Scholars@Duke
Dennis Alfred Clements III

Dennis Alfred Clements III

Professor Emeritus of Pediatrics
Pediatrics, General Pediatrics and Adolescent Health
dennis.clements@duke.edu
Box 90519, Duke University, Durham, NC 27708-0519
Room 116, Trent Hall, 310 Trent Drive, Durham, NC 27708
Office hours call 919-584-7790 or email dennis.clemsnts@duke.edu  

Selected Publications

Open-Label Pilot Study to Compare the Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5) Administered on an Early Alternative Dosing Schedule with Those of RV5 Administered on the Recommended Standard Schedule.

Journal Article J Pediatric Infect Dis Soc · February 19, 2018 This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5) administered on an alternative schedule (initiated at 2-5 weeks of age) with those of RV5 administered on the recommended standard schedule. Our findings support the f ... Full text Link to item Cite

International Clinical Education.

Chapter · August 28, 2017 Provides one-of-a-kind, in-depth guidance for improving effectiveness in the classroom This is the only book for new and midcareer faculty that delivers practical, evidence-based strategies for physician assistants, nurse practitioners, and ... ... Cite

Vaccination to Prevent Cancer.

Journal Article N C Med J · 2016 Vaccines stimulate the immune system, mimicking infectious attacks and thereby promoting the development of protective antibodies and/or cellular immunity so that the body is immune to infection when live native infections attack. Some of these infections ... Full text Link to item Cite

Nutritional quality of foods marketed to children in Honduras.

Journal Article Appetite · February 2014 Evidence suggests that exposure to advertising of unhealthy foods may contribute to increased rates of obesity in children. This study examined the extent to which television stations marketed unhealthy foods to children during after-school programming air ... Full text Link to item Cite

Large injection site reactions after a second dose of varicella vaccine.

Journal Article Pediatr Infect Dis J · August 2008 A second dose of varicella vaccine is routinely recommended. We report 2 cases of large local reactions after receipt of a second dose of varicella vaccine administered in the thigh. The reactions resolved with symptomatic therapy. Clinicians should contin ... Full text Link to item Cite

Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.

Journal Article Clin Infect Dis · May 1, 2004 The Burkholderia cepacia complex includes 9 genomovars. The relative virulence of each is unknown. Host and pathogen features associated with mortality were evaluated among patients with B. cepacia complex bacteremia. Cases were ascertained through review ... Full text Link to item Cite

Economic analysis of influenza vaccination and antiviral treatment for healthy working adults.

Journal Article Ann Intern Med · August 20, 2002 Featured Publication BACKGROUND: Physicians have several treatment options for influenza, including vaccination and various antiviral therapies. However, the optimal influenza prevention and treatment strategy is unknown. OBJECTIVE: To compare the relative health values of con ... Full text Link to item Cite

Partial uptake of varicella vaccine and the epidemiological effect on varicella disease in 11 day-care centers in North Carolina.

Journal Article Arch Pediatr Adolesc Med · April 2001 Featured Publication BACKGROUND: The increasing use of varicella vaccine in children attending day care has rapidly decreased the incidence of wild-type varicella disease. The herd immunity noted is significant and will have an effect on the epidemiology of natural varicella. ... Full text Link to item Cite

Varicella vaccination in children.

Journal Article BioDrugs · July 2000 Varicella vaccines have been developed, studied, tested and used since the early 1970s, first in Japan and subsequently in Europe, the US, Asia and South and Central America. Varicella vaccination was first used to immunise Japanese children in cancer remi ... Full text Link to item Cite

Postlicensure study of varicella vaccine effectiveness in a day-care setting.

Journal Article Pediatr Infect Dis J · December 1999 BACKGROUND: Varicella vaccine has been licensed for use in the United States since the spring of 1995. The acceptance of the vaccine and its effect on varicella incidence in children is important. AIM: To document the effectiveness of the varicella vaccine ... Full text Link to item Cite

Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.

Journal Article J Infect Dis · December 1999 A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and ... Full text Link to item Cite

Concurrent administration of inactivated hepatitis A vaccine with immune globulin in healthy adults.

Journal Article Vaccine · March 17, 1999 Featured Publication 301 healthy adult volunteers were randomized to one of three treatment groups: inactivated hepatitis A vaccine alone; inactivated hepatitis A vaccine with immune globulin (Ig) concurrently; or Ig alone. The first two treatment groups received a second dose ... Full text Link to item Cite

Varicella vaccination in a primary care pediatric practice.

Journal Article Arch Pediatr Adolesc Med · June 1998 Link to item Cite

Modified varicella-like syndrome.

Journal Article Infect Dis Clin North Am · September 1996 After incidental exposure to natural varicella, up to 18% of vaccinees reported a breakthrough infection known as modified varicella-like syndrome (MVLS) over up to 10 years of postvaccination follow-up, compared with natural varicella occurring in similar ... Full text Link to item Cite

Safety and immunogenicity of one vs. two injections of Oka/Merck varicella vaccine in healthy children.

Journal Article Pediatr Infect Dis J · January 1996 OBJECTIVE: To compare the safety and immunogenicity of a one- vs. two-dose regimen of Oka/Merck varicella vaccine in approximately 2000 healthy children 12 months to 12 years of age. METHODOLOGY: Subjects with a negative history of varicella were randomize ... Full text Link to item Cite

Influenza A Vaccine and the Incidence of Otitis Media-Reply

Journal Article Archives of Pediatrics & Adolescent Medicine · January 1, 1996 Full text Cite

A case-control study examining risk factors for invasive Haemophilus influenzae type b disease in Victoria, Australia 1988-90.

Journal Article J Paediatr Child Health · December 1995 Featured Publication OBJECTIVE: To determine whether day-care attendance was a risk factor for Haemophilus influenzae type b (Hib) disease, particularly for epiglottitis. METHODOLOGY: A case-control analysis of risk factors for invasive Hib disease was performed in Victoria, A ... Full text Link to item Cite

Over five-year follow-up of Oka/Merck varicella vaccine recipients in 465 infants and adolescents.

Journal Article Pediatr Infect Dis J · October 1995 Featured Publication A total of 465 healthy infants and adolescents ages 12 months to 17 years without a known history of varicella or recent exposure to varicella-zoster virus VZV were immunized with live attenuated Oka/Merck varicella vaccine from November, 1984, through Apr ... Full text Link to item Cite

Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care.

Journal Article Arch Pediatr Adolesc Med · October 1995 Featured Publication OBJECTIVE: To determine if the use of influenza vaccine in children in day care decreases the incidence of otitis media during the influenza season. DESIGN: Prospective cohort study. SETTING: Eight day-care centers in North Carolina. PARTICIPANTS: One hund ... Full text Link to item Cite

Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.

Journal Article J Infect Dis · July 1995 Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing approximately 3300 pfu of virus. Of the subjects, 99% (4 ... Full text Link to item Cite

Varicella prevalence in day-care centers.

Journal Article Pediatr Infect Dis J · May 1995 Full text Link to item Cite

Maternal acceptance of voluntary human immunodeficiency virus antibody testing during the newborn period with the Guthrie card.

Journal Article Pediatr Infect Dis J · May 1995 In order to provide the opportunity for women delivering newborns to have human immunodeficiency virus (HIV) testing we piloted a hospital-based voluntary HIV testing program during the newborn period using the Guthrie card. During the study period 789 wom ... Full text Link to item Cite

Clinical manifestations and outcome of Haemophilus influenzae type b disease.

Journal Article J Paediatr Child Health · April 1995 OBJECTIVE: To document clinical manifestations, laboratory findings and outcome of childhood Haemophilus influenzae type b (Hib) infections. METHODOLOGY: Medical records of 235 children with Hib disease admitted to hospital during a 2 year period were revi ... Full text Link to item Cite

Cost of treatment and prevention of Haemophilus influenzae type b disease. An international perspective.

Journal Article Pharmacoeconomics · November 1994 On the basis of immunogenicity and protective efficacy studies, 4 Haemophilus influenzae type b (Hib) conjugate vaccines have been licensed for administration to infants and children. Population based studies of Hib disease from Australia, Chile, Finland, ... Full text Link to item Cite

Comparison of the epidemiology and cost of Haemophilus influenzae type b disease in five western countries.

Journal Article Pediatr Infect Dis J · May 1993 Featured Publication To determine and compare the cost of Haemophilus influenzae type b (Hib) disease in Australia, Finland, Israel, Switzerland and the United Kingdom a collaborative study was undertaken. The incidence of Hib disease varies in these 5 countries from 34 to 58. ... Full text Link to item Cite

Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.

Journal Article Oncogene · May 1993 We have purified biologically active recombinant human fibroblast growth factor 5 (FGF-5) from Escherichia coli. In the presence of heparin, recombinant FGF-5 is as active as native growth factor, demonstrating that glycosylation does not significantly pot ... Link to item Cite

Day care in Victoria.

Journal Article J Paediatr Child Health · February 1993 Full text Link to item Cite

Varicella in a susceptible pregnant woman.

Journal Article Curr Clin Top Infect Dis · 1993 Link to item Cite

Outer membrane protein subtypes of Haemophilus influenzae type b isolates causing invasive disease in Victoria, Australia, from 1988 to 1990.

Journal Article J Clin Microbiol · July 1992 Outer membrane protein subtyping of 187 isolates of Haemophilus influenzae type b (Hib), isolated from children with invasive Hib disease in Victoria, Australia, showed that a single outer membrane protein subtype (1VA) was responsible for 83% of the infec ... Full text Link to item Cite

Socioeconomic risk factors for invasive Haemophilus influenzae type b disease.

Journal Article J Infect Dis · June 1992 Featured Publication Socioeconomic risk factors for primary invasive Haemophilus influenzae type b (Hib) disease include factors that increase exposure to Hib (day care attendance, presence of siblings, and crowded households) and factors that increase an individual's suscepti ... Full text Link to item Cite

Pertussis immunization in eight-month-old children in North Carolina.

Journal Article Am J Public Health · June 1990 Featured Publication Between 1984 and 1987 reported pertussis cases in North Carolina increased threefold. Pertussis immunization rates were examined for those years in three one-year cohorts drawn from a random selection of North Carolina birth records. The percentage of chil ... Full text Link to item Cite

Immunization against Haemophilus influenzae.

Journal Article Med J Aust · April 16, 1990 Full text Link to item Cite

Haemophilus influenzae type b infections in Victoria, Australia, 1985 to 1987.

Journal Article Pediatr Infect Dis J · April 1990 Invasive Haemophilus influenzae type b (HIB) infections occurring from 1985 to 1987 in children younger than 16 years of age living in the state of Victoria were reviewed. There were 547 cases which fulfilled the case definition, including 231 cases of men ... Full text Link to item Cite

Antibody response of 18 month old children 1 month and 18 months following Haemophilus influenzae type b vaccine administered singly or with DTP vaccine.

Journal Article J Paediatr Child Health · February 1990 Seventy-six children (aged 17-19 months) received 10 micrograms of Haemophilus influenzae type b polyribosyl-ribitol phosphate (PRP) vaccine, diluted with either phosphate-buffered saline (PBS) or diphtheria-tetanus-pertussis (DTP) vaccine, in a single-bli ... Full text Link to item Cite

HAEMOPHILUS-B (HIB) VACCINE IN INFANTS

Conference PEDIATRIC RESEARCH · April 1, 1986 Link to item Cite

Problems of deaf children and their parents.

Journal Article Med J Aust · August 3, 1968 Link to item Cite