David Severson

Journal Article Sci Immunol · December 19, 2025 Tumor antigen vaccination represents an appealing approach for cancer but has failed to materialize as oncologic standard of care. To understand long-term vaccine efficacy, we conducted a retrospective analysis of patients with human epidermal growth recep ... Full text Link to item Cite

Multi-omics, histologic, and scRNA-seq profiling of pleural mesothelioma reveals negative prognosis associated with a novel uncommitted molecular phenotype.

Journal Article Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · November 2025 IntroductionMulti-omics pleural mesothelioma (PM) studies have identified prognostic molecular subsets of PM histologic types: epithelioid (ePM), biphasic (bPM), and sarcomatoid (sPM) defined by relative tumor cell content. However, the underlying ... Full text Cite

Abstract 95: Uncommitted cells and phenotypic plasticity elucidate the complexity of the epithelial-mesenchymal molecular gradient of pleural mesothelioma

Journal Article Cancer Research · April 4, 2023 AbstractPleural mesothelioma (PM) comprises three major histologic types: epithelioid, sarcomatoid, and a mixture of the two types termed biphasic. We and others have investigated whole transcriptome profile ... Full text Cite

Association of RERG Expression with Female Survival Advantage in Malignant Pleural Mesothelioma.

Journal Article Cancers · February 2021 Sex differences in incidence, prognosis, and treatment response have been described for many cancers. In malignant pleural mesothelioma (MPM), a lethal disease associated with asbestos exposure, men outnumber women 4 to 1, but women consistently live longe ... Full text Cite

Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.

Journal Article The Journal of pathology · January 2021 BRCA1-associated protein-1 (BAP1) expression is commonly lost in several tumors including malignant pleural mesothelioma (MPM). Presence or absence of immunohistochemical BAP1 nuclear staining in tumor cells is currently used for differential diagnosis of ... Full text Cite

Mesothelioma in the age of "Omics": Before and after The Cancer Genome Atlas.

Journal Article The Journal of thoracic and cardiovascular surgery · October 2020 Featured Publication Full text Cite

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.

Journal Article CA: a cancer journal for clinicians · September 2019 Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts o ... Full text Cite

Integrative Molecular Characterization of Malignant Pleural Mesothelioma.

Journal Article Cancer discovery · December 2018 Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to ... Full text Cite

Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands.

Journal Article Nature communications · October 2018 Featured Publication Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett's oesophagus is highly heterogeneous and its relations ... Full text Cite

BEARscc determines robustness of single-cell clusters using simulated technical replicates.

Journal Article Nature communications · March 2018 Featured Publication Single-cell messenger RNA sequencing (scRNA-seq) has emerged as a powerful tool to study cellular heterogeneity within complex tissues. Subpopulations of cells with common gene expression profiles can be identified by applying unsupervised clustering algor ... Full text Cite

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · July 2014 Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. A central question in both diseases is how the loss of cell polarity is sensed by cell death machinery. Here, we identify apoptosis-stimulating protein of p53 with s ... Full text Cite

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.

Journal Article Cell · May 2014 Regulation of nuclear import is fundamental to eukaryotic biology. The majority of nuclear import pathways are mediated by importin-cargo interactions. Yet not all nuclear proteins interact with importins, necessitating the identification of a general impo ... Full text Cite