Research Interests
Elucidating factors predisposing to thrombotic or hemorrhagic complications and adverse outcomes related to transfusion after cardiac surgery. Utilizing outcomes data after cardiac surgery to optimize transfusion safety in this patient group.
The clinical implications of the generation of antibodies to the composite heparin/platelet factor 4 antigen and the management of heparin induced thrombocytopenia (HIT), in collaboration with Dr TL Ortel, Duke Hematology, and exploring alternative anticoagulant regimens to improve anticoagulation during and after cardiac surgery for patients with HIT.
Improving the outcome associated with blood product transfusion in the cardiac surgical patient by developing techniques of microparticle elimination prior to RBC transfusion and autologous platelet harvest during cardiac surgery.
Selected Grants
Integrated Training in Anesthesiology Research
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2026Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 1975 - 2026Cerus/BARDA CLI 00125 ReCePI study
Clinical TrialPrincipal Investigator · Awarded by Cerus Corporation · 2019 - 2024A Phase 2b Open-Label, Single Arm Study to Evaluate the Efficacy of Voxelotor for Improving Oxygen Saturation and Reducing Ventilatory Support Requirements in Adult Patients with New or Increased Oxygen Requirement.
Clinical TrialPrincipal Investigator · Awarded by Global Blood Therapeutics, Inc. · 2022 - 2024Aridis 301
Clinical TrialPrincipal Investigator · Awarded by Aridis Pharmaceuticals Inc. · 2019 - 2023Single cell RNA-Seq of stored RBC to detect Autologous Blood Transfusion
ResearchCollaborator · Awarded by Partnership for Clean Competition · 2021 - 2023Clinical Study of a Method Comparison of Plasma Low in Mechanical Circulatory Support(MCS) procedures
Clinical TrialPrincipal Investigator · Awarded by HemoCue AB · 2022 - 2023CytoSorbents REFRESH II
Clinical TrialPrincipal Investigator · Awarded by CytoSorbents Corporation · 2018 - 2022HEMCS-037 Qstat Multi-site Precision Study
Clinical TrialPrincipal Investigator · Awarded by HemoSonics, LLC · 2021 - 2022Rejuvenated RBC in Healthy Subjects
Clinical TrialPrincipal Investigator · Awarded by Biomet Biologics, LLC · 2017 - 2021Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
ResearchPrincipal Investigator · Awarded by Mayo Clinic · 2014 - 2020ARrest RESpiraTory failure due to PNEUMONIA Phase 1
ResearchPrincipal Investigator · Awarded by Stanford University · 2020 - 2020Aridis AR-105 Aerucin
Clinical TrialPrincipal Investigator · Awarded by Aridis Pharmaceuticals Inc. · 2018 - 2019Detect autologous transfusion by novel separation and characterization of RBC storage exosomes
ResearchCo Investigator · Awarded by Partnership for Clean Competition · 2018 - 2019A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiac Surgery with Cardiopulmonary Bypass
Clinical TrialPrincipal Investigator · Awarded by Grifols USA, LLC · 2014 - 2019Rejuvesol Ex Vivo ECMO
ResearchPrincipal Investigator · Awarded by Biomet Biologics, LLC · 2016 - 201914-505-Andexanet Alfa in Patients Receiving a Factor Xa Inhibitor Who Have Acute Major Bleeding
Clinical TrialPrincipal Investigator · Awarded by Portola Pharmaceuticals · 2015 - 2019Evaluation of Quantra System in Adult Patients Undergoing Major Surgical Procedures
ResearchPrincipal Investigator · Awarded by HemoSonics, LLC · 2017 - 2018In Vitro Removal of Rejuvesol from Rejuvenated Units by Cell Saver
ResearchPrincipal Investigator · Awarded by Biomet Biologics, LLC · 2016 - 2018Rejuvesol Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions
ResearchPrincipal Investigator · Awarded by Biomet Biologics, LLC · 2016 - 2017LIPS-A: Lung Injury Prevention Study with Aspirin
Clinical TrialPrincipal Investigator · Awarded by Mayo Clinic · 2011 - 2016Clinical Significance of protamine/heparin antibodies after CPB
ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2014Thrombosis and Hemostasis Centers Research and Prevention Network
ResearchConsultant · Awarded by Centers for Disease Control and Prevention · 2002 - 2013Rare Thrombotic Diseases Clinical Research Network
ResearchAnesthesiologist · Awarded by National Institutes of Health · 2004 - 2010Integrated Program for Persons with Hemostatic Disorders
ResearchCollaborator · Awarded by Centers for Disease Control · 2001 - 2007External Relationships
- Anesthesia Labs
- Global Blood Therapeutics now bought by Pfizer
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.