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Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.

Publication ,  Journal Article
Posner, S; Mehta, K; Parish, A; Niedzwiecki, D; Gupta, RT; Fisher, DA; Leiman, DA
Published in: Dysphagia
October 2020

Gastroesophageal reflux disease and esophageal dysmotility are common in patients with advanced lung disease (ALD) and are associated with worse outcomes. Assessing esophageal function in these patients is relevant for determining pulmonary transplant eligibility and prognosticating post-transplant outcomes. Barium Swallow (BaS) is a non-invasive testing modality often performed as a complement to formal esophageal function tests (EFTs), but its role and clinical utility in this context is unknown. Therefore, we aimed to determine the relationship between BaS and EFTs with high-resolution manometry (HRM) and 24-h ambulatory pH-metry in patients with ALD. We performed a retrospective study of 226 consecutive patients undergoing evaluation for lung transplantation at a single center. All patients underwent EFTs and BaS independent of clinical history or symptoms per institutional protocol. Appropriate statistical tests were performed to evaluate the relationship between EFTs and BaS. Mucosal, reflux and motility findings were categorized. Abnormal motility was reported in 133 (59%) patients by BaS and 99 (44%) by HRM, with a significant difference in the proportions of patients with abnormal studies (p < 0.01). There were 7 (26%) patients with abnormal barium tablet passage who had normal HRM. The sensitivity (35%) and specificity (77%) for detecting pathologic reflux with BaS was poor. Inducibility of reflux and barium column height were not associated with pH-metry results. No clinically significant luminal irregularities were identified. In conclusion, while BaS can non-invasively assess esophageal mucosa, its findings are not associated with EFTs in patients with ALD.

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Published In

Dysphagia

DOI

EISSN

1432-0460

Publication Date

October 2020

Volume

35

Issue

5

Start / End Page

864 / 870

Location

United States

Related Subject Headings

  • Speech-Language Pathology & Audiology
  • Retrospective Studies
  • Manometry
  • Lung Diseases
  • Humans
  • Esophageal Motility Disorders
  • Barium
  • 4201 Allied health and rehabilitation science
  • 3203 Dentistry
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Posner, S., Mehta, K., Parish, A., Niedzwiecki, D., Gupta, R. T., Fisher, D. A., & Leiman, D. A. (2020). Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease. Dysphagia, 35(5), 864–870. https://doi.org/10.1007/s00455-020-10113-2
Posner, Shai, Kurren Mehta, Alice Parish, Donna Niedzwiecki, Rajan T. Gupta, Deborah A. Fisher, and David A. Leiman. “Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.Dysphagia 35, no. 5 (October 2020): 864–70. https://doi.org/10.1007/s00455-020-10113-2.
Posner S, Mehta K, Parish A, Niedzwiecki D, Gupta RT, Fisher DA, et al. Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease. Dysphagia. 2020 Oct;35(5):864–70.
Posner, Shai, et al. “Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease.Dysphagia, vol. 35, no. 5, Oct. 2020, pp. 864–70. Pubmed, doi:10.1007/s00455-020-10113-2.
Posner S, Mehta K, Parish A, Niedzwiecki D, Gupta RT, Fisher DA, Leiman DA. Esophageal Function Tests are Not Associated with Barium Swallow Findings in Advanced Lung Disease. Dysphagia. 2020 Oct;35(5):864–870.
Journal cover image

Published In

Dysphagia

DOI

EISSN

1432-0460

Publication Date

October 2020

Volume

35

Issue

5

Start / End Page

864 / 870

Location

United States

Related Subject Headings

  • Speech-Language Pathology & Audiology
  • Retrospective Studies
  • Manometry
  • Lung Diseases
  • Humans
  • Esophageal Motility Disorders
  • Barium
  • 4201 Allied health and rehabilitation science
  • 3203 Dentistry
  • 3202 Clinical sciences