Skip to main content
Scholars@Duke
Menu
About
Schools / Institutes
Browse
David MacAlpine
Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
david.macalpine@duke.edu
Duke Box 3813, Durham, NC 27710
LSRC C333, Durham, NC 27710
Research
More About This Person
glance {hide_children: true, active: false, enabled: true}
At a Glance
credentials {hide_children: true, active: false, enabled: true}
Credentials
Education
academic-experience {hide_children: true, active: false, enabled: true}
Academic Experience
Current Appointments & Affiliations
Previous Appointments & Affiliations
expertise {hide_children: true, active: false, enabled: false}
Expertise
research {hide_children: false, active: true, enabled: true}
Research
Selected Grants
publications {hide_children: true, active: false, enabled: true}
Publications
Selected Publications
artistic-works {hide_children: true, active: false, enabled: false}
Artistic Works / Events
teaching {hide_children: true, active: false, enabled: true}
Teaching
Recent Courses
advising-mentoring {hide_children: true, active: false, enabled: false}
Advising & Mentoring
recognition {hide_children: true, active: false, enabled: false}
Recognition
professional-activities {hide_children: true, active: false, enabled: false}
Professional Activities
Manage Profile
Embed Profile Data
Manage Profile
Embed Profile Data
Selected Grants
Pharmacological Sciences Training Program
Inst. Training Prgm or CME
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2025 - 2030
Chromatin-mediated mechanisms of genome integrity
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2018 - 2028
Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institute of General Medical Sciences ·
2022 - 2027
Cell and Molecular Biology Training Program
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institute of General Medical Sciences ·
2021 - 2026
Genetic and Genomics Training Grant
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2020 - 2025
Medical Scientist Training Program
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
1997 - 2022
Defining RAS isoform- and mutation-specific roles in oncogenesis
Research
Collaborating Investigator ·
Awarded by University of North Carolina - Chapel Hill ·
2016 - 2022
Understanding methionine metabolism and its therapeutic potential in cancer
Research
Advisor ·
Awarded by National Institutes of Health ·
2019 - 2021
Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2005 - 2021
Genetics Training Grant
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
1979 - 2020
Pharmacological Sciences Training Program
Inst. Training Prgm or CME
Participating Faculty Member ·
Awarded by National Institutes of Health ·
1975 - 2020
Organization and Function of Cellular Structure
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
1975 - 2020
Pharmacology Industry Internships for Ph.D. Students
Inst. Training Prgm or CME
Participating Faculty Member ·
Awarded by American Society for Pharmacology and Experimental Therapeutics ·
2017 - 2019
Effects of dietary methionine restriction on tumor growth and epigenetics
Fellowship
Co-Mentor ·
Awarded by American Cancer Society, Inc. ·
2018 - 2019
RalA signal transduction
Research
Collaborator ·
Awarded by National Institutes of Health ·
2002 - 2019
Chromatin architecture defines DNA replication origins
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2013 - 2018
Defining chromatin architecture and maturation at sites of DNA replication in the Drosophila melanogaster genome
Fellowship
Principal Investigator ·
Awarded by National Institutes of Health ·
2015 - 2018
Non-Canonical Responses to DNA damage in Drosophila Polyploid Cells
Fellowship
Collaborator ·
Awarded by National Institutes of Health ·
2015 - 2017
The role of H3K27M-induced aberrant PRC2 activity in brainstem gliomagenesis
Fellowship
Co-Sponsor ·
Awarded by National Institutes of Health ·
2015 - 2017
Cancer Biology Training Grant
Inst. Training Prgm or CME
Mentor ·
Awarded by National Cancer Institute ·
1993 - 2016
Defining The Human DNA Replication Program-First Resubmission
Research
Principal Investigator ·
Awarded by American Cancer Society, Inc. ·
2011 - 2015
Illumina Hi-Seq 2000 Sequencing System
Equipment
Major User ·
Awarded by National Institutes of Health ·
2012 - 2013
The Systematic Identification and Analysis of Replication Origins in Drosophila
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2007 - 2013
High-performance Computing System for Bioinformatics
Equipment
Major User ·
Awarded by National Institutes of Health ·
2009 - 2010
