-Smith, Daniel T. Laskowitz, Daniel Rossignol, James A. Blumenthal, Mark F. Newman, Mark F. Neurologic Outcome Research Group of the Duke Heart Center, and Mark F. Cardiothoracic Anesthesiology Research Endeavors Investigators of the Duke Heart Center. “Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.” Stroke 34, no. 2 (February 2003): 508–13. https://doi.org/10.1161/01.str.0000053844.09493.58.Full Text Link to Item
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Welsby, Ian J., J Mark Ryan, John V. Booth, Ellen Flanagan, Robert H. Messier, and Cecil O. Borel. “The bispectral index in the diagnosis of perioperative stroke: a case report and discussion.” Anesth Analg 96, no. 2 (February 2003): 435–37. https://doi.org/10.1097/00000539-200302000-00026.Full Text Link to Item
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Toffaletti, J. G., E. H. McDonnell, I. Welsby, I. R. Shearer, M. H. Sketch, and J. E. Tcheng. “Implementing a New Method for Activated Clotting Time.” Plastic Surgical Nursing 2, no. 2 (January 1, 2003): 125–28. https://doi.org/10.1097/00134384-200306000-00009.Full Text
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Booth, John V., David Schinderle, and Ian J. Welsby. “Pro: Vasopressin is the vasoconstrictor of choice after cardiopulmonary bypass.” J Cardiothorac Vasc Anesth 16, no. 6 (December 2002): 773–75. https://doi.org/10.1053/jcan.2002.128432.Full Text Link to Item
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Welsby, Ian J., Elizabeth McDonnell, Habib El-Moalem, Mark Stafford-Smith, and John G. Toffaletti. “Activated clotting time systems vary in precision and bias and are not interchangeable when following heparin management protocols during cardiopulmonary bypass.” J Clin Monit Comput 17, no. 5 (July 2002): 287–92. https://doi.org/10.1023/a:1021298103264.Full Text Link to Item
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Welsby, Ian J., Elliott Bennett-Guerrero, Darryl Atwell, William D. White, Mark F. Newman, Peter K. Smith, and Michael G. Mythen. “The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass.” Anesth Analg 94, no. 5 (May 2002): 1072–78. https://doi.org/10.1097/00000539-200205000-00004.Full Text Link to Item
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Klein, S. M., T. F. Slaughter, P. T. Vail, B. Ginsberg, H. E. El-Moalem, R. Alexander, F. D’Ercole, et al. “Thromboelastography as a perioperative measure of anticoagulation resulting from low molecular weight heparin: a comparison with anti-Xa concentrations.” Anesth Analg 91, no. 5 (November 2000): 1091–95. https://doi.org/10.1097/00000539-200011000-00009.Full Text Link to Item
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Bennett-Guerrero, E., I. Welsby, T. J. Dunn, L. R. Young, T. A. Wahl, T. L. Diers, B. G. Phillips-Bute, M. F. Newman, and M. G. Mythen. “The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery.” Anesth Analg 89, no. 2 (August 1999): 514–19. https://doi.org/10.1097/00000539-199908000-00050.Full Text Link to Item
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Welsby, I., and M. G. Mythen. “Gut perfusion during cardiac surgery.” Current Opinion in Anaesthesiology 10, no. 1 (April 8, 1997): 34–39. https://doi.org/10.1097/00001503-199702000-00010.Full Text
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Book Sections
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Hashmi, N. K., and I. J. Welsby. “What Drugs Decrease Perioperative Bleeding?” In Evidence-Based Practice of Anesthesiology, 506–18, 2022. https://doi.org/10.1016/B978-0-323-77846-6.00057-4.Full Text
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Levy, J. H., K. Ghadimi, and I. J. Welsby. “The Bleeding Cardiac Surgical Patient.” In Core Topics in Cardiothoracic Critical Care: Second Edition, 307–12, 2018. https://doi.org/10.1017/9781316443415.039.Full Text
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Levy, J. H., K. Ghadimi, and I. Welsby. “Haematological Disorders and Cardiothoracic Intensive Care.” In Core Topics in Cardiothoracic Critical Care: Second Edition, 402–7, 2018. https://doi.org/10.1017/9781316443415.051.Full Text
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Levy, J. H., R. M. Sniecinski, and I. Welsby. “Blood and coagulation.” In Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 837–48, 2018. https://doi.org/10.1016/B978-0-323-48110-6.00043-0.Full Text
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Boyd, T. M., E. Lockhart, and I. Welsby. “Split blood products.” In Perioperative Hemostasis: Coagulation for Anesthesiologists, 151–75, 2015. https://doi.org/10.1007/978-3-642-55004-1_10.Full Text
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Mitchell, J. D., and I. J. Welsby. “Central venous access,” 1:35–37, 2005. https://doi.org/10.1053/S1744-1889(06)70033-0.Full Text
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Welsby, I., and M. Mythen. “Plasma volume support in cardiac surgery,” 11:105–25, 1997. https://doi.org/10.1016/S0950-3501(97)80007-4.Full Text
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Other Articles
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Raphael, Jacob, C David Mazer, Linda Shore-Lesserson, Bruce Bollen, Jerrold H. Levy, Nanette Schwann, Sudhakar Subramani, et al. “In Response.” Anesth Analg, May 2020. https://doi.org/10.1213/ANE.0000000000004709.Full Text Link to Item
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Ghadimi, Kamrouz, Jerrold H. Levy, and Ian J. Welsby. “Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting.” Anesth Analg, May 2016. https://doi.org/10.1213/ANE.0000000000001188.Full Text Open Access Copy Link to Item
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Levy, Jerrold H., Roman M. Sniecinski, Ian J. Welsby, and Marcel Levi. “Antithrombin: anti-inflammatory properties and clinical applications.” Thromb Haemost, April 2016. https://doi.org/10.1160/TH15-08-0687.Full Text Link to Item
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Ghadimi, Kamrouz, Keith E. Dombrowski, Jerrold H. Levy, and Ian J. Welsby. “Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation.” Expert Rev Hematol, 2016. https://doi.org/10.1586/17474086.2016.1135046.Full Text Link to Item
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Welsby, Ian J., and Jerrold H. Levy. “Factor concentrates for perioperative bleeding: old drugs with new approaches.” Anesth Analg, July 2015. https://doi.org/10.1213/ANE.0000000000000806.Full Text Link to Item
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Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.Full Text Link to Item
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Levy, Jerrold H., Ian Welsby, and Lawrence T. Goodnough. “Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.” Transfusion, May 2014. https://doi.org/10.1111/trf.12431.Full Text Link to Item
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Welsby, Ian J., Barbara Phillips-Bute, and Mark W. Onaitis. “Invited commentary.” Ann Thorac Surg, July 2010. https://doi.org/10.1016/j.athoracsur.2010.04.053.Full Text Link to Item
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Conference Papers
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Daughety, Molly, Thomas L. Ortel, Erin Frost, Andrew Morgan, Chester Kao, Joyce Hwang, Bhavik Patel, and Ian J. Welsby. “COVID-19 Associated Coagulopathy: Thrombosis, Hemorrhage and Mortality Rates with an Escalated-Thromboprophylaxis Strategy.” In Blood, 136:23–24. American Society of Hematology, 2020. https://doi.org/10.1182/blood-2020-142944.Full Text
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Pollak, A. L., J. Poisson, M. Cooter, Y. D. Barac, B. Bryner, J. Haney, M. G. Hartwig, et al. “Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S330, 2020. https://doi.org/10.1016/j.healun.2020.01.349.Full Text
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Wagner, Matthew A., Hanghang Wang, Ehsan Benrashid, Jeffrey E. Keenan, Yamini Krishnamurthy, Jerrold H. Levy, Ian J. Welsby, and G Chad Hughes. “Protocolized hemostatic factor use in major thoracic aortic surgery.” In J Cardiovasc Surg (Torino), 60:633–36, 2019. https://doi.org/10.23736/S0021-9509.19.10819-1.Full Text Link to Item
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Evans, Brooke A., Reed W. Kamyszek, Andrea K. Ansari, Mark G. Piegore, Micah J. Mooberry, and Ian J. Welsby. “The Effect of Pathogen Reduction on Microparticle Prothrombinase Activity in Cryoprecipitate.” In Transfusion, 58:85A-85A. WILEY, 2018.Link to Item
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Srinivasan, Amudan J., Jessica Poisson, Erica Falcon, Andrea Ansari, Matthew Landrigan, Nirmish Shah, and Ian J. Welsby. “Pre-Transfusion Rejuvenation of RBCs for Red Blood Cell Exchange: Report of Feasibility.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.Link to Item
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Hashmi, Nazish Khalid, Kamrouz Ghadimi, Jacob Schroder, Jerrold Levy, and Ian J. Welsby. “Three Factor Prothrombin Complex Concentrates in Cardiac Surgery: A Novel Algorithmic Approach to Perioperative Bleeding.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.Link to Item
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Ghadmi, Kamrouz, Nazish Hashmi, Jerrold Levy, Thomas L. Ortel, and Ian J. Welsby. “Prothrombin Complex Concentrates and Cardiac Surgery.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.Link to Item
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Angiolillo, Dominick J., Michael S. Firstenberg, Matthew J. Price, Pradyumna E. Tummala, Martin Hutyra, Ian J. Welsby, Michele D. Voeltz, et al. “The Safety and Efficacy Of Cangrelor, a Short Acting, Intravenous, Reversible, Platelet P2Y12 Inhibiror In Patients Awaiting Cardiac Surgery: Results Of the BRIDGE Trial.” In Journal of the American College of Cardiology, 58:XIII–XIII. ELSEVIER SCIENCE INC, 2011.Link to Item
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Shah, A. A., J. B. Williams, B. Phillips-Bute, R. Bartz, G. C. Hughes, and I. J. Welsby. “Pulmonary Dysfunction After Thoracic Aortic Surgery Utilizing Deep Hypothermic Circulatory Arrest.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.Link to Item
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Balsara, K. R., S. T. Morozowich, E. L. Bush, B. Phillips-Bute, M. Hill, R. D. Davis, S. S. Lin, and I. J. Welsby. “115: Aprotinin use and primary allograft dysfunction following off-pump bilateral orthotopic lung transplantation.” In The Journal of Heart and Lung Transplantation, 26:S101–S101. Elsevier BV, 2007. https://doi.org/10.1016/j.healun.2006.11.131.Full Text
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Bush, E. L., K. R. Balsara, M. Hartwig, B. G. Phillips-Bute, A. Shaw, E. Cantu, J. Z. Appel, R. D. Davis, I. J. Welsby, and S. S. Lin. “157: Perioperative predictors of renal failure following off-pump primary double lung transplantation.” In The Journal of Heart and Lung Transplantation, 26:S116–S116. Elsevier BV, 2007. https://doi.org/10.1016/j.healun.2006.11.174.Full Text
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Podgoreanu, M. V., W. D. White, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, M. F. Newman, and D. A. Schwinn. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery.” In Circulation, 112:U432–U432. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Podgoreanu, M. V., W. D. White, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, M. F. Newman, and D. A. Schwinn. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery.” In Circulation, 112:U37–U37. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Welsby, I. J., M. Podgoreanu, J. Mathew, B. Phillips-Bute, M. F. Newman, D. A. Schwinn, and M. Stafford-Smith. “The genetics of bleeding after cardiac surgery.” In American Journal of Human Genetics, 73:517–517. UNIV CHICAGO PRESS, 2003.Link to Item
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Verma, R. K., B. Williams, and I. J. Welsby. “Differential diagnosis of perioperative metabolic acidosis.” In Critical Care Medicine, Vol. 27, 1999. https://doi.org/10.1097/00003246-199912001-00078.Full Text
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Welsby, I. J., T. J. Gan, A. Cooper, M. Mythen, and P. S. A. Glass. “A136 Thromboelastographic Changes Following 6% Hetastarch Administration for the Treatment of Perioperative Hypovolemia.” In Anesthesiology, 87:136A-136A. Ovid Technologies (Wolters Kluwer Health), 1997. https://doi.org/10.1097/00000542-199709001-00136.Full Text
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Right ventricular failure, pulmonary hypertension and pulmonary vasodilators.. Cuban Society of Anesthesiology & Reanimation Conference (SCAR) . Cuban Society of Anesthesiology & Reanimation Conference (SCAR) . November 14, 2018 2018
- Reversal of NOACs. 19th Annual Duke Anesthesiology Conference. Duke Anesthesiology Conference. June 19, 2018 2018
- The Anesthetic Care of Patients with a Left Ventricular Assist Device Undergoing Non-Cardiac Surgery. 19th Annual Duke Anesthesiology Conference. Duke Anesthesiology . June 19, 2018 2018
- Complication of ECMO, an ICU perspective (a.m. lecture) Should manipulation of p50 become a therapeutic goal in the critically ill . TriService General Hospital. October 5, 2017 2017
- Manipulating p50 to improve tissue oxygen availability, a rationale for clinical application.. University Hospitals of Leicester. September 11, 2017 2017
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Clinical Activities
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My main area of clinical practice is in the division of cardiothoracic anesthesiology and critical care medicine. I am involved in the care of adult patients undergoing cardiac and thoracic surgery, including all thoracic transplants, and electrophysiology procedures. I also have regular responsibilities as a principal intensivist in the Adult Cardiothoracic Unit, which is the postoperative critical care unit for cardiothoracic surgery. My clinical responsibilities account for 45% of my overall time commitment to the department. I also spend 10% of my clinical time providing general anesthesia at the Durham VA operating rooms, staffing the TEE service and chairing the Transfusion Committee. Additional responsibilities include teaching medical students, residents, and fellows in all clinical work areas.
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