Dennis Alfred Clements III

Dennis Alfred Clements III
Professor Emeritus of Pediatrics

1) Vaccine Research - safety, tolerability, and immunogenicity, effectiveness.
2) Infectious Disease Epidemiology - otitis media, day care, outbreaks
3) Cost effectiveness of vaccination strategies.
4)Latino health issues, medical Spanish education, cultural sensitivity.
5) Health Care Delivery Systems - contracting, business plans, access to care, management, finances
6) Health Manpower needs in the third world
7) Education - medical school, nursing school, graduate school and undergraduates
8) Director of Undergraduate Studies, Duke Global Health Institute

Office Hours

call 919-584-7790 or email dennis.clemsnts@duke.edu

Current Appointments & Affiliations

Professor Emeritus of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 2019
Senior Advisor, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2022
Adjunct Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2022

Contact Information

Box 90519, Duke University, Durham, NC 27708-0519
Room 116, Trent Hall, 310 Trent Drive, Durham, NC 27708
dennis.clements@duke.edu (919) 684-7790
DGHI profile

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 1990
- M.P.H., University of North Carolina - Chapel Hill 1988
- M.D., University of Rochester 1973
Previous Appointments & Affiliations
- Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2011 - 2022
- Interim Director, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2020 - 2022
- Professor in Family Medicine and Community Health, Family Medicine and Community Health, Clinical Science Departments 2010 - 2020
- Professor in the School of Nursing, School of Nursing, Duke University 2010 - 2020
- Professor of Medicine, Medicine, Infectious Diseases, Medicine 2004 - 2019
- Professor of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 2002 - 2019
- Chief, Division of Primary Care Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 1995 - 2017
- Professor in the School of Nursing, School of Nursing, Duke University 2008 - 2010
- Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2002 - 2009
- Chief, Medical Officer, Duke Children's Hospital, Pediatrics, Clinical Science Departments 1995 - 2007
- Executive Vice-chair, Clinical Operations, Pediatrics, Clinical Science Departments 2005 - 2007
- Vice-chair, Primary Care Services, Department of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 1997 - 2005
- Vice-chair, Extramural Relations, Department of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 2003 - 2005
- Interim Chair, Department of Pediatrics, Pediatrics, Clinical Science Departments 2004 - 2005
- Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 1999 - 2003
- Associate Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 1999 - 2002
- Associate Professor of Pediatrics with tenure, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 1998 - 2002
- Associate Professor of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 1996 - 1997
- Assistant Professor of Pediatrics, Pediatrics, General Pediatrics and Adolescent Health, Pediatrics 1990 - 1996
Leadership & Clinical Positions at Duke
- Chief, Pediatrics, Primary Care Pediatrics, Pediatrics 1995 - 2017Professor in the School of Nursing, School of Nursing, Duke University 2008 - 2010Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2002 - 2009Chief, Pediatrics, Clinical Science Departments 1995 - 2007Executive Vice-chair, Pediatrics, Clinical Science Departments 2005 - 2007Vice-chair, Pediatrics, Primary Care Pediatrics, Pediatrics 2003 - 2005Interim Chair, Pediatrics, Clinical Science Departments 2004 - 2005Vice-chair, Pediatrics, Primary Care Pediatrics, Pediatrics 1997 - 2005
Recognition
In the News
- JUN 12, 2020
  
  Dennis Clements Named Interim Director for Duke Global Health Institute
- MAY 3, 2015
  
  Global Health Capstones Promote Real-World Problem Solving
- APR 23, 2014
  
  Developing Practical Solutions to Global Health Problems
- MAR 20, 2014 National Journal
  
  Dr. Dennis Clements: Speaking the language of health care
- NOV 6, 2013 Duke Today
  
  Children in Honduras Targeted in 9 out of 10 Television Advertisements for Unhealthy Foods
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Expertise
  - Ghana (Country)
  - Honduras (Country)
- Research
  - Honduras (Country)
  - Kenya (Country)
Research
Selected Grants
- UNC-Duke Consortium Title VI FLAS Fellowships grant awarded by University of North Carolina - Chapel Hill 2018 - 2026
- UNC-Duke Consortium Title VI NRC grant awarded by University of North Carolina - Chapel Hill 2018 - 2022
- RISK Renewal - Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings awarded by University of Michigan 2014 - 2022
- RAPID: Poirot: From Contact Tracing to Private Exposure Detection awarded by National Science Foundation 2020 - 2022
- An open-label, pilot study to compare the safety and immunogenicity of an alternate dosing schedule (2-5 weeks, 2, and 4 months) for pentavalent rotavirus vaccine (RotaTeq) to the standard recommended schedule (2, 4 and 6 months). awarded by Merck Sharp & Dohme 2013 - 2021
- CLACS NRC Title VI awarded by Department of Education 2014 - 2019
- CLACS Title VI FLAS awarded by Department of Education 2014 - 2018
- Tinker Field Research Grants awarded by University of North Carolina - Chapel Hill 2015 - 2017
- Art of Transformation awarded by NC Humanities Council 2014 - 2015
- Title VI National Resource Center and FLAS Fellowships (Latin American Studies) NRC awarded by University of North Carolina - Chapel Hill 2010 - 2014
- National Resource Center awarded by Department of Education 2006 - 2010
- Health of Latino Infants: Interventions to Assure Care awarded by National Institutes of Health 2006 - 2009
External Relationships
- Up To Date Inc/Wolters Kluwer Health
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Saleh, Ezzeldin, Brian Eichner, Douglas W. Clark, Martha E. Gagliano, James M. Troutman, Lynn Harrington, Monica McNeal, and Dennis Clements. “Open-Label Pilot Study to Compare the Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5) Administered on an Early Alternative Dosing Schedule with Those of RV5 Administered on the Recommended Standard Schedule.” J Pediatric Infect Dis Soc 7, no. 1 (February 19, 2018): 82–85. https://doi.org/10.1093/jpids/pix005.
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  - Clements, Dennis. “Vaccination to Prevent Cancer.” N C Med J 77, no. 5 (2016): 337–40. https://doi.org/10.18043/ncm.77.5.337.
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  - Gunderson, Matthew D., Dennis Clements, and Sara E. Benjamin Neelon. “Nutritional quality of foods marketed to children in Honduras.” Appetite 73 (February 2014): 1–6. https://doi.org/10.1016/j.appet.2013.10.009.
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  - Walter, Emmanuel B., and Dennis A. Clements. “Pneumococcal conjugate vaccine: are 3 doses equal to 4 doses?” Pediatrics 132, no. 2 (August 2013): e498–99. https://doi.org/10.1542/peds.2013-1573.
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  - Walter, Emmanuel B., Martha A. Snyder, Dennis A. Clements, and Samuel L. Katz. “Large injection site reactions after a second dose of varicella vaccine.” Pediatr Infect Dis J 27, no. 8 (August 2008): 757–59. https://doi.org/10.1097/INF.0b013e31816fc323.
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  - Woods, Christopher W., Adam M. Bressler, John J. LiPuma, Barbara D. Alexander, Dennis A. Clements, David J. Weber, Christopher M. Moore, L Barth Reller, and Keith S. Kaye. “Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.” Clin Infect Dis 38, no. 9 (May 1, 2004): 1243–50. https://doi.org/10.1086/383313.
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  - Lee, Patrick Y., David B. Matchar, Dennis A. Clements, Joel Huber, John D. Hamilton, and Eric D. Peterson. “Economic analysis of influenza vaccination and antiviral treatment for healthy working adults.” Ann Intern Med 137, no. 4 (August 20, 2002): 225–31. https://doi.org/10.7326/0003-4819-137-4-200208200-00005.
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  - Clements, D. A., J. I. Zaref, C. L. Bland, E. B. Walter, and P. M. Coplan. “Partial uptake of varicella vaccine and the epidemiological effect on varicella disease in 11 day-care centers in North Carolina.” Arch Pediatr Adolesc Med 155, no. 4 (April 2001): 455–61. https://doi.org/10.1001/archpedi.155.4.455.
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  - Clements, D. A. “Varicella vaccination in children.” Biodrugs 14, no. 1 (July 2000): 49–60. https://doi.org/10.2165/00063030-200014010-00005.
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  - Clements, D. A., J. I. Zaref, P. M. Coplan, C. L. Bland, and E. B. Walter. “Decreased incidence of varicella in day care children after the initiation of varicella vaccination: A herd immunity effect?” Clinical Infectious Diseases 31, no. 1 (July 1, 2000): 323–323.
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  - Abraham, B., D. Parenti, S. Frey, R. Dagan, Y. Ashur, X. Q. Chen, J. Ibarra, et al. “Antibody production in response to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine [1] (multiple letters).” Journal of Infectious Diseases 182, no. 3 (2000): 1005–6.
  - Clements, D. A., S. P. Moreira, P. M. Coplan, C. L. Bland, and E. B. Walter. “Postlicensure study of varicella vaccine effectiveness in a day-care setting.” Pediatr Infect Dis J 18, no. 12 (December 1999): 1047–50. https://doi.org/10.1097/00006454-199912000-00004.
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  - Frey, S., R. Dagan, Y. Ashur, X. Q. Chen, J. Ibarra, H. Kollaritsch, M. H. Mazur, et al. “Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.” J Infect Dis 180, no. 6 (December 1999): 2018–22. https://doi.org/10.1086/315119.
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  - Walter, E. B., R. B. Hornick, G. A. Poland, R. Tucker, C. L. Bland, D. A. Clements, C. C. Rhamstine, et al. “Concurrent administration of inactivated hepatitis A vaccine with immune globulin in healthy adults.” Vaccine 17, no. 11–12 (March 17, 1999): 1468–73. https://doi.org/10.1016/s0264-410x(98)00370-3.
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  - Walter, E. B., and D. A. Clements. “Travel consultation for children in a university-affiliated primary care setting.” Pediatr Infect Dis J 17, no. 9 (September 1998): 841–43. https://doi.org/10.1097/00006454-199809000-00021.
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  - Meine, E. K., S. R. Bailey, R. P. Drucker, D. A. Clements, and E. Walter. “Varicella vaccination in a primary care pediatric practice.” Arch Pediatr Adolesc Med 152, no. 6 (June 1998): 608–9.
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  - Rennels, M. B., M. J. Hohenboken, K. S. Reisinger, D. A. Clements, E. B. Walter, M. M. Blatter, J. Nonenmacher, and J. G. Hackell. “Comparison of acellular pertussis-diphtheria-tetanus toxoids and Haemophilus influenzae type b vaccines administered separately vs. combined in younger vs. older toddlers.” Pediatr Infect Dis J 17, no. 2 (February 1998): 164–66. https://doi.org/10.1097/00006454-199802000-00019.
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  - Walter, E., J. Sung, E. Kahn Meine, R. P. Drucker, and D. A. Clements. “Lack of effectiveness of a letter reminder for annual influenza immunization of asthmatic children.” Pediatr Infect Dis J 16, no. 12 (December 1997): 1187–88. https://doi.org/10.1097/00006454-199712000-00022.
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  - Walter, E. B., S. S. Simmons, C. L. Bland, and D. A. Clements. “Modified varicella-like syndrome in children previously vaccinated with live attenuated measles, mumps, rubella and varicella vaccine.” Pediatr Infect Dis J 16, no. 6 (June 1997): 626–27. https://doi.org/10.1097/00006454-199706000-00016.
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  - Clements, D. A. “Modified varicella-like syndrome.” Infect Dis Clin North Am 10, no. 3 (September 1996): 617–29. https://doi.org/10.1016/s0891-5520(05)70317-2.
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  - Clements, D. A. “Influenza A Vaccine and the Incidence of Otitis Media-Reply.” Archives of Pediatrics &Amp; Adolescent Medicine 150, no. 6 (January 1, 1996): 653. https://doi.org/10.1001/archpedi.1996.02170310087025.
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  - Ngai, A. L., B. O. Staehle, B. J. Kuter, N. M. Cyanovich, I. Cho, H. Matthews, P. Keller, A. M. Arvin, B. Watson, and C. J. White. “Safety and immunogenicity of one vs. two injections of Oka/Merck varicella vaccine in healthy children.” Pediatr Infect Dis J 15, no. 1 (January 1996): 49–54. https://doi.org/10.1097/00006454-199601000-00011.
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  - Combs, S. P., E. B. Walter, R. P. Drucker, and D. A. Clements. “Removing a major barrier to universal hepatitis B immunization in infants.” Arch Pediatr Adolesc Med 150, no. 1 (January 1996): 112–14. https://doi.org/10.1001/archpedi.1996.02170260116024.
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  - Clements, D. A., K. A. Weigle, and G. L. Gilbert. “A case-control study examining risk factors for invasive Haemophilus influenzae type b disease in Victoria, Australia 1988-90.” J Paediatr Child Health 31, no. 6 (December 1995): 513–18. https://doi.org/10.1111/j.1440-1754.1995.tb00874.x.
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  - Clements, D. A., C. B. Armstrong, A. M. Ursano, M. M. Moggio, E. B. Walter, and C. M. Wilfert. “Over five-year follow-up of Oka/Merck varicella vaccine recipients in 465 infants and adolescents.” Pediatr Infect Dis J 14, no. 10 (October 1995): 874–79. https://doi.org/10.1097/00006454-199510000-00011.
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  - Clements, D. A., L. Langdon, C. Bland, and E. Walter. “Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care.” Arch Pediatr Adolesc Med 149, no. 10 (October 1995): 1113–17. https://doi.org/10.1001/archpedi.1995.02170230067009.
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  - Watson, B., E. Rothstein, H. Bernstein, A. Arbeter, A. Arvin, S. Chartrand, D. Clements, M. L. Kumar, K. Reisinger, and M. Blatter. “Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.” J Infect Dis 172, no. 1 (July 1995): 217–19. https://doi.org/10.1093/infdis/172.1.217.
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  - Jones, S. E., C. B. Armstrong, C. Bland, E. B. Walter, and D. A. Clements. “Varicella prevalence in day-care centers.” Pediatr Infect Dis J 14, no. 5 (May 1995): 404–5. https://doi.org/10.1097/00006454-199505000-00021.
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  - Walter, E. B., A. J. Elliott, A. N. Regan, R. P. Drucker, D. A. Clements, and C. M. Wilfert. “Maternal acceptance of voluntary human immunodeficiency virus antibody testing during the newborn period with the Guthrie card.” Pediatr Infect Dis J 14, no. 5 (May 1995): 376–81. https://doi.org/10.1097/00006454-199505000-00008.
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  - Gilbert, G. L., P. D. Johnson, and D. A. Clements. “Clinical manifestations and outcome of Haemophilus influenzae type b disease.” J Paediatr Child Health 31, no. 2 (April 1995): 99–104. https://doi.org/10.1111/j.1440-1754.1995.tb00755.x.
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  - Clements, D. A. “Cost of treatment and prevention of Haemophilus influenzae type b disease. An international perspective.” Pharmacoeconomics 6, no. 5 (November 1994): 442–52. https://doi.org/10.2165/00019053-199406050-00006.
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  - Walter, E. B., S. S. Simmons, and D. A. Clements. “Anti-polyribosylribitol phosphate antibody levels 5 years after a primary series of Haemophilus influenzae type B conjugate vaccine.” J Infect Dis 170, no. 4 (October 1994): 1050–51. https://doi.org/10.1093/infdis/170.4.1050.
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  - Walter, E. B., R. P. Drucker, and D. A. Clements. “A major barrier to universal hepatitis B immunization of infants.” Arch Pediatr Adolesc Med 148, no. 5 (May 1994): 538–39. https://doi.org/10.1001/archpedi.1994.02170050096023.
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  - Gilbert, G. L., and D. A. Clements. “Distribution of Haemophilus influenzae type b outer membrane protein subtypes in different ethnic groups in Australia.” J Infect Dis 168, no. 1 (July 1993): 255. https://doi.org/10.1093/infdis/168.1.255.
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  - Clements, D. A., J. K. Wang, C. A. Dionne, and M. Goldfarb. “Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.” Oncogene 8, no. 5 (May 1993): 1311–16.
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  - Clements, D. A., R. Booy, R. Dagan, G. L. Gilbert, E. R. Moxon, M. P. Slack, A. Takala, H. P. Zimmermann, P. L. Zuber, and J. Eskola. “Comparison of the epidemiology and cost of Haemophilus influenzae type b disease in five western countries.” Pediatr Infect Dis J 12, no. 5 (May 1993): 362–67. https://doi.org/10.1097/00006454-199305000-00002.
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  - Clements, D. A., I. Guise, and A. Sherry. “Day care in Victoria.” J Paediatr Child Health 29, no. 1 (February 1993): 71. https://doi.org/10.1111/j.1440-1754.1993.tb00447.x.
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  - Clements, D. A., and S. L. Katz. “Varicella in a susceptible pregnant woman.” Curr Clin Top Infect Dis 13 (1993): 123–30.
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  - Clements, D. A., S. J. MacInnes, and G. L. Gilbert. “Outer membrane protein subtypes of Haemophilus influenzae type b isolates causing invasive disease in Victoria, Australia, from 1988 to 1990.” J Clin Microbiol 30, no. 7 (July 1992): 1879–81. https://doi.org/10.1128/jcm.30.7.1879-1881.1992.
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  - Clements, D. A., I. A. Guise, S. J. MacInnes, and G. L. Gilbert. “Haemophilus influenzae type b infections in Victoria, Australia, 1985-1989.” J Infect Dis 165 Suppl 1 (June 1992): S33–34. https://doi.org/10.1093/infdis/165-supplement_1-s33.
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  - Takala, A. K., and D. A. Clements. “Socioeconomic risk factors for invasive Haemophilus influenzae type b disease.” J Infect Dis 165 Suppl 1 (June 1992): S11–15. https://doi.org/10.1093/infdis/165-supplement_1-s11.
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  - Clements, D. A. “Ear disease in three aboriginal communities in Western Australia.” Med J Aust 154, no. 7 (April 1, 1991): 491.
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  - Clements, D. A., and G. L. Gilbert. “Immunisation for the prevention of Haemophilus influenzae type b infections: a review.” Aust N Z J Med 20, no. 6 (December 1990): 828–34. https://doi.org/10.1111/j.1445-5994.1990.tb00435.x.
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  - Clements, D. A., C. M. Wilfert, J. N. MacCormack, K. A. Weigle, and F. W. Denny. “Pertussis immunization in eight-month-old children in North Carolina.” Am J Public Health 80, no. 6 (June 1990): 734–36. https://doi.org/10.2105/ajph.80.6.734.
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  - Clements, D. A., and G. L. Gilbert. “Immunization against Haemophilus influenzae.” Med J Aust 152, no. 8 (April 16, 1990): 397–98. https://doi.org/10.5694/j.1326-5377.1990.tb125265.x.
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  - Gilbert, G. L., D. A. Clements, and S. J. Broughton. “Haemophilus influenzae type b infections in Victoria, Australia, 1985 to 1987.” Pediatr Infect Dis J 9, no. 4 (April 1990): 252–57. https://doi.org/10.1097/00006454-199004000-00006.
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  - Clements, D. A., J. B. Rouse, W. L. London, W. S. Yancy, M. V. Moggio, and C. M. Wilfert. “Antibody response of 18 month old children 1 month and 18 months following Haemophilus influenzae type b vaccine administered singly or with DTP vaccine.” J Paediatr Child Health 26, no. 1 (February 1990): 46–49. https://doi.org/10.1111/j.1440-1754.1990.tb02378.x.
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  - Clements, D. A., and G. L. Gilbert. “Increase in admissions for Neisseria meningitidis infection in Australia.” Lancet 2, no. 8677 (December 16, 1989): 1464. https://doi.org/10.1016/s0140-6736(89)92078-3.
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  - Clements, D. A. “Problems of deaf children and their parents.” Med J Aust 2, no. 5 (August 3, 1968): 240–41.
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  - Clements, D. A. “Otitis media and hearing loss in a small aboriginal community.” Med J Aust 1, no. 16 (April 20, 1968): 665–67. https://doi.org/10.5694/j.1326-5377.1968.tb29015.x.
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- Book Sections
  - Relf, M. V., nick Hudak, and dennis Clements. “International Clinical Education.” In The Health Professions Educator A Practical Guide for New and Established Faculty, 151–65. New York, NY: Springer Publishing Company, 2017.
- Conference Papers
  - Rennels, M. B., D. A. Clements, K. S. Reisinger, M. J. Hohenboken, J. Nonenmacher, and J. G. Hackell. “Anti-PRP responses induced by DTaP and HbOC administered concurrently versus combined in children <15 months versus >=15 months.” In Pediatric Research, 39:1081–1081. WILLIAMS & WILKINS, 1996.
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  - CLEMENTS, D. A., J. B. ROUSE, W. L. LONDON, W. S. YANCY, M. V. MOGGIO, J. SCHNEIDER, L. RADICK, J. KUO, and C. M. WILFERT. “HAEMOPHILUS-B (HIB) VACCINE IN INFANTS.” In Pediatric Research, 20:A307–A307. WILLIAMS & WILKINS, 1986.
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  - WILFERT, C. M., M. V. MOGGIO, B. J. NEFF, W. L. LONDON, J. B. ROUSE, W. S. YANCY, and D. A. CLEMENTS. “OKA MERCK VARICELLA VACCINE IMMUNOGENICITY TRIAL IN NORMAL INFANTS.” In Pediatric Research, 20:A323–A323. WILLIAMS & WILKINS, 1986.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

In the News

Awards & Honors

Subject Headings

Global Scholarship

Expertise

Research

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses

Outreach & Engaged Scholarship