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David Severson

House Staff
Surgery

Current Appointments & Affiliations


Recent Publications


CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity.

Journal Article Sci Immunol · December 19, 2025 Tumor antigen vaccination represents an appealing approach for cancer but has failed to materialize as oncologic standard of care. To understand long-term vaccine efficacy, we conducted a retrospective analysis of patients with human epidermal growth recep ... Full text Link to item Cite

Multiomic, Histologic, and scRNA-seq Profiling of Pleural Mesothelioma Reveals Negative Prognosis Associated With a Novel Uncommitted Molecular Phenotype.

Journal Article Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · November 2025 IntroductionMultiomics pleural mesothelioma (PM) studies have identified prognostic molecular subsets of PM histologic types, epithelioid (ePM), biphasic (bPM), and sarcomatoid (sPM), defined by relative tumor cell content. However, the underlying ... Full text Cite

Abstract 95: Uncommitted cells and phenotypic plasticity elucidate the complexity of the epithelial-mesenchymal molecular gradient of pleural mesothelioma

Journal Article Cancer Research · April 4, 2023 AbstractPleural mesothelioma (PM) comprises three major histologic types: epithelioid, sarcomatoid, and a mixture of the two types termed biphasic. We and others have investigated whole transcriptome profile ... Full text Cite
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Recent Grants


Decoding tumor-defining crosstalk between mesothelioma malignant cells and their microenvironment

FellowshipPI-Fellow · Awarded by American Cancer Society, Inc. · 2025 - 2026

Decoding tumor-defining crosstalk between mesothelioma malignant cells and their associated microenvironment

ResearchPI-Fellow · Awarded by American Association for Thoracic Surgery · 2024 - 2026

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