Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction.

Publication ,  Journal Article
Reddy, AT; Shimpi, RA; Parish, A; Niedzwiecki, D; Leiman, DA
Published in: Dig Dis Sci
November 2021

BACKGROUND: Esophagogastric junction outflow obstruction (EGJOO) is a common but nonspecific motility pattern identified by esophageal high-resolution manometry (HRM). Functional luminal impedance planimetry (FLIP) provides information regarding lower esophageal sphincter (LES) mechanics, which can identify achalasia spectrum disorders and is useful in evaluating EGJOO. However, the relationship between HRM and FLIP parameters in EGJOO is not clearly defined. AIMS: To identify predictors of abnormal FLIP findings in patients with non-mechanical EGJOO. METHODS: This is a retrospective cohort study of patients with non-mechanical EGJOO who underwent FLIP between 10/1/16 and 7/1/19. Demographic data including age and gender, examination indication, concomitant medications, HRM parameters, symptom burden, and FLIP metrics of diameter and distensibility index (DI) were collected. DI was categorized as not low (DI > 2.8), borderline low (DI 1.1-2.8), and definitely low (DI ≤ 1). Kruskal-Wallis and Fisher's exact tests were used to assess the relationship between HRM and FLIP parameters and to identify predictors of abnormal FLIP. RESULTS: Among the 44 patients studied, most were female (n = 33, 75%) and the median age was 63. The median IRP was 18.2, and 10 (23%) patients used chronic narcotics. Lower total heartburn and regurgitation scores, and LES diameter by FLIP are associated with definitely low DI. CONCLUSIONS: In patients with non-mechanical EGJOO, reflux burden scores and FLIP diameters can aid in predicting DI. These results may provide useful adjunctive data to help in differentiating which patients have meaningful outflow obstruction.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

November 2021

Volume

66

Issue

11

Start / End Page

3968 / 3975

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Male
  • Intestinal Obstruction
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Esophagogastric Junction
  • Electric Impedance
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reddy, A. T., Shimpi, R. A., Parish, A., Niedzwiecki, D., & Leiman, D. A. (2021). Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction. Dig Dis Sci, 66(11), 3968–3975. https://doi.org/10.1007/s10620-020-06726-0
Reddy, Alexander T., Rahul A. Shimpi, Alice Parish, Donna Niedzwiecki, and David A. Leiman. “Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction.Dig Dis Sci 66, no. 11 (November 2021): 3968–75. https://doi.org/10.1007/s10620-020-06726-0.
Reddy AT, Shimpi RA, Parish A, Niedzwiecki D, Leiman DA. Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction. Dig Dis Sci. 2021 Nov;66(11):3968–75.
Reddy, Alexander T., et al. “Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction.Dig Dis Sci, vol. 66, no. 11, Nov. 2021, pp. 3968–75. Pubmed, doi:10.1007/s10620-020-06726-0.
Reddy AT, Shimpi RA, Parish A, Niedzwiecki D, Leiman DA. Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction. Dig Dis Sci. 2021 Nov;66(11):3968–3975.
Journal cover image

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

November 2021

Volume

66

Issue

11

Start / End Page

3968 / 3975

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Middle Aged
  • Male
  • Intestinal Obstruction
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Esophagogastric Junction
  • Electric Impedance
  • Cohort Studies