Debra Lynn Silver
Associate Professor of Molecular Genetics and Microbiology
How is the brain assembled and sculpted during embryonic development? Addressing this question has enormous implications for understanding neurodevelopmental disorders affecting brain size and function. In evolutionary terms, our newest brain structure is the cerebral cortex, which drives higher cognitive capacities. The overall mission of my research lab is to elucidate genetic and cellular mechanisms controlling cortical development and contributing to neurodevelopmental pathologies and brain evolution. We study neural progenitors, essential cells which generate neurons and are the root of brain development. We are guided by the premise that the same mechanisms at play during normal development were co-opted during evolution and when dysregulated, can cause neurodevelopmental disease.
My research program employs a multifaceted strategy to bridge developmental neurobiology, RNA biology, and evolution. 1) We investigate how cell fates are specified, by studying how progenitor divisions influence development and disease. 2) We study diverse layers of post-transcriptional regulation in neural progenitors. We investigate RNA binding proteins implicated in development and neurological disease. Using live imaging, we also investigate how sub-cellular control of mRNA localization and translation influences neural progenitors. 3) A parallel research focus is to understand how human-specific genetic changes influence species-specific brain development. Our goal is to integrate our efforts across these three major lines of research to understand the intricacies controlling brain development.
Current Appointments & Affiliations
- Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2017
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2017
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2017
- Investigator in the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2010
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2010
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Background
-
Education, Training, & Certifications
- Postdoctoral Fellowship, National Human Genome Research Institute, National Institutes of Health 2003 - 2010
- Ph.D., Johns Hopkins University 2003
- B.S., Tufts University 1993
-
Previous Appointments & Affiliations
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2017
- Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2011 - 2017
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2011 - 2017
-
Leadership & Clinical Positions at Duke
-
T32 Director, Developmental and Stem Cell Biology PhD program
Co-Director, Duke Regeneration Center
-
T32 Director, Developmental and Stem Cell Biology PhD program
- Recognition
-
In the News
-
NOV 23, 2022 -
JUN 28, 2022 -
FEB 10, 2021 -
MAR 4, 2020 -
SEP 5, 2018 -
DEC 1, 2016 -
SEP 12, 2016 -
JAN 5, 2016 -
FEB 24, 2015 The New York Times -
FEB 20, 2015 The Washington Post -
FEB 20, 2015 NPR -
FEB 19, 2015 -
JAN 6, 2015
-
- Expertise
-
Subject Headings
- Animals
- Brain
- Cell Line
- Cell Proliferation
- Electroporation
- Embryo, Mammalian
- Evolution
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genetic Predisposition to Disease
- Haploinsufficiency
- Humans
- Image Processing, Computer-Assisted
- Infant, Newborn
- Intellectual Disability
- Malformations of Cortical Development
- Mice
- Mice, Transgenic
- Microcephaly
- Mitosis
- Muser Mentor
- Mutation, Missense
- Neural Crest
- Neural Stem Cells
- Organoids
- RNA Processing, Post-Transcriptional
- Research
-
Selected Grants
- Roles for uniquely human enhancers in brain development and Wnt signaling awarded by National Institutes of Health 2023 - 2027
- RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Mechanisms underlying DDX3X pathology in autism spectrum disorder awarded by National Institutes of Health 2021 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- The Role of mRNA decay factor CNOT3 in cortical development awarded by National Institutes of Health 2022 - 2025
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Dynamic control of cortical development and disease by mRNA stability awarded by National Institutes of Health 2022 - 2024
- Essential requirements of Eif4a3 in brain development and disease awarded by National Institutes of Health 2013 - 2024
- Dysregulation of RNA metabolism and cytoskeleton dynamics during neuronal maturation. awarded by Brain and Behavior Research Foundation 2023 - 2024
- Elucidating the molecular pathogenesis of DDX3X missense mutations associated with dominant negative phenotypes in DDX3X-ID awarded by National Institutes of Health 2021 - 2023
- Role of ATAD3A in lysosomal homeostasis and neurogenesis awarded by Oklahoma Medical Research Foundation 2021 - 2023
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation 2019 - 2023
- Cell-based assays to elucidate how DD3X missense mutations influence neural cell fate awarded by The DDX3X Foundation 2021 - 2022
- The role of an Intellectual Disability gene, DDX3X, in neural progenitors during brain development awarded by National Institutes of Health 2019 - 2022
- Zeiss Lightsheet Upgrade to Expand Imaging Capabilities awarded by National Institutes of Health 2021 - 2022
- Epitranscriptomic Control of Local Gene Expression in Neural Stem Cells awarded by National Institutes of Health 2019 - 2021
- Using mouse models to uncover molecular and cellular impacts of DDX3X mutation awarded by The DDX3X Foundation 2020 - 2021
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
- Uncovering the role of Rho-GTPase in brain development and neural disorders awarded by Ruth K. Broad Biomedical Research Foundation 2020 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Amelioration of neural stem cell defects underlying Zika virus induced microcephaly awarded by Hartwell Foundation 2017 - 2020
- Post-transcriptional RNA regulation in mammalian neural stem cells awarded by National Institutes of Health 2017 - 2020
- Role of RNA-binding proteins in neural stem cell biology and disease awarded by Ruth K. Broad Biomedical Research Foundation 2018 - 2019
- Control of cell fate by progenitor mitosis length and microcephaly-linked genes during cortical development awarded by National Institutes of Health 2017 - 2019
- Innate Immune Inhibition of the Mevalonate Pathway impairs Neurodevelopment during ZIKv infection awarded by National Institutes of Health 2017 - 2019
- Zika virus infection of neural stem cells to model pathogen-induced microcephaly awarded by National Institutes of Health 2016 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Asymmetric RNA localization in neural stem cells during cortical development awarded by National Institutes of Health 2016 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Dissecting the role of the exon junction complex in embryonic corticogenesis awarded by National Institutes of Health 2016 - 2017
- Analysis of the Exon Junction Complex in Neural Development and Microcephaly awarded by National Institutes of Health 2008 - 2013
-
External Relationships
- CUNY/The City college of NY
- Columbia University
- Company of Biologists
- Emory University School of Medicine
- National Institutes of Health
- Nomis Foundation
- Sanford Health
- Simons Foundation
- University of California at Santa Cruz
- University of Chicago
- University of Geneva
- University of Oxford
- University of Pennsylvania Medical Center
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Lupan, Bianca M., Rachel A. Solecki, Camila M. Musso, Fernando C. Alsina, and Debra L. Silver. “The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis.” Development 150, no. 10 (May 15, 2023). https://doi.org/10.1242/dev.201619.Full Text Link to Item
-
Pilaz, Louis-Jan, Jing Liu, Kaumudi Joshi, Yuji Tsunekawa, Camila M. Musso, Brooke R. D’Arcy, Ikuo K. Suzuki, et al. “Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.” Neuron 111, no. 6 (March 15, 2023): 839-856.e5. https://doi.org/10.1016/j.neuron.2023.02.023.Full Text Link to Item
-
D’Arcy, Brooke R., Ashley L. Lennox, Camila Manso Musso, Annalise Bracher, Carla Escobar-Tomlienovich, Stephany Perez-Sanchez, and Debra L. Silver. “Non-muscle myosins control radial glial basal endfeet to mediate interneuron organization.” Plos Biol 21, no. 2 (February 2023): e3001926. https://doi.org/10.1371/journal.pbio.3001926.Full Text Link to Item
-
Mangan, Riley J., Fernando C. Alsina, Federica Mosti, Jesús Emiliano Sotelo-Fonseca, Daniel A. Snellings, Eric H. Au, Juliana Carvalho, et al. “Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.” Cell 185, no. 24 (November 23, 2022): 4587-4603.e23. https://doi.org/10.1016/j.cell.2022.10.016.Full Text Link to Item
-
Hoye, Mariah L., Lorenzo Calviello, Abigail J. Poff, Nna-Emeka Ejimogu, Carly R. Newman, Maya D. Montgomery, Jianhong Ou, Stephen N. Floor, and Debra L. Silver. “Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.” Elife 11 (June 28, 2022). https://doi.org/10.7554/eLife.78203.Full Text Link to Item
-
Liu, Jing, Federica Mosti, and Debra L. Silver. “Human brain evolution: Emerging roles for regulatory DNA and RNA.” Curr Opin Neurobiol 71 (December 2021): 170–77. https://doi.org/10.1016/j.conb.2021.11.005.Full Text Link to Item
-
Mosti, Federica, and Debra L. Silver. “Uncovering the HARbingers of human brain evolution.” Neuron 109, no. 20 (October 20, 2021): 3231–33. https://doi.org/10.1016/j.neuron.2021.09.022.Full Text Link to Item
-
Baldwin, Katherine T., and Debra L. Silver. “Expanding gliogenesis.” Science 372, no. 6547 (June 11, 2021): 1151–52. https://doi.org/10.1126/science.abj1139.Full Text Link to Item
-
Liu, Jing, and Debra L. Silver. “Founder cells shape brain evolution.” Cell 184, no. 8 (April 15, 2021): 1965–67. https://doi.org/10.1016/j.cell.2021.03.045.Full Text Link to Item
-
Hoye, Mariah L., and Debra L. Silver. “Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.” Curr Opin Neurobiol 66 (February 2021): 93–102. https://doi.org/10.1016/j.conb.2020.10.001.Full Text Link to Item
-
D’Arcy, Brooke R., and Debra L. Silver. “Local gene regulation in radial glia: Lessons from across the nervous system.” Traffic 21, no. 12 (December 2020): 737–48. https://doi.org/10.1111/tra.12769.Full Text Link to Item
-
Lupan, Bianca M., and Debra L. Silver. “Evolution: Does More Time Buy More Neurons?” Curr Biol 30, no. 21 (November 2, 2020): R1316–18. https://doi.org/10.1016/j.cub.2020.08.098.Full Text Link to Item
-
Pilaz, Louis-Jan, Kaumudi Joshi, Jing Liu, Yuji Tsunekawa, Fernando Alsina, Sahil Sethi, Ikuo Suzuki, Pierre Vanderhaeghen, Franck Polleux, and Debra Silver. “Subcellular mRNA localization and local translation of Arhgap11a in radial glial cells regulates cortical development.” Biorxiv, July 31, 2020. https://doi.org/10.1101/2020.07.30.229724.Full Text Open Access Copy
-
Lennox, Ashley L., Mariah L. Hoye, Ruiji Jiang, Bethany L. Johnson-Kerner, Lindsey A. Suit, Srivats Venkataramanan, Charles J. Sheehan, et al. “Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.” Neuron 106, no. 3 (May 6, 2020): 404-420.e8. https://doi.org/10.1016/j.neuron.2020.01.042.Full Text Link to Item
-
Huang, Qiang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, et al. “Intravital imaging of mouse embryos.” Science 368, no. 6487 (April 10, 2020): 181–86. https://doi.org/10.1126/science.aba0210.Full Text Open Access Copy Link to Item
-
Sheehan, Charles J., John J. McMahon, Lucas D. Serdar, and Debra L. Silver. “Dosage-dependent requirements of Magoh for cortical interneuron generation and survival.” Development 147, no. 1 (January 13, 2020). https://doi.org/10.1242/dev.182295.Full Text Link to Item
-
Alsina, Fernando C., and Debra L. Silver. “Damage Control in the Developing Brain: Tradeoffs and Consequences.” Trends Neurosci 42, no. 10 (October 2019): 661–63. https://doi.org/10.1016/j.tins.2019.08.004.Full Text Link to Item
-
Mitchell-Dick, Aaron, Andrea Chalem, Louis-Jan Pilaz, and Debra L. Silver. “Acute Lengthening of Progenitor Mitosis Influences Progeny Fate during Cortical Development in vivo.” Dev Neurosci 41, no. 5–6 (2019): 300–317. https://doi.org/10.1159/000507113.Full Text Link to Item
-
Risher, W Christopher, Namsoo Kim, Sehwon Koh, Ji-Eun Choi, Petar Mitev, Erin F. Spence, Louis-Jan Pilaz, et al. “Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.” J Cell Biol 217, no. 10 (October 1, 2018): 3747–65. https://doi.org/10.1083/jcb.201802057.Full Text Link to Item
-
Vitali, Ilaria, Sabine Fièvre, Ludovic Telley, Polina Oberst, Sebastiano Bariselli, Laura Frangeul, Natalia Baumann, et al. “Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.” Cell 174, no. 5 (August 23, 2018): 1264-1276.e15. https://doi.org/10.1016/j.cell.2018.06.036.Full Text Link to Item
-
Mitchell, Caitlyn, and Debra L. Silver. “Enhancing our brains: Genomic mechanisms underlying cortical evolution.” Semin Cell Dev Biol 76 (April 2018): 23–32. https://doi.org/10.1016/j.semcdb.2017.08.045.Full Text Link to Item
-
McFadden, Michael J., Aaron Mitchell-Dick, Christine Vazquez, Allison E. Roder, Kevin F. Labagnara, John J. McMahon, Debra L. Silver, and Stacy M. Horner. “A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time.” Viruses 10, no. 2 (February 24, 2018). https://doi.org/10.3390/v10020095.Full Text Link to Item
-
Lennox, Ashley L., Hanqian Mao, and Debra L. Silver. “RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development.” Wiley Interdiscip Rev Dev Biol 7, no. 1 (January 2018). https://doi.org/10.1002/wdev.290.Full Text Link to Item
-
Miller, Emily E., Gerson S. Kobayashi, Camila M. Musso, Miranda Allen, Felipe A. A. Ishiy, Luiz Carlos de Caires, Ernesto Goulart, et al. “EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome.” Hum Mol Genet 26, no. 12 (June 15, 2017): 2177–91. https://doi.org/10.1093/hmg/ddx078.Full Text Link to Item
-
Pilaz, Louis-Jan, and Debra L. Silver. “Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.” Febs Lett 591, no. 11 (June 2017): 1526–39. https://doi.org/10.1002/1873-3468.12626.Full Text Link to Item
-
Mao, Hanqian, Hannah E. Brown, and Debra L. Silver. “Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.” Rna 23, no. 1 (January 2017): 23–31. https://doi.org/10.1261/rna.058826.116.Full Text Link to Item
-
Pilaz, Louis-Jan, Ashley L. Lennox, Jeremy P. Rouanet, and Debra L. Silver. “Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain.” Curr Biol 26, no. 24 (December 19, 2016): 3383–92. https://doi.org/10.1016/j.cub.2016.10.040.Full Text Link to Item
-
McMahon, J. J., E. E. Miller, and D. L. Silver. “The exon junction complex in neural development and neurodevelopmental disease.” Int J Dev Neurosci 55 (December 2016): 117–23. https://doi.org/10.1016/j.ijdevneu.2016.03.006.Full Text Link to Item
-
Roko Rasin, Mladen, and Debra Silver. “The crossroads of RNA regulation and function in neurodevelopment.” Int J Dev Neurosci 55 (December 2016): 101. https://doi.org/10.1016/j.ijdevneu.2016.11.002.Full Text Link to Item
-
Mao, Hanqian, John J. McMahon, Yi-Hsuan Tsai, Zefeng Wang, and Debra L. Silver. “Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.” Plos Genet 12, no. 9 (September 2016): e1006282. https://doi.org/10.1371/journal.pgen.1006282.Full Text Open Access Copy Link to Item
-
Silver, Debra L. “Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex.” Bioessays 38, no. 2 (February 2016): 162–71. https://doi.org/10.1002/bies.201500108.Full Text Link to Item
-
Singh, Sandeep K., Jeff A. Stogsdill, Nisha S. Pulimood, Hayley Dingsdale, Yong Ho Kim, Louis-Jan Pilaz, Il Hwan Kim, et al. “Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.” Cell 164, no. 1–2 (January 14, 2016): 183–96. https://doi.org/10.1016/j.cell.2015.11.034.Full Text Link to Item
-
Pilaz, Louis-Jan, John J. McMahon, Emily E. Miller, Ashley L. Lennox, Aussie Suzuki, Edward Salmon, and Debra L. Silver. “Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.” Neuron 89, no. 1 (January 6, 2016): 83–99. https://doi.org/10.1016/j.neuron.2015.12.007.Full Text Link to Item
-
Mao, Hanqian, Louis-Jan Pilaz, John J. McMahon, Christelle Golzio, Danwei Wu, Lei Shi, Nicholas Katsanis, and Debra L. Silver. “Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.” J Neurosci 35, no. 18 (May 6, 2015): 7003–18. https://doi.org/10.1523/JNEUROSCI.0018-15.2015.Full Text Link to Item
-
Boyd, J Lomax, Stephanie L. Skove, Jeremy P. Rouanet, Louis-Jan Pilaz, Tristan Bepler, Raluca Gordân, Gregory A. Wray, and Debra L. Silver. “Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.” Curr Biol 25, no. 6 (March 16, 2015): 772–79. https://doi.org/10.1016/j.cub.2015.01.041.Full Text Open Access Copy Link to Item
-
Pilaz, Louis-Jan, and Debra L. Silver. “Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain.” Wiley Interdiscip Rev Rna 6, no. 5 (2015): 501–15. https://doi.org/10.1002/wrna.1289.Full Text Link to Item
-
Risher, W Christopher, Sagar Patel, Il Hwan Kim, Akiyoshi Uezu, Srishti Bhagat, Daniel K. Wilton, Louis-Jan Pilaz, et al. “Astrocytes refine cortical connectivity at dendritic spines.” Elife 3 (December 17, 2014). https://doi.org/10.7554/eLife.04047.Full Text Open Access Copy Link to Item
-
McMahon, John J., Lei Shi, and Debra L. Silver. “Generation of a Magoh conditional allele in mice.” Genesis 52, no. 8 (August 2014): 752–58. https://doi.org/10.1002/dvg.22788.Full Text Link to Item
-
Pilaz, Louis-Jan, and Debra L. Silver. “Live imaging of mitosis in the developing mouse embryonic cortex.” J Vis Exp, no. 88 (June 4, 2014). https://doi.org/10.3791/51298.Full Text Link to Item
-
Ruzzo, Elizabeth K., José-Mario Capo-Chichi, Bruria Ben-Zeev, David Chitayat, Hanqian Mao, Andrea L. Pappas, Yuki Hitomi, et al. “Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.” Neuron 80, no. 2 (October 16, 2013): 429–41. https://doi.org/10.1016/j.neuron.2013.08.013.Full Text Link to Item
-
Geisbrecht, Erika R., Ketki Sawant, Ying Su, Ze Cindy Liu, Debra L. Silver, Ashley Burtscher, Xuejiao Wang, Alan Jian Zhu, and Jocelyn A. McDonald. “Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration.” Dev Dyn 242, no. 5 (May 2013): 414–31. https://doi.org/10.1002/dvdy.23926.Full Text Link to Item
-
Silver, Debra L., Karen E. Leeds, Hun-Way Hwang, Emily E. Miller, and William J. Pavan. “The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.” Dev Biol 375, no. 2 (March 15, 2013): 172–81. https://doi.org/10.1016/j.ydbio.2013.01.004.Full Text Link to Item
-
Silver, Debra L., Dawn E. Watkins-Chow, Karisa C. Schreck, Tarran J. Pierfelice, Denise M. Larson, Anthony J. Burnetti, Hung-Jiun Liaw, et al. “The exon junction complex component Magoh controls brain size by regulating neural stem cell division.” Nat Neurosci 13, no. 5 (May 2010): 551–58. https://doi.org/10.1038/nn.2527.Full Text Open Access Copy Link to Item
-
McCulloch, Daniel R., Courtney M. Nelson, Laura J. Dixon, Debra L. Silver, James D. Wylie, Volkhard Lindner, Takako Sasaki, Marion A. Cooley, W Scott Argraves, and Suneel S. Apte. “ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.” Dev Cell 17, no. 5 (November 2009): 687–98. https://doi.org/10.1016/j.devcel.2009.09.008.Full Text Link to Item
-
Matera, Ivana, Dawn E. Watkins-Chow, Stacie K. Loftus, Ling Hou, Arturo Incao, Debra L. Silver, Cecelia Rivas, Eugene C. Elliott, Laura L. Baxter, and William J. Pavan. “A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.” Hum Mol Genet 17, no. 14 (July 15, 2008): 2118–31. https://doi.org/10.1093/hmg/ddn110.Full Text Link to Item
-
Silver, Debra L., Ling Hou, Robert Somerville, Mary E. Young, Suneel S. Apte, and William J. Pavan. “The secreted metalloprotease ADAMTS20 is required for melanoblast survival.” Plos Genet 4, no. 2 (February 29, 2008): e1000003. https://doi.org/10.1371/journal.pgen.1000003.Full Text Open Access Copy Link to Item
-
Silver, D. L., and W. J. Pavan. “The origin and development of neural crest-derived melanocytes,” December 1, 2006, 3–26. https://doi.org/10.1007/978-1-59259-994-3_1.Full Text
-
Silver, Debra L., Ling Hou, and William J. Pavan. “The genetic regulation of pigment cell development.” Adv Exp Med Biol 589 (2006): 155–69. https://doi.org/10.1007/978-0-387-46954-6_9.Full Text Link to Item
-
Silver, Debra L., Erika R. Geisbrecht, and Denise J. Montell. “Requirement for JAK/STAT signaling throughout border cell migration in Drosophila.” Development 132, no. 15 (August 2005): 3483–92. https://doi.org/10.1242/dev.01910.Full Text Link to Item
-
Silver, Debra L., Honami Naora, Jinsong Liu, Wenjun Cheng, and Denise J. Montell. “Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.” Cancer Res 64, no. 10 (May 15, 2004): 3550–58. https://doi.org/10.1158/0008-5472.CAN-03-3959.Full Text Link to Item
-
Silver, Debra L., and Denise J. Montell. “A new trick for Cyclin-Cdk: activation of STAT.” Dev Cell 4, no. 2 (February 2003): 148–49. https://doi.org/10.1016/s1534-5807(03)00028-5.Full Text Link to Item
-
Silver, D. L., and D. J. Montell. “Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.” Cell 107, no. 7 (December 28, 2001): 831–41. https://doi.org/10.1016/s0092-8674(01)00607-9.Full Text Link to Item
-
Tinker, R., D. Silver, and D. J. Montell. “Requirement for the vasa RNA helicase in gurken mRNA localization.” Dev Biol 199, no. 1 (July 1, 1998): 1–10. https://doi.org/10.1006/dbio.1998.8941.Full Text Link to Item
-
Jenkins, A. L., L. Nannizzi-Alaimo, D. Silver, J. R. Sellers, M. H. Ginsberg, D. A. Law, and D. R. Phillips. “Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions.” J Biol Chem 273, no. 22 (May 29, 1998): 13878–85. https://doi.org/10.1074/jbc.273.22.13878.Full Text Link to Item
-
Ford, H. L., D. L. Silver, B. Kachar, J. R. Sellers, and S. B. Zain. “Effect of Mts1 on the structure and activity of nonmuscle myosin II.” Biochemistry 36, no. 51 (December 23, 1997): 16321–27. https://doi.org/10.1021/bi971182l.Full Text Link to Item
-
Silver, D. L., A. V. Vorotnikov, D. M. Watterson, V. P. Shirinsky, and J. R. Sellers. “Sites of interaction between kinase-related protein and smooth muscle myosin.” J Biol Chem 272, no. 40 (October 3, 1997): 25353–59. https://doi.org/10.1074/jbc.272.40.25353.Full Text Link to Item
-
-
Book Sections
-
Alsina, F. C., and D. L. Silver. “Posttranscriptional and translational control of neurogenesis.” In Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, Second Edition, 731–50, 2020. https://doi.org/10.1016/B978-0-12-814405-3.00028-X.Full Text
-
Silver, Debra L., Pasko Rakic, Elizabeth A. Grove, Tarik F. Haydar, Takao K. Hensch, Wieland B. Huttner, Zoltan Molnar, et al. “Evolution and Ontogenetic Development of Cortical Structures.” In NEOCORTEX, 61–93, 2019.Link to Item
-
-
Conference Papers
-
Miller, E. E., A. Suzuki, L. Pilaz, E. D. Salmon, and D. L. Silver. “Elucidating the role of the RNA binding exon junction complex in mitosis.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
-
-
Preprints
-
Jowhar, Ziad, Albert Xu, Srivats Venkataramanan, Mariah L. Hoye, Debra L. Silver, Stephen N. Floor, and Lorenzo Calviello. “A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X.,” May 12, 2023. https://doi.org/10.1101/2023.05.11.540322.Full Text Link to Item
-
Lupan, Bianca M., Rachel A. Solecki, Camila Manso Musso, Fernando C. Alsina, and Debra L. Silver. “The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis.,” January 14, 2023. https://doi.org/10.1101/2023.01.13.524010.Full Text Link to Item
-
Alsina, Fernando, Bianca Lupan, Lydia Lin, Camila Musso, Federica Mosti, Carly Newman, Lisa Wood, Mark Agostino, Jeffrey Moore, and Debra Silver. “The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton.” BioRxiv, 2022. https://doi.org/10.1101/2022.03.18.484888.Full Text
-
D’Arcy, Brooke, Ashley Lennox, Camila Manso Musso, Annalise Bracher, Carla Escobar-Tomlienovich, Stephany Perez-Sanchez, and Debra Silver. “Subcellular proteome of radial glia reveals non-muscle myosins control basal endfeet to mediate interneuron organization.” BioRxiv, 2022. https://doi.org/10.1101/2022.11.18.517018.Full Text
-
Hoye, Mariah, Lorenzo Calviello, Abigail Poff, Nna-Emeka Ejimogu, Carly Newman, Jianhong Ou, Stephen Floor, and Debra Silver. “Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.21.481343.Full Text
-
-
- Teaching & Mentoring
-
Recent Courses
- CMB 710A: Cell & Molecular Biology Module I 2023
- NEUROSCI 493: Research Independent Study 1 2023
- NEUROSCI 494: Research Independent Study 2 2023
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2023
- MGM 593: Research Independent Study 2022
- NEUROSCI 493: Research Independent Study 1 2022
- MGM 293: Research Independent Study I 2021
- MGM 593: Research Independent Study 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- NEUROSCI 496: Research Independent Study 4 2021
- Scholarly, Clinical, & Service Activities
-
Outreach & Engaged Scholarship
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.