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Debra Lynn Silver

Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology

Selected Grants


Roles for uniquely human enhancers in brain development and Wnt signaling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2027

RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2027

A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2023 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Roles for uniquely human enhancers in brain development and Wnt signaling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2027

RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2027

A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2023 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Mechanisms underlying DDX3X pathology in autism spectrum disorder

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2025

Investigating the Role of WNT Signaling Modulation in the Evolution of the Developing Human Cerebral Cortex

FellowshipPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2023 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

The Role of mRNA decay factor CNOT3 in cortical development

FellowshipPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2022 - 2025

Role of ATAD3A in lysosomal homeostasis and neurogenesis

ResearchPrincipal Investigator · Awarded by Oklahoma Medical Research Foundation · 2021 - 2024

Neurobiology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2024

Dynamic control of cortical development and disease by mRNA stability

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

Essential requirements of Eif4a3 in brain development and disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2024

Dysregulation of RNA metabolism and cytoskeleton dynamics during neuronal maturation.

FellowshipMentor · Awarded by Brain and Behavior Research Foundation · 2023 - 2024

Elucidating the molecular pathogenesis of DDX3X missense mutations associated with dominant negative phenotypes in DDX3X-ID

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2023

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome

ResearchMentor · Awarded by National Science Foundation · 2019 - 2023

Cell-based assays to elucidate how DD3X missense mutations influence neural cell fate

ResearchPrincipal Investigator · Awarded by The DDX3X Foundation · 2021 - 2022

The role of an Intellectual Disability gene, DDX3X, in neural progenitors during brain development

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022

Zeiss Lightsheet Upgrade to Expand Imaging Capabilities

EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022

Epitranscriptomic Control of Local Gene Expression in Neural Stem Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

Using mouse models to uncover molecular and cellular impacts of DDX3X mutation

ResearchPrincipal Investigator · Awarded by The DDX3X Foundation · 2020 - 2021

Transmission electron microscope (TEM)

EquipmentMajor User · Awarded by National Institutes of Health · 2019 - 2021

Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7

EquipmentMajor User · Awarded by National Institutes of Health · 2020 - 2021

Uncovering the role of Rho-GTPase in brain development and neural disorders

FellowshipPrincipal Investigator · Awarded by Ruth K. Broad Biomedical Research Foundation · 2020 - 2021

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Post-transcriptional RNA regulation in mammalian neural stem cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2020

Amelioration of neural stem cell defects underlying Zika virus induced microcephaly

ResearchPrincipal Investigator · Awarded by Hartwell Foundation · 2017 - 2020

Role of RNA-binding proteins in neural stem cell biology and disease

FellowshipPrincipal Investigator · Awarded by Ruth K. Broad Biomedical Research Foundation · 2018 - 2019

Control of cell fate by progenitor mitosis length and microcephaly-linked genes during cortical development

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019

Innate Immune Inhibition of the Mevalonate Pathway impairs Neurodevelopment during ZIKv infection

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2019

Zika virus infection of neural stem cells to model pathogen-induced microcephaly

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018

Basic predoctoral training in neuroscience

Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 1992 - 2018

Asymmetric RNA localization in neural stem cells during cortical development

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018

Serial Block Face Scanning Electron Microscope

EquipmentMajor User · Awarded by National Institutes of Health · 2016 - 2018

Dissecting the role of the exon junction complex in embryonic corticogenesis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2017

Analysis of the Exon Junction Complex in Neural Development and Microcephaly

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2013

External Relationships


  • Cold Spring Harbor Labs
  • Company of Biologists
  • Cortical Evolution meeting
  • Gordon Research Conferences
  • University of California Los Angeles
  • Cold Spring Harbor Labs
  • Company of Biologists
  • Cortical Evolution meeting
  • Gordon Research Conferences
  • University of California Los Angeles
  • Washington University in St. Louis
  • european molecular biology organization (EMBO)

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.